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Fusion Protein:KMT2C-DENND2A |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: KMT2C-DENND2A | FusionPDB ID: 43241 | FusionGDB2.0 ID: 54202 | Hgene | Tgene | Gene symbol | KMT2C | DENND2A | Gene ID | 58508 | 27147 |
Gene name | lysine methyltransferase 2C | DENN domain containing 2A | |
Synonyms | HALR|KLEFS2|MLL3 | FAM31D|KIAA1277 | |
Cytomap | 7q36.1 | 7q34 | |
Type of gene | protein-coding | protein-coding | |
Description | histone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage le | DENN domain-containing protein 2ADENN/MADD domain containing 2A | |
Modification date | 20200320 | 20200313 | |
UniProtAcc | Q8NEZ4 | Q9ULE3 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000262189, ENST00000355193, ENST00000485241, ENST00000485655, | ENST00000275884, ENST00000492720, ENST00000496613, ENST00000537639, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 26 X 23 X 12=7176 | 9 X 7 X 8=504 |
# samples | 32 | 11 | |
** MAII score | log2(32/7176*10)=-4.4870360800319 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(11/504*10)=-2.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: KMT2C [Title/Abstract] AND DENND2A [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KMT2C(152132711)-DENND2A(140255513), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | KMT2C | GO:0097692 | histone H3-K4 monomethylation | 26324722 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | UCEC | TCGA-FI-A2D2-01A | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000262189 | KMT2C | chr7 | 152132711 | - | ENST00000275884 | DENND2A | chr7 | 140255513 | - | 1738 | 380 | 431 | 1450 | 339 |
ENST00000262189 | KMT2C | chr7 | 152132711 | - | ENST00000537639 | DENND2A | chr7 | 140255513 | - | 1728 | 380 | 431 | 1450 | 339 |
ENST00000262189 | KMT2C | chr7 | 152132711 | - | ENST00000496613 | DENND2A | chr7 | 140255513 | - | 1694 | 380 | 431 | 1450 | 339 |
ENST00000262189 | KMT2C | chr7 | 152132711 | - | ENST00000492720 | DENND2A | chr7 | 140255513 | - | 1788 | 380 | 1457 | 744 | 237 |
ENST00000355193 | KMT2C | chr7 | 152132711 | - | ENST00000275884 | DENND2A | chr7 | 140255513 | - | 1738 | 380 | 431 | 1450 | 339 |
ENST00000355193 | KMT2C | chr7 | 152132711 | - | ENST00000537639 | DENND2A | chr7 | 140255513 | - | 1728 | 380 | 431 | 1450 | 339 |
ENST00000355193 | KMT2C | chr7 | 152132711 | - | ENST00000496613 | DENND2A | chr7 | 140255513 | - | 1694 | 380 | 431 | 1450 | 339 |
ENST00000355193 | KMT2C | chr7 | 152132711 | - | ENST00000492720 | DENND2A | chr7 | 140255513 | - | 1788 | 380 | 1457 | 744 | 237 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000262189 | ENST00000275884 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.018605674 | 0.9813943 |
ENST00000262189 | ENST00000537639 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.01883899 | 0.98116106 |
ENST00000262189 | ENST00000496613 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.019258669 | 0.9807413 |
ENST00000262189 | ENST00000492720 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.20899737 | 0.79100263 |
ENST00000355193 | ENST00000275884 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.018605674 | 0.9813943 |
ENST00000355193 | ENST00000537639 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.01883899 | 0.98116106 |
ENST00000355193 | ENST00000496613 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.019258669 | 0.9807413 |
ENST00000355193 | ENST00000492720 | KMT2C | chr7 | 152132711 | - | DENND2A | chr7 | 140255513 | - | 0.20899737 | 0.79100263 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >43241_43241_1_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000275884_length(amino acids)=339AA_BP=0 MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK -------------------------------------------------------------- >43241_43241_2_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000492720_length(amino acids)=237AA_BP= MRWNVILLLRLECNGAISAHCSLCLLGSSDSCTSASQVAGVTSTSHHDWLIFVSLVETEFHHVGQAGLELLTSGDPPASASRSARITGMS HRAWPSFICGGRREGLPLLPKLECSGEISAHCNVHLPGSIDSRASASQVAGITSVGHHGWLIFLFLVETEFHHVAQAGLELLVSSDPPTS -------------------------------------------------------------- >43241_43241_3_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000496613_length(amino acids)=339AA_BP=0 MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK -------------------------------------------------------------- >43241_43241_4_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000537639_length(amino acids)=339AA_BP=0 MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK -------------------------------------------------------------- >43241_43241_5_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000275884_length(amino acids)=339AA_BP=0 MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK -------------------------------------------------------------- >43241_43241_6_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000492720_length(amino acids)=237AA_BP= MRWNVILLLRLECNGAISAHCSLCLLGSSDSCTSASQVAGVTSTSHHDWLIFVSLVETEFHHVGQAGLELLTSGDPPASASRSARITGMS HRAWPSFICGGRREGLPLLPKLECSGEISAHCNVHLPGSIDSRASASQVAGITSVGHHGWLIFLFLVETEFHHVAQAGLELLVSSDPPTS -------------------------------------------------------------- >43241_43241_7_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000496613_length(amino acids)=339AA_BP=0 MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK -------------------------------------------------------------- >43241_43241_8_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000537639_length(amino acids)=339AA_BP=0 MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:152132711/chr7:140255513) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
KMT2C | DENND2A |
FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}. | FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 34_46 | 53.666666666666664 | 4912.0 | DNA binding | Note=A.T hook |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 34_46 | 53.666666666666664 | 4969.0 | DNA binding | Note=A.T hook |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000275884 | 9 | 19 | 737_870 | 653.0 | 1010.0 | Domain | cDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000275884 | 9 | 19 | 872_969 | 653.0 | 1010.0 | Domain | dDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000492720 | 9 | 13 | 737_870 | 653.0 | 796.0 | Domain | cDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000492720 | 9 | 13 | 872_969 | 653.0 | 796.0 | Domain | dDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000496613 | 10 | 20 | 737_870 | 653.0 | 1010.0 | Domain | cDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000496613 | 10 | 20 | 872_969 | 653.0 | 1010.0 | Domain | dDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000537639 | 8 | 18 | 737_870 | 653.0 | 1010.0 | Domain | cDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000537639 | 8 | 18 | 872_969 | 653.0 | 1010.0 | Domain | dDENN |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 1338_1366 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 1754_1787 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 3054_3081 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 3173_3272 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 3391_3433 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 644_672 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 92_112 | 53.666666666666664 | 4912.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 1338_1366 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 1754_1787 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 3054_3081 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 3173_3272 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 3391_3433 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 644_672 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 92_112 | 53.666666666666664 | 4969.0 | Coiled coil | Ontology_term=ECO:0000255 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 1719_1796 | 53.666666666666664 | 4912.0 | Compositional bias | Note=Gln-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 1834_2281 | 53.666666666666664 | 4912.0 | Compositional bias | Note=Pro-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 2412_2630 | 53.666666666666664 | 4912.0 | Compositional bias | Note=Pro-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 2690_2786 | 53.666666666666664 | 4912.0 | Compositional bias | Note=Asp-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 3012_3509 | 53.666666666666664 | 4912.0 | Compositional bias | Note=Gln-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 3277_3381 | 53.666666666666664 | 4912.0 | Compositional bias | Note=Pro-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 1719_1796 | 53.666666666666664 | 4969.0 | Compositional bias | Note=Gln-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 1834_2281 | 53.666666666666664 | 4969.0 | Compositional bias | Note=Pro-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 2412_2630 | 53.666666666666664 | 4969.0 | Compositional bias | Note=Pro-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 2690_2786 | 53.666666666666664 | 4969.0 | Compositional bias | Note=Asp-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 3012_3509 | 53.666666666666664 | 4969.0 | Compositional bias | Note=Gln-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 3277_3381 | 53.666666666666664 | 4969.0 | Compositional bias | Note=Pro-rich |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 436_489 | 53.666666666666664 | 4912.0 | Domain | DHHC |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4545_4605 | 53.666666666666664 | 4912.0 | Domain | FYR N-terminal |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4606_4691 | 53.666666666666664 | 4912.0 | Domain | FYR C-terminal |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4771_4887 | 53.666666666666664 | 4912.0 | Domain | SET |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4895_4911 | 53.666666666666664 | 4912.0 | Domain | Post-SET |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 436_489 | 53.666666666666664 | 4969.0 | Domain | DHHC |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4545_4605 | 53.666666666666664 | 4969.0 | Domain | FYR N-terminal |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4606_4691 | 53.666666666666664 | 4969.0 | Domain | FYR C-terminal |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4771_4887 | 53.666666666666664 | 4969.0 | Domain | SET |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4895_4911 | 53.666666666666664 | 4969.0 | Domain | Post-SET |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4848_4849 | 53.666666666666664 | 4912.0 | Region | S-adenosyl-L-methionine binding |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4848_4849 | 53.666666666666664 | 4969.0 | Region | S-adenosyl-L-methionine binding |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 1007_1057 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 6 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 1084_1139 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 7 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 227_262 | 53.666666666666664 | 4912.0 | Zinc finger | C2HC pre-PHD-type 1%3B degenerate |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 283_331 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 1 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 341_391 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 2 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 344_389 | 53.666666666666664 | 4912.0 | Zinc finger | RING-type |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 388_438 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 3 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4399_4439 | 53.666666666666664 | 4912.0 | Zinc finger | C2HC pre-PHD-type 2 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 4460_4507 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 8 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 464_520 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 4 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000262189 | - | 1 | 59 | 957_1010 | 53.666666666666664 | 4912.0 | Zinc finger | PHD-type 5 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 1007_1057 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 6 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 1084_1139 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 7 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 227_262 | 53.666666666666664 | 4969.0 | Zinc finger | C2HC pre-PHD-type 1%3B degenerate |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 283_331 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 1 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 341_391 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 2 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 344_389 | 53.666666666666664 | 4969.0 | Zinc finger | RING-type |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 388_438 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 3 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4399_4439 | 53.666666666666664 | 4969.0 | Zinc finger | C2HC pre-PHD-type 2 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 4460_4507 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 8 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 464_520 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 4 |
Hgene | KMT2C | chr7:152132711 | chr7:140255513 | ENST00000355193 | - | 1 | 60 | 957_1010 | 53.666666666666664 | 4969.0 | Zinc finger | PHD-type 5 |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000275884 | 9 | 19 | 566_715 | 653.0 | 1010.0 | Domain | uDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000492720 | 9 | 13 | 566_715 | 653.0 | 796.0 | Domain | uDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000496613 | 10 | 20 | 566_715 | 653.0 | 1010.0 | Domain | uDENN | |
Tgene | DENND2A | chr7:152132711 | chr7:140255513 | ENST00000537639 | 8 | 18 | 566_715 | 653.0 | 1010.0 | Domain | uDENN |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
KMT2C | |
DENND2A |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to KMT2C-DENND2A |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KMT2C-DENND2A |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |