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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KMT2C-DENND2A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KMT2C-DENND2A
FusionPDB ID: 43241
FusionGDB2.0 ID: 54202
HgeneTgene
Gene symbol

KMT2C

DENND2A

Gene ID

58508

27147

Gene namelysine methyltransferase 2CDENN domain containing 2A
SynonymsHALR|KLEFS2|MLL3FAM31D|KIAA1277
Cytomap

7q36.1

7q34

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage leDENN domain-containing protein 2ADENN/MADD domain containing 2A
Modification date2020032020200313
UniProtAcc

Q8NEZ4

Q9ULE3

Ensembl transtripts involved in fusion geneENST idsENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000275884, ENST00000492720, 
ENST00000496613, ENST00000537639, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 23 X 12=71769 X 7 X 8=504
# samples 3211
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/504*10)=-2.19592020997526
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KMT2C [Title/Abstract] AND DENND2A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2C(152132711)-DENND2A(140255513), # samples:1
Anticipated loss of major functional domain due to fusion event.KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-DENND2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DENND2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A2D2-01AKMT2Cchr7

152132711

-DENND2Achr7

140255513

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000262189KMT2Cchr7152132711-ENST00000275884DENND2Achr7140255513-17383804311450339
ENST00000262189KMT2Cchr7152132711-ENST00000537639DENND2Achr7140255513-17283804311450339
ENST00000262189KMT2Cchr7152132711-ENST00000496613DENND2Achr7140255513-16943804311450339
ENST00000262189KMT2Cchr7152132711-ENST00000492720DENND2Achr7140255513-17883801457744237
ENST00000355193KMT2Cchr7152132711-ENST00000275884DENND2Achr7140255513-17383804311450339
ENST00000355193KMT2Cchr7152132711-ENST00000537639DENND2Achr7140255513-17283804311450339
ENST00000355193KMT2Cchr7152132711-ENST00000496613DENND2Achr7140255513-16943804311450339
ENST00000355193KMT2Cchr7152132711-ENST00000492720DENND2Achr7140255513-17883801457744237

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000275884KMT2Cchr7152132711-DENND2Achr7140255513-0.0186056740.9813943
ENST00000262189ENST00000537639KMT2Cchr7152132711-DENND2Achr7140255513-0.018838990.98116106
ENST00000262189ENST00000496613KMT2Cchr7152132711-DENND2Achr7140255513-0.0192586690.9807413
ENST00000262189ENST00000492720KMT2Cchr7152132711-DENND2Achr7140255513-0.208997370.79100263
ENST00000355193ENST00000275884KMT2Cchr7152132711-DENND2Achr7140255513-0.0186056740.9813943
ENST00000355193ENST00000537639KMT2Cchr7152132711-DENND2Achr7140255513-0.018838990.98116106
ENST00000355193ENST00000496613KMT2Cchr7152132711-DENND2Achr7140255513-0.0192586690.9807413
ENST00000355193ENST00000492720KMT2Cchr7152132711-DENND2Achr7140255513-0.208997370.79100263

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43241_43241_1_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000275884_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

>43241_43241_2_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000492720_length(amino acids)=237AA_BP=
MRWNVILLLRLECNGAISAHCSLCLLGSSDSCTSASQVAGVTSTSHHDWLIFVSLVETEFHHVGQAGLELLTSGDPPASASRSARITGMS
HRAWPSFICGGRREGLPLLPKLECSGEISAHCNVHLPGSIDSRASASQVAGITSVGHHGWLIFLFLVETEFHHVAQAGLELLVSSDPPTS

--------------------------------------------------------------

>43241_43241_3_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000496613_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

>43241_43241_4_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000262189_DENND2A_chr7_140255513_ENST00000537639_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

>43241_43241_5_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000275884_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

>43241_43241_6_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000492720_length(amino acids)=237AA_BP=
MRWNVILLLRLECNGAISAHCSLCLLGSSDSCTSASQVAGVTSTSHHDWLIFVSLVETEFHHVGQAGLELLTSGDPPASASRSARITGMS
HRAWPSFICGGRREGLPLLPKLECSGEISAHCNVHLPGSIDSRASASQVAGITSVGHHGWLIFLFLVETEFHHVAQAGLELLVSSDPPTS

--------------------------------------------------------------

>43241_43241_7_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000496613_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

>43241_43241_8_KMT2C-DENND2A_KMT2C_chr7_152132711_ENST00000355193_DENND2A_chr7_140255513_ENST00000537639_length(amino acids)=339AA_BP=0
MGCFSLFSRILDEVEKRRGISPALVQPLMRSVMEAPFPALGKTILVKNFLPGSGTEVIELCRPLDSRLEHVDFESLFSSLSVRHLVCVFA
SLLLERRVIFIADKLSILSKCCHAMVALIYPFAWQHTYIPVLPPAMVDIVCSPTPFLIGLLSSSLPLLRELPLEEVLVVDLVNSRFLRQM
DDEDSILPRKLQVALEHILEQRNELACEQDEGPLDGRHGPESSPLNEVVSEAFVRFFVEIVGHYSLFLTSGEREERTLQREAFRKAVSSK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:152132711/chr7:140255513)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

DENND2A

Q9ULE3

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May play a role in late endosomes back to trans-Golgi network/TGN transport. {ECO:0000269|PubMed:20937701}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-15934_4653.6666666666666644912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-16034_4653.6666666666666644969.0DNA bindingNote=A.T hook
TgeneDENND2Achr7:152132711chr7:140255513ENST00000275884919737_870653.01010.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000275884919872_969653.01010.0DomaindDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000492720913737_870653.0796.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000492720913872_969653.0796.0DomaindDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST000004966131020737_870653.01010.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST000004966131020872_969653.01010.0DomaindDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000537639818737_870653.01010.0DomaincDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000537639818872_969653.01010.0DomaindDENN

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591338_136653.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591754_178753.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593054_308153.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593173_327253.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593391_343353.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159644_67253.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-15992_11253.6666666666666644912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601338_136653.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601754_178753.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603054_308153.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603173_327253.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603391_343353.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160644_67253.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-16092_11253.6666666666666644969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591719_179653.6666666666666644912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591834_228153.6666666666666644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1592412_263053.6666666666666644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1592690_278653.6666666666666644912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593012_350953.6666666666666644912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1593277_338153.6666666666666644912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601719_179653.6666666666666644969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601834_228153.6666666666666644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1602412_263053.6666666666666644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1602690_278653.6666666666666644969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603012_350953.6666666666666644969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1603277_338153.6666666666666644969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159436_48953.6666666666666644912.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594545_460553.6666666666666644912.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594606_469153.6666666666666644912.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594771_488753.6666666666666644912.0DomainSET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594895_491153.6666666666666644912.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160436_48953.6666666666666644969.0DomainDHHC
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604545_460553.6666666666666644969.0DomainFYR N-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604606_469153.6666666666666644969.0DomainFYR C-terminal
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604771_488753.6666666666666644969.0DomainSET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604895_491153.6666666666666644969.0DomainPost-SET
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594848_484953.6666666666666644912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604848_484953.6666666666666644969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591007_105753.6666666666666644912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1591084_113953.6666666666666644912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159227_26253.6666666666666644912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159283_33153.6666666666666644912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159341_39153.6666666666666644912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159344_38953.6666666666666644912.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159388_43853.6666666666666644912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594399_443953.6666666666666644912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-1594460_450753.6666666666666644912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159464_52053.6666666666666644912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000262189-159957_101053.6666666666666644912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601007_105753.6666666666666644969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1601084_113953.6666666666666644969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160227_26253.6666666666666644969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160283_33153.6666666666666644969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160341_39153.6666666666666644969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160344_38953.6666666666666644969.0Zinc fingerRING-type
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160388_43853.6666666666666644969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604399_443953.6666666666666644969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-1604460_450753.6666666666666644969.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160464_52053.6666666666666644969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:152132711chr7:140255513ENST00000355193-160957_101053.6666666666666644969.0Zinc fingerPHD-type 5
TgeneDENND2Achr7:152132711chr7:140255513ENST00000275884919566_715653.01010.0DomainuDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000492720913566_715653.0796.0DomainuDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST000004966131020566_715653.01010.0DomainuDENN
TgeneDENND2Achr7:152132711chr7:140255513ENST00000537639818566_715653.01010.0DomainuDENN


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KMT2C
DENND2A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KMT2C-DENND2A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KMT2C-DENND2A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource