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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KMT2C-GTF2IRD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KMT2C-GTF2IRD1
FusionPDB ID: 43248
FusionGDB2.0 ID: 54207
HgeneTgene
Gene symbol

KMT2C

GTF2IRD1

Gene ID

58508

9569

Gene namelysine methyltransferase 2CGTF2I repeat domain containing 1
SynonymsHALR|KLEFS2|MLL3BEN|CREAM1|GTF3|MUSTRD1|RBAP2|WBS|WBSCR11|WBSCR12|hMusTRD1alpha1
Cytomap

7q36.1

7q11.23

Type of geneprotein-codingprotein-coding
Descriptionhistone-lysine N-methyltransferase 2CALR-like proteinhistone-lysine N-methyltransferase MLL3histone-lysine N-methyltransferase, H3 lysine-4 specifichomologous to ALR proteinlysine (K)-specific methyltransferase 2Cmyeloid/lymphoid or mixed-lineage legeneral transcription factor II-I repeat domain-containing protein 1USE B1-binding proteinWilliams-Beuren syndrome chromosome region 11binding factor for early enhancergeneral transcription factor 3general transcription factor IIImuscle TFII-I repea
Modification date2020032020200313
UniProtAcc

Q8NEZ4

Q9UHL9

Ensembl transtripts involved in fusion geneENST idsENST00000262189, ENST00000355193, 
ENST00000485241, ENST00000485655, 
ENST00000489094, ENST00000265755, 
ENST00000424337, ENST00000455841, 
ENST00000476977, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 23 X 12=717612 X 10 X 9=1080
# samples 3212
** MAII scorelog2(32/7176*10)=-4.4870360800319
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/1080*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KMT2C [Title/Abstract] AND GTF2IRD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KMT2C(151902191)-GTF2IRD1(74004180), # samples:1
Anticipated loss of major functional domain due to fusion event.KMT2C-GTF2IRD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-GTF2IRD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-GTF2IRD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KMT2C-GTF2IRD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKMT2C

GO:0097692

histone H3-K4 monomethylation

26324722


check buttonFusion gene breakpoints across KMT2C (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GTF2IRD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7440-01AKMT2Cchr7

151902191

-GTF2IRD1chr7

74004180

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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000262189KMT2Cchr7151902191-ENST00000265755GTF2IRD1chr774004180+4852418020746941495
ENST00000262189KMT2Cchr7151902191-ENST00000455841GTF2IRD1chr774004180+4866418020746941495
ENST00000262189KMT2Cchr7151902191-ENST00000424337GTF2IRD1chr774004180+4863418020746941495
ENST00000262189KMT2Cchr7151902191-ENST00000476977GTF2IRD1chr774004180+6037418020747421511
ENST00000355193KMT2Cchr7151902191-ENST00000265755GTF2IRD1chr774004180+4852418020746941495
ENST00000355193KMT2Cchr7151902191-ENST00000455841GTF2IRD1chr774004180+4866418020746941495
ENST00000355193KMT2Cchr7151902191-ENST00000424337GTF2IRD1chr774004180+4863418020746941495
ENST00000355193KMT2Cchr7151902191-ENST00000476977GTF2IRD1chr774004180+6037418020747421511

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000262189ENST00000265755KMT2Cchr7151902191-GTF2IRD1chr774004180+0.000483460.9995165
ENST00000262189ENST00000455841KMT2Cchr7151902191-GTF2IRD1chr774004180+0.0004543850.99954563
ENST00000262189ENST00000424337KMT2Cchr7151902191-GTF2IRD1chr774004180+0.0004607430.99953926
ENST00000262189ENST00000476977KMT2Cchr7151902191-GTF2IRD1chr774004180+0.0005268940.99947315
ENST00000355193ENST00000265755KMT2Cchr7151902191-GTF2IRD1chr774004180+0.000483460.9995165
ENST00000355193ENST00000455841KMT2Cchr7151902191-GTF2IRD1chr774004180+0.0004543850.99954563
ENST00000355193ENST00000424337KMT2Cchr7151902191-GTF2IRD1chr774004180+0.0004607430.99953926
ENST00000355193ENST00000476977KMT2Cchr7151902191-GTF2IRD1chr774004180+0.0005268940.99947315

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43248_43248_1_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000262189_GTF2IRD1_chr7_74004180_ENST00000265755_length(amino acids)=1495AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_2_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000262189_GTF2IRD1_chr7_74004180_ENST00000424337_length(amino acids)=1495AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_3_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000262189_GTF2IRD1_chr7_74004180_ENST00000455841_length(amino acids)=1495AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_4_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000262189_GTF2IRD1_chr7_74004180_ENST00000476977_length(amino acids)=1511AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_5_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000355193_GTF2IRD1_chr7_74004180_ENST00000265755_length(amino acids)=1495AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_6_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000355193_GTF2IRD1_chr7_74004180_ENST00000424337_length(amino acids)=1495AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_7_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000355193_GTF2IRD1_chr7_74004180_ENST00000455841_length(amino acids)=1495AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

>43248_43248_8_KMT2C-GTF2IRD1_KMT2C_chr7_151902191_ENST00000355193_GTF2IRD1_chr7_74004180_ENST00000476977_length(amino acids)=1511AA_BP=1324
MVTRMSSEEDKSVEQPQPPPPPPEEPGAPAPSPAAADKRPRGRPRKDGASPFQRARKKPRSRGKTAVEDEDSMDGLETTETETIVETEIK
EQSAEEDAEAEVDNSKQLIPTLQRSVSEESANSLVSVGVEAKISEQLCAFCYCGEKSSLGQGDLKQFRITPGFILPWRNQPSNKKDIDDN
SNGTYEKMQNSAPRKQRGQRKERSPQQNIVSCVSVSTQTASDDQAGKLWDELSLVGLPDAIDIQALFDSTGTCWAHHRCVEWSLGVCQME
EPLLVNVDKAVVSGSTERCAFCKHLGATIKCCEEKCTQMYHYPCAAGAGTFQDFSHIFLLCPEHIDQAPERSKEDANCAVCDSPGDLLDQ
FFCTTCGQHYHGMCLDIAVTPLKRAGWQCPECKVCQNCKQSGEDSKMLVCDTCDKGYHTFCLQPVMKSVPTNGWKCKNCRICIECGTRSS
SQWHHNCLICDNCYQQQDNLCPFCGKCYHPELQKDMLHCNMCKRWVHLECDKPTDHELDTQLKEEYICMYCKHLGAEMDRLQPGEEVEIA
ELTTDYNNEMEVEGPEDQMVFSEQAANKDVNGQESTPGIVPDAVQVHTEEQQKSHPSESLDTDSLLIAVSSQHTVNTELEKQISNEVDSE
DLKMSSEVKHICGEDQIEDKMEVTENIEVVTHQITVQQEQLQLLEEPETVVSREESRPPKLVMESVTLPLETLVSPHEESISLCPEEQLV
IERLQGEKEQKENSELSTGLMDSEMTPTIEGCVKDVSYQGGKSIKLSSETESSFSSSADISKADVSSSPTPSSDLPSHDMLHNYPSALSS
SAGNIMPTTYISVTPKIGMGKPAITKRKFSPGRPRSKQGAWSTHNTVSPPSWSPDISEGREIFKPRQLPGSAIWSIKVGRGSGFPGKRRP
RGAGLSGRGGRGRSKLKSGIGAVVLPGVSTADISSNKDDEENSMHNTVVLFSSSDKFTLNQDMCVVCGSFGQGAEGRLLACSQCGQCYHP
YCVSIKITKVVLSKGWRCLECTVCEACGKATDPGRLLLCDDCDISYHTYCLDPPLQTVPKGGWKCKWCVWCRHCGATSAGLRCEWQNNYT
QCAPCASLSSCPVCYRNYREEDLILQCRQCDRWMHAVCQNLNTEEEVENVADIGFDCSMCRPYMPASNVPSSDCCESSLVAQIVTKVKEL
DPPKTYTQDGVCLTESGMTQLQSLTVTVPRRKRSKPKLKLKIINQNSVAVLQTPPDIQSEHSRDGEMDDSREGELMDCDGKSESSPEREA
VDDETKGVEGTDGVKKRKRKPYRPGIGGFMVRQRSRTGQGKTKRSVIRKDSSGSISEQLPCRDDDEDDANRLGEKVILREQVKELFNEKY
GEALGLNRPVLVPYKLIRDSPDAVEVTGLPDDIPFRNPNTYDIHRLEKILKAREHVRMVIINQLQPFAEICNDAKVPAKDSSIPKRKRKR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151902191/chr7:74004180)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KMT2C

Q8NEZ4

GTF2IRD1

Q9UHL9

FUNCTION: Histone methyltransferase that methylates 'Lys-4' of histone H3 (PubMed:22266653). H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. Central component of the MLL2/3 complex, a coactivator complex of nuclear receptors, involved in transcriptional coactivation. KMT2C/MLL3 may be a catalytic subunit of this complex. May be involved in leukemogenesis and developmental disorder. {ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:22266653}.FUNCTION: May be a transcription regulator involved in cell-cycle progression and skeletal muscle differentiation. May repress GTF2I transcriptional functions, by preventing its nuclear residency, or by inhibiting its transcriptional activation. May contribute to slow-twitch fiber type specificity during myogenesis and in regenerating muscles. Binds troponin I slow-muscle fiber enhancer (USE B1). Binds specifically and with high affinity to the EFG sequences derived from the early enhancer of HOXC8 (By similarity). {ECO:0000250, ECO:0000269|PubMed:11438732}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559644_6721320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-255992_1121320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560644_6721320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-256092_1121320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-255934_461320.33333333333334912.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-256034_461320.33333333333334969.0DNA bindingNote=A.T hook
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559436_4891320.33333333333334912.0DomainDHHC
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560436_4891320.33333333333334969.0DomainDHHC
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591007_10571320.33333333333334912.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591084_11391320.33333333333334912.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559227_2621320.33333333333334912.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559283_3311320.33333333333334912.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559341_3911320.33333333333334912.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559344_3891320.33333333333334912.0Zinc fingerRING-type
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559388_4381320.33333333333334912.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559464_5201320.33333333333334912.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-2559957_10101320.33333333333334912.0Zinc fingerPHD-type 5
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601007_10571320.33333333333334969.0Zinc fingerPHD-type 6
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601084_11391320.33333333333334969.0Zinc fingerPHD-type 7
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560227_2621320.33333333333334969.0Zinc fingerC2HC pre-PHD-type 1%3B degenerate
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560283_3311320.33333333333334969.0Zinc fingerPHD-type 1
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560341_3911320.33333333333334969.0Zinc fingerPHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560344_3891320.33333333333334969.0Zinc fingerRING-type
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560388_4381320.33333333333334969.0Zinc fingerPHD-type 3
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560464_5201320.33333333333334969.0Zinc fingerPHD-type 4
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-2560957_10101320.33333333333334969.0Zinc fingerPHD-type 5
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127906_930788.3333333333334960.0Compositional biasNote=Ser-rich
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127906_930773.3333333333334945.0Compositional biasNote=Ser-rich
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127906_930805.3333333333334977.0Compositional biasNote=Ser-rich
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127898_905788.3333333333334960.0MotifNuclear localization signal
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127898_905773.3333333333334945.0MotifNuclear localization signal
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127898_905805.3333333333334977.0MotifNuclear localization signal
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127793_887788.3333333333334960.0RepeatNote=GTF2I-like 5
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127793_887773.3333333333334945.0RepeatNote=GTF2I-like 5

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591338_13661320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591754_17871320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593054_30811320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593173_32721320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593391_34331320.33333333333334912.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601338_13661320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601754_17871320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603054_30811320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603173_32721320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603391_34331320.33333333333334969.0Coiled coilOntology_term=ECO:0000255
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591719_17961320.33333333333334912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25591834_22811320.33333333333334912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25592412_26301320.33333333333334912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25592690_27861320.33333333333334912.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593012_35091320.33333333333334912.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25593277_33811320.33333333333334912.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601719_17961320.33333333333334969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25601834_22811320.33333333333334969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25602412_26301320.33333333333334969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25602690_27861320.33333333333334969.0Compositional biasNote=Asp-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603012_35091320.33333333333334969.0Compositional biasNote=Gln-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25603277_33811320.33333333333334969.0Compositional biasNote=Pro-rich
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594545_46051320.33333333333334912.0DomainFYR N-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594606_46911320.33333333333334912.0DomainFYR C-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594771_48871320.33333333333334912.0DomainSET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594895_49111320.33333333333334912.0DomainPost-SET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604545_46051320.33333333333334969.0DomainFYR N-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604606_46911320.33333333333334969.0DomainFYR C-terminal
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604771_48871320.33333333333334969.0DomainSET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604895_49111320.33333333333334969.0DomainPost-SET
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594848_48491320.33333333333334912.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604848_48491320.33333333333334969.0RegionS-adenosyl-L-methionine binding
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594399_44391320.33333333333334912.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000262189-25594460_45071320.33333333333334912.0Zinc fingerPHD-type 8
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604399_44391320.33333333333334969.0Zinc fingerC2HC pre-PHD-type 2
HgeneKMT2Cchr7:151902191chr7:74004180ENST00000355193-25604460_45071320.33333333333334969.0Zinc fingerPHD-type 8
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127119_213788.3333333333334960.0RepeatNote=GTF2I-like 1
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127342_436788.3333333333334960.0RepeatNote=GTF2I-like 2
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127556_650788.3333333333334960.0RepeatNote=GTF2I-like 3
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000002657552127696_790788.3333333333334960.0RepeatNote=GTF2I-like 4
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127119_213773.3333333333334945.0RepeatNote=GTF2I-like 1
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127342_436773.3333333333334945.0RepeatNote=GTF2I-like 2
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127556_650773.3333333333334945.0RepeatNote=GTF2I-like 3
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004243372127696_790773.3333333333334945.0RepeatNote=GTF2I-like 4
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127119_213805.3333333333334977.0RepeatNote=GTF2I-like 1
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127342_436805.3333333333334977.0RepeatNote=GTF2I-like 2
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127556_650805.3333333333334977.0RepeatNote=GTF2I-like 3
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127696_790805.3333333333334977.0RepeatNote=GTF2I-like 4
TgeneGTF2IRD1chr7:151902191chr7:74004180ENST000004558412127793_887805.3333333333334977.0RepeatNote=GTF2I-like 5


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KMT2C
GTF2IRD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KMT2C-GTF2IRD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KMT2C-GTF2IRD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource