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Fusion Protein:KNSTRN-BUB1B |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: KNSTRN-BUB1B | FusionPDB ID: 43337 | FusionGDB2.0 ID: 43337 | Hgene | Tgene | Gene symbol | KNSTRN | BUB1B | Gene ID | 90417 | 701 |
| Gene name | kinetochore localized astrin (SPAG5) binding protein | BUB1 mitotic checkpoint serine/threonine kinase B | |
| Synonyms | C15orf23|HSD11|SKAP|TRAF4AF1 | BUB1beta|BUBR1|Bub1A|MAD3L|MVA1|SSK1|hBUBR1 | |
| Cytomap | 15q15.1 | 15q15.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small kinetochore-associated proteinTRAF4 associated factor 1kinastrinkinetochore-localized astrin-binding proteinputative TRAF4-associated factor 1small kinetochore associated proteinsmall kinetochore-associated protein, kinetochore-localized astri | mitotic checkpoint serine/threonine-protein kinase BUB1 betaBUB1B, mitotic checkpoint serine/threonine kinaseMAD3/BUB1-related protein kinasebudding uninhibited by benzimidazoles 1 homolog betamitotic checkpoint kinase MAD3L | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9Y448 | O60566 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000448395, ENST00000249776, ENST00000416151, ENST00000608100, | ENST00000287598, ENST00000412359, ENST00000560120, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 2 X 2 X 2=8 | 8 X 10 X 5=400 |
| # samples | 2 | 9 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(9/400*10)=-2.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: KNSTRN [Title/Abstract] AND BUB1B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | KNSTRN(40684224)-BUB1B(40498385), # samples:2 | ||
| Anticipated loss of major functional domain due to fusion event. | KNSTRN-BUB1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KNSTRN-BUB1B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KNSTRN-BUB1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KNSTRN-BUB1B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene breakpoints across KNSTRN (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BUB1B (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | OV | TCGA-25-1323-01A | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000416151 | KNSTRN | chr15 | 40684224 | + | ENST00000287598 | BUB1B | chr15 | 40498385 | + | 2733 | 937 | 115 | 2355 | 746 |
| ENST00000416151 | KNSTRN | chr15 | 40684224 | + | ENST00000412359 | BUB1B | chr15 | 40498385 | + | 2635 | 937 | 115 | 2355 | 746 |
| ENST00000249776 | KNSTRN | chr15 | 40684224 | + | ENST00000287598 | BUB1B | chr15 | 40498385 | + | 2733 | 937 | 115 | 2355 | 746 |
| ENST00000249776 | KNSTRN | chr15 | 40684224 | + | ENST00000412359 | BUB1B | chr15 | 40498385 | + | 2635 | 937 | 115 | 2355 | 746 |
| ENST00000608100 | KNSTRN | chr15 | 40684224 | + | ENST00000287598 | BUB1B | chr15 | 40498385 | + | 2513 | 717 | 129 | 2135 | 668 |
| ENST00000608100 | KNSTRN | chr15 | 40684224 | + | ENST00000412359 | BUB1B | chr15 | 40498385 | + | 2415 | 717 | 129 | 2135 | 668 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000416151 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + | 0.00071992 | 0.99928015 |
| ENST00000416151 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + | 0.001177625 | 0.9988224 |
| ENST00000249776 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + | 0.00071992 | 0.99928015 |
| ENST00000249776 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + | 0.001177625 | 0.9988224 |
| ENST00000608100 | ENST00000287598 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + | 0.00044874 | 0.99955124 |
| ENST00000608100 | ENST00000412359 | KNSTRN | chr15 | 40684224 | + | BUB1B | chr15 | 40498385 | + | 0.000764626 | 0.9992354 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >43337_43337_1_KNSTRN-BUB1B_KNSTRN_chr15_40684224_ENST00000249776_BUB1B_chr15_40498385_ENST00000287598_length(amino acids)=746AA_BP=273 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTL QDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD -------------------------------------------------------------- >43337_43337_2_KNSTRN-BUB1B_KNSTRN_chr15_40684224_ENST00000249776_BUB1B_chr15_40498385_ENST00000412359_length(amino acids)=746AA_BP=273 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTL QDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD -------------------------------------------------------------- >43337_43337_3_KNSTRN-BUB1B_KNSTRN_chr15_40684224_ENST00000416151_BUB1B_chr15_40498385_ENST00000287598_length(amino acids)=746AA_BP=273 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTL QDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD -------------------------------------------------------------- >43337_43337_4_KNSTRN-BUB1B_KNSTRN_chr15_40684224_ENST00000416151_BUB1B_chr15_40498385_ENST00000412359_length(amino acids)=746AA_BP=273 MAAPEAPPLDRVFRTTWLSTECDSHPLPPSYRKFLFETQAADLAGGTTVAAGNLLNESEKDCGQDRRAPGVQPCRLVTMTSVVKTVYSLQ PPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSKQKSEEELKDKNQ LLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEELKLFNETAKKQM EELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQQTACGTIYSQTL SIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAELCIEDRPMPKLE IEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGCIVWHQYINCFTL QDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQLDVFTLSGFRTVQ ILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVLGELAAEMNGVFD -------------------------------------------------------------- >43337_43337_5_KNSTRN-BUB1B_KNSTRN_chr15_40684224_ENST00000608100_BUB1B_chr15_40498385_ENST00000287598_length(amino acids)=668AA_BP=195 MTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSK QKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE LKLFNETAKKQMEELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQ QTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAE LCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGC IVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQL DVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVL -------------------------------------------------------------- >43337_43337_6_KNSTRN-BUB1B_KNSTRN_chr15_40684224_ENST00000608100_BUB1B_chr15_40498385_ENST00000412359_length(amino acids)=668AA_BP=195 MTSVVKTVYSLQPPSALSGGQPADTQTRATSKSLLPVRSKEVDVSKQLHSGGPENDVTKITKLRRENGQMKATDTATRRNVRKGYKPLSK QKSEEELKDKNQLLEAVNKQLHQKLTETQGELKDLTQKVELLEKFRDNCLAILESKGLDPALGSETLASRQESTTDHMDSMLLLETLQEE LKLFNETAKKQMEELQDEFTGIEPLSEDAIITGFRNVTICPNPEDTCDFARAARFVSTPFHEIMSLKDLPSDPERLLPEEDLDVKTSEDQ QTACGTIYSQTLSIKKLSPIIEDSREATHSSGFSGSSASVASTSSIKCLQIPEKLELTNETSENPTQSPWCSQYRRQLLKSLPELSASAE LCIEDRPMPKLEIEKEIELGNEDYCIKREYLICEDYKLFWVAPRNSAELTVIKVSSQPVPWDFYINLKLKERLNEDFDHFCSCYQYQDGC IVWHQYINCFTLQDLLQHSEYITHEITVLIIYNLLTIVEMLHKAEIVHGDLSPRCLILRNRIHDPYDCNKNNQALKIVDFSYSVDLRVQL DVFTLSGFRTVQILEGQKILANCSSPYQVDLFGIADLAHLLLFKEHLQVFWDGSFWKLSQNISELKDGELWNKFFVRILNANDEATVSVL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:40684224/chr15:40498385) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| KNSTRN | BUB1B |
| FUNCTION: Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257). {ECO:0000269|PubMed:19667759, ECO:0000269|PubMed:21402792, ECO:0000269|PubMed:22110139, ECO:0000269|PubMed:23035123, ECO:0000305|PubMed:24718257}. | FUNCTION: Essential component of the mitotic checkpoint. Required for normal mitosis progression. The mitotic checkpoint delays anaphase until all chromosomes are properly attached to the mitotic spindle. One of its checkpoint functions is to inhibit the activity of the anaphase-promoting complex/cyclosome (APC/C) by blocking the binding of CDC20 to APC/C, independently of its kinase activity. The other is to monitor kinetochore activities that depend on the kinetochore motor CENPE. Required for kinetochore localization of CENPE. Negatively regulates PLK1 activity in interphase cells and suppresses centrosome amplification. Also implicated in triggering apoptosis in polyploid cells that exit aberrantly from mitotic arrest. May play a role for tumor suppression. {ECO:0000269|PubMed:10477750, ECO:0000269|PubMed:11702782, ECO:0000269|PubMed:14706340, ECO:0000269|PubMed:15020684, ECO:0000269|PubMed:19411850, ECO:0000269|PubMed:19503101}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000249776 | + | 8 | 9 | 166_216 | 274.0 | 317.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000416151 | + | 8 | 9 | 166_216 | 274.0 | 287.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000448395 | + | 7 | 8 | 166_216 | 253.33333333333334 | 407.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | 13 | 23 | 766_1050 | 578.0 | 1051.0 | Domain | Note=Protein kinase | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | 13 | 23 | 766_1050 | 592.0 | 1065.0 | Domain | Note=Protein kinase | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | 13 | 23 | 772_780 | 578.0 | 1051.0 | Nucleotide binding | ATP | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | 13 | 23 | 772_780 | 592.0 | 1065.0 | Nucleotide binding | ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000249776 | + | 8 | 9 | 248_316 | 274.0 | 317.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000416151 | + | 8 | 9 | 248_316 | 274.0 | 287.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000448395 | + | 7 | 8 | 248_316 | 253.33333333333334 | 407.0 | Coiled coil | Ontology_term=ECO:0000255 |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | 13 | 23 | 209_215 | 578.0 | 1051.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | 13 | 23 | 209_215 | 592.0 | 1065.0 | Compositional bias | Note=Poly-Glu | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | 13 | 23 | 62_226 | 578.0 | 1051.0 | Domain | BUB1 N-terminal | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | 13 | 23 | 62_226 | 592.0 | 1065.0 | Domain | BUB1 N-terminal | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | 13 | 23 | 111_118 | 578.0 | 1051.0 | Motif | Nuclear localization signal | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000287598 | 13 | 23 | 224_232 | 578.0 | 1051.0 | Motif | Note=D-box | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | 13 | 23 | 111_118 | 592.0 | 1065.0 | Motif | Nuclear localization signal | |
| Tgene | BUB1B | chr15:40684224 | chr15:40498385 | ENST00000412359 | 13 | 23 | 224_232 | 592.0 | 1065.0 | Motif | Note=D-box |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| KNSTRN | |
| BUB1B |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000249776 | + | 8 | 9 | 159_316 | 274.0 | 317.0 | SPAG5 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000416151 | + | 8 | 9 | 159_316 | 274.0 | 287.0 | SPAG5 |
| Hgene | KNSTRN | chr15:40684224 | chr15:40498385 | ENST00000448395 | + | 7 | 8 | 159_316 | 253.33333333333334 | 407.0 | SPAG5 |
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Related Drugs to KNSTRN-BUB1B |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to KNSTRN-BUB1B |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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