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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KRI1-DNM2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KRI1-DNM2
FusionPDB ID: 43458
FusionGDB2.0 ID: 43458
HgeneTgene
Gene symbol

KRI1

DNM2

Gene ID

65095

1785

Gene nameKRI1 homologdynamin 2
Synonyms-CMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionprotein KRI1 homologdynamin-2dynamin II
Modification date2020031320200329
UniProtAcc

Q8N9T8

P50570

Ensembl transtripts involved in fusion geneENST idsENST00000312962, ENST00000361821, 
ENST00000537964, 		ENST00000591819, 
ENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 6 X 4=12019 X 24 X 14=6384
# samples 734
** MAII scorelog2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/6384*10)=-4.23085400008464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KRI1 [Title/Abstract] AND DNM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KRI1(10672343)-DNM2(10916592), # samples:2
Anticipated loss of major functional domain due to fusion event.KRI1-DNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KRI1-DNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KRI1-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KRI1-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313


check buttonFusion gene breakpoints across KRI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1626-01AKRI1chr19

10672343

-DNM2chr19

10916592

+
ChimerDB4OVTCGA-25-1626KRI1chr19

10672342

-DNM2chr19

10916591

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000312962KRI1chr1910672343-ENST00000585892DNM2chr1910916592+1643526201642541
ENST00000312962KRI1chr1910672343-ENST00000314646DNM2chr1910916592+2502526201645541
ENST00000312962KRI1chr1910672343-ENST00000359692DNM2chr1910916592+2471526201633537
ENST00000312962KRI1chr1910672343-ENST00000389253DNM2chr1910916592+2502526201645541
ENST00000312962KRI1chr1910672343-ENST00000355667DNM2chr1910916592+2494526201645541
ENST00000312962KRI1chr1910672343-ENST00000408974DNM2chr1910916592+2011526201633537
ENST00000361821KRI1chr1910672343-ENST00000585892DNM2chr1910916592+1741624671740558
ENST00000361821KRI1chr1910672343-ENST00000314646DNM2chr1910916592+2600624671743558
ENST00000361821KRI1chr1910672343-ENST00000359692DNM2chr1910916592+2569624671731554
ENST00000361821KRI1chr1910672343-ENST00000389253DNM2chr1910916592+2600624671743558
ENST00000361821KRI1chr1910672343-ENST00000355667DNM2chr1910916592+2592624671743558
ENST00000361821KRI1chr1910672343-ENST00000408974DNM2chr1910916592+2109624671731554
ENST00000312962KRI1chr1910672342-ENST00000585892DNM2chr1910916591+1643526201642541
ENST00000312962KRI1chr1910672342-ENST00000314646DNM2chr1910916591+2502526201645541
ENST00000312962KRI1chr1910672342-ENST00000359692DNM2chr1910916591+2471526201633537
ENST00000312962KRI1chr1910672342-ENST00000389253DNM2chr1910916591+2502526201645541
ENST00000312962KRI1chr1910672342-ENST00000355667DNM2chr1910916591+2494526201645541
ENST00000312962KRI1chr1910672342-ENST00000408974DNM2chr1910916591+2011526201633537
ENST00000361821KRI1chr1910672342-ENST00000585892DNM2chr1910916591+1741624671740558
ENST00000361821KRI1chr1910672342-ENST00000314646DNM2chr1910916591+2600624671743558
ENST00000361821KRI1chr1910672342-ENST00000359692DNM2chr1910916591+2569624671731554
ENST00000361821KRI1chr1910672342-ENST00000389253DNM2chr1910916591+2600624671743558
ENST00000361821KRI1chr1910672342-ENST00000355667DNM2chr1910916591+2592624671743558
ENST00000361821KRI1chr1910672342-ENST00000408974DNM2chr1910916591+2109624671731554

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000312962ENST00000585892KRI1chr1910672343-DNM2chr1910916592+0.0174836140.9825164
ENST00000312962ENST00000314646KRI1chr1910672343-DNM2chr1910916592+0.0166201440.9833799
ENST00000312962ENST00000359692KRI1chr1910672343-DNM2chr1910916592+0.0179999080.98200005
ENST00000312962ENST00000389253KRI1chr1910672343-DNM2chr1910916592+0.0157617460.9842383
ENST00000312962ENST00000355667KRI1chr1910672343-DNM2chr1910916592+0.01602030.9839797
ENST00000312962ENST00000408974KRI1chr1910672343-DNM2chr1910916592+0.0211024270.9788976
ENST00000361821ENST00000585892KRI1chr1910672343-DNM2chr1910916592+0.0111605890.98883945
ENST00000361821ENST00000314646KRI1chr1910672343-DNM2chr1910916592+0.0065565780.99344337
ENST00000361821ENST00000359692KRI1chr1910672343-DNM2chr1910916592+0.0049595050.9950405
ENST00000361821ENST00000389253KRI1chr1910672343-DNM2chr1910916592+0.0065838710.9934161
ENST00000361821ENST00000355667KRI1chr1910672343-DNM2chr1910916592+0.0068115820.9931884
ENST00000361821ENST00000408974KRI1chr1910672343-DNM2chr1910916592+0.0073631550.9926368
ENST00000312962ENST00000585892KRI1chr1910672342-DNM2chr1910916591+0.0174836140.9825164
ENST00000312962ENST00000314646KRI1chr1910672342-DNM2chr1910916591+0.0166201440.9833799
ENST00000312962ENST00000359692KRI1chr1910672342-DNM2chr1910916591+0.0179999080.98200005
ENST00000312962ENST00000389253KRI1chr1910672342-DNM2chr1910916591+0.0157617460.9842383
ENST00000312962ENST00000355667KRI1chr1910672342-DNM2chr1910916591+0.01602030.9839797
ENST00000312962ENST00000408974KRI1chr1910672342-DNM2chr1910916591+0.0211024270.9788976
ENST00000361821ENST00000585892KRI1chr1910672342-DNM2chr1910916591+0.0111605890.98883945
ENST00000361821ENST00000314646KRI1chr1910672342-DNM2chr1910916591+0.0065565780.99344337
ENST00000361821ENST00000359692KRI1chr1910672342-DNM2chr1910916591+0.0049595050.9950405
ENST00000361821ENST00000389253KRI1chr1910672342-DNM2chr1910916591+0.0065838710.9934161
ENST00000361821ENST00000355667KRI1chr1910672342-DNM2chr1910916591+0.0068115820.9931884
ENST00000361821ENST00000408974KRI1chr1910672342-DNM2chr1910916591+0.0073631550.9926368

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43458_43458_1_KRI1-DNM2_KRI1_chr19_10672342_ENST00000312962_DNM2_chr19_10916591_ENST00000314646_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQPETLVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLL

--------------------------------------------------------------

>43458_43458_2_KRI1-DNM2_KRI1_chr19_10672342_ENST00000312962_DNM2_chr19_10916591_ENST00000355667_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLL

--------------------------------------------------------------

>43458_43458_3_KRI1-DNM2_KRI1_chr19_10672342_ENST00000312962_DNM2_chr19_10916591_ENST00000359692_length(amino acids)=537AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQI
ELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHH
ELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPA

--------------------------------------------------------------

>43458_43458_4_KRI1-DNM2_KRI1_chr19_10672342_ENST00000312962_DNM2_chr19_10916591_ENST00000389253_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLL

--------------------------------------------------------------

>43458_43458_5_KRI1-DNM2_KRI1_chr19_10672342_ENST00000312962_DNM2_chr19_10916591_ENST00000408974_length(amino acids)=537AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQI
ELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHH
ELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPA

--------------------------------------------------------------

>43458_43458_6_KRI1-DNM2_KRI1_chr19_10672342_ENST00000312962_DNM2_chr19_10916591_ENST00000585892_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAPSRPTIIRPAEPSLLD

--------------------------------------------------------------

>43458_43458_7_KRI1-DNM2_KRI1_chr19_10672342_ENST00000361821_DNM2_chr19_10916591_ENST00000314646_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQPETLVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPP

--------------------------------------------------------------

>43458_43458_8_KRI1-DNM2_KRI1_chr19_10672342_ENST00000361821_DNM2_chr19_10916591_ENST00000355667_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPP

--------------------------------------------------------------

>43458_43458_9_KRI1-DNM2_KRI1_chr19_10672342_ENST00000361821_DNM2_chr19_10916591_ENST00000359692_length(amino acids)=554AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVF
AIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>43458_43458_10_KRI1-DNM2_KRI1_chr19_10672342_ENST00000361821_DNM2_chr19_10916591_ENST00000389253_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPP

--------------------------------------------------------------

>43458_43458_11_KRI1-DNM2_KRI1_chr19_10672342_ENST00000361821_DNM2_chr19_10916591_ENST00000408974_length(amino acids)=554AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVF
AIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>43458_43458_12_KRI1-DNM2_KRI1_chr19_10672342_ENST00000361821_DNM2_chr19_10916591_ENST00000585892_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPA

--------------------------------------------------------------

>43458_43458_13_KRI1-DNM2_KRI1_chr19_10672343_ENST00000312962_DNM2_chr19_10916592_ENST00000314646_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQPETLVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLL

--------------------------------------------------------------

>43458_43458_14_KRI1-DNM2_KRI1_chr19_10672343_ENST00000312962_DNM2_chr19_10916592_ENST00000355667_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLL

--------------------------------------------------------------

>43458_43458_15_KRI1-DNM2_KRI1_chr19_10672343_ENST00000312962_DNM2_chr19_10916592_ENST00000359692_length(amino acids)=537AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQI
ELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHH
ELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPA

--------------------------------------------------------------

>43458_43458_16_KRI1-DNM2_KRI1_chr19_10672343_ENST00000312962_DNM2_chr19_10916592_ENST00000389253_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPSRPTIIRPAEPSLL

--------------------------------------------------------------

>43458_43458_17_KRI1-DNM2_KRI1_chr19_10672343_ENST00000312962_DNM2_chr19_10916592_ENST00000408974_length(amino acids)=537AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKDLRQI
ELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHH
ELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPA

--------------------------------------------------------------

>43458_43458_18_KRI1-DNM2_KRI1_chr19_10672343_ENST00000312962_DNM2_chr19_10916592_ENST00000585892_length(amino acids)=541AA_BP=168
MGHRTAMPEPRGSSQLRVNAAFAARYNRYREREELQRLKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFYKTLSLLKKKDPRIYQKD
ATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQKQLKESAQQRSTQLNKK
RAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVFAIFNTEQRNVYKD
LRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKA
FIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPG
RPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAPSRPTIIRPAEPSLLD

--------------------------------------------------------------

>43458_43458_19_KRI1-DNM2_KRI1_chr19_10672343_ENST00000361821_DNM2_chr19_10916592_ENST00000314646_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQPETLVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPP

--------------------------------------------------------------

>43458_43458_20_KRI1-DNM2_KRI1_chr19_10672343_ENST00000361821_DNM2_chr19_10916592_ENST00000355667_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPP

--------------------------------------------------------------

>43458_43458_21_KRI1-DNM2_KRI1_chr19_10672343_ENST00000361821_DNM2_chr19_10916592_ENST00000359692_length(amino acids)=554AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVF
AIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>43458_43458_22_KRI1-DNM2_KRI1_chr19_10672343_ENST00000361821_DNM2_chr19_10916592_ENST00000389253_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPP

--------------------------------------------------------------

>43458_43458_23_KRI1-DNM2_KRI1_chr19_10672343_ENST00000361821_DNM2_chr19_10916592_ENST00000408974_length(amino acids)=554AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSNKHVF
AIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>43458_43458_24_KRI1-DNM2_KRI1_chr19_10672343_ENST00000361821_DNM2_chr19_10916592_ENST00000585892_length(amino acids)=558AA_BP=185
MPRGTTATGSARNCSGVSAGRMRAGACARRPVGKWGVEWPRRLTWGGASRLCPAVKDRYGDRDSSSDSSSESDSSDERVEFDPQQERDFY
KTLSLLKKKDPRIYQKDATFYNRTASSSDSEEDPEALEKQKKVRPMYLKDYERKVILEKAGKYVDEENSDGETSNHRLQETSSQSYVEEQ
KQLKESAQQRSTQLNKKRAIPNQGEILVIRRGWLTINNISLMKGGSKEYWFVLTAESLSWYKDEEEKEKKYMLPLDNLKIRDVEKGFMSN
KHVFAIFNTEQRNVYKDLRQIELACDSQEDVDSWKASFLRAGVYPEKDQAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIR
DLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASS
HSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:10672343/chr19:10916592)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRI1

Q8N9T8

DNM2

P50570

FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121747_866497.6666666666667871.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120747_866497.6666666666667867.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121747_866497.6666666666667871.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120747_866497.6666666666667867.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121747_866497.6666666666667870.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121747_866497.6666666666667871.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120747_866497.6666666666667867.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121747_866497.6666666666667871.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120747_866497.6666666666667867.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121747_866497.6666666666667870.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121519_625497.6666666666667871.0DomainPH
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121653_744497.6666666666667871.0DomainGED
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120519_625497.6666666666667867.0DomainPH
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120653_744497.6666666666667867.0DomainGED
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121519_625497.6666666666667871.0DomainPH
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121653_744497.6666666666667871.0DomainGED
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120519_625497.6666666666667867.0DomainPH
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120653_744497.6666666666667867.0DomainGED
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121519_625497.6666666666667870.0DomainPH
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121653_744497.6666666666667870.0DomainGED
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121519_625497.6666666666667871.0DomainPH
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121653_744497.6666666666667871.0DomainGED
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120519_625497.6666666666667867.0DomainPH
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120653_744497.6666666666667867.0DomainGED
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121519_625497.6666666666667871.0DomainPH
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121653_744497.6666666666667871.0DomainGED
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120519_625497.6666666666667867.0DomainPH
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120653_744497.6666666666667867.0DomainGED
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121519_625497.6666666666667870.0DomainPH
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121653_744497.6666666666667870.0DomainGED

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKRI1chr19:10672342chr19:10916591ENST00000312962-61998_423168.66666666666666710.0Compositional biasNote=Glu-rich
HgeneKRI1chr19:10672343chr19:10916592ENST00000312962-61998_423168.66666666666666710.0Compositional biasNote=Glu-rich
TgeneDNM2chr19:10672342chr19:10916591ENST00000355667112128_294497.6666666666667871.0DomainDynamin-type G
TgeneDNM2chr19:10672342chr19:10916591ENST00000359692112028_294497.6666666666667867.0DomainDynamin-type G
TgeneDNM2chr19:10672342chr19:10916591ENST00000389253112128_294497.6666666666667871.0DomainDynamin-type G
TgeneDNM2chr19:10672342chr19:10916591ENST00000408974112028_294497.6666666666667867.0DomainDynamin-type G
TgeneDNM2chr19:10672342chr19:10916591ENST00000585892112128_294497.6666666666667870.0DomainDynamin-type G
TgeneDNM2chr19:10672343chr19:10916592ENST00000355667112128_294497.6666666666667871.0DomainDynamin-type G
TgeneDNM2chr19:10672343chr19:10916592ENST00000359692112028_294497.6666666666667867.0DomainDynamin-type G
TgeneDNM2chr19:10672343chr19:10916592ENST00000389253112128_294497.6666666666667871.0DomainDynamin-type G
TgeneDNM2chr19:10672343chr19:10916592ENST00000408974112028_294497.6666666666667867.0DomainDynamin-type G
TgeneDNM2chr19:10672343chr19:10916592ENST00000585892112128_294497.6666666666667870.0DomainDynamin-type G
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121205_211497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121236_239497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST00000355667112138_46497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120205_211497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120236_239497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST00000359692112038_46497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121205_211497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121236_239497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST00000389253112138_46497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120205_211497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120236_239497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST00000408974112038_46497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121205_211497.6666666666667870.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121236_239497.6666666666667870.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST00000585892112138_46497.6666666666667870.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121205_211497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121236_239497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST00000355667112138_46497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120205_211497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120236_239497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST00000359692112038_46497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121205_211497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121236_239497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST00000389253112138_46497.6666666666667871.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120205_211497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120236_239497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST00000408974112038_46497.6666666666667867.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121205_211497.6666666666667870.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121236_239497.6666666666667870.0Nucleotide bindingGTP
TgeneDNM2chr19:10672343chr19:10916592ENST00000585892112138_46497.6666666666667870.0Nucleotide bindingGTP
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121136_139497.6666666666667871.0RegionG3 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121205_208497.6666666666667871.0RegionG4 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003556671121235_238497.6666666666667871.0RegionG5 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000355667112138_45497.6666666666667871.0RegionG1 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000355667112164_66497.6666666666667871.0RegionG2 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120136_139497.6666666666667867.0RegionG3 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120205_208497.6666666666667867.0RegionG4 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003596921120235_238497.6666666666667867.0RegionG5 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000359692112038_45497.6666666666667867.0RegionG1 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000359692112064_66497.6666666666667867.0RegionG2 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121136_139497.6666666666667871.0RegionG3 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121205_208497.6666666666667871.0RegionG4 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000003892531121235_238497.6666666666667871.0RegionG5 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000389253112138_45497.6666666666667871.0RegionG1 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000389253112164_66497.6666666666667871.0RegionG2 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120136_139497.6666666666667867.0RegionG3 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120205_208497.6666666666667867.0RegionG4 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000004089741120235_238497.6666666666667867.0RegionG5 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000408974112038_45497.6666666666667867.0RegionG1 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000408974112064_66497.6666666666667867.0RegionG2 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121136_139497.6666666666667870.0RegionG3 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121205_208497.6666666666667870.0RegionG4 motif
TgeneDNM2chr19:10672342chr19:10916591ENST000005858921121235_238497.6666666666667870.0RegionG5 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000585892112138_45497.6666666666667870.0RegionG1 motif
TgeneDNM2chr19:10672342chr19:10916591ENST00000585892112164_66497.6666666666667870.0RegionG2 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121136_139497.6666666666667871.0RegionG3 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121205_208497.6666666666667871.0RegionG4 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003556671121235_238497.6666666666667871.0RegionG5 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000355667112138_45497.6666666666667871.0RegionG1 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000355667112164_66497.6666666666667871.0RegionG2 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120136_139497.6666666666667867.0RegionG3 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120205_208497.6666666666667867.0RegionG4 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003596921120235_238497.6666666666667867.0RegionG5 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000359692112038_45497.6666666666667867.0RegionG1 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000359692112064_66497.6666666666667867.0RegionG2 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121136_139497.6666666666667871.0RegionG3 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121205_208497.6666666666667871.0RegionG4 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000003892531121235_238497.6666666666667871.0RegionG5 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000389253112138_45497.6666666666667871.0RegionG1 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000389253112164_66497.6666666666667871.0RegionG2 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120136_139497.6666666666667867.0RegionG3 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120205_208497.6666666666667867.0RegionG4 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000004089741120235_238497.6666666666667867.0RegionG5 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000408974112038_45497.6666666666667867.0RegionG1 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000408974112064_66497.6666666666667867.0RegionG2 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121136_139497.6666666666667870.0RegionG3 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121205_208497.6666666666667870.0RegionG4 motif
TgeneDNM2chr19:10672343chr19:10916592ENST000005858921121235_238497.6666666666667870.0RegionG5 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000585892112138_45497.6666666666667870.0RegionG1 motif
TgeneDNM2chr19:10672343chr19:10916592ENST00000585892112164_66497.6666666666667870.0RegionG2 motif


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KRI1
DNM2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KRI1-DNM2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KRI1-DNM2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource