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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KRR1-KCNC2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KRR1-KCNC2
FusionPDB ID: 43466
FusionGDB2.0 ID: 43466
HgeneTgene
Gene symbol

KRR1

KCNC2

Gene ID

11103

3747

Gene nameKRR1 small subunit processome component homologpotassium voltage-gated channel subfamily C member 2
SynonymsHRB2|RIP-1KV3.2
Cytomap

12q21.2

12q21.1

Type of geneprotein-codingprotein-coding
DescriptionKRR1 small subunit processome component homologHIV-1 Rev-binding protein 2HIV-1 rev binding protein 2KRR-R motif-containing protein 1KRR1, small subunit (SSU) processome component, homologRev interacting proteinrev-interacting protein 1potassium voltage-gated channel subfamily C member 2potassium channel, voltage gated Shaw related subfamily C, member 2potassium voltage-gated channel, Shaw-related subfamily, member 2shaw-like potassium channelvoltage-gated potassium channel Kv3.2
Modification date2020032720200313
UniProtAcc

Q13601

.
Ensembl transtripts involved in fusion geneENST idsENST00000229214, ENST00000438169, 
ENST00000548243, ENST00000298972, 
ENST00000341669, ENST00000350228, 
ENST00000393288, ENST00000540018, 
ENST00000548513, ENST00000549446, 
ENST00000550433, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 2=3215 X 5 X 6=450
# samples 416
** MAII scorelog2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(16/450*10)=-1.49185309632967
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: KRR1 [Title/Abstract] AND KCNC2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KRR1(75900562)-KCNC2(75445097), # samples:1
Anticipated loss of major functional domain due to fusion event.KRR1-KCNC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KRR1-KCNC2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KRR1-KCNC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KRR1-KCNC2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across KRR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNC2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6BF-01AKRR1chr12

75900562

-KCNC2chr12

75445097

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000229214KRR1chr1275900562-ENST00000550433KCNC2chr1275445097-2640417181619533
ENST00000229214KRR1chr1275900562-ENST00000548513KCNC2chr1275445097-2735417181571517
ENST00000229214KRR1chr1275900562-ENST00000549446KCNC2chr1275445097-4674417181646542
ENST00000229214KRR1chr1275900562-ENST00000298972KCNC2chr1275445097-2696417181571517
ENST00000229214KRR1chr1275900562-ENST00000341669KCNC2chr1275445097-2601417181619533
ENST00000229214KRR1chr1275900562-ENST00000350228KCNC2chr1275445097-2530417181406462
ENST00000229214KRR1chr1275900562-ENST00000540018KCNC2chr1275445097-1626417181481487
ENST00000229214KRR1chr1275900562-ENST00000393288KCNC2chr1275445097-1967417181586522
ENST00000438169KRR1chr1275900562-ENST00000550433KCNC2chr1275445097-261639301595531
ENST00000438169KRR1chr1275900562-ENST00000548513KCNC2chr1275445097-271139301547515
ENST00000438169KRR1chr1275900562-ENST00000549446KCNC2chr1275445097-465039301622540
ENST00000438169KRR1chr1275900562-ENST00000298972KCNC2chr1275445097-267239301547515
ENST00000438169KRR1chr1275900562-ENST00000341669KCNC2chr1275445097-257739301595531
ENST00000438169KRR1chr1275900562-ENST00000350228KCNC2chr1275445097-250639301382460
ENST00000438169KRR1chr1275900562-ENST00000540018KCNC2chr1275445097-160239301457485
ENST00000438169KRR1chr1275900562-ENST00000393288KCNC2chr1275445097-194339301562520

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000229214ENST00000550433KRR1chr1275900562-KCNC2chr1275445097-0.0002899170.99971
ENST00000229214ENST00000548513KRR1chr1275900562-KCNC2chr1275445097-0.0002665550.9997334
ENST00000229214ENST00000549446KRR1chr1275900562-KCNC2chr1275445097-0.0002601250.9997398
ENST00000229214ENST00000298972KRR1chr1275900562-KCNC2chr1275445097-0.0002695240.9997304
ENST00000229214ENST00000341669KRR1chr1275900562-KCNC2chr1275445097-0.0002949380.999705
ENST00000229214ENST00000350228KRR1chr1275900562-KCNC2chr1275445097-0.0002828870.99971706
ENST00000229214ENST00000540018KRR1chr1275900562-KCNC2chr1275445097-0.0006887180.9993113
ENST00000229214ENST00000393288KRR1chr1275900562-KCNC2chr1275445097-0.0004081730.9995919
ENST00000438169ENST00000550433KRR1chr1275900562-KCNC2chr1275445097-0.0002710780.99972886
ENST00000438169ENST00000548513KRR1chr1275900562-KCNC2chr1275445097-0.0002494470.99975055
ENST00000438169ENST00000549446KRR1chr1275900562-KCNC2chr1275445097-0.0002483060.99975175
ENST00000438169ENST00000298972KRR1chr1275900562-KCNC2chr1275445097-0.0002521790.9997478
ENST00000438169ENST00000341669KRR1chr1275900562-KCNC2chr1275445097-0.0002746060.9997254
ENST00000438169ENST00000350228KRR1chr1275900562-KCNC2chr1275445097-0.0002647740.9997352
ENST00000438169ENST00000540018KRR1chr1275900562-KCNC2chr1275445097-0.0005850520.9994149
ENST00000438169ENST00000393288KRR1chr1275900562-KCNC2chr1275445097-0.0003639750.99963605

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43466_43466_1_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000298972_length(amino acids)=517AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDST

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>43466_43466_2_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000341669_length(amino acids)=533AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDST

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>43466_43466_3_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000350228_length(amino acids)=462AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSDNCKEVVI

--------------------------------------------------------------

>43466_43466_4_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000393288_length(amino acids)=522AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDST

--------------------------------------------------------------

>43466_43466_5_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000540018_length(amino acids)=487AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSGYEKSRSL

--------------------------------------------------------------

>43466_43466_6_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000548513_length(amino acids)=517AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDST

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>43466_43466_7_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000549446_length(amino acids)=542AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDST
GSEPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPS

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>43466_43466_8_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000229214_KCNC2_chr12_75445097_ENST00000550433_length(amino acids)=533AA_BP=1
MQMASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHV
NATLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEI
ETDPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFV
GLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGAL
CALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDST

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>43466_43466_9_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000298972_length(amino acids)=515AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGS

--------------------------------------------------------------

>43466_43466_10_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000341669_length(amino acids)=531AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGS

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>43466_43466_11_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000350228_length(amino acids)=460AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSDNCKEVVITG

--------------------------------------------------------------

>43466_43466_12_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000393288_length(amino acids)=520AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGS

--------------------------------------------------------------

>43466_43466_13_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000540018_length(amino acids)=485AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSGYEKSRSLNN

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>43466_43466_14_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000548513_length(amino acids)=515AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGS

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>43466_43466_15_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000549446_length(amino acids)=540AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGS
EPPLSPPERLPIRRSSTRDKNRRGETCFLLTTGDYTCASDGGIRKGYEKSRSLNNIAGLAGNALRLSPVTSPYNSPCPLRRSRSPIPSIL

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>43466_43466_16_KRR1-KCNC2_KRR1_chr12_75900562_ENST00000438169_KCNC2_chr12_75445097_ENST00000550433_length(amino acids)=531AA_BP=0
MASPSLERPEKGAGKSEFRNQKPKPENQDESELLTVPDGWKEPAFSKEDNPRGLLEESSFATLFPKYREAYLKECWPLVQKALNEHHVNA
TLDLIEGSMTVCTTKKTFDPYIIIRARDLIKLLARSVSFEQFIAFASLFFILVSITTFCLETHEAFNIVKNKTEPVINGTSVVLQYEIET
DPALTYVEGVCVVWFTFEFLVRIVFSPNKLEFIKNLLNIIDFVAILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGL
RVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCA
LAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPRKRKKHIPPAPQASSPTFCKTELNMACNSTQSDTCLGKDNRLLEHNRSVLSGDDSTGS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:75900562/chr12:75445097)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KRR1

Q13601

.
FUNCTION: Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216437_442229.0599.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915437_442229.0630.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815437_442229.0543.6666666666666RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815437_442229.0619.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814437_442229.0584.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305437_442229.0477.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615437_442229.0639.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304437_442229.0630.0RegionSelectivity filter
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216304_313229.0599.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216369_381229.0599.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216474_638229.0599.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915304_313229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915369_381229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915474_638229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815304_313229.0543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815369_381229.0543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815474_638229.0543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815304_313229.0619.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815369_381229.0619.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815474_638229.0619.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814304_313229.0584.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814369_381229.0584.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814474_638229.0584.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305304_313229.0477.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305369_381229.0477.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305474_638229.0477.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615304_313229.0639.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615369_381229.0639.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615474_638229.0639.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304304_313229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304369_381229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304474_638229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216230_250229.0599.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216284_303229.0599.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216314_334229.0599.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216346_368229.0599.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216382_402229.0599.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000029897216453_473229.0599.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915230_250229.0630.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915284_303229.0630.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915314_334229.0630.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915346_368229.0630.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915382_402229.0630.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000034166915453_473229.0630.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815230_250229.0543.6666666666666TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815284_303229.0543.6666666666666TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815314_334229.0543.6666666666666TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815346_368229.0543.6666666666666TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815382_402229.0543.6666666666666TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000035022815453_473229.0543.6666666666666TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815230_250229.0619.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815284_303229.0619.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815314_334229.0619.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815346_368229.0619.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815382_402229.0619.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000039328815453_473229.0619.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814230_250229.0584.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814284_303229.0584.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814314_334229.0584.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814346_368229.0584.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814382_402229.0584.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054001814453_473229.0584.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305230_250229.0477.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305284_303229.0477.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305314_334229.0477.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305346_368229.0477.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305382_402229.0477.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054851305453_473229.0477.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615230_250229.0639.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615284_303229.0639.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615314_334229.0639.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615346_368229.0639.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615382_402229.0639.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000054944615453_473229.0639.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304230_250229.0630.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304284_303229.0630.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304314_334229.0630.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304346_368229.0630.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304382_402229.0630.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNC2chr12:75900562chr12:75445097ENST0000055043304453_473229.0630.0TransmembraneHelical%3B Name%3DSegment S6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKRR1chr12:75900562chr12:75445097ENST00000229214-310247_381131.0382.0Compositional biasNote=Lys-rich
HgeneKRR1chr12:75900562chr12:75445097ENST00000438169-39247_381131.0325.0Compositional biasNote=Lys-rich
HgeneKRR1chr12:75900562chr12:75445097ENST00000229214-310154_206131.0382.0DomainNote=KH
HgeneKRR1chr12:75900562chr12:75445097ENST00000438169-39154_206131.0325.0DomainNote=KH
TgeneKCNC2chr12:75900562chr12:75445097ENST000002989721656_99229.0599.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000003416691556_99229.0630.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000003502281556_99229.0543.6666666666666Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000003932881556_99229.0619.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000005400181456_99229.0584.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000005485130556_99229.0477.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000005494461556_99229.0639.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST000005504330456_99229.0630.0Compositional biasNote=Gly/Pro-rich (insert)
TgeneKCNC2chr12:75900562chr12:75445097ENST00000298972161_229229.0599.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000341669151_229229.0630.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000350228151_229229.0543.6666666666666Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000393288151_229229.0619.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000540018141_229229.0584.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000548513051_229229.0477.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000549446151_229229.0639.0Topological domainCytoplasmic
TgeneKCNC2chr12:75900562chr12:75445097ENST00000550433041_229229.0630.0Topological domainCytoplasmic


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KRR1
KCNC2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to KRR1-KCNC2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KRR1-KCNC2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource