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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANK2-ALPK1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANK2-ALPK1
FusionPDB ID: 4351
FusionGDB2.0 ID: 4351
HgeneTgene
Gene symbol

ANK2

ALPK1

Gene ID

287

80216

Gene nameankyrin 2alpha kinase 1
SynonymsANK-2|CFAP87|FAP87|LQT4|brank-28430410J10Rik|LAK
Cytomap

4q25-q26

4q25

Type of geneprotein-codingprotein-coding
Descriptionankyrin-2ankyrin 2, neuronalankyrin Bankyrin, brainankyrin-2, nonerythrocyticnon-erythroid ankyrinalpha-protein kinase 1chromosome 4 kinaselymphocyte alpha-kinaselymphocyte alpha-protein kinase
Modification date2020031320200320
UniProtAcc

Q01484

Q96QP1

Ensembl transtripts involved in fusion geneENST idsENST00000506722, ENST00000264366, 
ENST00000357077, ENST00000394537, 
ENST00000504887, ENST00000509550, 
ENST00000510275, 		ENST00000505912, 
ENST00000177648, ENST00000458497, 
ENST00000504176, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 12 X 4=5283 X 5 X 4=60
# samples 155
** MAII scorelog2(15/528*10)=-1.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANK2 [Title/Abstract] AND ALPK1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANK2(113825670)-ALPK1(113350305), # samples:3
Anticipated loss of major functional domain due to fusion event.ANK2-ALPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ALPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ALPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ALPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK2-ALPK1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ANK2-ALPK1 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneALPK1

GO:0002753

cytoplasmic pattern recognition receptor signaling pathway

28222186|28877472|30111836

TgeneALPK1

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

28222186|28877472|30111836

TgeneALPK1

GO:0045087

innate immune response

28222186|28877472|30111836


check buttonFusion gene breakpoints across ANK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ALPK1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-8104-01AANK2chr4

113825670

-ALPK1chr4

113350305

+
ChimerDB4LGGTCGA-HT-8104-01AANK2chr4

113825670

+ALPK1chr4

113350305

+
ChimerDB4LGGTCGA-HT-8104ANK2chr4

113825670

+ALPK1chr4

113350304

+
ChimerDB4LGGTCGA-HT-8104ANK2chr4

113825670

+ALPK1chr4

113350305

+
ChimerDB4LUADTCGA-50-6592-01AANK2chr4

113825670

-ALPK1chr4

113359640

+
ChimerDB4LUADTCGA-50-6592-01AANK2chr4

113825670

+ALPK1chr4

113359640

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000506722ANK2chr4113825670+ENST00000458497ALPK1chr4113350305+455221610831551015
ENST00000506722ANK2chr4113825670+ENST00000177648ALPK1chr4113350305+375821610831551015
ENST00000506722ANK2chr4113825670+ENST00000504176ALPK1chr4113350305+331721610831551015
ENST00000506722ANK2chr4113825670+ENST00000458497ALPK1chr4113350304+455221610831551015
ENST00000506722ANK2chr4113825670+ENST00000177648ALPK1chr4113350304+375821610831551015
ENST00000506722ANK2chr4113825670+ENST00000504176ALPK1chr4113350304+331721610831551015

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000506722ENST00000458497ANK2chr4113825670+ALPK1chr4113350305+0.0002909320.99970907
ENST00000506722ENST00000177648ANK2chr4113825670+ALPK1chr4113350305+0.0002930320.9997069
ENST00000506722ENST00000504176ANK2chr4113825670+ALPK1chr4113350305+0.0004782570.99952173
ENST00000506722ENST00000458497ANK2chr4113825670+ALPK1chr4113350304+0.0002909320.99970907
ENST00000506722ENST00000177648ANK2chr4113825670+ALPK1chr4113350304+0.0002930320.9997069
ENST00000506722ENST00000504176ANK2chr4113825670+ALPK1chr4113350304+0.0004782570.99952173

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4351_4351_1_ANK2-ALPK1_ANK2_chr4_113825670_ENST00000506722_ALPK1_chr4_113350304_ENST00000177648_length(amino acids)=1015AA_BP=36
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN

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>4351_4351_2_ANK2-ALPK1_ANK2_chr4_113825670_ENST00000506722_ALPK1_chr4_113350304_ENST00000458497_length(amino acids)=1015AA_BP=36
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN

--------------------------------------------------------------

>4351_4351_3_ANK2-ALPK1_ANK2_chr4_113825670_ENST00000506722_ALPK1_chr4_113350304_ENST00000504176_length(amino acids)=1015AA_BP=36
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN

--------------------------------------------------------------

>4351_4351_4_ANK2-ALPK1_ANK2_chr4_113825670_ENST00000506722_ALPK1_chr4_113350305_ENST00000177648_length(amino acids)=1015AA_BP=36
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN

--------------------------------------------------------------

>4351_4351_5_ANK2-ALPK1_ANK2_chr4_113825670_ENST00000506722_ALPK1_chr4_113350305_ENST00000458497_length(amino acids)=1015AA_BP=36
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN

--------------------------------------------------------------

>4351_4351_6_ANK2-ALPK1_ANK2_chr4_113825670_ENST00000506722_ALPK1_chr4_113350305_ENST00000504176_length(amino acids)=1015AA_BP=36
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:113825670/chr4:113350305)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK2

Q01484

ALPK1

Q96QP1

FUNCTION: Plays an essential role in the localization and membrane stabilization of ion transporters and ion channels in several cell types, including cardiomyocytes, as well as in striated muscle cells. In skeletal muscle, required for proper localization of DMD and DCTN4 and for the formation and/or stability of a special subset of microtubules associated with costameres and neuromuscular junctions. In cardiomyocytes, required for coordinate assembly of Na/Ca exchanger, SLC8A1/NCX1, Na/K ATPases ATP1A1 and ATP1A2 and inositol 1,4,5-trisphosphate (InsP3) receptors at sarcoplasmic reticulum/sarcolemma sites. Required for expression and targeting of SPTBN1 in neonatal cardiomyocytes and for the regulation of neonatal cardiomyocyte contraction rate (PubMed:12571597). In the inner segment of rod photoreceptors, required for the coordinated expression of the Na/K ATPase, Na/Ca exchanger and beta-2-spectrin (SPTBN1) (By similarity). Plays a role in endocytosis and intracellular protein transport. Associates with phosphatidylinositol 3-phosphate (PI3P)-positive organelles and binds dynactin to promote long-range motility of cells. Recruits RABGAP1L to (PI3P)-positive early endosomes, where RABGAP1L inactivates RAB22A, and promotes polarized trafficking to the leading edge of the migrating cells. Part of the ANK2/RABGAP1L complex which is required for the polarized recycling of fibronectin receptor ITGA5 ITGB1 to the plasma membrane that enables continuous directional cell migration (By similarity). {ECO:0000250|UniProtKB:Q8C8R3, ECO:0000269|PubMed:12571597}.FUNCTION: Serine/threonine-protein kinase that detects bacterial pathogen-associated molecular pattern metabolites (PAMPs) and initiates an innate immune response, a critical step for pathogen elimination and engagement of adaptive immunity (PubMed:28877472, PubMed:28222186, PubMed:30111836). Specifically recognizes and binds ADP-D-glycero-beta-D-manno-heptose (ADP-Heptose), a potent PAMP present in all Gram-negative and some Gram-positive bacteria (PubMed:30111836). ADP-Heptose-binding stimulates its kinase activity to phosphorylate and activate TIFA, triggering proinflammatory NF-kappa-B signaling (PubMed:30111836). May be involved in monosodium urate monohydrate (MSU)-induced inflammation by mediating phosphorylation of unconventional myosin MYO9A (PubMed:27169898). May also play a role in apical protein transport by mediating phosphorylation of unconventional myosin MYO1A (PubMed:15883161). {ECO:0000269|PubMed:15883161, ECO:0000269|PubMed:27169898, ECO:0000269|PubMed:28222186, ECO:0000269|PubMed:28877472, ECO:0000269|PubMed:30111836}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneALPK1chr4:113825670chr4:113350304ENST00000177648816921_960265.01245.0Compositional biasNote=Ser-rich
TgeneALPK1chr4:113825670chr4:113350304ENST00000458497816921_960265.01245.0Compositional biasNote=Ser-rich
TgeneALPK1chr4:113825670chr4:113350304ENST00000504176715921_960187.01167.0Compositional biasNote=Ser-rich
TgeneALPK1chr4:113825670chr4:113350305ENST00000177648816921_960265.01245.0Compositional biasNote=Ser-rich
TgeneALPK1chr4:113825670chr4:113350305ENST00000458497816921_960265.01245.0Compositional biasNote=Ser-rich
TgeneALPK1chr4:113825670chr4:113350305ENST00000504176715921_960187.01167.0Compositional biasNote=Ser-rich
TgeneALPK1chr4:113825670chr4:113350304ENST000001776488161017_1237265.01245.0DomainAlpha-type protein kinase
TgeneALPK1chr4:113825670chr4:113350304ENST000004584978161017_1237265.01245.0DomainAlpha-type protein kinase
TgeneALPK1chr4:113825670chr4:113350304ENST000005041767151017_1237187.01167.0DomainAlpha-type protein kinase
TgeneALPK1chr4:113825670chr4:113350305ENST000001776488161017_1237265.01245.0DomainAlpha-type protein kinase
TgeneALPK1chr4:113825670chr4:113350305ENST000004584978161017_1237265.01245.0DomainAlpha-type protein kinase
TgeneALPK1chr4:113825670chr4:113350305ENST000005041767151017_1237187.01167.0DomainAlpha-type protein kinase
TgeneALPK1chr4:113825670chr4:113350304ENST00000504176715236_237187.01167.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350305ENST00000504176715236_237187.01167.0RegionADP-D-glycero-beta-D-manno-heptose binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461158_130403958.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461450_153503958.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1463569_365303958.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146968_115603958.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451158_130401873.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451450_153501873.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1453569_365301873.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145968_115601873.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471158_13047.01864.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471450_15357.01864.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2473569_36537.01864.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247968_11567.01864.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141158_13040556.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141450_15350556.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1143569_36530556.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114968_11560556.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461158_130403958.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461450_153503958.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1463569_365303958.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146968_115603958.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451158_130401873.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451450_153501873.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1453569_365301873.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145968_115601873.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471158_13047.01864.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471450_15357.01864.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2473569_36537.01864.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247968_11567.01864.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141158_13040556.0DomainZU5 2
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141450_15350556.0DomainDeath 1
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1143569_36530556.0DomainDeath 2
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114968_11560556.0DomainZU5 1
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461289_142303958.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461806_198303958.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451289_142301873.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451806_198301873.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471289_14237.01864.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471806_19837.01864.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141289_14230556.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141806_19830556.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461289_142303958.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461806_198303958.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451289_142301873.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451806_198301873.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471289_14237.01864.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471806_19837.01864.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141289_14230556.0RegionNote=UPA domain
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141806_19830556.0RegionNote=Repeat-rich region
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146129_15803958.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146162_19103958.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461806_181703958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461818_182903958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461830_184103958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461842_185303958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461854_186503958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461866_187703958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461878_188903958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461890_190003958.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461901_191203958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461913_192403958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461925_193503958.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461936_194703958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146193_22003958.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461948_195903958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461960_197103958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+1461972_198303958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146232_26103958.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146265_29403958.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146298_32703958.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+14630_6203958.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146331_36003958.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146364_39303958.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146397_42603958.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146430_45903958.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146463_49203958.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146496_52503958.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146529_55803958.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146562_59103958.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146595_62403958.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146628_65703958.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+14663_9203958.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146661_69003958.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146694_72303958.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146727_75603958.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146760_78903958.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146793_82203958.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+14696_12503958.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145129_15801873.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145162_19101873.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451806_181701873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451818_182901873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451830_184101873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451842_185301873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451854_186501873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451866_187701873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451878_188901873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451890_190001873.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451901_191201873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451913_192401873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451925_193501873.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451936_194701873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145193_22001873.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451948_195901873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451960_197101873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+1451972_198301873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145232_26101873.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145265_29401873.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145298_32701873.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+14530_6201873.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145331_36001873.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145364_39301873.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145397_42601873.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145430_45901873.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145463_49201873.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145496_52501873.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145529_55801873.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145562_59101873.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145595_62401873.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145628_65701873.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+14563_9201873.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145661_69001873.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145694_72301873.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145727_75601873.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145760_78901873.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145793_82201873.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+14596_12501873.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247129_1587.01864.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247162_1917.01864.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471806_18177.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471818_18297.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471830_18417.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471842_18537.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471854_18657.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471866_18777.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471878_18897.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471890_19007.01864.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471901_19127.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471913_19247.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471925_19357.01864.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471936_19477.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247193_2207.01864.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471948_19597.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471960_19717.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+2471972_19837.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247232_2617.01864.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247265_2947.01864.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247298_3277.01864.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+24730_627.01864.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247331_3607.01864.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247364_3937.01864.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247397_4267.01864.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247430_4597.01864.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247463_4927.01864.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247496_5257.01864.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247529_5587.01864.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247562_5917.01864.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247595_6247.01864.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247628_6577.01864.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+24763_927.01864.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247661_6907.01864.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247694_7237.01864.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247727_7567.01864.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247760_7897.01864.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247793_8227.01864.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+24796_1257.01864.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114129_1580556.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114162_1910556.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141806_18170556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141818_18290556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141830_18410556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141842_18530556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141854_18650556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141866_18770556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141878_18890556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141890_19000556.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141901_19120556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141913_19240556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141925_19350556.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141936_19470556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114193_2200556.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141948_19590556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141960_19710556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+1141972_19830556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114232_2610556.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114265_2940556.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114298_3270556.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+11430_620556.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114331_3600556.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114364_3930556.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114397_4260556.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114430_4590556.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114463_4920556.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114496_5250556.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114529_5580556.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114562_5910556.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114595_6240556.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114628_6570556.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+11463_920556.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114661_6900556.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114694_7230556.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114727_7560556.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114760_7890556.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114793_8220556.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+11496_1250556.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146129_15803958.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146162_19103958.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461806_181703958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461818_182903958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461830_184103958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461842_185303958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461854_186503958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461866_187703958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461878_188903958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461890_190003958.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461901_191203958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461913_192403958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461925_193503958.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461936_194703958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146193_22003958.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461948_195903958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461960_197103958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+1461972_198303958.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146232_26103958.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146265_29403958.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146298_32703958.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+14630_6203958.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146331_36003958.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146364_39303958.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146397_42603958.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146430_45903958.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146463_49203958.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146496_52503958.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146529_55803958.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146562_59103958.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146595_62403958.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146628_65703958.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+14663_9203958.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146661_69003958.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146694_72303958.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146727_75603958.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146760_78903958.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146793_82203958.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+14696_12503958.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145129_15801873.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145162_19101873.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451806_181701873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451818_182901873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451830_184101873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451842_185301873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451854_186501873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451866_187701873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451878_188901873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451890_190001873.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451901_191201873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451913_192401873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451925_193501873.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451936_194701873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145193_22001873.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451948_195901873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451960_197101873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+1451972_198301873.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145232_26101873.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145265_29401873.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145298_32701873.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+14530_6201873.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145331_36001873.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145364_39301873.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145397_42601873.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145430_45901873.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145463_49201873.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145496_52501873.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145529_55801873.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145562_59101873.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145595_62401873.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145628_65701873.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+14563_9201873.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145661_69001873.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145694_72301873.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145727_75601873.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145760_78901873.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145793_82201873.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+14596_12501873.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247129_1587.01864.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247162_1917.01864.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471806_18177.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471818_18297.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471830_18417.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471842_18537.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471854_18657.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471866_18777.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471878_18897.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471890_19007.01864.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471901_19127.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471913_19247.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471925_19357.01864.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471936_19477.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247193_2207.01864.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471948_19597.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471960_19717.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+2471972_19837.01864.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247232_2617.01864.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247265_2947.01864.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247298_3277.01864.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+24730_627.01864.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247331_3607.01864.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247364_3937.01864.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247397_4267.01864.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247430_4597.01864.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247463_4927.01864.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247496_5257.01864.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247529_5587.01864.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247562_5917.01864.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247595_6247.01864.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247628_6577.01864.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+24763_927.01864.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247661_6907.01864.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247694_7237.01864.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247727_7567.01864.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247760_7897.01864.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247793_8227.01864.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+24796_1257.01864.0RepeatNote=ANK 3
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114129_1580556.0RepeatNote=ANK 4
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114162_1910556.0RepeatNote=ANK 5
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141806_18170556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141818_18290556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141830_18410556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141842_18530556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141854_18650556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141866_18770556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141878_18890556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141890_19000556.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141901_19120556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141913_19240556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141925_19350556.0RepeatNote=Repeat A%3B approximate
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141936_19470556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114193_2200556.0RepeatNote=ANK 6
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141948_19590556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141960_19710556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+1141972_19830556.0RepeatNote=Repeat A
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114232_2610556.0RepeatNote=ANK 7
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114265_2940556.0RepeatNote=ANK 8
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114298_3270556.0RepeatNote=ANK 9
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+11430_620556.0RepeatNote=ANK 1
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114331_3600556.0RepeatNote=ANK 10
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114364_3930556.0RepeatNote=ANK 11
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114397_4260556.0RepeatNote=ANK 12
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114430_4590556.0RepeatNote=ANK 13
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114463_4920556.0RepeatNote=ANK 14
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114496_5250556.0RepeatNote=ANK 15
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114529_5580556.0RepeatNote=ANK 16
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114562_5910556.0RepeatNote=ANK 17
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114595_6240556.0RepeatNote=ANK 18
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114628_6570556.0RepeatNote=ANK 19
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+11463_920556.0RepeatNote=ANK 2
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114661_6900556.0RepeatNote=ANK 20
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114694_7230556.0RepeatNote=ANK 21
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114727_7560556.0RepeatNote=ANK 22
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114760_7890556.0RepeatNote=ANK 23
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114793_8220556.0RepeatNote=ANK 24
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+11496_1250556.0RepeatNote=ANK 3
TgeneALPK1chr4:113825670chr4:113350304ENST00000177648816105_109265.01245.0Compositional biasNote=Poly-Ala
TgeneALPK1chr4:113825670chr4:113350304ENST00000458497816105_109265.01245.0Compositional biasNote=Poly-Ala
TgeneALPK1chr4:113825670chr4:113350304ENST00000504176715105_109187.01167.0Compositional biasNote=Poly-Ala
TgeneALPK1chr4:113825670chr4:113350305ENST00000177648816105_109265.01245.0Compositional biasNote=Poly-Ala
TgeneALPK1chr4:113825670chr4:113350305ENST00000458497816105_109265.01245.0Compositional biasNote=Poly-Ala
TgeneALPK1chr4:113825670chr4:113350305ENST00000504176715105_109187.01167.0Compositional biasNote=Poly-Ala
TgeneALPK1chr4:113825670chr4:113350304ENST00000177648816150_153265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350304ENST00000177648816236_237265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350304ENST00000458497816150_153265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350304ENST00000458497816236_237265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350304ENST00000504176715150_153187.01167.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350305ENST00000177648816150_153265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350305ENST00000177648816236_237265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350305ENST00000458497816150_153265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350305ENST00000458497816236_237265.01245.0RegionADP-D-glycero-beta-D-manno-heptose binding
TgeneALPK1chr4:113825670chr4:113350305ENST00000504176715150_153187.01167.0RegionADP-D-glycero-beta-D-manno-heptose binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1796_ANK2_113825670_ALPK1_113350305_ranked_0.pdbANK2113825670113825670ENST00000504176ALPK1chr4113350305+
MLRDSQAHCREKLPLPVSNEKRHEELVFQMTTMLQKSLLKEFDHHLLSAAEACKLAAAFSAYTPLFVLTAVNIRGTCLLSYSSSNDCPPE
LKNLHLCEAKEAFEIGLLTKRDDEPVTGKQELHSFVKAAFGLTTVHRRLHGETGTVHAASQLCKEAMGKLYNFSTSSRSQDREALSQEVM
SVIAQVKEHLQVQSFSNVDDRSYVPESFECRLDKLILHGQGDFQKILDTYSQHHTSVCEVFESDCGNNKNEQKDAKTGVCITALKTEIKN
IDTVSTTQEKPHCQRDTGISSSLMGKNVQRELRRGGRRNWTHSDAFRVSLDQDVETETEPSDYSNGEGAVFNKSLSGSQTSSAWSNLSGF
SSSASWEEVNYHVDDRSARKEPGKEHLVDTQCSTALSEELENDREGRAMHSLHSQLHDLSLQEPNNDNLEPSQNQPQQQMPLTPFSPHNT
PGIFLAPGAGLLEGAPEGIQEVRNMGPRNTSAHSRPSYRSASWSSDSGRPKNMGTHPSVQKEEAFEIIVEFPETNCDVKDRQGKEQGEEI
SERGAGPTFKASPSWVDPEGETAESTEDAPLDFHRVLHNSLGNISMLPCSSFTPNWPVQNPDSRKSGGPVAEQGIDPDASTVDEEGQLLD
SMDVPCTNGHGSHRLCILRQPPGQRAETPNSSVSGNILFPVLSEDCTTTEEGNQPGNMLNCSQNSSSSSVWWLKSPAFSSGSSEGDSPWS
YLNSSGSSWVSLPGKMRKEILEARTLQPDDFEKLLAGVRHDWLFQRLENTGVFKPSQLHRAHSALLLKYSKKSELWTAQETIVYLGDYLT
VKKKGRQRNAFWVHHLHQEEILGRYVGKDYKEQKGLWHHFTDVERQMTAQHYVTEFNKRLYEQNIPTQIFYIPSTILLILEDKTIKGCIS
VEPYILGEFVKLSNNTKVVKTEYKATEYGLAYGHFSYEFSNHRDVVVDLQGWVTGNGKGLIYLTDPQIHSVDQKVFTTNFGKRGIFYFFN
1015


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ANK2_pLDDT.png
all structure
all structure
ALPK1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANK2
ALPK1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANK2chr4:113825670chr4:113350304ENST00000357077+146966_112503958.0SPTBN1
HgeneANK2chr4:113825670chr4:113350304ENST00000394537+145966_112501873.0SPTBN1
HgeneANK2chr4:113825670chr4:113350304ENST00000506722+247966_11257.01864.0SPTBN1
HgeneANK2chr4:113825670chr4:113350304ENST00000510275+114966_11250556.0SPTBN1
HgeneANK2chr4:113825670chr4:113350305ENST00000357077+146966_112503958.0SPTBN1
HgeneANK2chr4:113825670chr4:113350305ENST00000394537+145966_112501873.0SPTBN1
HgeneANK2chr4:113825670chr4:113350305ENST00000506722+247966_11257.01864.0SPTBN1
HgeneANK2chr4:113825670chr4:113350305ENST00000510275+114966_11250556.0SPTBN1


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Related Drugs to ANK2-ALPK1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANK2-ALPK1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource