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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KTN1-RET

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KTN1-RET
	FusionPDB ID: 43755
	FusionGDB2.0 ID: 43755
		Hgene	Tgene
	Gene symbol	KTN1	RET
	Gene ID	3895	5979
	Gene name	kinectin 1	ret proto-oncogene
	Synonyms	CG1\|KNT\|MU-RMS-40.19	CDHF12\|CDHR16\|HSCR1\|MEN2A\|MEN2B\|MTC1\|PTC\|RET-ELE1
	Cytomap	14q22.3	10q11.21
	Type of gene	protein-coding	protein-coding
	Description	kinectinCG-1 antigenkinesin receptor	proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
	Modification date	20200313	20200322
	UniProtAcc	Q86SY8	RTL1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000395308, ENST00000395309, ENST00000395311, ENST00000395314, ENST00000413890, ENST00000416613, ENST00000438792, ENST00000554507, ENST00000555573,	ENST00000340058, ENST00000355710,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 19 X 8=2584	32 X 31 X 11=10912
	# samples	20	48
	** MAII score	log2(20/2584*10)=-3.6915341649192 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(48/10912*10)=-4.50673733341565 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KTN1 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	KTN1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KTN1-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KTN1-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KTN1-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RET	GO:0030155	regulation of cell adhesion	21357690
Tgene	RET	GO:0030335	positive regulation of cell migration	20702524
Tgene	RET	GO:0033619	membrane protein proteolysis	21357690
Tgene	RET	GO:0033630	positive regulation of cell adhesion mediated by integrin	20702524
Tgene	RET	GO:0035860	glial cell-derived neurotrophic factor receptor signaling pathway	28953886
Tgene	RET	GO:0043410	positive regulation of MAPK cascade	28846099

Fusion gene breakpoints across KTN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	KTN1	chr14	56120314	+	RET	chr10	43612031	+
ChimerKB3	.	.	KTN1	chr14	56122850	+	RET	chr10	43612031	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000395309	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6361	3070	178	4278	1366
ENST00000395309	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4903	3070	178	4152	1324
ENST00000413890	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6292	3001	178	4209	1343
ENST00000413890	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4834	3001	178	4083	1301
ENST00000438792	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6253	2962	70	4170	1366
ENST00000438792	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4795	2962	70	4044	1324
ENST00000395314	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6251	2960	68	4168	1366
ENST00000395314	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4793	2960	68	4042	1324
ENST00000395308	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6299	3008	185	4216	1343
ENST00000395308	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4841	3008	185	4090	1301
ENST00000395311	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6233	2942	119	4150	1343
ENST00000395311	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4775	2942	119	4024	1301
ENST00000416613	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	6255	2964	72	4172	1366
ENST00000416613	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	4797	2964	72	4046	1324
ENST00000554507	KTN1	chr14	56122850	+	ENST00000355710	RET	chr10	43612031	+	4180	889	112	2097	661
ENST00000554507	KTN1	chr14	56122850	+	ENST00000340058	RET	chr10	43612031	+	2722	889	112	1971	619

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43755_43755_1_KTN1-RET_KTN1_chr14_56122850_ENST00000395308_RET_chr10_43612031_ENST00000340058_length(amino acids)=1301AA_BP=941
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL
ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD

--------------------------------------------------------------

>43755_43755_2_KTN1-RET_KTN1_chr14_56122850_ENST00000395308_RET_chr10_43612031_ENST00000355710_length(amino acids)=1343AA_BP=941
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL
ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD

--------------------------------------------------------------

>43755_43755_3_KTN1-RET_KTN1_chr14_56122850_ENST00000395309_RET_chr10_43612031_ENST00000340058_length(amino acids)=1324AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM

--------------------------------------------------------------

>43755_43755_4_KTN1-RET_KTN1_chr14_56122850_ENST00000395309_RET_chr10_43612031_ENST00000355710_length(amino acids)=1366AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM
MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYAN

--------------------------------------------------------------

>43755_43755_5_KTN1-RET_KTN1_chr14_56122850_ENST00000395311_RET_chr10_43612031_ENST00000340058_length(amino acids)=1301AA_BP=941
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL
ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD

--------------------------------------------------------------

>43755_43755_6_KTN1-RET_KTN1_chr14_56122850_ENST00000395311_RET_chr10_43612031_ENST00000355710_length(amino acids)=1343AA_BP=941
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL
ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD

--------------------------------------------------------------

>43755_43755_7_KTN1-RET_KTN1_chr14_56122850_ENST00000395314_RET_chr10_43612031_ENST00000340058_length(amino acids)=1324AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM

--------------------------------------------------------------

>43755_43755_8_KTN1-RET_KTN1_chr14_56122850_ENST00000395314_RET_chr10_43612031_ENST00000355710_length(amino acids)=1366AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM
MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYAN

--------------------------------------------------------------

>43755_43755_9_KTN1-RET_KTN1_chr14_56122850_ENST00000413890_RET_chr10_43612031_ENST00000340058_length(amino acids)=1301AA_BP=941
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL
ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD

--------------------------------------------------------------

>43755_43755_10_KTN1-RET_KTN1_chr14_56122850_ENST00000413890_RET_chr10_43612031_ENST00000355710_length(amino acids)=1343AA_BP=941
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS
SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDL
ISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLL
WEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDD

--------------------------------------------------------------

>43755_43755_11_KTN1-RET_KTN1_chr14_56122850_ENST00000416613_RET_chr10_43612031_ENST00000340058_length(amino acids)=1324AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM

--------------------------------------------------------------

>43755_43755_12_KTN1-RET_KTN1_chr14_56122850_ENST00000416613_RET_chr10_43612031_ENST00000355710_length(amino acids)=1366AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM
MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYAN

--------------------------------------------------------------

>43755_43755_13_KTN1-RET_KTN1_chr14_56122850_ENST00000438792_RET_chr10_43612031_ENST00000340058_length(amino acids)=1324AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM

--------------------------------------------------------------

>43755_43755_14_KTN1-RET_KTN1_chr14_56122850_ENST00000438792_RET_chr10_43612031_ENST00000355710_length(amino acids)=1366AA_BP=964
MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPTKTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDAL
AVEDDQVAPVPLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTKQPTPPSEAAASKKKPGQKKSKNGSDDQDKK
VETLMVPSKRQEALPLHQETKQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKREVIDLLKPDQVEGIQKSGTKK
LKTETDKENAEVKFKDFLLSLKTMMFSEDEALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAATKDRCKQLTQ
EMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQETQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK
LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEVQSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTL
VSKQQLEQRLMQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASVLAEELHKVIAEKDKQIKQTEDSLASERDRL
TSKEEELKDIQNMNFLLKAEVQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEFKILNDQNKALKSEVQKLQTL
VSEQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHEKDGKI
KSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL
QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKV
VKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLG
SGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWM
AIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKM
MVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYAN

--------------------------------------------------------------

>43755_43755_15_KTN1-RET_KTN1_chr14_56122850_ENST00000554507_RET_chr10_43612031_ENST00000340058_length(amino acids)=619AA_BP=259
MVPSCCFFRCRKQKDNRYQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASL
VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEE
KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKN
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD

--------------------------------------------------------------

>43755_43755_16_KTN1-RET_KTN1_chr14_56122850_ENST00000554507_RET_chr10_43612031_ENST00000355710_length(amino acids)=661AA_BP=259
MVPSCCFFRCRKQKDNRYQPNKDVVEQMEKCIQEKDEKLKTVEELLETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASL
VEELKKVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEE
KEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPRKN
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD
KRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGT

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:/chr10:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KTN1 Q86SY8	RET RTL1
	1358

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (491) >>>491.pdbFusion protein BP residue: 259 CIF file (491) >>>491.cif	KTN1	chr14	56122850	+	RET	chr10	43612031	+	MVPSCCFFRCRKQKDNRYQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE KDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD LSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT TVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK DLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP	619
3D view using mol* of 491 (AA BP:259)


PDB file (539) >>>539.pdbFusion protein BP residue: 259 CIF file (539) >>>539.cif	KTN1	chr14	56122850	+	RET	chr10	43612031	+	MVPSCCFFRCRKQKDNRYQPNKDVVEQMEKCIQEKDEKLKTVEELLETGL IQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELKKVIHE KDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQLEKAQQ LSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDLQEENE SLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKERESD LSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT TVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK DLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP STWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSP	661
3D view using mol* of 539 (AA BP:259)


PDB file (880)CIF file (880) >>>880.cif	KTN1	chr14	56122850	+	RET	chr10	43612031	+	MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPT KTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPV PLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTK QPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQET KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE VIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV QSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF KILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK KVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKE EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPR KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS TPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTR	1301
3D view using mol* of 880 (AA BP:)


PDB file (886)CIF file (886) >>>886.cif	KTN1	chr14	56122850	+	RET	chr10	43612031	+	MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPT KTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPV PLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTK QPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQET KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE VIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV QSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF KILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQL EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK ERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKG RAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG GNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL	1324
3D view using mol* of 886 (AA BP:)


PDB file (893)CIF file (893) >>>893.cif	KTN1	chr14	56122850	+	RET	chr10	43612031	+	MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPT KTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPV PLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTK QPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQET KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE VIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV QSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF KILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK KVIHEKDGKIKSVEELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKE EQMNTMKAVLEEKEKDLANTGKWLQDLQEENESLKAHVQEVAQHNLKEAS SASQFEELEIVLKEKENELKRLEAMLKERESDLSSKTQLLQEDPKWEFPR KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS TPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPG	1343
3D view using mol* of 893 (AA BP:)


PDB file (897)CIF file (897) >>>897.cif	KTN1	chr14	56122850	+	RET	chr10	43612031	+	MEFYESAYFIVLIPSIVITVIFLFFWLFMKETLYDEVLAKQKREQKLIPT KTDKKKAEKKKNKKKEIQNGNLHESDSESVPRDFKLSDALAVEDDQVAPV PLNVVETSSSVRERKKKEKKQKPVLEEQVIKESDASKIPGKKVEPVPVTK QPTPPSEAAASKKKPGQKKSKNGSDDQDKKVETLMVPSKRQEALPLHQET KQESGSGKKKASSKKQKTENVFVDEPLIHATTYIPLMDNADSSPVVDKRE VIDLLKPDQVEGIQKSGTKKLKTETDKENAEVKFKDFLLSLKTMMFSEDE ALCVVDLLKEKSGVIQDALKKSSKGELTTLIHQLQEKDKLLAAVKEDAAA TKDRCKQLTQEMMTEKERSNVVITRMKDRIGTLEKEHNVFQNKIHVSYQE TQQMQMKFQQVREQMEAEIAHLKQENGILRDAVSNTTNQLESKQSAELNK LRQDYARLVNELTEKTGKLQQEEVQKKNAEQAATQLKVQLQEAERRWEEV QSYIRKRTAEHEAAQQDLQSKFVAKENEVQSLHSKLTDTLVSKQQLEQRL MQLMESEQKRVNKEESLQMQVQDILEQNEALKAQIQQFHSQIAAQTSASV LAEELHKVIAEKDKQIKQTEDSLASERDRLTSKEEELKDIQNMNFLLKAE VQKLQALANEQAAAAHELEKMQQSVYVKDDKIRLLEEQLQHEISNKMEEF KILNDQNKALKSEVQKLQTLVSEQPNKDVVEQMEKCIQEKDEKLKTVEEL LETGLIQVATKEEELNAIRTENSSLTKEVQDLKAKQNDQVSFASLVEELK KVIHEKDGKIKSVEELLEAELLKVANKEKTVQDLKQEIKALKEEIGNVQL EKAQQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKWLQDL QEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLK ERESDLSSKTQLLQEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKG RAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDG PLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTM GDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRD VYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLG GNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVF ADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPL PRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYAN	1366
3D view using mol* of 897 (AA BP:)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RET_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

KTN1_RET_491_pLDDT.png (AA BP:259)

KTN1_RET_491_pLDDT_and_active_sites.png (AA BP:259)

KTN1_RET_491_violinplot.png (AA BP:259)

KTN1_RET_539_pLDDT.png (AA BP:259)

KTN1_RET_539_pLDDT_and_active_sites.png (AA BP:259)

KTN1_RET_539_violinplot.png (AA BP:259)

KTN1_RET_880_pLDDT_and_active_sites.png (AA BP:)

KTN1_RET_880_violinplot.png (AA BP:)

KTN1_RET_886_pLDDT_and_active_sites.png (AA BP:)

KTN1_RET_886_violinplot.png (AA BP:)

KTN1_RET_893_pLDDT_and_active_sites.png (AA BP:)

KTN1_RET_893_violinplot.png (AA BP:)

KTN1_RET_897_pLDDT_and_active_sites.png (AA BP:)

KTN1_RET_897_violinplot.png (AA BP:)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

KTN1_RET_491.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
491	1.071	120	1.121	294.637	0.487	0.735	0.953	1.272	0.797	1.596	1.434	Chain A: 277,278,279,280,282,283,285,303,305,322,3 26,335,349,351,352,353,354,356,357,358,361,362,425 ,426,428,438,439
539	1.063	181	1.031	538.51	0.484	0.792	1.095	0.747	1.178	0.635	0.732	Chain A: 280,281,282,305,308,314,315,317,318,319,3 22,360,420,421,423,425,426,439,441,442,444,452,454 ,458,459,460,461,462,463,464,465,475,490,496,497,4 98,504,646,647,648,649,650
880	1.086	125	1.104	325.164	0.439	0.814	1.048	1.441	0.995	1.448	1.1	Chain A: 959,960,961,962,964,965,966,967,985,987,1 004,1008,1017,1031,1033,1034,1035,1036,1037,1039,1 040,1043,1103,1107,1108,1110,1120,1121
886	1.096	120	1.141	311.444	0.492	0.777	0.985	1.684	0.814	2.07	1.24	Chain A: 980,982,983,984,985,987,988,989,990,992,1 008,1010,1027,1031,1040,1054,1056,1058,1059,1062,1 126,1130,1131,1133,1143,1144,1145
893	1.028	190	1.061	543.998	0.591	0.708	0.888	0.838	0.931	0.901	0.857	Chain A: 959,960,962,963,964,965,967,985,987,990,9 94,996,997,999,1000,1001,1004,1008,1017,1031,1033, 1034,1035,1036,1037,1039,1040,1102,1103,1107,1108, 1110,1120,1121,1124,1126,1134,1136,1138,1140,1141, 1142,1143
897	1.043	135	1.112	367.01	0.553	0.662	0.88	1.111	0.692	1.605	1.596	Chain A: 818,821,822,825,826,828,829,832,1108,1112 ,1115,1231,1234,1235,1238,1248,1251,1254,1255,1256 ,1258,1259,1260,1262,1263

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
880	ZINC000253632968	DB06290	Simeprevir	-8.78316	-8.78976
880	Baricitinib	DB06290		-8.72193	-8.72193
880	ZINC000019632917	DB00475	Chlordiazepoxide	-6.99512	-8.57112
880	ZINC000019203912	DB00623	Fluphenazine	-7.58221	-8.12951
880	ZINC000150338698	DB00314	Capreomycin	-7.55275	-8.06505
880	ZINC000008214418	DB09135	Ioxilan	-8.05279	-8.05279
880	ZINC000002005305	DB11256	Levomefolic acid	-7.98488	-8.00108
880	ZINC000003874185	DB00358	Mefloquine	-7.76126	-7.76376
880	Upadacitinib	DB00358		-7.72796	-7.72896
880	ZINC000022059930	DB01155	Gemifloxacin	-7.60526	-7.64616
880	ZINC000000897089	DB00358	Mefloquine	-7.64013	-7.64263
880	ZINC000005733652	DB11259	Diosmetin	-7.43223	-7.46823
880	ZINC000000897085	DB00358	Mefloquine	-7.46068	-7.46318
880	ZINC000000057255	DB00310	Chlorthalidone	-7.45027	-7.45167
880	ZINC000019228902	DB00850	Perphenazine	-6.83967	-7.38697
880	ZINC000019418959	DB00831	Trifluoperazine	-7.08777	-7.36787
880	ZINC000022059926	DB01155	Gemifloxacin	-7.30222	-7.34312
880	ZINC000001536779	DB00476	Duloxetine	-7.31646	-7.31716
880	ZINC000049637509	DB06636	Isavuconazonium	-6.87861	-7.31061
880	Pexidartinib	DB06636		-7.07422	-7.29102

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000253632968	DB06290	Simeprevir	Small molecule	[H][C@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](C[C@@]1([H])C(=O)N(C)CCCCC=C/2)OC1=CC(=NC2=C1C=CC(OC)=C2C)C1=NC(=CS1)C(C)C)C(=O)NS(=O)(=O)C1CC1	Approved
ZINC000019632917	DB00475	Chlordiazepoxide	Small molecule	CNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1	Approved\|Illicit\|Investigational
ZINC000019203912	DB00623	Fluphenazine	Small molecule	OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	Approved
ZINC000150338698	DB00314	Capreomycin	Small molecule	[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O.[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O	Approved
ZINC000008214418	DB09135	Ioxilan	Small molecule	CC(=O)N(CC(O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCCO)=C1I	Approved
ZINC000002005305	DB11256	Levomefolic acid	Small molecule	CN1[C@@H](CNC2=CC=C(C=C2)C(=O)N[C@@H](CCC(O)=O)C(O)=O)CNC2=C1C(=O)N=C(N)N2	Approved\|Investigational
ZINC000022059930	DB01155	Gemifloxacin	Small molecule	CON=C1/CN(CC1CN)C1=NC2=C(C=C1F)C(=O)C(=CN2C1CC1)C(O)=O	Approved\|Investigational
ZINC000005733652	DB11259	Diosmetin	Small molecule	COC1=C(O)C=C(C=C1)C1=CC(=O)C2=C(O1)C=C(O)C=C2O	Experimental
ZINC000000057255	DB00310	Chlorthalidone	Small molecule	NS(=O)(=O)C1=C(Cl)C=CC(=C1)C1(O)NC(=O)C2=CC=CC=C12	Approved
ZINC000019228902	DB00850	Perphenazine	Small molecule	OCCN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(Cl)C=C3)CC1	Approved
ZINC000019418959	DB00831	Trifluoperazine	Small molecule	CN1CCN(CCCN2C3=CC=CC=C3SC3=C2C=C(C=C3)C(F)(F)F)CC1	Approved\|Investigational
ZINC000001536779	DB00476	Duloxetine	Small molecule	CNCC[C@H](OC1=CC=CC2=CC=CC=C12)C1=CC=CS1	Approved
ZINC000049637509	DB06636	Isavuconazonium	Small molecule	[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1	Approved\|Investigational

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000253632968	749.939	6.957	1148.652	820.732	134.162	154.915	38.842	2228.629	1.25	13.75	8.419	1	62.525	3	2
ZINC000253632968	749.939	11.135	1103.653	772.655	146.278	144.582	40.138	2184.383	1.25	13.75	8.499	1	57.804	3	2
ZINC000253632968	749.939	9.298	1114.226	794.485	125.878	154.692	39.17	2200.5	1.25	13.75	8.41	1	63.806	3	2
ZINC000253632968	749.939	8.17	1081.392	774.076	143.601	146.311	17.404	2179.154	1.25	13.75	8.604	1	61.006	3	2
ZINC000019632917	299.759	4.645	553.04	137.022	64.707	279.788	71.524	941.819	1	3	8.565	3	100	0	0
ZINC000019632917	299.759	5.502	549.003	118.965	74.766	283.82	71.453	935.577	1	3	8.408	3	100	0	0
ZINC000019203912	437.522	1.866	667.705	280.393	37.632	229.684	119.996	1257.681	1	6.2	8.126	3	95.44	0	1
ZINC000019203912	437.522	3.481	669.797	259.989	57.21	232.5	120.098	1250.575	1	6.2	8.155	3	91.657	0	1
ZINC000019203912	437.522	3.695	710.047	257.018	59.375	274.093	119.561	1303.382	1	6.2	8.086	3	92.087	0	1
ZINC000150338698	668.712	6.387	969.107	438.187	507.607	23.314	0	1886.358	10	14.7	8.085	1	0	3	2
ZINC000150338698	668.712	1.97	1011.384	430.014	557.991	23.379	0	1920.75	10	14.7	8.063	1	0	3	2
ZINC000008214418	791.116	1.945	763.111	318.983	317.048	9.77	117.31	1418.936	7	16.5	9.199	1	1.209	3	1
ZINC000002005305	459.461	11.831	783.577	206.681	420.974	155.922	0	1372.034	7.25	12.25	7.655	1	0	2	1
ZINC000002005305	459.461	12.273	767.829	200.116	415.916	151.796	0	1360.76	7.25	12.25	7.578	1	0	2	1
ZINC000003874185	378.317	7.567	591.505	189.633	58.939	124.18	218.753	1037.435	2	4.2	9.501	3	100	0	0
ZINC000022059930	389.385	5.771	675.499	333.722	232.902	67.773	41.101	1199.671	2	8.7	9.049	2	36.482	0	1
ZINC000022059930	389.385	7.083	660.215	323.57	227.182	68.271	41.191	1181.717	2	8.7	9.157	2	37.113	0	1
ZINC000000897089	378.317	7.024	589.936	192.765	54.441	122.198	220.532	1034.587	2	4.2	9.632	3	100	0	0
ZINC000005733652	300.267	4.88	528.855	93.31	204.424	231.12	0	896.841	2	4.5	8.9	3	73.982	0	0
ZINC000005733652	300.267	6.652	527.118	93.294	202.511	231.313	0	894.005	2	4.5	8.908	3	74.287	0	0
ZINC000000897085	378.317	7.557	589.939	192.626	54.6	122.313	220.401	1034.647	2	4.2	9.439	3	100	0	0
ZINC000000057255	338.765	9.032	531.758	0.001	243.761	234.495	53.501	911.032	4	7.75	10.165	2	59.138	0	0
ZINC000019228902	403.969	2.241	681.728	285.579	49.866	237.154	109.129	1238.384	1	6.2	7.99	3	92.981	0	1
ZINC000019228902	403.969	0.857	656.909	279.144	54.566	228.099	95.1	1217.57	1	6.2	7.966	3	91.987	0	1
ZINC000019228902	403.969	3.277	692.477	277.369	47.722	284.844	82.542	1254.469	1	6.2	7.879	3	93.303	0	1
ZINC000019418959	407.496	3.166	685.963	284.038	6.797	242.502	152.626	1250.669	0	4.5	8.057	3	92.213	1	0
ZINC000019418959	407.496	2.336	654.93	278.085	11.45	232.074	133.321	1198.509	0	4.5	8.184	3	100	0	0
ZINC000019418959	407.496	3.508	684.003	297.4	7.942	225.738	152.923	1221.056	0	4.5	8.132	3	100	0	0
ZINC000022059926	389.385	5.386	675.076	333.398	232.638	67.96	41.08	1199.522	2	8.7	9.053	2	36.535	0	1
ZINC000022059926	389.385	4.357	656.741	321.575	225.557	68.441	41.167	1178.176	2	8.7	9.183	2	37.346	0	1
ZINC000001536779	297.414	0.915	589.154	161.205	24.056	372.401	31.491	1019.209	1	2.25	8.31	3	100	0	0

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000253632968	COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCN(C)C(=O)[C@@H]4C3)cc(-c3nc(C(C)C)cs3)nc2c1C	0.014845215	0.273382605
ZINC000019632917	CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1	0.147320673	0.447326601
ZINC000019203912	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	0.241606725	0.269532671
ZINC000150338698	NCCC[C@H](N)CC(=O)NC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@H]([C@H]2CCN=C(N)N2)NC(=O)/C(=CNC(N)=O)NC1=O	0.008886696	0.175052227
ZINC000008214418	CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I	0.055075912	0.216199147
ZINC000002005305	CN1c2c(nc(N)[nH]c2=O)NC[C@@H]1CNc1ccc(C(=O)N[C@@H](CCC(=O)O)C(=O)O)cc1	0.073417915	0.401979429
ZINC000003874185	O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN1	0.082724827	0.290697747
ZINC000022059930	CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@H]1CN	0.077611514	0.258972331
ZINC000000897089	O[C@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@@H]1CCCCN1	0.082724827	0.290697747
ZINC000005733652	COc1ccc(-c2cc(=O)c3c(O)cc(O)cc3o2)cc1O	0.260199086	0.67867566
ZINC000000897085	O[C@@H](c1cc(C(F)(F)F)nc2c(C(F)(F)F)cccc12)[C@H]1CCCCN1	0.082724827	0.290697747
ZINC000000057255	NS(=O)(=O)c1cc([C@@]2(O)NC(=O)c3ccccc32)ccc1Cl	0.128141978	0.345401829
ZINC000019228902	OCCN1CCN(CCCN2c3ccccc3Sc3ccc(Cl)cc32)CC1	0.278366114	0.273715485
ZINC000019418959	CN1CCN(CCCN2c3ccccc3Sc3ccc(C(F)(F)F)cc32)CC1	0.258825995	0.284976043
ZINC000022059926	CO/N=C1CN(c2nc3c(cc2F)c(=O)c(C(=O)O)cn3C2CC2)C[C@@H]1CN	0.077611514	0.258972331
ZINC000001536779	CNCC[C@H](Oc1cccc2ccccc12)c1cccs1	0.198580477	0.408385121
ZINC000049637509	CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1	0.025416027	0.235213823

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
KTN1	EEF1D, IKBKE, RHOA, RHOG, RAC1, PSMD7, PLEKHA5, ARRB1, HERC2, NEURL4, CDH2, NPM1, CTPS2, EHD1, HEXA, WARS, BNIP3, MEOX2, SGTA, CLEC7A, SYNE4, BMI1, DTNBP1, RTN4, PTGER3, EEF1G, C17orf59, LPAR1, FAM134C, SPC25, NTRK1, TMEM237, TMEM17, TMEM216, PKN2, XRCC3, RAB7A, EMC2, ATP6AP2, GOLT1B, MMGT1, Eef1a1, Kcnk1, Rab5c, Tmed2, Chmp4b, FOXN1, CDH1, CDR2, SPPL2B, YIPF3, NDEL1, CAPN1, SSX3, VTN, IPPK, ADAM32, FAM167A, TRIM25, ZNF598, PPIE, EFTUD2, TNIP2, SOCS6, RNF4, RNF123, AGR2, MB21D1, MYC, CANX, LAMP1, METTL14, SIRPA, ATG16L1, PHB, NRAS, KRAS, CSK, ARMCX3, ARMCX2, PGAM5, HIST1H4A, APEX1, TCF7L2, SCARB2, VAMP5, CYLD, RHBDD1, RHBDF2, IFT20, BIRC3, STAU1, LMBR1L, NFX1, WWP2, FAM105A, M6PR, FFAR2, CD68, HIATL1, STOM, SUSD3, CD3G, SYNPR, TMEM179B, PDCD1LG2, LHFPL5, CLEC4C, KIR2DL3, PLEKHA4, HCVgp1, ATF4, SPATA9, PHRF1, SLC16A7, EIF2S2, BCAP31, AKAP17A, FAM184A, TTN, MYO9A, DCLRE1A, FRA10AC1, CENPE, AKAP1, NEUROD6, HNRNPA1L2, E, M, nsp4, nsp6, ORF7a, ORF7b, ESR1, S, ORF8, ORF6, ABI1, UBE2I, SNAPIN, CAPRIN1, ST7, CIT, KIF20A, PRC1, FIS1, FKBP8, PTPN1, SLC25A46, LRRC59, Apc2, LGALS9, IFI16, NR3C1, DNAJC14, DNAJC16, DNAJC1, DNAJC25, SEC63, DDX58, ATP2A1, B3GAT1, CKAP4, CYP2C9, DERL1, DHFRL1, ELOVL5, EMD, ERGIC2, FBL, GJA1, GJD3, HSD17B11, HSD3B7, KRT19, LAMP2, LAMP3, LMAN1, KIAA1715, METTL7A, NUP155, PANX1, PFN1, PTK2, PXMP2, RAB11A, RAB3B, RAB4A, RAB5A, RAB5C, RAB9A, REEP5, RPN1, RPN2, SEC61B, SEC62, SERBP1, SSR1, STIM1, STX4, STX6, STX7, TMPO, WDR5, NAA40, IGSF3, TACR3, DYNLL1, SFT2D1, NUF2, CDR2L, EEF1A2, FBXW7, TMPRSS2, TOP3B, TFRC, ANPEP, DPP4, TMPRSS11B, CLEC4D, ACE2, CLEC4E, RB1CC1,
RET	STAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KTN1
RET

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to KTN1-RET

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KTN1-RET

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
KTN1	RET	Lung Adenocarcinoma	MyCancerGenome
KTN1	RET	Breast Invasive Ductal Carcinoma	MyCancerGenome
KTN1	RET	Thyroid Gland Papillary Carcinoma	MyCancerGenome
KTN1	RET	Adenocarcinoma Of Unknown Primary	MyCancerGenome
KTN1	RET	Bladder Urothelial Carcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KTN1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human
Tgene	RET	C1833921	Familial medullary thyroid carcinoma	23	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C3888239	HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 1	16	GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C0025268	Multiple Endocrine Neoplasia Type 2a	15	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C1708353	Hereditary Paraganglioma-Pheochromocytoma Syndrome	12	CLINGEN
Tgene	RET	C0025269	Multiple Endocrine Neoplasia Type 2b	10	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Tgene	RET	C0238463	Papillary thyroid carcinoma	3	CTD_human;ORPHANET
Tgene	RET	C1275808	Congenital central hypoventilation	3	CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C1859049	CCHS WITH HIRSCHSPRUNG DISEASE	3	CTD_human;ORPHANET
Tgene	RET	C0009402	Colorectal Carcinoma	2	CTD_human;UNIPROT
Tgene	RET	C0009404	Colorectal Neoplasms	2	CTD_human
Tgene	RET	C0019569	Hirschsprung Disease	2	CTD_human
Tgene	RET	C0027662	Multiple Endocrine Neoplasia	2	CTD_human;GENOMICS_ENGLAND
Tgene	RET	C0085758	Aganglionosis, Colonic	2	CTD_human
Tgene	RET	C0266294	Unilateral agenesis of kidney	2	ORPHANET
Tgene	RET	C1257840	Aganglionosis, Rectosigmoid Colon	2	CTD_human
Tgene	RET	C3661523	Congenital Intestinal Aganglionosis	2	CTD_human
Tgene	RET	C0006413	Burkitt Lymphoma	1	CTD_human
Tgene	RET	C0031511	Pheochromocytoma	1	CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
Tgene	RET	C0038220	Status Epilepticus	1	CTD_human
Tgene	RET	C0040136	Thyroid Neoplasm	1	CGI;CTD_human
Tgene	RET	C0151468	Thyroid Gland Follicular Adenoma	1	CTD_human
Tgene	RET	C0206693	Medullary carcinoma	1	CTD_human
Tgene	RET	C0238462	Medullary carcinoma of thyroid	1	CGI;CTD_human
Tgene	RET	C0270823	Petit mal status	1	CTD_human
Tgene	RET	C0311335	Grand Mal Status Epilepticus	1	CTD_human
Tgene	RET	C0343640	African Burkitt's lymphoma	1	CTD_human
Tgene	RET	C0393734	Complex Partial Status Epilepticus	1	CTD_human
Tgene	RET	C0549473	Thyroid carcinoma	1	CGI;CTD_human;UNIPROT
Tgene	RET	C0740340	Amyloidosis, Familial	1	CTD_human
Tgene	RET	C0751522	Status Epilepticus, Subclinical	1	CTD_human
Tgene	RET	C0751523	Non-Convulsive Status Epilepticus	1	CTD_human
Tgene	RET	C0751524	Simple Partial Status Epilepticus	1	CTD_human
Tgene	RET	C1257877	Pheochromocytoma, Extra-Adrenal	1	CTD_human
Tgene	RET	C1609433	Congenital absence of kidneys syndrome	1	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	RET	C3501843	Nonmedullary Thyroid Carcinoma	1	CTD_human
Tgene	RET	C3501844	Familial Nonmedullary Thyroid Cancer	1	CTD_human
Tgene	RET	C4721444	Burkitt Leukemia	1	CTD_human