UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ANK3-TES

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANK3-TES
FusionPDB ID: 4387
FusionGDB2.0 ID: 4387
HgeneTgene
Gene symbol

ANK3

TES

Gene ID

288

26136

Gene nameankyrin 3testin LIM domain protein
SynonymsANKYRIN-G|MRT37TESS|TESS-2
Cytomap

10q21.2

7q31.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)testintestis derived transcript (3 LIM domains)
Modification date2020031320200313
UniProtAcc

Q12955

PRSS21

Ensembl transtripts involved in fusion geneENST idsENST00000280772, ENST00000373827, 
ENST00000503366, ENST00000355288, 
ENST00000460468, ENST00000510382, 
ENST00000485009, ENST00000393481, 
ENST00000537767, ENST00000358204, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 22 X 9=55449 X 6 X 7=378
# samples 2910
** MAII scorelog2(29/5544*10)=-4.25680245212228
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/378*10)=-1.91838623444635
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANK3 [Title/Abstract] AND TES [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANK3(61994445)-TES(115874587), # samples:1
Anticipated loss of major functional domain due to fusion event.ANK3-TES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-TES seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-TES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-TES seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TES (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4GQANK3chr10

61994445

-TESchr7

115874587

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280772ANK3chr1061994445-ENST00000358204TESchr7115874587+362910891922327711
ENST00000373827ANK3chr1061994445-ENST00000358204TESchr7115874587+35901050242288754
ENST00000503366ANK3chr1061994445-ENST00000358204TESchr7115874587+35229821362220694

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280772ENST00000358204ANK3chr1061994445-TESchr7115874587+0.0020909610.99790907
ENST00000373827ENST00000358204ANK3chr1061994445-TESchr7115874587+0.0016373910.9983626
ENST00000503366ENST00000358204ANK3chr1061994445-TESchr7115874587+0.0010785610.9989215

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4387_4387_1_ANK3-TES_ANK3_chr10_61994445_ENST00000280772_TES_chr7_115874587_ENST00000358204_length(amino acids)=711AA_BP=299
MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV
SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA
LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT
PLHVASKRGNANMVKLLLDRGAKIDAKTRMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDT
KYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQD
PSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAI
YAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIY

--------------------------------------------------------------

>4387_4387_2_ANK3-TES_ANK3_chr10_61994445_ENST00000373827_TES_chr7_115874587_ENST00000358204_length(amino acids)=754AA_BP=342
MGGRRGAALGVPEPRPNFFPRSPTFGGPRSGTGRRDWSSWKEQQQQPHNMASSASSSPAGTEDSAPAQGGFGSDYSRSSRKSDANASYLR
AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS
QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNN
ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRMGLGHEQGFGAPCLKCKE
KCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMYKRNVMILTNPVAAKKNVSINTVTYEWAPPV
QNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQFVKKYKSEALGVGDVKLPCEMDAQGPKQMN
IPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFVCSTCHELLVDMIYFWKNEKLYCGRHYCDSE
KPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNHAVVCQGCHNAIDPEVQRVTYNNFSWHASTE

--------------------------------------------------------------

>4387_4387_3_ANK3-TES_ANK3_chr10_61994445_ENST00000503366_TES_chr7_115874587_ENST00000358204_length(amino acids)=694AA_BP=282
MSEEPKEKNAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG
NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT
KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL
LDRGAKIDAKTRMGLGHEQGFGAPCLKCKEKCEGFELHFWRKICRNCKCGQEEHDVLLSNEEDRKVGKLFEDTKYTTLIAKLKSDGIPMY
KRNVMILTNPVAAKKNVSINTVTYEWAPPVQNQALARQYMQMLPKEKQPVAGSEGAQYRKKQLAKQLPAHDQDPSKCHELSPREVKEMEQ
FVKKYKSEALGVGDVKLPCEMDAQGPKQMNIPGGDRSTPAAVGAMEDKSAEHKRTQYSCYCCKLSMKEGDPAIYAERAGYDKLWHPACFV
CSTCHELLVDMIYFWKNEKLYCGRHYCDSEKPRCAGCDELIFSNEYTQAENQNWHLKHFCCFDCDSILAGEIYVMVNDKPVCKPCYVKNH

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:61994445/chr7:115874587)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK3

Q12955

TES

PRSS21

FUNCTION: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {ECO:0000250, ECO:0000269|PubMed:17974005}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.314

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844106_135299.05447.666666666667RepeatNote=ANK 2
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844139_168299.05447.666666666667RepeatNote=ANK 3
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844172_201299.05447.666666666667RepeatNote=ANK 4
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844203_230299.05447.666666666667RepeatNote=ANK 5
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844234_263299.05447.666666666667RepeatNote=ANK 6
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844267_296299.05447.666666666667RepeatNote=ANK 7
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-84473_102299.05447.666666666667RepeatNote=ANK 1
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944106_135293.02277.6666666666665RepeatNote=ANK 2
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944139_168293.02277.6666666666665RepeatNote=ANK 3
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944172_201293.02277.6666666666665RepeatNote=ANK 4
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944203_230293.02277.6666666666665RepeatNote=ANK 5
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944234_263293.02277.6666666666665RepeatNote=ANK 6
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944267_296293.02277.6666666666665RepeatNote=ANK 7
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-94473_102293.02277.6666666666665RepeatNote=ANK 1
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844106_135282.01808.0RepeatNote=ANK 2
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844139_168282.01808.0RepeatNote=ANK 3
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844172_201282.01808.0RepeatNote=ANK 4
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844203_230282.01808.0RepeatNote=ANK 5
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844234_263282.01808.0RepeatNote=ANK 6
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-84473_102282.01808.0RepeatNote=ANK 1
TgeneTESchr10:61994445chr7:115874587ENST000003582040722_469.0422.0Compositional biasNote=Cys-rich
TgeneTESchr10:61994445chr7:115874587ENST000003934810722_460.0413.0Compositional biasNote=Cys-rich
TgeneTESchr10:61994445chr7:115874587ENST0000035820407234_2979.0422.0DomainLIM zinc-binding 1
TgeneTESchr10:61994445chr7:115874587ENST0000035820407299_3599.0422.0DomainLIM zinc-binding 2
TgeneTESchr10:61994445chr7:115874587ENST0000035820407362_4219.0422.0DomainLIM zinc-binding 3
TgeneTESchr10:61994445chr7:115874587ENST000003582040792_1999.0422.0DomainPET
TgeneTESchr10:61994445chr7:115874587ENST0000039348107234_2970.0413.0DomainLIM zinc-binding 1
TgeneTESchr10:61994445chr7:115874587ENST0000039348107299_3590.0413.0DomainLIM zinc-binding 2
TgeneTESchr10:61994445chr7:115874587ENST0000039348107362_4210.0413.0DomainLIM zinc-binding 3
TgeneTESchr10:61994445chr7:115874587ENST000003934810792_1990.0413.0DomainPET

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8441519_1898299.05447.666666666667Compositional biasNote=Ser-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8442247_2250299.05447.666666666667Compositional biasNote=Poly-Thr
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8442393_2396299.05447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8443205_3211299.05447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8443255_3259299.05447.666666666667Compositional biasNote=Poly-Pro
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8443482_3487299.05447.666666666667Compositional biasNote=Poly-Ser
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8443785_3791299.05447.666666666667Compositional biasNote=Poly-Asn
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8443957_3981299.05447.666666666667Compositional biasNote=Thr-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1211519_18980814.0Compositional biasNote=Ser-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1212247_22500814.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1212393_23960814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1213205_32110814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1213255_32590814.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1213482_34870814.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1213785_37910814.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1213957_39810814.0Compositional biasNote=Thr-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9441519_1898293.02277.6666666666665Compositional biasNote=Ser-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9442247_2250293.02277.6666666666665Compositional biasNote=Poly-Thr
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9442393_2396293.02277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9443205_3211293.02277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9443255_3259293.02277.6666666666665Compositional biasNote=Poly-Pro
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9443482_3487293.02277.6666666666665Compositional biasNote=Poly-Ser
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9443785_3791293.02277.6666666666665Compositional biasNote=Poly-Asn
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9443957_3981293.02277.6666666666665Compositional biasNote=Thr-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8441519_1898282.01808.0Compositional biasNote=Ser-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8442247_2250282.01808.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8442393_2396282.01808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8443205_3211282.01808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8443255_3259282.01808.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8443482_3487282.01808.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8443785_3791282.01808.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8443957_3981282.01808.0Compositional biasNote=Thr-rich
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8441141_1288299.05447.666666666667DomainZU5 2
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8444090_4174299.05447.666666666667DomainDeath
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844984_1139299.05447.666666666667DomainZU5 1
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1211141_12880814.0DomainZU5 2
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1214090_41740814.0DomainDeath
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121984_11390814.0DomainZU5 1
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9441141_1288293.02277.6666666666665DomainZU5 2
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9444090_4174293.02277.6666666666665DomainDeath
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944984_1139293.02277.6666666666665DomainZU5 1
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8441141_1288282.01808.0DomainZU5 2
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8444090_4174282.01808.0DomainDeath
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844984_1139282.01808.0DomainZU5 1
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-8441273_1407299.05447.666666666667RegionUPA domain
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-1211273_14070814.0RegionUPA domain
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-9441273_1407293.02277.6666666666665RegionUPA domain
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-8441273_1407282.01808.0RegionUPA domain
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844300_329299.05447.666666666667RepeatNote=ANK 8
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844333_362299.05447.666666666667RepeatNote=ANK 9
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844366_395299.05447.666666666667RepeatNote=ANK 10
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844399_428299.05447.666666666667RepeatNote=ANK 11
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844432_461299.05447.666666666667RepeatNote=ANK 12
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844465_494299.05447.666666666667RepeatNote=ANK 13
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844498_527299.05447.666666666667RepeatNote=ANK 14
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844531_560299.05447.666666666667RepeatNote=ANK 15
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844564_593299.05447.666666666667RepeatNote=ANK 16
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844597_626299.05447.666666666667RepeatNote=ANK 17
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844630_659299.05447.666666666667RepeatNote=ANK 18
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844663_692299.05447.666666666667RepeatNote=ANK 19
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844696_725299.05447.666666666667RepeatNote=ANK 20
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844729_758299.05447.666666666667RepeatNote=ANK 21
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844762_791299.05447.666666666667RepeatNote=ANK 22
HgeneANK3chr10:61994445chr7:115874587ENST00000280772-844795_825299.05447.666666666667RepeatNote=ANK 23
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121106_1350814.0RepeatNote=ANK 2
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121139_1680814.0RepeatNote=ANK 3
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121172_2010814.0RepeatNote=ANK 4
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121203_2300814.0RepeatNote=ANK 5
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121234_2630814.0RepeatNote=ANK 6
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121267_2960814.0RepeatNote=ANK 7
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121300_3290814.0RepeatNote=ANK 8
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121333_3620814.0RepeatNote=ANK 9
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121366_3950814.0RepeatNote=ANK 10
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121399_4280814.0RepeatNote=ANK 11
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121432_4610814.0RepeatNote=ANK 12
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121465_4940814.0RepeatNote=ANK 13
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121498_5270814.0RepeatNote=ANK 14
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121531_5600814.0RepeatNote=ANK 15
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121564_5930814.0RepeatNote=ANK 16
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121597_6260814.0RepeatNote=ANK 17
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121630_6590814.0RepeatNote=ANK 18
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121663_6920814.0RepeatNote=ANK 19
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121696_7250814.0RepeatNote=ANK 20
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121729_7580814.0RepeatNote=ANK 21
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-12173_1020814.0RepeatNote=ANK 1
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121762_7910814.0RepeatNote=ANK 22
HgeneANK3chr10:61994445chr7:115874587ENST00000355288-121795_8250814.0RepeatNote=ANK 23
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944300_329293.02277.6666666666665RepeatNote=ANK 8
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944333_362293.02277.6666666666665RepeatNote=ANK 9
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944366_395293.02277.6666666666665RepeatNote=ANK 10
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944399_428293.02277.6666666666665RepeatNote=ANK 11
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944432_461293.02277.6666666666665RepeatNote=ANK 12
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944465_494293.02277.6666666666665RepeatNote=ANK 13
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944498_527293.02277.6666666666665RepeatNote=ANK 14
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944531_560293.02277.6666666666665RepeatNote=ANK 15
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944564_593293.02277.6666666666665RepeatNote=ANK 16
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944597_626293.02277.6666666666665RepeatNote=ANK 17
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944630_659293.02277.6666666666665RepeatNote=ANK 18
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944663_692293.02277.6666666666665RepeatNote=ANK 19
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944696_725293.02277.6666666666665RepeatNote=ANK 20
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944729_758293.02277.6666666666665RepeatNote=ANK 21
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944762_791293.02277.6666666666665RepeatNote=ANK 22
HgeneANK3chr10:61994445chr7:115874587ENST00000373827-944795_825293.02277.6666666666665RepeatNote=ANK 23
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844267_296282.01808.0RepeatNote=ANK 7
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844300_329282.01808.0RepeatNote=ANK 8
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844333_362282.01808.0RepeatNote=ANK 9
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844366_395282.01808.0RepeatNote=ANK 10
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844399_428282.01808.0RepeatNote=ANK 11
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844432_461282.01808.0RepeatNote=ANK 12
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844465_494282.01808.0RepeatNote=ANK 13
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844498_527282.01808.0RepeatNote=ANK 14
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844531_560282.01808.0RepeatNote=ANK 15
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844564_593282.01808.0RepeatNote=ANK 16
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844597_626282.01808.0RepeatNote=ANK 17
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844630_659282.01808.0RepeatNote=ANK 18
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844663_692282.01808.0RepeatNote=ANK 19
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844696_725282.01808.0RepeatNote=ANK 20
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844729_758282.01808.0RepeatNote=ANK 21
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844762_791282.01808.0RepeatNote=ANK 22
HgeneANK3chr10:61994445chr7:115874587ENST00000503366-844795_825282.01808.0RepeatNote=ANK 23


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANK3
TES


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to ANK3-TES


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ANK3-TES


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource