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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANK3-USP9Y

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANK3-USP9Y
FusionPDB ID: 4390
FusionGDB2.0 ID: 4390
HgeneTgene
Gene symbol

ANK3

USP9Y

Gene ID

288

8287

Gene nameankyrin 3ubiquitin specific peptidase 9 Y-linked
SynonymsANKYRIN-G|MRT37DFFRY|SPGFY2
Cytomap

10q21.2

Yq11.221

Type of geneprotein-codingprotein-coding
Descriptionankyrin-3ankyrin 3, node of Ranvier (ankyrin G)probable ubiquitin carboxyl-terminal hydrolase FAF-Ydeubiquitinating enzyme FAF-Yfat facets protein-related, Y-linkedubiquitin specific peptidase 9, Y-linked (fat facets-like, Drosophila)ubiquitin thioesterase FAF-Yubiquitin thiolesterase FAF-Yubiqu
Modification date2020031320200320
UniProtAcc

Q12955

.
Ensembl transtripts involved in fusion geneENST idsENST00000280772, ENST00000355288, 
ENST00000373827, ENST00000503366, 
ENST00000460468, ENST00000510382, 
ENST00000426564, ENST00000338981, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score28 X 22 X 9=55448 X 8 X 2=128
# samples 298
** MAII scorelog2(29/5544*10)=-4.25680245212228
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/128*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANK3 [Title/Abstract] AND USP9Y [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANK3(61815416)-USP9Y(14968265), # samples:3
Anticipated loss of major functional domain due to fusion event.ANK3-USP9Y seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-USP9Y seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-USP9Y seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANK3-USP9Y seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANK3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP9Y (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A8IH-01AANK3chr10

61815416

-USP9YchrY

14968265

+
ChimerDB4PRADTCGA-KK-A8IHANK3chr10

61815416

-USP9YchrY

14968265

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000280772ANK3chr1061815416-ENST00000338981USP9YchrY14968265+1528413257192132654357
ENST00000373827ANK3chr1061815416-ENST00000338981USP9YchrY14968265+771556882456961890
ENST00000355288ANK3chr1061815416-ENST00000338981USP9YchrY14968265+561335866493594981
ENST00000503366ANK3chr1061815416-ENST00000338981USP9YchrY14968265+7701567413656821848

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000280772ENST00000338981ANK3chr1061815416-USP9YchrY14968265+0.000470560.9995295
ENST00000373827ENST00000338981ANK3chr1061815416-USP9YchrY14968265+0.0005594680.9994405
ENST00000355288ENST00000338981ANK3chr1061815416-USP9YchrY14968265+0.0004721450.9995278
ENST00000503366ENST00000338981ANK3chr1061815416-USP9YchrY14968265+0.0005452830.9994547

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4390_4390_1_ANK3-USP9Y_ANK3_chr10_61815416_ENST00000280772_USP9Y_chrY_14968265_ENST00000338981_length(amino acids)=4357AA_BP=
MAHAASQLKKNRDLEINAEEEPEKKRKHRKRSRDRKKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVV
SELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVA
LQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDIT
PLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPV
DDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVS
QLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSA
REGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKN
GYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQG
AHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYIS
VVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAE
GYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMV
DARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVL
RSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGA
LTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDI
TGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEE
VARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHK
KETESDQDDEIEKTDRRQSFASLALRKRYSYLTEPGMIERSTGATRSLPTTYSYKPFFSTRPYQSWTTAPITVPGPAKSGFTSLSSSSSN
TPSASPLKSIWSVSTPSPIKSTLGASTTSSVKSISDVASPIRSFRTMSSPIKTVVSQSPYNIQVSSGTLARAPAVTEATPLKGLASNSTF
SSRTSPVTTAGSLLERSSITMTPPASPKSNINMYSSSLPFKSIITSAAPLISSPLKSVVSPVKSAVDVISSAKITMASSLSSPVKQMPGH
AEVALVNGSISPLKYPSSSTLINGCKATATLQEKISSATNSVSSVVSAATDTVEKVFSTTTAMPFSPLRSYVSAAPSAFQSLRTPSASAL
YTSLGSSISATTSSVTSSIITVPVYSVVNVLPEPALKKLPDSNSFTKSAAALLSPIKTLTTETHPQPHFSRTSSPVKSSLFLAPSALKLS
TPSSLSSSQEILKDVAEMKEDLMRMTAILQTDVPEEKPFQPELPKEGRIDDEEPFKIVEKVKEDLVKVSEILKKDVCVDNKGSPKSPKSD
KGHSPEDDWIEFSSEEIREARQQAAASQSPSLPERVQVKAKAASEKDYNLTKVIDYLTNDIGSSSLTNLKYKFEDAKKDGEERQKRVLKP
AIALQEHKLKMPPASMRTSTSEKELCKMADSFFGTDTILESPDDFSQHDQDKSPLSDSGFETRSEKTPSAPQSAESTGPKPLFHEVPIPP
VITETRTEVVHVIRSYDPSAGDVPQTQPEEPVSPKPSPTFMELEPKPTTSSIKEKVKAFQMKASSEEDDHNRVLSKGMRVKEETHITTTT
RMVYHSPPGGEGASERIEETMSVHDIMKAFQSGRDPSKELAGLFEHKSAVSPDVHKSAAETSAQHAEKDNQMKPKLERIIEVHIEKGNQA
EPTEVIIRETKKHPEKEMYVYQKDLSRGDINLKDFLPEKHDAFPCSEEQGQQEEEELTAEESLPSYLESSRVNTPVSQEEDSRPSSAQLI
SDDSYKTLKLLSQHSIEYHDDELSELRGESYRFAEKMLLSEKLDVSHSDTEESVTDHAGPPSSELQGSDKRSREKIATAPKKEILSKIYK
DVSENGVGKVSKDEHFDKVTVLHYSGNVSSPKHAMWMRFTEDRLDRGREKLIYEDRVDRTVKEAEEKLTEVSQFFRDKTEKLNDELQSPE
KKARPKNGKEYSSQSPTSSSPEKVLLTELLASNDEWVKARQHGPDGQGFPKAEEKAPSLPSSPEKMVLSQQTEDSKSTVEAKGSISQSKA
PDGPQSGFQLKQSKLSSIRLKFEQGTHAKSKDMSQEDRKSDGQSRIPVKKIQESKLPVYQVFAREKQQKAIDLPDESVSVQKDFMVLKTK
DEHAQSNEIVVNDSGSDNVKKQRTEMSSKAMPDSFSEQQAKDLACHITSDLATRGPWDKKVFRTWESSGATNNKSQKEKLSHVLVHDVRE
NHIGHPESKSVDQKNEFMSVTERERKLLTNGSLSEIKEMTVKSPSKKVLYREYVVKEGDHPGGLLDQPSRRSESSAVSHIPVRVADERRM
LSSNIPDGFCEQSAFPKHELSQKLSQSSMSKETVETQHFNSIEDEKVTYSEISKVSKHQSYVGLCPPLEETETSPTKSPDSLEFSPGKES
PSSDVFDHSPIDGLEKLAPLAQTEGGKEIKTLPVYVSFVQVGKQYEKEIQQGGVKKIISQECKTVQETRGTFYTTRQQKQPPSPQGSPED
DTLEQVSFLDSSGKSPLTPETPSSEEVSYEFTSKTPDSLIAYIPGKPSPIPEVSEESEEEEQAKSTSLKQTTVEETAVEREMPNDVSKDS
NQRPKNNRVAYIEFPPPPPLDADQIESDKKHHYLPEKEVDMIEVNLQDEHDKYQLAEPVIRVQPPSPVPPGADVSDSSDDESIYQPVPVK
KYTFKLKEVDDEQKEKPKASAEKASNQKELESNGSGKDNEFGLGLDSPQNEIAQNGNNDQSITECSIATTAEFSHDTDATEIDSLDGYDL
QDEDDGLTESDSKLPIQAMEIKKDIWNTEGILKPADRSFSQSKLEVIEEEGKVGPDEDKPPSKSSSSEKTPDKTDQKSGAQFFTLEGRHP
DRSVFPDTYFSYKVDEEFATPFKTVATKGLDFDPWSNNRGDDEVFDSKSREDETKPFGLAVEDRSPATTPDTTPARTPTDESTPTSEPNP
FPFHEGKMFEMTRSGAIDMSKRDFVEERLQFFQIGEHTSEGKSGDQGEGDKSMVTATPQPQSGDTTVETNLERNVETPTVEPNPSIPTSG
ECQEGTSSSGSLEKSAAATNTSKVDPKLRTPIKMGISASTMTMKKEGPGEITDKIEAVMTSCQGLENETITMISNTANSQMGVRPHEKHD
FQKDNFNNNNNLDSSTIQTDNIMSNIVLTEHSAPTCTTEKDNPVKVSSGKKTGVLQGHCVRDKQKVLGEQQKTKELIGIRQKSKLPIKAT
SPKDTFPPNHMSNTKASKMKQVSQSEKTKALTTSSCVDVKSRIPVKNTHRDNIIAVRKACATQKQGQPEKGKAKQLPSKLPVKVRSTCVT
TTTTTATTTTTTTTTTTTSCTVKVRKSQLKEVCKHSIEYFKGISGETLKLVDRLSEEEKKMQSELSDEEESTSRNTSLSETSRGGQPSVT
TKSARDKKTEAAPLKSKSEKAGSEKRSSRRTGPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKK
WVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGWQNETSSGNLESCAQARRVTGGLLDRLDDSP
DQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKP

--------------------------------------------------------------

>4390_4390_2_ANK3-USP9Y_ANK3_chr10_61815416_ENST00000355288_USP9Y_chrY_14968265_ENST00000338981_length(amino acids)=981AA_BP=
MALPQSEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFD
SDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRL
VEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAV
VSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPS
GEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVV
FAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQ
EPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTELA
RELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDG
YPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSVPLTEMPEAV
DVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGK

--------------------------------------------------------------

>4390_4390_3_ANK3-USP9Y_ANK3_chr10_61815416_ENST00000373827_USP9Y_chrY_14968265_ENST00000338981_length(amino acids)=1890AA_BP=
MGGRRGAALGVPEPRPNFFPRSPTFGGPRSGTGRRDWSSWKEQQQQPHNMASSASSSPAGTEDSAPAQGGFGSDYSRSSRKSDANASYLR
AARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKGNTALHIASLAGQAEVVKVLVTNGANVNAQS
QNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDTKGKVRLPALHIAARKDDTKAAALLLQNDNN
ADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLLLDRGAKIDAKTRDGLTPLHCGARSGHEQVV
EMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHCGHYKVAKVLLDKKANPNAKALNGFTPLHIA
CKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGETALHMAARSGQAEVVRYLVQDGAQVEAKAK
DDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGASLSITTKKGFTPLHVAAKYGKLEVANLLLQK
SASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIATTLLEYGADANAVTRQGIASVHLAAQEGHV
DMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVGCHYGNIKIVNFLLQHSAKVNAKTKNGYTPL
HQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTTVTEKHKMNVPETMNEVLDMSDDEVRKANAP
EMLSDGEYISDVEEGEDAMTGDTDKYLGPQDLKELGDDSLPAEGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQ
HLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFMVDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMV
EGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIVLRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIIT
KDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEGALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPIT
MTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWEDITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELIC
VPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFEEVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPF
SIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAHKKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADH
LGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWVTRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADEN
NVFHDPVDGYPSLQVELETPTGLHYTPPTPFQQDDYFSDISSIESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSV
PLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVTGGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYF
PESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEETSKLIIEETKPCVPVSMKKMSRTSPADGKPRLSLHEEEGSSGSEQKNS

--------------------------------------------------------------

>4390_4390_4_ANK3-USP9Y_ANK3_chr10_61815416_ENST00000503366_USP9Y_chrY_14968265_ENST00000338981_length(amino acids)=1848AA_BP=
MSEEPKEKNAKPAHRKRKGKKSDANASYLRAARAGHLEKALDYIKNGVDINICNQNGLNALHLASKEGHVEVVSELLQREANVDAATKKG
NTALHIASLAGQAEVVKVLVTNGANVNAQSQNGFTPLYMAAQENHLEVVKFLLDNGASQSLATEDGFTPLAVALQQGHDQVVSLLLENDT
KGKVRLPALHIAARKDDTKAAALLLQNDNNADVESKSGFTPLHIAAHYGNINVATLLLNRAAAVDFTARNDITPLHVASKRGNANMVKLL
LDRGAKIDAKTRDGLTPLHCGARSGHEQVVEMLLDRAAPILSKTKNGLSPLHMATQGDHLNCVQLLLQHNVPVDDVTNDYLTALHVAAHC
GHYKVAKVLLDKKANPNAKALNGFTPLHIACKKNRIKVMELLLKHGASIQAVTESGLTPIHVAAFMGHVNIVSQLMHHGASPNTTNVRGE
TALHMAARSGQAEVVRYLVQDGAQVEAKAKDDQTPLHISARLGKADIVQQLLQQGASPNAATTSGYTPLHLSAREGHEDVAAFLLDHGAS
LSITTKKGFTPLHVAAKYGKLEVANLLLQKSASPDAAGKSGLTPLHVAAHYDNQKVALLLLDQGASPHAAAKNGYTPLHIAAKKNQMDIA
TTLLEYGADANAVTRQGIASVHLAAQEGHVDMVSLLLGRNANVNLSNKSGLTPLHLAAQEDRVNVAEVLVNQGAHVDAQTKMGYTPLHVG
CHYGNIKIVNFLLQHSAKVNAKTKNGYTPLHQAAQQGHTHIINVLLQNNASPNELTVNGNTALGIARRLGYISVVDTLKIVTEETMTTTT
VTEKHKMNVPETMNEVLDMSDDEVRKANAPEMLSDGEYISDVEEGNRCTWYKIPKVQEFTVKSEDAMTGDTDKYLGPQDLKELGDDSLPA
EGYMGFSLGARSASLRSFSSDRSYTLNRSSYARDSMMIEELLVPSKEQHLTFTREFDSDSLRHYSWAADTLDNVNLVSSPIHSGFLVSFM
VDARGGSMRGSRHHGMRIIIPPRKCTAPTRITCRLVKRHKLANPPPMVEGEGLASRLVEMGPAGAQFLGPVIVEIPHFGSMRGKERELIV
LRSENGETWKEHQFDSKNEDLTELLNGMDEELDSPEELGKKRICRIITKDFPQYFAVVSRIKQESNQIGPEGGILSSTTVPLVQASFPEG
ALTKRIRVGLQAQPVPDEIVKKILGNKATFSPIVTVEPRRRKFHKPITMTIPVPPPSGEGVSNGYKGDTTPNLRLLCSITGGTSPAQWED
ITGTTPLTFIKDCVSFTTNVSARFWLADCHQVLETVGLATQLYRELICVPYMAKFVVFAKMNDPVESSLRCFCMTDDKVDKTLEQQENFE
EVARSKDIEVLEGKPIYVDCYGNLAPLTKGGQQLVFNFYSFKENRLPFSIKIRDTSQEPCGRLSFLKEPKTTKGLPQTAVCNLNITLPAH
KKIEKTDRRQSFASLALRKRYSYLTEPGMSPQSPCERTDIRMAIVADHLGLSWTELARELNFSVDEINQIRVENPNSLISQSFMLLKKWV
TRDGKNATTDALTSVLTKINRIDIVTLLEGPIFDYGNISGTRSFADENNVFHDPVDGYPSLQVELETPTGLHYTPPTPFQQDDYFSDISS
IESPLRTPSRLSDGLVPSQGNIEHSADGPPVVTAEDASLEDSKLEDSVPLTEMPEAVDVDESQLENVCLSWQNETSSGNLESCAQARRVT
GGLLDRLDDSPDQCRDSITSYLKGEAGKFEANGSHTEITPEAKTKSYFPESQNDVGKQSTKETLKPKIHGSGHVEEPASPLAAYQKSLEE

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:61815416/chrY:14968265)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANK3

Q12955

.
FUNCTION: In skeletal muscle, required for costamere localization of DMD and betaDAG1 (By similarity). Membrane-cytoskeleton linker. May participate in the maintenance/targeting of ion channels and cell adhesion molecules at the nodes of Ranvier and axonal initial segments. Regulates KCNA1 channel activity in function of dietary Mg(2+) levels, and thereby contributes to the regulation of renal Mg(2+) reabsorption (PubMed:23903368). {ECO:0000250, ECO:0000269|PubMed:17974005}.; FUNCTION: [Isoform 5]: May be part of a Golgi-specific membrane cytoskeleton in association with beta-spectrin. {ECO:0000305|PubMed:17974005}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42441519_18984355.05447.666666666667Compositional biasNote=Ser-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42442247_22504355.05447.666666666667Compositional biasNote=Poly-Thr
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42442393_23964355.05447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42443205_32114355.05447.666666666667Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42443255_32594355.05447.666666666667Compositional biasNote=Poly-Pro
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42443482_34874355.05447.666666666667Compositional biasNote=Poly-Ser
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42443785_37914355.05447.666666666667Compositional biasNote=Poly-Asn
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42443957_39814355.05447.666666666667Compositional biasNote=Thr-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19211519_1898979.0814.0Compositional biasNote=Ser-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19212247_2250979.0814.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19212393_2396979.0814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19213205_3211979.0814.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19213255_3259979.0814.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19213482_3487979.0814.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19213785_3791979.0814.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19213957_3981979.0814.0Compositional biasNote=Thr-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42441519_18981846.01808.0Compositional biasNote=Ser-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42442247_22501846.01808.0Compositional biasNote=Poly-Thr
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42442393_23961846.01808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42443205_32111846.01808.0Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42443255_32591846.01808.0Compositional biasNote=Poly-Pro
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42443482_34871846.01808.0Compositional biasNote=Poly-Ser
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42443785_37911846.01808.0Compositional biasNote=Poly-Asn
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42443957_39811846.01808.0Compositional biasNote=Thr-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42441141_12884355.05447.666666666667DomainZU5 2
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42444090_41744355.05447.666666666667DomainDeath
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244984_11394355.05447.666666666667DomainZU5 1
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19211141_1288979.0814.0DomainZU5 2
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19214090_4174979.0814.0DomainDeath
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921984_1139979.0814.0DomainZU5 1
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42441141_12881839.02277.6666666666665DomainZU5 2
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244984_11391839.02277.6666666666665DomainZU5 1
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42441141_12881846.01808.0DomainZU5 2
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42444090_41741846.01808.0DomainDeath
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244984_11391846.01808.0DomainZU5 1
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-42441273_14074355.05447.666666666667RegionUPA domain
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-19211273_1407979.0814.0RegionUPA domain
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42441273_14071839.02277.6666666666665RegionUPA domain
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-42441273_14071846.01808.0RegionUPA domain
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244106_1354355.05447.666666666667RepeatNote=ANK 2
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244139_1684355.05447.666666666667RepeatNote=ANK 3
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244172_2014355.05447.666666666667RepeatNote=ANK 4
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244203_2304355.05447.666666666667RepeatNote=ANK 5
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244234_2634355.05447.666666666667RepeatNote=ANK 6
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244267_2964355.05447.666666666667RepeatNote=ANK 7
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244300_3294355.05447.666666666667RepeatNote=ANK 8
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244333_3624355.05447.666666666667RepeatNote=ANK 9
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244366_3954355.05447.666666666667RepeatNote=ANK 10
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244399_4284355.05447.666666666667RepeatNote=ANK 11
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244432_4614355.05447.666666666667RepeatNote=ANK 12
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244465_4944355.05447.666666666667RepeatNote=ANK 13
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244498_5274355.05447.666666666667RepeatNote=ANK 14
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244531_5604355.05447.666666666667RepeatNote=ANK 15
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244564_5934355.05447.666666666667RepeatNote=ANK 16
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244597_6264355.05447.666666666667RepeatNote=ANK 17
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244630_6594355.05447.666666666667RepeatNote=ANK 18
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244663_6924355.05447.666666666667RepeatNote=ANK 19
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244696_7254355.05447.666666666667RepeatNote=ANK 20
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244729_7584355.05447.666666666667RepeatNote=ANK 21
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-424473_1024355.05447.666666666667RepeatNote=ANK 1
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244762_7914355.05447.666666666667RepeatNote=ANK 22
HgeneANK3chr10:61815416chrY:14968265ENST00000280772-4244795_8254355.05447.666666666667RepeatNote=ANK 23
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921106_135979.0814.0RepeatNote=ANK 2
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921139_168979.0814.0RepeatNote=ANK 3
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921172_201979.0814.0RepeatNote=ANK 4
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921203_230979.0814.0RepeatNote=ANK 5
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921234_263979.0814.0RepeatNote=ANK 6
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921267_296979.0814.0RepeatNote=ANK 7
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921300_329979.0814.0RepeatNote=ANK 8
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921333_362979.0814.0RepeatNote=ANK 9
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921366_395979.0814.0RepeatNote=ANK 10
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921399_428979.0814.0RepeatNote=ANK 11
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921432_461979.0814.0RepeatNote=ANK 12
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921465_494979.0814.0RepeatNote=ANK 13
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921498_527979.0814.0RepeatNote=ANK 14
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921531_560979.0814.0RepeatNote=ANK 15
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921564_593979.0814.0RepeatNote=ANK 16
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921597_626979.0814.0RepeatNote=ANK 17
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921630_659979.0814.0RepeatNote=ANK 18
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921663_692979.0814.0RepeatNote=ANK 19
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921696_725979.0814.0RepeatNote=ANK 20
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921729_758979.0814.0RepeatNote=ANK 21
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-192173_102979.0814.0RepeatNote=ANK 1
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921762_791979.0814.0RepeatNote=ANK 22
HgeneANK3chr10:61815416chrY:14968265ENST00000355288-1921795_825979.0814.0RepeatNote=ANK 23
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244106_1351839.02277.6666666666665RepeatNote=ANK 2
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244139_1681839.02277.6666666666665RepeatNote=ANK 3
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244172_2011839.02277.6666666666665RepeatNote=ANK 4
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244203_2301839.02277.6666666666665RepeatNote=ANK 5
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244234_2631839.02277.6666666666665RepeatNote=ANK 6
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244267_2961839.02277.6666666666665RepeatNote=ANK 7
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244300_3291839.02277.6666666666665RepeatNote=ANK 8
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244333_3621839.02277.6666666666665RepeatNote=ANK 9
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244366_3951839.02277.6666666666665RepeatNote=ANK 10
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244399_4281839.02277.6666666666665RepeatNote=ANK 11
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244432_4611839.02277.6666666666665RepeatNote=ANK 12
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244465_4941839.02277.6666666666665RepeatNote=ANK 13
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244498_5271839.02277.6666666666665RepeatNote=ANK 14
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244531_5601839.02277.6666666666665RepeatNote=ANK 15
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244564_5931839.02277.6666666666665RepeatNote=ANK 16
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244597_6261839.02277.6666666666665RepeatNote=ANK 17
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244630_6591839.02277.6666666666665RepeatNote=ANK 18
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244663_6921839.02277.6666666666665RepeatNote=ANK 19
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244696_7251839.02277.6666666666665RepeatNote=ANK 20
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244729_7581839.02277.6666666666665RepeatNote=ANK 21
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-424473_1021839.02277.6666666666665RepeatNote=ANK 1
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244762_7911839.02277.6666666666665RepeatNote=ANK 22
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-4244795_8251839.02277.6666666666665RepeatNote=ANK 23
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244106_1351846.01808.0RepeatNote=ANK 2
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244139_1681846.01808.0RepeatNote=ANK 3
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244172_2011846.01808.0RepeatNote=ANK 4
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244203_2301846.01808.0RepeatNote=ANK 5
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244234_2631846.01808.0RepeatNote=ANK 6
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244267_2961846.01808.0RepeatNote=ANK 7
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244300_3291846.01808.0RepeatNote=ANK 8
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244333_3621846.01808.0RepeatNote=ANK 9
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244366_3951846.01808.0RepeatNote=ANK 10
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244399_4281846.01808.0RepeatNote=ANK 11
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244432_4611846.01808.0RepeatNote=ANK 12
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244465_4941846.01808.0RepeatNote=ANK 13
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244498_5271846.01808.0RepeatNote=ANK 14
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244531_5601846.01808.0RepeatNote=ANK 15
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244564_5931846.01808.0RepeatNote=ANK 16
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244597_6261846.01808.0RepeatNote=ANK 17
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244630_6591846.01808.0RepeatNote=ANK 18
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244663_6921846.01808.0RepeatNote=ANK 19
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244696_7251846.01808.0RepeatNote=ANK 20
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244729_7581846.01808.0RepeatNote=ANK 21
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-424473_1021846.01808.0RepeatNote=ANK 1
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244762_7911846.01808.0RepeatNote=ANK 22
HgeneANK3chr10:61815416chrY:14968265ENST00000503366-4244795_8251846.01808.0RepeatNote=ANK 23

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42441519_18981839.02277.6666666666665Compositional biasNote=Ser-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42442247_22501839.02277.6666666666665Compositional biasNote=Poly-Thr
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42442393_23961839.02277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42443205_32111839.02277.6666666666665Compositional biasNote=Poly-Glu
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42443255_32591839.02277.6666666666665Compositional biasNote=Poly-Pro
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42443482_34871839.02277.6666666666665Compositional biasNote=Poly-Ser
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42443785_37911839.02277.6666666666665Compositional biasNote=Poly-Asn
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42443957_39811839.02277.6666666666665Compositional biasNote=Thr-rich
HgeneANK3chr10:61815416chrY:14968265ENST00000373827-42444090_41741839.02277.6666666666665DomainDeath
TgeneUSP9Ychr10:61815416chrY:14968265ENST0000033898141461559_19582354.66666666666652556.0DomainNote=USP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ANK3_pLDDT.png
all structure
all structure
USP9Y_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANK3
USP9Y


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ANK3-USP9Y


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANK3-USP9Y


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource