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Fusion Protein:LBH-FLT4 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: LBH-FLT4 | FusionPDB ID: 44218 | FusionGDB2.0 ID: 44218 | Hgene | Tgene | Gene symbol | LBH | FLT4 | Gene ID | 221491 | 2324 |
| Gene name | small integral membrane protein 29 | fms related receptor tyrosine kinase 4 | |
| Synonyms | C6orf1|LBH | CHTD7|FLT-4|FLT41|LMPH1A|LMPHM1|PCL|VEGFR-3|VEGFR3 | |
| Cytomap | 6p21.31 | 5q35.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | small integral membrane protein 29uncharacterized protein C6orf1 | vascular endothelial growth factor receptor 3Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4VEGF receptor-3fms related tyrosine kinase 4fms-like tyrosine kinase 4primary congenital lymphedematyrosine-protein kinase receptor FLT4 | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9BQE6 | P35916 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000467242, ENST00000395323, ENST00000401506, ENST00000404397, ENST00000406087, ENST00000407930, | ENST00000261937, ENST00000393347, ENST00000502649, ENST00000424276, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 5 X 5 X 2=50 | 5 X 4 X 3=60 |
| # samples | 5 | 5 | |
| ** MAII score | log2(5/50*10)=0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: LBH [Title/Abstract] AND FLT4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LBH(30457373)-FLT4(180058778), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | LBH-FLT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LBH-FLT4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LBH-FLT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LBH-FLT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LBH-FLT4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. LBH-FLT4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. LBH-FLT4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. LBH-FLT4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | FLT4 | GO:0018108 | peptidyl-tyrosine phosphorylation | 7898938 |
| Tgene | FLT4 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 9435229 |
| Tgene | FLT4 | GO:0038084 | vascular endothelial growth factor signaling pathway | 23878260 |
| Tgene | FLT4 | GO:0046777 | protein autophosphorylation | 7675451|9435229|23878260 |
| Tgene | FLT4 | GO:0048010 | vascular endothelial growth factor receptor signaling pathway | 9012504 |
| Fusion gene breakpoints across LBH (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across FLT4 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-D3-A3CF-06A | LBH | chr2 | 30457373 | - | FLT4 | chr5 | 180058778 | - |
| ChimerDB4 | SKCM | TCGA-D3-A3CF-06A | LBH | chr2 | 30457373 | + | FLT4 | chr5 | 180058778 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000406087 | LBH | chr2 | 30457373 | + | ENST00000261937 | FLT4 | chr5 | 180058778 | - | 6055 | 335 | 202 | 4368 | 1388 |
| ENST00000406087 | LBH | chr2 | 30457373 | + | ENST00000393347 | FLT4 | chr5 | 180058778 | - | 4490 | 335 | 202 | 4173 | 1323 |
| ENST00000406087 | LBH | chr2 | 30457373 | + | ENST00000502649 | FLT4 | chr5 | 180058778 | - | 4362 | 335 | 202 | 4197 | 1331 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000406087 | ENST00000261937 | LBH | chr2 | 30457373 | + | FLT4 | chr5 | 180058778 | - | 0.003552398 | 0.99644756 |
| ENST00000406087 | ENST00000393347 | LBH | chr2 | 30457373 | + | FLT4 | chr5 | 180058778 | - | 0.004232271 | 0.9957677 |
| ENST00000406087 | ENST00000502649 | LBH | chr2 | 30457373 | + | FLT4 | chr5 | 180058778 | - | 0.004065583 | 0.99593437 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >44218_44218_1_LBH-FLT4_LBH_chr2_30457373_ENST00000406087_FLT4_chr5_180058778_ENST00000261937_length(amino acids)=1388AA_BP=45 MSIYFPIHCPDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQVSLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQ EAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMW VPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVG EKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISV EWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIH EKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKN KTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNP LLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSL EMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVI AVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDT VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVE LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICD FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIR RIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVS FPGCLARGAETRGSSRMKTFEEFPMTPTTYKGSVDNQTDSGMVLASEEFEQIESRHRQESGFSCKGPGQNVAVTRAHPDSQGRRRRPERG -------------------------------------------------------------- >44218_44218_2_LBH-FLT4_LBH_chr2_30457373_ENST00000406087_FLT4_chr5_180058778_ENST00000393347_length(amino acids)=1323AA_BP=45 MSIYFPIHCPDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQVSLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQ EAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMW VPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVG EKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISV EWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIH EKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKN KTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNP LLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSL EMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVI AVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDT VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVE LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICD FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIR RIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVS -------------------------------------------------------------- >44218_44218_3_LBH-FLT4_LBH_chr2_30457373_ENST00000406087_FLT4_chr5_180058778_ENST00000502649_length(amino acids)=1331AA_BP=45 MSIYFPIHCPDYLRSAKMTEVMMNTQPMEEIGLSPRKDGLSYQVSLVSGYSMTPPTLNITEESHVIDTGDSLSISCRGQHPLEWAWPGAQ EAPATGDKDSEDTGVVRDCEGTDARPYCKVLLLHEVHANDTGSYVCYYKYIKARIEGTTAASSYVFVRDFEQPFINKPDTLLVNRKDAMW VPCLVSIPGLNVTLRSQSSVLWPDGQEVVWDDRRGMLVSTPLLHDALYLQCETTWGDQDFLSNPFLVHITGNELYDIQLLPRKSLELLVG EKLVLNCTVWAEFNSGVTFDWDYPGKQAERGKWVPERRSQQTHTELSSILTIHNVSQHDLGSYVCKANNGIQRFRESTEVIVHENPFISV EWLKGPILEATAGDELVKLPVKLAAYPPPEFQWYKDGKALSGRHSPHALVLKEVTEASTGTYTLALWNSAAGLRRNISLELVVNVPPQIH EKEASSPSIYSRHSRQALTCTAYGVPLPLSIQWHWRPWTPCKMFAQRSLRRRQQQDLMPQCRDWRAVTTQDAVNPIESLDTWTEFVEGKN KTVSKLVIQNANVSAMYKCVVSNKVGQDERLIYFYVTTIPDGFTIESKPSEELLEGQPVLLSCQADSYKYEHLRWYRLNLSTLHDAHGNP LLLDCKNVHLFATPLAASLEEVAPGARHATLSLSIPRVAPEHEGHYVCEVQDRRSHDKHCHKKYLSVQALEAPRLTQNLTDLLVNVSDSL EMQCLVAGAHAPSIVWYKDERLLEEKSGVDLADSNQKLSIQRVREEDAGRYLCSVCNAKGCVNSSASVAVEGSEDKGSMEIVILVGTGVI AVFFWVLLLLIFCNMRRPAHADIKTGYLSIIMDPGEVPLEEQCEYLSYDASQWEFPRERLHLGRVLGYGAFGKVVEASAFGIHKGSSCDT VAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTKPQGPLMVIVEFCKYGNLSNFLRAKRDAFSPCAEKSPEQRGRFRAMVE LARLDRRRPGSSDRVLFARFSKTEGGARRASPDQEAEDLWLSPLTMEDLVCYSFQVARGMEFLASRKCIHRDLAARNILLSESDVVKICD FGLARDIYKDPDYVRKGSARLPLKWMAPESIFDKVYTTQSDVWSFGVLLWEIFSLGASPYPGVQINEEFCQRLRDGTRMRAPELATPAIR RIMLNCWSGDPKARPAFSELVEILGDLLQGRGLQEEEEVCMAPRSSQSSEEGSFSQVSTMALHIAQADAEDSPPSLQRHSLAARYYNWVS -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:30457373/chr5:180058778) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LBH | FLT4 |
| FUNCTION: Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosphorylation sites. Mediates activation of the MAPK1/ERK2, MAPK3/ERK1 signaling pathway, of MAPK8 and the JUN signaling pathway, and of the AKT1 signaling pathway. Phosphorylates SHC1. Mediates phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase. Promotes phosphorylation of MAPK8 at 'Thr-183' and 'Tyr-185', and of AKT1 at 'Ser-473'. {ECO:0000269|PubMed:11532940, ECO:0000269|PubMed:15102829, ECO:0000269|PubMed:15474514, ECO:0000269|PubMed:16076871, ECO:0000269|PubMed:16452200, ECO:0000269|PubMed:17210781, ECO:0000269|PubMed:19610651, ECO:0000269|PubMed:19779139, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:20431062, ECO:0000269|PubMed:20445537, ECO:0000269|PubMed:21273538, ECO:0000269|PubMed:7675451, ECO:0000269|PubMed:8700872, ECO:0000269|PubMed:9435229}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 151_213 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 219_326 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 30_127 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 331_415 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 422_552 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 555_671 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 678_764 | 19.333333333333332 | 1364.0 | Domain | Note=Ig-like C2-type 7 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 845_1173 | 19.333333333333332 | 1364.0 | Domain | Protein kinase | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 151_213 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 2 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 219_326 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 3 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 30_127 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 1 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 331_415 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 4 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 422_552 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 5 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 555_671 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 6 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 678_764 | 19.333333333333332 | 1299.0 | Domain | Note=Ig-like C2-type 7 | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 845_1173 | 19.333333333333332 | 1299.0 | Domain | Protein kinase | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 851_859 | 19.333333333333332 | 1364.0 | Nucleotide binding | ATP | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 851_859 | 19.333333333333332 | 1299.0 | Nucleotide binding | ATP | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 25_775 | 19.333333333333332 | 1364.0 | Topological domain | Extracellular | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 797_1363 | 19.333333333333332 | 1364.0 | Topological domain | Cytoplasmic | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 25_775 | 19.333333333333332 | 1299.0 | Topological domain | Extracellular | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 797_1363 | 19.333333333333332 | 1299.0 | Topological domain | Cytoplasmic | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000261937 | 0 | 30 | 776_796 | 19.333333333333332 | 1364.0 | Transmembrane | Helical | |
| Tgene | FLT4 | chr2:30457373 | chr5:180058778 | ENST00000393347 | 0 | 30 | 776_796 | 19.333333333333332 | 1299.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LBH | chr2:30457373 | chr5:180058778 | ENST00000395323 | + | 2 | 3 | 18_104 | 43.0 | 106.0 | Domain | LBH |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| LBH | |
| FLT4 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to LBH-FLT4 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LBH-FLT4 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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