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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANKFY1-SPINT2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANKFY1-SPINT2
FusionPDB ID: 4432
FusionGDB2.0 ID: 4432
HgeneTgene
Gene symbol

ANKFY1

SPINT2

Gene ID

51479

10653

Gene nameankyrin repeat and FYVE domain containing 1serine peptidase inhibitor, Kunitz type 2
SynonymsANKHZN|BTBD23|ZFYVE14DIAR3|HAI-2|HAI2|Kop|PB
Cytomap

17p13.2

19q13.2

Type of geneprotein-codingprotein-coding
Descriptionrabankyrin-5Rabankyrin-5ankyrin repeat and FYVE domain-containing protein 1ankyrin repeat hooked to zinc finger motifankyrin repeats hooked to a zinc finger motifrank-5kunitz-type protease inhibitor 2hepatocyte growth factor activator inhibitor type 2serine protease inhibitor, Kunitz type, 2testicular tissue protein Li 183
Modification date2020031320200315
UniProtAcc

Q9P2R3

.
Ensembl transtripts involved in fusion geneENST idsENST00000341657, ENST00000570535, 
ENST00000574367, ENST00000433651, 
ENST00000573722, 		ENST00000587090, 
ENST00000454580, ENST00000301244, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 9 X 7=50411 X 6 X 8=528
# samples 1213
** MAII scorelog2(12/504*10)=-2.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(13/528*10)=-2.02202630633
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANKFY1 [Title/Abstract] AND SPINT2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANKFY1(4077204)-SPINT2(38774267), # samples:2
Anticipated loss of major functional domain due to fusion event.ANKFY1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKFY1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKFY1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKFY1-SPINT2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANKFY1

GO:0034058

endosomal vesicle fusion

15328530

HgeneANKFY1

GO:0048549

positive regulation of pinocytosis

15328530

TgeneSPINT2

GO:0022408

negative regulation of cell-cell adhesion

19592578

TgeneSPINT2

GO:2000146

negative regulation of cell motility

19592578


check buttonFusion gene breakpoints across ANKFY1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SPINT2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-25-1632-01AANKFY1chr17

4077204

-SPINT2chr19

38774267

+
ChimerDB4OVTCGA-25-1632ANKFY1chr17

4077203

-SPINT2chr19

38774266

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000341657ANKFY1chr174077204-ENST00000301244SPINT2chr1938774267+422029593636111191
ENST00000570535ANKFY1chr174077204-ENST00000301244SPINT2chr1938774267+4427316611738181233
ENST00000574367ANKFY1chr174077204-ENST00000301244SPINT2chr1938774267+420229411535931192
ENST00000341657ANKFY1chr174077203-ENST00000301244SPINT2chr1938774266+422029593636111191
ENST00000570535ANKFY1chr174077203-ENST00000301244SPINT2chr1938774266+4427316611738181233
ENST00000574367ANKFY1chr174077203-ENST00000301244SPINT2chr1938774266+420229411535931192

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000341657ENST00000301244ANKFY1chr174077204-SPINT2chr1938774267+0.0029445620.9970554
ENST00000570535ENST00000301244ANKFY1chr174077204-SPINT2chr1938774267+0.0031649260.99683505
ENST00000574367ENST00000301244ANKFY1chr174077204-SPINT2chr1938774267+0.0024778370.9975222
ENST00000341657ENST00000301244ANKFY1chr174077203-SPINT2chr1938774266+0.0029445620.9970554
ENST00000570535ENST00000301244ANKFY1chr174077203-SPINT2chr1938774266+0.0031649260.99683505
ENST00000574367ENST00000301244ANKFY1chr174077203-SPINT2chr1938774266+0.0024778370.9975222

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4432_4432_1_ANKFY1-SPINT2_ANKFY1_chr17_4077203_ENST00000341657_SPINT2_chr19_38774266_ENST00000301244_length(amino acids)=1191AA_BP=974
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARS
DSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES
IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHT
DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS
VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAI
QRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG
PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVA
ISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR
VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNDFCLVSKVVGRCRASM
PRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGP
CRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERA

--------------------------------------------------------------

>4432_4432_2_ANKFY1-SPINT2_ANKFY1_chr17_4077203_ENST00000570535_SPINT2_chr19_38774266_ENST00000301244_length(amino acids)=1233AA_BP=1016
MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSE
SFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL
MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKV
EREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA
TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA
VQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA
CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSR
DQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRG
ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEAR
DGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILK
RESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQ
QDLPTICSVLLENGVDFAAVDENGNNDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL
ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN

--------------------------------------------------------------

>4432_4432_3_ANKFY1-SPINT2_ANKFY1_chr17_4077203_ENST00000574367_SPINT2_chr19_38774266_ENST00000301244_length(amino acids)=1192AA_BP=975
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARS
DSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES
IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHT
DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS
VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAI
QRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP
GPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHV
AISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNS
RVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNDFCLVSKVVGRCRAS
MPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG
PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQER

--------------------------------------------------------------

>4432_4432_4_ANKFY1-SPINT2_ANKFY1_chr17_4077204_ENST00000341657_SPINT2_chr19_38774267_ENST00000301244_length(amino acids)=1191AA_BP=974
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARS
DSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES
IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHT
DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS
VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAI
QRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPG
PGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVA
ISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSR
VQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNDFCLVSKVVGRCRASM
PRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGP
CRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQERA

--------------------------------------------------------------

>4432_4432_5_ANKFY1-SPINT2_ANKFY1_chr17_4077204_ENST00000570535_SPINT2_chr19_38774267_ENST00000301244_length(amino acids)=1233AA_BP=1016
MPTPRDCGRLRSRAGRSRAGAACSRGAPRAAREALDCRRCRDAGGKEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSE
SFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARSDSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTEL
MKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNASTLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKV
EREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLESIATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAA
TLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANPNMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLA
VQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHTDAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTA
CRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADSVHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSR
DQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAIQRQDSKSALFLLEHQADINVRTQDGETALQLAIRNQLPLVVDAICTRG
ADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGPGPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEAR
DGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHVAISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILK
RESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNSRVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQ
QDLPTICSVLLENGVDFAAVDENGNNDFCLVSKVVGRCRASMPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDL
ATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTGPCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQEN

--------------------------------------------------------------

>4432_4432_6_ANKFY1-SPINT2_ANKFY1_chr17_4077204_ENST00000574367_SPINT2_chr19_38774267_ENST00000301244_length(amino acids)=1192AA_BP=975
MAEEEVAKLEKHLMLLRQEYVKLQKKLAETEKRCALLAAQANKESSSESFISRLLAIVADLYEQEQYSDLKIKVGDRHISAHKFVLAARS
DSWSLANLSSTKELDLSDANPEVTMTMLRWIYTDELEFREDDVFLTELMKLANRFQLQLLRERCEKGVMSLVNVRNCIRFYQTAEELNAS
TLMNYCAEIIASHWDDLRKEDFSSMSAQLLYKMIKSKTEYPLHKAIKVEREDVVFLYLIEMDSQLPGKLNEADHNGDLALDLALSRRLES
IATTLVSHKADVDMVDKSGWSLLHKGIQRGDLFAATFLIKNGAFVNAATLGAQETPLHLVALYSSKKHSADVMSEMAQIAEALLQAGANP
NMQDSKGRTPLHVSIMAGNEYVFSQLLQCKQLDLELKDHEGSTALWLAVQHITVSSDQSVNPFEDVPVVNGTSFDENSFAARLIQRGSHT
DAPDTATGNCLLQRAAGAGNEAAALFLATNGAHVNHRNKWGETPLHTACRHGLANLTAELLQQGANPNLQTEEALPLPKEAASLTSLADS
VHLQTPLHMAIAYNHPDVVSVILEQKANALHATNNLQIIPDFSLKDSRDQTVLGLALWTGMHTIAAQLLGSGAAINDTMSDGQTLLHMAI
QRQDSKSALFLLEHQADINVSRTQDGETALQLAIRNQLPLVVDAICTRGADMSVPDEKGNPPLWLALANNLEDIASTLVRHGCDATCWGP
GPGGCLQTLLHRAIDENNEPTACFLIRSGCDVNSPRQPGANGEGEEEARDGQTPLHLAASWGLEETVQCLLEFGANVNAQDAEGRTPIHV
AISSQHGVIIQLLVSHPDIHLNVRDRQGLTPFACAMTFKNNKSAEAILKRESGAAEQVDNKGRNFLHVAVQNSDIESVLFLISVHANVNS
RVQDASKLTPLHLAVQAGSEIIVRNLLLAGAKVNELTKHRQTALHLAAQQDLPTICSVLLENGVDFAAVDENGNNDFCLVSKVVGRCRAS
MPRWWYNVTDGSCQLFVYGGCDGNSNNYLTKEECLKKCATVTENATGDLATSRNAADSSVPSAPRRQDSEDHSSDMFNYEEYCTANAVTG
PCRASFPRWYFDVERNSCNNFIYGGCRGNKNSYRSEEACMLRCFRQQENPPLPLGSKVVVLAGLFVMVLILFLGASMVYLIRVARRNQER

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:4077204/chr19:38774267)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKFY1

Q9P2R3

.
FUNCTION: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. {ECO:0000269|PubMed:15328530, ECO:0000269|PubMed:22284051, ECO:0000269|PubMed:24102721}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-202568_130974.33333333333341170.0DomainBTB
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-202568_1301016.33333333333341212.0DomainBTB
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-202568_130975.33333333333341171.0DomainBTB
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-202568_130974.33333333333341170.0DomainBTB
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-202568_1301016.33333333333341212.0DomainBTB
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-202568_130975.33333333333341171.0DomainBTB
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025217_247974.33333333333341170.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025255_284974.33333333333341170.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025288_317974.33333333333341170.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025322_362974.33333333333341170.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025366_396974.33333333333341170.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025490_519974.33333333333341170.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025542_572974.33333333333341170.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025588_617974.33333333333341170.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025621_650974.33333333333341170.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025654_683974.33333333333341170.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025687_716974.33333333333341170.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025724_753974.33333333333341170.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025769_798974.33333333333341170.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025802_832974.33333333333341170.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025836_865974.33333333333341170.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025870_899974.33333333333341170.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025905_934974.33333333333341170.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025938_967974.33333333333341170.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025217_2471016.33333333333341212.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025255_2841016.33333333333341212.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025288_3171016.33333333333341212.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025322_3621016.33333333333341212.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025366_3961016.33333333333341212.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025490_5191016.33333333333341212.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025542_5721016.33333333333341212.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025588_6171016.33333333333341212.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025621_6501016.33333333333341212.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025654_6831016.33333333333341212.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025687_7161016.33333333333341212.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025724_7531016.33333333333341212.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025769_7981016.33333333333341212.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025802_8321016.33333333333341212.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025836_8651016.33333333333341212.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025870_8991016.33333333333341212.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025905_9341016.33333333333341212.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025938_9671016.33333333333341212.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-2025971_10011016.33333333333341212.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025217_247975.33333333333341171.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025255_284975.33333333333341171.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025288_317975.33333333333341171.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025322_362975.33333333333341171.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025366_396975.33333333333341171.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025490_519975.33333333333341171.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025542_572975.33333333333341171.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025588_617975.33333333333341171.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025621_650975.33333333333341171.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025654_683975.33333333333341171.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025687_716975.33333333333341171.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025724_753975.33333333333341171.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025769_798975.33333333333341171.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025802_832975.33333333333341171.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025836_865975.33333333333341171.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025870_899975.33333333333341171.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025905_934975.33333333333341171.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025938_967975.33333333333341171.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025217_247974.33333333333341170.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025255_284974.33333333333341170.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025288_317974.33333333333341170.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025322_362974.33333333333341170.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025366_396974.33333333333341170.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025490_519974.33333333333341170.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025542_572974.33333333333341170.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025588_617974.33333333333341170.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025621_650974.33333333333341170.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025654_683974.33333333333341170.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025687_716974.33333333333341170.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025724_753974.33333333333341170.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025769_798974.33333333333341170.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025802_832974.33333333333341170.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025836_865974.33333333333341170.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025870_899974.33333333333341170.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025905_934974.33333333333341170.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025938_967974.33333333333341170.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025217_2471016.33333333333341212.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025255_2841016.33333333333341212.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025288_3171016.33333333333341212.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025322_3621016.33333333333341212.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025366_3961016.33333333333341212.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025490_5191016.33333333333341212.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025542_5721016.33333333333341212.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025588_6171016.33333333333341212.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025621_6501016.33333333333341212.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025654_6831016.33333333333341212.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025687_7161016.33333333333341212.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025724_7531016.33333333333341212.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025769_7981016.33333333333341212.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025802_8321016.33333333333341212.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025836_8651016.33333333333341212.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025870_8991016.33333333333341212.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025905_9341016.33333333333341212.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025938_9671016.33333333333341212.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-2025971_10011016.33333333333341212.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025217_247975.33333333333341171.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025255_284975.33333333333341171.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025288_317975.33333333333341171.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025322_362975.33333333333341171.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025366_396975.33333333333341171.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025490_519975.33333333333341171.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025542_572975.33333333333341171.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025588_617975.33333333333341171.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025621_650975.33333333333341171.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025654_683975.33333333333341171.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025687_716975.33333333333341171.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025724_753975.33333333333341171.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025769_798975.33333333333341171.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025802_832975.33333333333341171.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025836_865975.33333333333341171.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025870_899975.33333333333341171.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025905_934975.33333333333341171.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025938_967975.33333333333341171.0RepeatNote=ANK 18
TgeneSPINT2chr17:4077203chr19:38774266ENST0000030124407219_25235.333333333333336253.0Topological domainCytoplasmic
TgeneSPINT2chr17:4077203chr19:38774266ENST0000045458006219_2520196.0Topological domainCytoplasmic
TgeneSPINT2chr17:4077203chr19:38774266ENST000004545800628_1970196.0Topological domainExtracellular
TgeneSPINT2chr17:4077204chr19:38774267ENST0000030124407219_25235.333333333333336253.0Topological domainCytoplasmic
TgeneSPINT2chr17:4077204chr19:38774267ENST0000045458006219_2520196.0Topological domainCytoplasmic
TgeneSPINT2chr17:4077204chr19:38774267ENST000004545800628_1970196.0Topological domainExtracellular
TgeneSPINT2chr17:4077203chr19:38774266ENST0000030124407198_21835.333333333333336253.0TransmembraneHelical
TgeneSPINT2chr17:4077203chr19:38774266ENST0000045458006198_2180196.0TransmembraneHelical
TgeneSPINT2chr17:4077204chr19:38774267ENST0000030124407198_21835.333333333333336253.0TransmembraneHelical
TgeneSPINT2chr17:4077204chr19:38774267ENST0000045458006198_2180196.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-11068_1300488.0DomainBTB
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-11068_1300488.0DomainBTB
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-20251005_1037974.33333333333341170.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-20251043_1072974.33333333333341170.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-2025971_1001974.33333333333341170.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-1101005_10370488.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-1101043_10720488.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110217_2470488.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110255_2840488.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110288_3170488.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110322_3620488.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110366_3960488.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110490_5190488.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110542_5720488.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110588_6170488.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110621_6500488.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110654_6830488.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110687_7160488.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110724_7530488.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110769_7980488.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110802_8320488.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110836_8650488.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110870_8990488.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110905_9340488.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110938_9670488.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110971_10010488.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-20251005_10371016.33333333333341212.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-20251043_10721016.33333333333341212.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-20251005_1037975.33333333333341171.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-20251043_1072975.33333333333341171.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-2025971_1001975.33333333333341171.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-20251005_1037974.33333333333341170.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-20251043_1072974.33333333333341170.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-2025971_1001974.33333333333341170.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-1101005_10370488.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-1101043_10720488.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110217_2470488.0RepeatNote=ANK 1
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110255_2840488.0RepeatNote=ANK 2
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110288_3170488.0RepeatNote=ANK 3
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110322_3620488.0RepeatNote=ANK 4
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110366_3960488.0RepeatNote=ANK 5
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110490_5190488.0RepeatNote=ANK 6
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110542_5720488.0RepeatNote=ANK 7
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110588_6170488.0RepeatNote=ANK 8
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110621_6500488.0RepeatNote=ANK 9
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110654_6830488.0RepeatNote=ANK 10
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110687_7160488.0RepeatNote=ANK 11
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110724_7530488.0RepeatNote=ANK 12
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110769_7980488.0RepeatNote=ANK 13
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110802_8320488.0RepeatNote=ANK 14
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110836_8650488.0RepeatNote=ANK 15
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110870_8990488.0RepeatNote=ANK 16
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110905_9340488.0RepeatNote=ANK 17
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110938_9670488.0RepeatNote=ANK 18
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110971_10010488.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-20251005_10371016.33333333333341212.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-20251043_10721016.33333333333341212.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-20251005_1037975.33333333333341171.0RepeatNote=ANK 20
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-20251043_1072975.33333333333341171.0RepeatNote=ANK 21
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-2025971_1001975.33333333333341171.0RepeatNote=ANK 19
HgeneANKFY1chr17:4077203chr19:38774266ENST00000341657-20251104_1164974.33333333333341170.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-1101104_11640488.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077203chr19:38774266ENST00000570535-20251104_11641016.33333333333341212.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077203chr19:38774266ENST00000574367-20251104_1164975.33333333333341171.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077204chr19:38774267ENST00000341657-20251104_1164974.33333333333341170.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-1101104_11640488.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077204chr19:38774267ENST00000570535-20251104_11641016.33333333333341212.0Zinc fingerFYVE-type
HgeneANKFY1chr17:4077204chr19:38774267ENST00000574367-20251104_1164975.33333333333341171.0Zinc fingerFYVE-type
TgeneSPINT2chr17:4077203chr19:38774266ENST000003012440728_19735.333333333333336253.0Topological domainExtracellular
TgeneSPINT2chr17:4077204chr19:38774267ENST000003012440728_19735.333333333333336253.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANKFY1
SPINT2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneANKFY1chr17:4077203chr19:38774266ENST00000433651-110650_7590488.0RHOD and RAB5A
HgeneANKFY1chr17:4077204chr19:38774267ENST00000433651-110650_7590488.0RHOD and RAB5A


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Related Drugs to ANKFY1-SPINT2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANKFY1-SPINT2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource