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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LDLR-DNM2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LDLR-DNM2
FusionPDB ID: 44406
FusionGDB2.0 ID: 44406
HgeneTgene
Gene symbol

LDLR

DNM2

Gene ID

3949

1785

Gene namelow density lipoprotein receptordynamin 2
SynonymsFH|FHC|FHCL1|LDLCQ2CMT2M|CMTDI1|CMTDIB|DI-CMTB|DYN2|DYNII|LCCS5
Cytomap

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptorLDL receptorlow-density lipoprotein receptor class A domain-containing protein 3dynamin-2dynamin II
Modification date2020032220200329
UniProtAcc

Q5SW96

P50570

Ensembl transtripts involved in fusion geneENST idsENST00000455727, ENST00000535915, 
ENST00000545707, ENST00000557933, 
ENST00000558013, ENST00000558518, 
ENST00000560628, 		ENST00000591819, 
ENST00000314646, ENST00000355667, 
ENST00000359692, ENST00000389253, 
ENST00000408974, ENST00000585892, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 17 X 15=586519 X 24 X 14=6384
# samples 3334
** MAII scorelog2(33/5865*10)=-4.15159317867005
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/6384*10)=-4.23085400008464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LDLR [Title/Abstract] AND DNM2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LDLR(11200291)-DNM2(10935733), # samples:2
Anticipated loss of major functional domain due to fusion event.LDLR-DNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-DNM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LDLR-DNM2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LDLR-DNM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LDLR-DNM2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
LDLR-DNM2 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDNM2

GO:1903526

negative regulation of membrane tubulation

18388313


check buttonFusion gene breakpoints across LDLR (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DNM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CN-5367-01ALDLRchr19

11240346

-DNM2chr19

10935733

+
ChimerDB4OVTCGA-20-1684LDLRchr19

11218190

+DNM2chr19

10935732

+
ChimerDB4SKCMTCGA-WE-A8ZT-06ALDLRchr19

11231198

-DNM2chr19

10922940

+
ChimerDB4UCECTCGA-AJ-A3NH-01ALDLRchr19

11200291

-DNM2chr19

10935733

+
ChimerDB4UCECTCGA-AJ-A3NH-01ALDLRchr19

11200291

+DNM2chr19

10935733

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000558518LDLRchr1911240346-ENST00000585892DNM2chr1910935733+3451273416934501094
ENST00000558518LDLRchr1911240346-ENST00000314646DNM2chr1910935733+4310273416934531094
ENST00000558518LDLRchr1911240346-ENST00000359692DNM2chr1910935733+4291273416934531094
ENST00000558518LDLRchr1911240346-ENST00000389253DNM2chr1910935733+4310273416934531094
ENST00000558518LDLRchr1911240346-ENST00000355667DNM2chr1910935733+4302273416934531094
ENST00000558518LDLRchr1911240346-ENST00000408974DNM2chr1910935733+3831273416934531094
ENST00000455727LDLRchr1911240346-ENST00000585892DNM2chr1910935733+28462129682845926
ENST00000455727LDLRchr1911240346-ENST00000314646DNM2chr1910935733+37052129682848926
ENST00000455727LDLRchr1911240346-ENST00000359692DNM2chr1910935733+36862129682848926
ENST00000455727LDLRchr1911240346-ENST00000389253DNM2chr1910935733+37052129682848926
ENST00000455727LDLRchr1911240346-ENST00000355667DNM2chr1910935733+36972129682848926
ENST00000455727LDLRchr1911240346-ENST00000408974DNM2chr1910935733+32262129682848926
ENST00000535915LDLRchr1911240346-ENST00000585892DNM2chr1910935733+322725106832261053
ENST00000535915LDLRchr1911240346-ENST00000314646DNM2chr1910935733+408625106832291053
ENST00000535915LDLRchr1911240346-ENST00000359692DNM2chr1910935733+406725106832291053
ENST00000535915LDLRchr1911240346-ENST00000389253DNM2chr1910935733+408625106832291053
ENST00000535915LDLRchr1911240346-ENST00000355667DNM2chr1910935733+407825106832291053
ENST00000535915LDLRchr1911240346-ENST00000408974DNM2chr1910935733+360725106832291053
ENST00000545707LDLRchr1911240346-ENST00000585892DNM2chr1910935733+28162099682815916
ENST00000545707LDLRchr1911240346-ENST00000314646DNM2chr1910935733+36752099682818916
ENST00000545707LDLRchr1911240346-ENST00000359692DNM2chr1910935733+36562099682818916
ENST00000545707LDLRchr1911240346-ENST00000389253DNM2chr1910935733+36752099682818916
ENST00000545707LDLRchr1911240346-ENST00000355667DNM2chr1910935733+36672099682818916
ENST00000545707LDLRchr1911240346-ENST00000408974DNM2chr1910935733+31962099682818916
ENST00000558013LDLRchr1911240346-ENST00000585892DNM2chr1910935733+333526185333341094
ENST00000558013LDLRchr1911240346-ENST00000314646DNM2chr1910935733+419426185333371094
ENST00000558013LDLRchr1911240346-ENST00000359692DNM2chr1910935733+417526185333371094
ENST00000558013LDLRchr1911240346-ENST00000389253DNM2chr1910935733+419426185333371094
ENST00000558013LDLRchr1911240346-ENST00000355667DNM2chr1910935733+418626185333371094
ENST00000558013LDLRchr1911240346-ENST00000408974DNM2chr1910935733+371526185333371094

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000558518ENST00000585892LDLRchr1911240346-DNM2chr1910935733+0.0048060730.9951939
ENST00000558518ENST00000314646LDLRchr1911240346-DNM2chr1910935733+0.0040367260.9959632
ENST00000558518ENST00000359692LDLRchr1911240346-DNM2chr1910935733+0.0041384090.9958616
ENST00000558518ENST00000389253LDLRchr1911240346-DNM2chr1910935733+0.0040367260.9959632
ENST00000558518ENST00000355667LDLRchr1911240346-DNM2chr1910935733+0.0041004450.9958995
ENST00000558518ENST00000408974LDLRchr1911240346-DNM2chr1910935733+0.0050866060.99491334
ENST00000455727ENST00000585892LDLRchr1911240346-DNM2chr1910935733+0.007030240.9929698
ENST00000455727ENST00000314646LDLRchr1911240346-DNM2chr1910935733+0.0042423420.99575764
ENST00000455727ENST00000359692LDLRchr1911240346-DNM2chr1910935733+0.0043801150.99561983
ENST00000455727ENST00000389253LDLRchr1911240346-DNM2chr1910935733+0.0042423420.99575764
ENST00000455727ENST00000355667LDLRchr1911240346-DNM2chr1910935733+0.0043382440.9956618
ENST00000455727ENST00000408974LDLRchr1911240346-DNM2chr1910935733+0.0057403020.9942597
ENST00000535915ENST00000585892LDLRchr1911240346-DNM2chr1910935733+0.004536190.9954638
ENST00000535915ENST00000314646LDLRchr1911240346-DNM2chr1910935733+0.0039785930.99602145
ENST00000535915ENST00000359692LDLRchr1911240346-DNM2chr1910935733+0.0040899120.99591005
ENST00000535915ENST00000389253LDLRchr1911240346-DNM2chr1910935733+0.0039785930.99602145
ENST00000535915ENST00000355667LDLRchr1911240346-DNM2chr1910935733+0.0040528520.9959472
ENST00000535915ENST00000408974LDLRchr1911240346-DNM2chr1910935733+0.0050986840.9949013
ENST00000545707ENST00000585892LDLRchr1911240346-DNM2chr1910935733+0.0056028210.99439716
ENST00000545707ENST00000314646LDLRchr1911240346-DNM2chr1910935733+0.0034874890.9965125
ENST00000545707ENST00000359692LDLRchr1911240346-DNM2chr1910935733+0.0036033240.9963967
ENST00000545707ENST00000389253LDLRchr1911240346-DNM2chr1910935733+0.0034874890.9965125
ENST00000545707ENST00000355667LDLRchr1911240346-DNM2chr1910935733+0.0035754340.9964245
ENST00000545707ENST00000408974LDLRchr1911240346-DNM2chr1910935733+0.004693970.99530596
ENST00000558013ENST00000585892LDLRchr1911240346-DNM2chr1910935733+0.0043456410.99565434
ENST00000558013ENST00000314646LDLRchr1911240346-DNM2chr1910935733+0.0035823960.99641764
ENST00000558013ENST00000359692LDLRchr1911240346-DNM2chr1910935733+0.0036755240.9963245
ENST00000558013ENST00000389253LDLRchr1911240346-DNM2chr1910935733+0.0035823960.99641764
ENST00000558013ENST00000355667LDLRchr1911240346-DNM2chr1910935733+0.0036406850.9963593
ENST00000558013ENST00000408974LDLRchr1911240346-DNM2chr1910935733+0.004561190.9954389

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44406_44406_1_LDLR-DNM2_LDLR_chr19_11240346_ENST00000455727_DNM2_chr19_10935733_ENST00000314646_length(amino acids)=926AA_BP=687
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVAL
DTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAI
VVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLA
VFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM
LLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSI
VLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDD
TWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP

--------------------------------------------------------------

>44406_44406_2_LDLR-DNM2_LDLR_chr19_11240346_ENST00000455727_DNM2_chr19_10935733_ENST00000355667_length(amino acids)=926AA_BP=687
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVAL
DTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAI
VVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLA
VFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM
LLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSI
VLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDD
TWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP

--------------------------------------------------------------

>44406_44406_3_LDLR-DNM2_LDLR_chr19_11240346_ENST00000455727_DNM2_chr19_10935733_ENST00000359692_length(amino acids)=926AA_BP=687
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVAL
DTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAI
VVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLA
VFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM
LLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSI
VLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDD
TWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP

--------------------------------------------------------------

>44406_44406_4_LDLR-DNM2_LDLR_chr19_11240346_ENST00000455727_DNM2_chr19_10935733_ENST00000389253_length(amino acids)=926AA_BP=687
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVAL
DTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAI
VVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLA
VFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM
LLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSI
VLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDD
TWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP

--------------------------------------------------------------

>44406_44406_5_LDLR-DNM2_LDLR_chr19_11240346_ENST00000455727_DNM2_chr19_10935733_ENST00000408974_length(amino acids)=926AA_BP=687
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVAL
DTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAI
VVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLA
VFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM
LLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSI
VLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDD
TWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP

--------------------------------------------------------------

>44406_44406_6_LDLR-DNM2_LDLR_chr19_11240346_ENST00000455727_DNM2_chr19_10935733_ENST00000585892_length(amino acids)=926AA_BP=687
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCLTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPD
GFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVAL
DTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAI
VVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLA
VFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGM
LLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSI
VLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYV
AIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDD
TWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPP

--------------------------------------------------------------

>44406_44406_7_LDLR-DNM2_LDLR_chr19_11240346_ENST00000535915_DNM2_chr19_10935733_ENST00000314646_length(amino acids)=1053AA_BP=814
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH
SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN
WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA
TPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGY
SYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQ
RRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAP

--------------------------------------------------------------

>44406_44406_8_LDLR-DNM2_LDLR_chr19_11240346_ENST00000535915_DNM2_chr19_10935733_ENST00000355667_length(amino acids)=1053AA_BP=814
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH
SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN
WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA
TPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGY
SYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQ
RRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAP

--------------------------------------------------------------

>44406_44406_9_LDLR-DNM2_LDLR_chr19_11240346_ENST00000535915_DNM2_chr19_10935733_ENST00000359692_length(amino acids)=1053AA_BP=814
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH
SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN
WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA
TPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGY
SYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQ
RRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAP

--------------------------------------------------------------

>44406_44406_10_LDLR-DNM2_LDLR_chr19_11240346_ENST00000535915_DNM2_chr19_10935733_ENST00000389253_length(amino acids)=1053AA_BP=814
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH
SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN
WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA
TPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGY
SYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQ
RRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAP

--------------------------------------------------------------

>44406_44406_11_LDLR-DNM2_LDLR_chr19_11240346_ENST00000535915_DNM2_chr19_10935733_ENST00000408974_length(amino acids)=1053AA_BP=814
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH
SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN
WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA
TPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGY
SYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQ
RRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAP

--------------------------------------------------------------

>44406_44406_12_LDLR-DNM2_LDLR_chr19_11240346_ENST00000535915_DNM2_chr19_10935733_ENST00000585892_length(amino acids)=1053AA_BP=814
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCSPKTCSQDEFRCHDGKCISRQ
FVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCEDGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWR
CDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDW
SDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAV
GSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIH
SNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRL
YWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVN
WCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTEAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGA
TPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGY
SYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQ
RRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAP

--------------------------------------------------------------

>44406_44406_13_LDLR-DNM2_LDLR_chr19_11240346_ENST00000545707_DNM2_chr19_10935733_ENST00000314646_length(amino acids)=916AA_BP=677
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV
DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL
SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQP
REAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFL
CLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDL
MPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHS
PTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAA

--------------------------------------------------------------

>44406_44406_14_LDLR-DNM2_LDLR_chr19_11240346_ENST00000545707_DNM2_chr19_10935733_ENST00000355667_length(amino acids)=916AA_BP=677
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV
DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL
SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQP
REAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFL
CLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDL
MPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHS
PTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAA

--------------------------------------------------------------

>44406_44406_15_LDLR-DNM2_LDLR_chr19_11240346_ENST00000545707_DNM2_chr19_10935733_ENST00000359692_length(amino acids)=916AA_BP=677
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV
DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL
SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQP
REAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFL
CLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDL
MPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHS
PTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAA

--------------------------------------------------------------

>44406_44406_16_LDLR-DNM2_LDLR_chr19_11240346_ENST00000545707_DNM2_chr19_10935733_ENST00000389253_length(amino acids)=916AA_BP=677
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV
DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL
SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQP
REAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFL
CLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDL
MPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHS
PTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAA

--------------------------------------------------------------

>44406_44406_17_LDLR-DNM2_LDLR_chr19_11240346_ENST00000545707_DNM2_chr19_10935733_ENST00000408974_length(amino acids)=916AA_BP=677
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV
DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL
SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQP
REAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFL
CLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDL
MPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHS
PTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAA

--------------------------------------------------------------

>44406_44406_18_LDLR-DNM2_LDLR_chr19_11240346_ENST00000545707_DNM2_chr19_10935733_ENST00000585892_length(amino acids)=916AA_BP=677
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPVATCRPDEFQCSDGNCIHGSRQCDREYDCKDMSDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARD
CRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCEDIDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKA
CKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWSDLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAV
DWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWTDWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLL
SGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDIINEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQP
REAEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFL
CLGVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDL
MPKTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHS
PTPQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAP

--------------------------------------------------------------

>44406_44406_19_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558013_DNM2_chr19_10935733_ENST00000314646_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_20_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558013_DNM2_chr19_10935733_ENST00000355667_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_21_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558013_DNM2_chr19_10935733_ENST00000359692_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_22_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558013_DNM2_chr19_10935733_ENST00000389253_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_23_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558013_DNM2_chr19_10935733_ENST00000408974_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_24_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558013_DNM2_chr19_10935733_ENST00000585892_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAPSR

--------------------------------------------------------------

>44406_44406_25_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558518_DNM2_chr19_10935733_ENST00000314646_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_26_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558518_DNM2_chr19_10935733_ENST00000355667_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_27_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558518_DNM2_chr19_10935733_ENST00000359692_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_28_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558518_DNM2_chr19_10935733_ENST00000389253_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_29_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558518_DNM2_chr19_10935733_ENST00000408974_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPSRRPPAAPS

--------------------------------------------------------------

>44406_44406_30_LDLR-DNM2_LDLR_chr19_11240346_ENST00000558518_DNM2_chr19_10935733_ENST00000585892_length(amino acids)=1094AA_BP=855
MAEAASMGPWGWKLRWTVALLLAAAGTAVGDRCERNEFQCQDGKCISYKWVCDGSAECQDGSDESQETCLSVTCKSGDFSCGGRVNRCIP
QFWRCDGQVDCDNGSDEQGCPPKTCSQDEFRCHDGKCISRQFVCDSDRDCLDGSDEASCPVLTCGPASFQCNSSTCIPQLWACDNDPDCE
DGSDEWPQRCRGLYVFQGDSSPCSAFEFHCLSGECIHSSWRCDGGPDCKDKSDEENCAVATCRPDEFQCSDGNCIHGSRQCDREYDCKDM
SDEVGCVNVTLCEGPNKFKCHSGECITLDKVCNMARDCRDWSDEPIKECGTNECLDNNGGCSHVCNDLKIGYECLCPDGFQLVAQRRCED
IDECQDPDTCSQLCVNLEGGYKCQCEEGFQLDPHTKACKAVGSIAYLFFTNRHEVRKMTLDRSEYTSLIPNLRNVVALDTEVASNRIYWS
DLSQRMICSTQLDRAHGVSSYDTVISRDIQAPDGLAVDWIHSNIYWTDSVLGTVSVADTKGVKRKTLFRENGSKPRAIVVDPVHGFMYWT
DWGTPAKIKKGGLNGVDIYSLVTENIQWPNGITLDLLSGRLYWVDSKLHSISSIDVNGGNRKTILEDEKRLAHPFSLAVFEDKVFWTDII
NEAIFSANRLTGSDVNLLAENLLSPEDMVLFHNLTQPRGVNWCERTTLSNGGCQYLCLPAPQINPHSPKFTCACPDGMLLARDMRSCLTE
AEAAVATQETSTVRLKVSSTAVRTQHTTTRPVPDTSRLPGATPGLTTVEIVTMSHQALGDVAGRGNEKKPSSVRALSIVLPIVLLVFLCL
GVFLLWKNWRLKNINSINFDNPVYQKTTEDEVHICHNQDGYSYPSAENEDGAQENTFSMDPQLERQVETIRNLVDSYVAIINKSIRDLMP
KTIMHLMINNTKAFIHHELLAYLYSSADQSSLMEESADQAQRRDDMLRMYHALKEALNIIGDISTSTVSTPVPPPVDDTWLQSASSHSPT
PQRRPVSSIHPPGRPPAVRGPTPGPPLIPVPVGAAASFSAPPIPSRPGPQSVFANSDLFPAPPQIPSRPVRIPPGIPPGVPRRPPAAPSR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11200291/chr19:10935733)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LDLR

Q5SW96

DNM2

P50570

FUNCTION: Adapter protein (clathrin-associated sorting protein (CLASP)) required for efficient endocytosis of the LDL receptor (LDLR) in polarized cells such as hepatocytes and lymphocytes, but not in non-polarized cells (fibroblasts). May be required for LDL binding and internalization but not for receptor clustering in coated pits. May facilitate the endocytocis of LDLR and LDLR-LDL complexes from coated pits by stabilizing the interaction between the receptor and the structural components of the pits. May also be involved in the internalization of other LDLR family members. Binds to phosphoinositides, which regulate clathrin bud assembly at the cell surface. Required for trafficking of LRP2 to the endocytic recycling compartment which is necessary for LRP2 proteolysis, releasing a tail fragment which translocates to the nucleus and mediates transcriptional repression (By similarity). {ECO:0000250|UniProtKB:D3ZAR1, ECO:0000269|PubMed:15728179}.FUNCTION: Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). {ECO:0000250|UniProtKB:P39052, ECO:0000250|UniProtKB:P39054, ECO:0000269|PubMed:12498685}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516107_145681.0693.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516146_186681.0693.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516195_233681.0693.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516234_272681.0693.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-151625_65681.0693.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516274_313681.0693.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516314_353681.0693.0DomainEGF-like 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516354_393681.0693.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-151666_106681.0693.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617107_145808.0820.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617146_186808.0820.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617195_233808.0820.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617234_272808.0820.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-161725_65808.0820.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617274_313808.0820.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617314_353808.0820.0DomainEGF-like 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617354_393808.0820.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617663_712808.0820.0DomainEGF-like 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-161766_106808.0820.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516107_145671.0683.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516146_186671.0683.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516195_233671.0683.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516234_272671.0683.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-151625_65671.0683.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516274_313671.0683.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516314_353671.0683.0DomainEGF-like 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516354_393671.0683.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-151666_106671.0683.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718107_145849.0859.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718146_186849.0859.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718195_233849.0859.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718234_272849.0859.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-171825_65849.0859.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718274_313849.0859.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718314_353849.0859.0DomainEGF-like 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718354_393849.0859.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718663_712849.0859.0DomainEGF-like 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-171866_106849.0859.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718107_145849.0861.0DomainLDL-receptor class A 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718146_186849.0861.0DomainLDL-receptor class A 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718195_233849.0861.0DomainLDL-receptor class A 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718234_272849.0861.0DomainLDL-receptor class A 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-171825_65849.0861.0DomainLDL-receptor class A 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718274_313849.0861.0DomainLDL-receptor class A 7
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718314_353849.0861.0DomainEGF-like 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718354_393849.0861.0DomainEGF-like 2%3B calcium-binding
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718663_712849.0861.0DomainEGF-like 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-171866_106849.0861.0DomainLDL-receptor class A 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718823_828849.0859.0MotifNPXY motif
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718823_828849.0861.0MotifNPXY motif
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617721_768808.0820.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718721_768849.0859.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718721_768849.0861.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516397_438681.0693.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516439_485681.0693.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516486_528681.0693.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516529_572681.0693.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516573_615681.0693.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516616_658681.0693.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617397_438808.0820.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617439_485808.0820.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617486_528808.0820.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617529_572808.0820.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617573_615808.0820.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617616_658808.0820.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516397_438671.0683.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516439_485671.0683.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516486_528671.0683.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516529_572671.0683.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516573_615671.0683.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516616_658671.0683.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718397_438849.0859.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718439_485849.0859.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718486_528849.0859.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718529_572849.0859.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718573_615849.0859.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718616_658849.0859.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718397_438849.0861.0RepeatNote=LDL-receptor class B 1
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718439_485849.0861.0RepeatNote=LDL-receptor class B 2
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718486_528849.0861.0RepeatNote=LDL-receptor class B 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718529_572849.0861.0RepeatNote=LDL-receptor class B 4
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718573_615849.0861.0RepeatNote=LDL-receptor class B 5
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718616_658849.0861.0RepeatNote=LDL-receptor class B 6
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-161722_788808.0820.0Topological domainExtracellular
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-171822_788849.0859.0Topological domainExtracellular
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-171822_788849.0861.0Topological domainExtracellular
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617789_810808.0820.0TransmembraneHelical
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718789_810849.0859.0TransmembraneHelical
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718789_810849.0861.0TransmembraneHelical
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621747_866631.0871.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520747_866627.0867.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621747_866631.0871.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520747_866627.0867.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621747_866631.0870.0Compositional biasNote=Pro-rich
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621653_744631.0871.0DomainGED
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520653_744627.0867.0DomainGED
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621653_744631.0871.0DomainGED
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520653_744627.0867.0DomainGED
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621653_744631.0870.0DomainGED

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516663_712681.0693.0DomainEGF-like 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516663_712671.0683.0DomainEGF-like 3
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516823_828681.0693.0MotifNPXY motif
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617823_828808.0820.0MotifNPXY motif
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516823_828671.0683.0MotifNPXY motif
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516721_768681.0693.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516811_860681.0693.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11240346chr19:10935733ENST00000535915-1617811_860808.0820.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516721_768671.0683.0RegionNote=Clustered O-linked oligosaccharides
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516811_860671.0683.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11240346chr19:10935733ENST00000558013-1718811_860849.0859.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11240346chr19:10935733ENST00000558518-1718811_860849.0861.0RegionRequired for MYLIP-triggered down-regulation of LDLR
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-151622_788681.0693.0Topological domainExtracellular
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-151622_788671.0683.0Topological domainExtracellular
HgeneLDLRchr19:11240346chr19:10935733ENST00000455727-1516789_810681.0693.0TransmembraneHelical
HgeneLDLRchr19:11240346chr19:10935733ENST00000545707-1516789_810671.0683.0TransmembraneHelical
TgeneDNM2chr19:11240346chr19:10935733ENST00000355667162128_294631.0871.0DomainDynamin-type G
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621519_625631.0871.0DomainPH
TgeneDNM2chr19:11240346chr19:10935733ENST00000359692152028_294627.0867.0DomainDynamin-type G
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520519_625627.0867.0DomainPH
TgeneDNM2chr19:11240346chr19:10935733ENST00000389253162128_294631.0871.0DomainDynamin-type G
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621519_625631.0871.0DomainPH
TgeneDNM2chr19:11240346chr19:10935733ENST00000408974152028_294627.0867.0DomainDynamin-type G
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520519_625627.0867.0DomainPH
TgeneDNM2chr19:11240346chr19:10935733ENST00000585892162128_294631.0870.0DomainDynamin-type G
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621519_625631.0870.0DomainPH
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621205_211631.0871.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621236_239631.0871.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST00000355667162138_46631.0871.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520205_211627.0867.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520236_239627.0867.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST00000359692152038_46627.0867.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621205_211631.0871.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621236_239631.0871.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST00000389253162138_46631.0871.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520205_211627.0867.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520236_239627.0867.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST00000408974152038_46627.0867.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621205_211631.0870.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621236_239631.0870.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST00000585892162138_46631.0870.0Nucleotide bindingGTP
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621136_139631.0871.0RegionG3 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621205_208631.0871.0RegionG4 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003556671621235_238631.0871.0RegionG5 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000355667162138_45631.0871.0RegionG1 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000355667162164_66631.0871.0RegionG2 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520136_139627.0867.0RegionG3 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520205_208627.0867.0RegionG4 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003596921520235_238627.0867.0RegionG5 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000359692152038_45627.0867.0RegionG1 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000359692152064_66627.0867.0RegionG2 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621136_139631.0871.0RegionG3 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621205_208631.0871.0RegionG4 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000003892531621235_238631.0871.0RegionG5 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000389253162138_45631.0871.0RegionG1 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000389253162164_66631.0871.0RegionG2 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520136_139627.0867.0RegionG3 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520205_208627.0867.0RegionG4 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000004089741520235_238627.0867.0RegionG5 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000408974152038_45627.0867.0RegionG1 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000408974152064_66627.0867.0RegionG2 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621136_139631.0870.0RegionG3 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621205_208631.0870.0RegionG4 motif
TgeneDNM2chr19:11240346chr19:10935733ENST000005858921621235_238631.0870.0RegionG5 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000585892162138_45631.0870.0RegionG1 motif
TgeneDNM2chr19:11240346chr19:10935733ENST00000585892162164_66631.0870.0RegionG2 motif


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LDLR
DNM2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LDLR-DNM2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LDLR-DNM2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource