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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LGR6-RNPEP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LGR6-RNPEP
FusionPDB ID: 44599
FusionGDB2.0 ID: 44599
HgeneTgene
Gene symbol

LGR6

RNPEP

Gene ID

59352

6051

Gene nameleucine rich repeat containing G protein-coupled receptor 6arginyl aminopeptidase
SynonymsGPCR|VTS20631AP-B|APB
Cytomap

1q32.1

1q32.1

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeat-containing G-protein coupled receptor 6gonadotropin receptoraminopeptidase Barginine aminopeptidase
Modification date2020031320200320
UniProtAcc

Q9HBX8

.
Ensembl transtripts involved in fusion geneENST idsENST00000367278, ENST00000255432, 
ENST00000308543, ENST00000439764, 
ENST00000471105, ENST00000367286, 
ENST00000295640, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 2 X 3=247 X 7 X 5=245
# samples 89
** MAII scorelog2(8/24*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(9/245*10)=-1.4447848426729
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LGR6 [Title/Abstract] AND RNPEP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LGR6(202163329)-RNPEP(201965275), # samples:2
Anticipated loss of major functional domain due to fusion event.LGR6-RNPEP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-RNPEP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-RNPEP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-RNPEP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LGR6-RNPEP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LGR6-RNPEP seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLGR6

GO:0030177

positive regulation of Wnt signaling pathway

22615920

HgeneLGR6

GO:0030335

positive regulation of cell migration

22615920


check buttonFusion gene breakpoints across LGR6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RNPEP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-23-1122-01ALGR6chr1

202163329

+RNPEPchr1

201965275

+
ChimerDB4OVTCGA-23-1122LGR6chr1

202163329

+RNPEPchr1

201965274

+
ChimerDB4STADTCGA-CD-8527-01ALGR6chr1

202163329

+RNPEPchr1

201958032

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367278LGR6chr1202163329+ENST00000295640RNPEPchr1201965275+1948301891516475
ENST00000367278LGR6chr1202163329+ENST00000295640RNPEPchr1201965274+1948301891516475

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367278ENST00000295640LGR6chr1202163329+RNPEPchr1201965275+0.0057294780.99427056
ENST00000367278ENST00000295640LGR6chr1202163329+RNPEPchr1201965274+0.0057294780.99427056

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44599_44599_1_LGR6-RNPEP_LGR6_chr1_202163329_ENST00000367278_RNPEP_chr1_201965274_ENST00000295640_length(amino acids)=475AA_BP=71
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLSRVWAEPCLIDAAKEEYNG
VIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQ
RRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEF
KFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQL
VYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKET

--------------------------------------------------------------

>44599_44599_2_LGR6-RNPEP_LGR6_chr1_202163329_ENST00000367278_RNPEP_chr1_201965275_ENST00000295640_length(amino acids)=475AA_BP=71
MPSPPGLRALWLCAALCASRRAGGAPQPGPGPTACPAPCHCQEDGIMLSADCSELGLSAVPGDLDPLTAYLSRVWAEPCLIDAAKEEYNG
VIEEFLATGEKLFGPYVWGRYDLLFMPPSFPFGGMENPCLTFVTPCLLAGDRSLADVIIHEISHSWFGNLVTNANWGEFWLNEGFTMYAQ
RRISTILFGAAYTCLEAATGRALLRQHMDITGEENPLNKLRVKIEPGVDPDDTYNETPYEKGFCFVSYLAHLVGDQDQFDSFLKAYVHEF
KFRSILADDFLDFYLEYFPELKKKRVDIIPGFEFDRWLNTPGWPPYLPDLSPGDSLMKPAEELAQLWAAEELDMKAIEAVAISPWKTYQL
VYFLDKILQKSPLPPGNVKKLGDTYPSISNARNAELRLRWGQIVLKNDHQEDFWKVKEFLHNQGKQKYTLPLYHAMMGGSEVAQTLAKET

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:202163329/chr1:201965275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LGR6

Q9HBX8

.
FUNCTION: Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a marker of multipotent stem cells in the epidermis. Upon binding to R-spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. May act as a tumor suppressor. {ECO:0000269|PubMed:21727895, ECO:0000269|PubMed:22615920}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+11826_6670.66666666666667968.0DomainNote=LRRNT
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+11826_6670.66666666666667968.0DomainNote=LRRNT
TgeneRNPEPchr1:202163329chr1:201965274ENST00000295640211298_302245.66666666666666651.0RegionSubstrate binding
TgeneRNPEPchr1:202163329chr1:201965275ENST00000295640211298_302245.66666666666666651.0RegionSubstrate binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118952_9550916.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118952_95570.66666666666667968.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116952_9550.0829.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118952_9550916.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118952_95570.66666666666667968.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116952_9550.0829.0Compositional biasNote=Poly-Gly
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+11826_660916.0DomainNote=LRRNT
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+11626_660.0829.0DomainNote=LRRNT
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+11826_660916.0DomainNote=LRRNT
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+11626_660.0829.0DomainNote=LRRNT
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118115_1360916.0RepeatNote=LRR 2
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118139_1600916.0RepeatNote=LRR 3
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118163_1860916.0RepeatNote=LRR 4
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118187_2080916.0RepeatNote=LRR 5
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118211_2320916.0RepeatNote=LRR 6
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118235_2560916.0RepeatNote=LRR 7
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118258_2790916.0RepeatNote=LRR 8
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118282_3030916.0RepeatNote=LRR 9
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118306_3280916.0RepeatNote=LRR 10
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118329_3500916.0RepeatNote=LRR 11
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118353_3740916.0RepeatNote=LRR 12
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118375_3960916.0RepeatNote=LRR 13
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118399_4200916.0RepeatNote=LRR 14
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118423_4430916.0RepeatNote=LRR 15
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+11891_1120916.0RepeatNote=LRR 1
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118115_13670.66666666666667968.0RepeatNote=LRR 2
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118139_16070.66666666666667968.0RepeatNote=LRR 3
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118163_18670.66666666666667968.0RepeatNote=LRR 4
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118187_20870.66666666666667968.0RepeatNote=LRR 5
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118211_23270.66666666666667968.0RepeatNote=LRR 6
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118235_25670.66666666666667968.0RepeatNote=LRR 7
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118258_27970.66666666666667968.0RepeatNote=LRR 8
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118282_30370.66666666666667968.0RepeatNote=LRR 9
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118306_32870.66666666666667968.0RepeatNote=LRR 10
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118329_35070.66666666666667968.0RepeatNote=LRR 11
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118353_37470.66666666666667968.0RepeatNote=LRR 12
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118375_39670.66666666666667968.0RepeatNote=LRR 13
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118399_42070.66666666666667968.0RepeatNote=LRR 14
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118423_44370.66666666666667968.0RepeatNote=LRR 15
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+11891_11270.66666666666667968.0RepeatNote=LRR 1
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116115_1360.0829.0RepeatNote=LRR 2
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116139_1600.0829.0RepeatNote=LRR 3
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116163_1860.0829.0RepeatNote=LRR 4
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116187_2080.0829.0RepeatNote=LRR 5
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116211_2320.0829.0RepeatNote=LRR 6
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116235_2560.0829.0RepeatNote=LRR 7
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116258_2790.0829.0RepeatNote=LRR 8
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116282_3030.0829.0RepeatNote=LRR 9
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116306_3280.0829.0RepeatNote=LRR 10
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116329_3500.0829.0RepeatNote=LRR 11
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116353_3740.0829.0RepeatNote=LRR 12
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116375_3960.0829.0RepeatNote=LRR 13
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116399_4200.0829.0RepeatNote=LRR 14
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116423_4430.0829.0RepeatNote=LRR 15
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+11691_1120.0829.0RepeatNote=LRR 1
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118115_1360916.0RepeatNote=LRR 2
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118139_1600916.0RepeatNote=LRR 3
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118163_1860916.0RepeatNote=LRR 4
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118187_2080916.0RepeatNote=LRR 5
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118211_2320916.0RepeatNote=LRR 6
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118235_2560916.0RepeatNote=LRR 7
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118258_2790916.0RepeatNote=LRR 8
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118282_3030916.0RepeatNote=LRR 9
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118306_3280916.0RepeatNote=LRR 10
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118329_3500916.0RepeatNote=LRR 11
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118353_3740916.0RepeatNote=LRR 12
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118375_3960916.0RepeatNote=LRR 13
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118399_4200916.0RepeatNote=LRR 14
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118423_4430916.0RepeatNote=LRR 15
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+11891_1120916.0RepeatNote=LRR 1
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118115_13670.66666666666667968.0RepeatNote=LRR 2
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118139_16070.66666666666667968.0RepeatNote=LRR 3
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118163_18670.66666666666667968.0RepeatNote=LRR 4
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118187_20870.66666666666667968.0RepeatNote=LRR 5
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118211_23270.66666666666667968.0RepeatNote=LRR 6
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118235_25670.66666666666667968.0RepeatNote=LRR 7
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118258_27970.66666666666667968.0RepeatNote=LRR 8
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118282_30370.66666666666667968.0RepeatNote=LRR 9
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118306_32870.66666666666667968.0RepeatNote=LRR 10
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118329_35070.66666666666667968.0RepeatNote=LRR 11
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118353_37470.66666666666667968.0RepeatNote=LRR 12
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118375_39670.66666666666667968.0RepeatNote=LRR 13
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118399_42070.66666666666667968.0RepeatNote=LRR 14
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118423_44370.66666666666667968.0RepeatNote=LRR 15
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+11891_11270.66666666666667968.0RepeatNote=LRR 1
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116115_1360.0829.0RepeatNote=LRR 2
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116139_1600.0829.0RepeatNote=LRR 3
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116163_1860.0829.0RepeatNote=LRR 4
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116187_2080.0829.0RepeatNote=LRR 5
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116211_2320.0829.0RepeatNote=LRR 6
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116235_2560.0829.0RepeatNote=LRR 7
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116258_2790.0829.0RepeatNote=LRR 8
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116282_3030.0829.0RepeatNote=LRR 9
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116306_3280.0829.0RepeatNote=LRR 10
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116329_3500.0829.0RepeatNote=LRR 11
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116353_3740.0829.0RepeatNote=LRR 12
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116375_3960.0829.0RepeatNote=LRR 13
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116399_4200.0829.0RepeatNote=LRR 14
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116423_4430.0829.0RepeatNote=LRR 15
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+11691_1120.0829.0RepeatNote=LRR 1
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+11825_5670916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118589_5980916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118620_6440916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118666_6870916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118709_7270916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118749_7740916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118796_8090916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118831_9670916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+11825_56770.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118589_59870.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118620_64470.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118666_68770.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118709_72770.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118749_77470.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118796_80970.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118831_96770.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+11625_5670.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116589_5980.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116620_6440.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116666_6870.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116709_7270.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116749_7740.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116796_8090.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116831_9670.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+11825_5670916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118589_5980916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118620_6440916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118666_6870916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118709_7270916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118749_7740916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118796_8090916.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118831_9670916.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+11825_56770.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118589_59870.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118620_64470.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118666_68770.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118709_72770.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118749_77470.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118796_80970.66666666666667968.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118831_96770.66666666666667968.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+11625_5670.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116589_5980.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116620_6440.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116666_6870.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116709_7270.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116749_7740.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116796_8090.0829.0Topological domainExtracellular
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116831_9670.0829.0Topological domainCytoplasmic
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118568_5880916.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118599_6190916.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118645_6650916.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118688_7080916.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118728_7480916.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118775_7950916.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202163329chr1:201965274ENST00000255432+118810_8300916.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118568_58870.66666666666667968.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118599_61970.66666666666667968.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118645_66570.66666666666667968.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118688_70870.66666666666667968.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118728_74870.66666666666667968.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118775_79570.66666666666667968.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202163329chr1:201965274ENST00000367278+118810_83070.66666666666667968.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116568_5880.0829.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116599_6190.0829.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116645_6650.0829.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116688_7080.0829.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116728_7480.0829.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116775_7950.0829.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202163329chr1:201965274ENST00000439764+116810_8300.0829.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118568_5880916.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118599_6190916.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118645_6650916.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118688_7080916.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118728_7480916.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118775_7950916.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202163329chr1:201965275ENST00000255432+118810_8300916.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118568_58870.66666666666667968.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118599_61970.66666666666667968.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118645_66570.66666666666667968.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118688_70870.66666666666667968.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118728_74870.66666666666667968.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118775_79570.66666666666667968.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202163329chr1:201965275ENST00000367278+118810_83070.66666666666667968.0TransmembraneHelical%3B Name%3D7
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116568_5880.0829.0TransmembraneHelical%3B Name%3D1
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116599_6190.0829.0TransmembraneHelical%3B Name%3D2
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116645_6650.0829.0TransmembraneHelical%3B Name%3D3
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116688_7080.0829.0TransmembraneHelical%3B Name%3D4
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116728_7480.0829.0TransmembraneHelical%3B Name%3D5
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116775_7950.0829.0TransmembraneHelical%3B Name%3D6
HgeneLGR6chr1:202163329chr1:201965275ENST00000439764+116810_8300.0829.0TransmembraneHelical%3B Name%3D7


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LGR6
RNPEP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LGR6-RNPEP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LGR6-RNPEP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource