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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LIMCH1-HOPX

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LIMCH1-HOPX
	FusionPDB ID: 44698
	FusionGDB2.0 ID: 44698
		Hgene	Tgene
	Gene symbol	LIMCH1	HOPX
	Gene ID	22998	84525
	Gene name	LIM and calponin homology domains 1	HOP homeobox
	Synonyms	LIMCH1A\|LMO7B	CAMEO\|HOD\|HOP\|LAGY\|NECC1\|OB1\|SMAP31\|TOTO
	Cytomap	4p13	4q12
	Type of gene	protein-coding	protein-coding
	Description	LIM and calponin homology domains-containing protein 1	homeodomain-only proteinlung cancer-associated Y proteinnot expressed in choriocarcinoma clone 1odd homeobox protein 1
	Modification date	20200313	20200313
	UniProtAcc	Q9UPQ0	Q9BPY8
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000313860, ENST00000508501, ENST00000512632, ENST00000512820, ENST00000512946, ENST00000509638, ENST00000513024, ENST00000381753, ENST00000396595, ENST00000503057, ENST00000509277, ENST00000509454, ENST00000511496, ENST00000514096, ENST00000515785,	ENST00000317745, ENST00000337881, ENST00000381255, ENST00000381260, ENST00000503639, ENST00000553379, ENST00000555760, ENST00000556376, ENST00000556614, ENST00000508121, ENST00000605395, ENST00000420433, ENST00000554144,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 12 X 9=1512	6 X 5 X 3=90
	# samples	19	7
	** MAII score	log2(19/1512*10)=-2.99238681589013 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LIMCH1 [Title/Abstract] AND HOPX [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LIMCH1(41362953)-HOPX(57522178), # samples:2
Anticipated loss of major functional domain due to fusion event.	LIMCH1-HOPX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIMCH1-HOPX seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIMCH1-HOPX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIMCH1-HOPX seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	HOPX	GO:0001829	trophectodermal cell differentiation	17576768
Tgene	HOPX	GO:0045596	negative regulation of cell differentiation	17576768
Tgene	HOPX	GO:0051131	chaperone-mediated protein complex assembly	10811660

Fusion gene breakpoints across LIMCH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HOPX (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-J4-A67T-01A	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-
ChimerDB4	PRAD	TCGA-J4-A67T	LIMCH1	chr4	41361820	+	HOPX	chr4	57522178	-
ChimerDB4	PRAD	TCGA-J4-A67T	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000508501	LIMCH1	chr4	41362953	+	ENST00000554144	HOPX	chr4	57522178	-	1247	152	32	448	138
ENST00000508501	LIMCH1	chr4	41362953	+	ENST00000420433	HOPX	chr4	57522178	-	1117	152	48	419	123
ENST00000512946	LIMCH1	chr4	41362953	+	ENST00000554144	HOPX	chr4	57522178	-	1247	152	32	448	138
ENST00000512946	LIMCH1	chr4	41362953	+	ENST00000420433	HOPX	chr4	57522178	-	1117	152	48	419	123
ENST00000313860	LIMCH1	chr4	41362953	+	ENST00000554144	HOPX	chr4	57522178	-	1245	150	30	446	138
ENST00000313860	LIMCH1	chr4	41362953	+	ENST00000420433	HOPX	chr4	57522178	-	1115	150	46	417	123
ENST00000512632	LIMCH1	chr4	41362953	+	ENST00000554144	HOPX	chr4	57522178	-	1225	130	10	426	138
ENST00000512632	LIMCH1	chr4	41362953	+	ENST00000420433	HOPX	chr4	57522178	-	1095	130	26	397	123
ENST00000512820	LIMCH1	chr4	41362953	+	ENST00000554144	HOPX	chr4	57522178	-	1217	122	2	418	138
ENST00000512820	LIMCH1	chr4	41362953	+	ENST00000420433	HOPX	chr4	57522178	-	1087	122	18	389	123

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000508501	ENST00000554144	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.008130836	0.9918691
ENST00000508501	ENST00000420433	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.04365949	0.95634055
ENST00000512946	ENST00000554144	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.008130836	0.9918691
ENST00000512946	ENST00000420433	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.04365949	0.95634055
ENST00000313860	ENST00000554144	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.008190354	0.99180967
ENST00000313860	ENST00000420433	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.05403154	0.94596845
ENST00000512632	ENST00000554144	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.014017018	0.98598295
ENST00000512632	ENST00000420433	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.058404107	0.94159585
ENST00000512820	ENST00000554144	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.010899064	0.989101
ENST00000512820	ENST00000420433	LIMCH1	chr4	41362953	+	HOPX	chr4	57522178	-	0.056942027	0.94305795

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44698_44698_1_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000313860_HOPX_chr4_57522178_ENST00000420433_length(amino acids)=123AA_BP=14
MRKWLVPLSVWKLFSPCSPSRPPSPPSPRRRSGLSAQGPCRRRPRAAPQRTRWKSWSTTSTRSTSTRIPPRCASSRPRQAFPRRRPRNGL

--------------------------------------------------------------

>44698_44698_2_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000313860_HOPX_chr4_57522178_ENST00000554144_length(amino acids)=138AA_BP=40
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIERAGTMSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEE

--------------------------------------------------------------

>44698_44698_3_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000508501_HOPX_chr4_57522178_ENST00000420433_length(amino acids)=123AA_BP=14
MRKWLVPLSVWKLFSPCSPSRPPSPPSPRRRSGLSAQGPCRRRPRAAPQRTRWKSWSTTSTRSTSTRIPPRCASSRPRQAFPRRRPRNGL

--------------------------------------------------------------

>44698_44698_4_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000508501_HOPX_chr4_57522178_ENST00000554144_length(amino acids)=138AA_BP=40
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIERAGTMSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEE

--------------------------------------------------------------

>44698_44698_5_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000512632_HOPX_chr4_57522178_ENST00000420433_length(amino acids)=123AA_BP=14
MRKWLVPLSVWKLFSPCSPSRPPSPPSPRRRSGLSAQGPCRRRPRAAPQRTRWKSWSTTSTRSTSTRIPPRCASSRPRQAFPRRRPRNGL

--------------------------------------------------------------

>44698_44698_6_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000512632_HOPX_chr4_57522178_ENST00000554144_length(amino acids)=138AA_BP=40
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIERAGTMSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEE

--------------------------------------------------------------

>44698_44698_7_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000512820_HOPX_chr4_57522178_ENST00000420433_length(amino acids)=123AA_BP=14
MRKWLVPLSVWKLFSPCSPSRPPSPPSPRRRSGLSAQGPCRRRPRAAPQRTRWKSWSTTSTRSTSTRIPPRCASSRPRQAFPRRRPRNGL

--------------------------------------------------------------

>44698_44698_8_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000512820_HOPX_chr4_57522178_ENST00000554144_length(amino acids)=138AA_BP=40
LRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIERAGTMSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEE

--------------------------------------------------------------

>44698_44698_9_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000512946_HOPX_chr4_57522178_ENST00000420433_length(amino acids)=123AA_BP=14
MRKWLVPLSVWKLFSPCSPSRPPSPPSPRRRSGLSAQGPCRRRPRAAPQRTRWKSWSTTSTRSTSTRIPPRCASSRPRQAFPRRRPRNGL

--------------------------------------------------------------

>44698_44698_10_LIMCH1-HOPX_LIMCH1_chr4_41362953_ENST00000512946_HOPX_chr4_57522178_ENST00000554144_length(amino acids)=138AA_BP=40
MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIERAGTMSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:41362953/chr4:57522178)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIMCH1 Q9UPQ0	HOPX Q9BPY8
FUNCTION: Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration. {ECO:0000269\|PubMed:28228547}.	FUNCTION: Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. Acts as a co-chaperone for HSPA1A and HSPA1B chaperone proteins and assists in chaperone-mediated protein refolding (PubMed:27708256). {ECO:0000250\|UniProtKB:Q8R1H0, ECO:0000269\|PubMed:27708256}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000317745

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000337881

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000381255

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000381260

3_62

95.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000503639

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000553379

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000555760

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000556376

3_62

74.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000556614

3_62

74.0

DNA binding

Homeobox%3B atypical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000313860

354_439

32.0

1084.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000313860

782_823

32.0

1084.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000381753

354_439

891.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000381753

782_823

891.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000396595

354_439

903.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000396595

782_823

903.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000508501

354_439

32.0

1057.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000508501

782_823

32.0

1057.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000511496

354_439

898.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000511496

782_823

898.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512820

354_439

32.0

1070.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512820

782_823

32.0

1070.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512946

354_439

32.0

1058.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512946

782_823

32.0

1058.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000513024

354_439

911.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000513024

782_823

911.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000313860

1011_1077

32.0

1084.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000313860

21_125

32.0

1084.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000381753

1011_1077

891.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000381753

21_125

891.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000396595

1011_1077

903.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000396595

21_125

903.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000508501

1011_1077

32.0

1057.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000508501

21_125

32.0

1057.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000511496

1011_1077

898.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000511496

21_125

898.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512820

1011_1077

32.0

1070.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512820

21_125

32.0

1070.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512946

1011_1077

32.0

1058.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000512946

21_125

32.0

1058.0

Domain

Calponin-homology (CH)

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000513024

1011_1077

911.0

Domain

LIM zinc-binding

Hgene

LIMCH1

chr4:41362953

chr4:57522178

ENST00000513024

21_125

911.0

Domain

Calponin-homology (CH)

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000420433

3_62

14.0

92.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000508121

3_62

14.0

92.0

DNA binding

Homeobox%3B atypical

Tgene

HOPX

chr4:41362953

chr4:57522178

ENST00000554144

3_62

14.0

113.0

DNA binding

Homeobox%3B atypical

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>93_LIMCH1_41362953_HOPX_57522178_ranked_0.pdb	LIMCH1	41362953	41362953	ENST00000420433	HOPX	chr4	57522178	-	MRGRGAAQMACPALGLEALQPLQPEPPPEPAFSEAQKWIERAGTMSAETASGPTEDQVEILEYNFNKVDKHPDSTTLCLIAAEAGLSEEE	138

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

LIMCH1_pLDDT.png

HOPX_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LIMCH1
HOPX

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to LIMCH1-HOPX

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LIMCH1-HOPX

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source