| UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
|
|||||||
|
Fusion Protein:LIMD1-DSP |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: LIMD1-DSP | FusionPDB ID: 44707 | FusionGDB2.0 ID: 44707 | Hgene | Tgene | Gene symbol | LIMD1 | DSP | Gene ID | 8994 | 1834 |
| Gene name | LIM domains containing 1 | dentin sialophosphoprotein | |
| Synonyms | - | DFNA39|DGI1|DMP3|DPP|DSP | |
| Cytomap | 3p21.31 | 4q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | LIM domain-containing protein 1 | dentin sialophosphoproteindeafness, autosomal dominant 39dentin phosphophoryndentin phosphoproteindentin phosphoryndentin sialoprotein | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9UGP4 | P15924 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000273317, ENST00000440097, ENST00000465039, | ENST00000379802, ENST00000418664, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 3 X 4 X 4=48 | 22 X 19 X 10=4180 |
| # samples | 5 | 26 | |
| ** MAII score | log2(5/48*10)=0.0588936890535686 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(26/4180*10)=-4.00691941393979 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: LIMD1 [Title/Abstract] AND DSP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LIMD1(45718426)-DSP(7579755), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | LIMD1-DSP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIMD1-DSP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIMD1-DSP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIMD1-DSP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LIMD1 | GO:0001666 | response to hypoxia | 22286099 |
| Hgene | LIMD1 | GO:0016310 | phosphorylation | 18439753 |
| Hgene | LIMD1 | GO:0035331 | negative regulation of hippo signaling | 20303269 |
| Hgene | LIMD1 | GO:0045892 | negative regulation of transcription, DNA-templated | 15542589 |
| Fusion gene breakpoints across LIMD1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
| Fusion gene breakpoints across DSP (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
 |
Top |
Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS5.0 | N/A | BF871822 | LIMD1 | chr3 | 45718426 | - | DSP | chr6 | 7579755 | - |
Top |
Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000273317 | LIMD1 | chr3 | 45718426 | - | ENST00000379802 | DSP | chr6 | 7579755 | - | 17441 | 11318 | 11325 | 16601 | 1758 |
| ENST00000273317 | LIMD1 | chr3 | 45718426 | - | ENST00000418664 | DSP | chr6 | 7579755 | - | 15499 | 11318 | 11325 | 14804 | 1159 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000273317 | ENST00000379802 | LIMD1 | chr3 | 45718426 | - | DSP | chr6 | 7579755 | - | 0.44201282 | 0.5579872 |
| ENST00000273317 | ENST00000418664 | LIMD1 | chr3 | 45718426 | - | DSP | chr6 | 7579755 | - | 0.80758977 | 0.19241026 |
Top |
Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >44707_44707_1_LIMD1-DSP_LIMD1_chr3_45718426_ENST00000273317_DSP_chr6_7579755_ENST00000379802_length(amino acids)=1758AA_BP= MTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEM SNLRNKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQRRRAEENALQQKACGSEIMQKKQHLEI ELKQVMQQRSEDNARHKQSLEEAAKTIQDKNKEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQ KEEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRKQQLEVELRQVTQMRTEESVRYKQSLDDAA KTIQDKNKEIERLKQLIDKETNDRKCLEDENARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSL KELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKRSEDDLRQQRDVLDGHLREKQRTQEE LRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQKAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEADS DKNATILELRSQLQISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASNRIQESKNQCTQVVQERESLLVKIKVLEQDKARLQRLE DELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKRIEERCRRKLEDSTRE TQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYECQLIDKTTLDKLLKGKKSVEEVASEIQPFLR GAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSAIARDLIDFDDRQQIYAAEKAITGFDDPFSGK TVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSLNDPRDSQKNFVDPVTKKKVSYVQLKERCRIE PHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKDFLQGSSCIAGIYNETTKQKLGIYEAMKIGLV RPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDPETGNIISLFQAMNKELIEKGHGIRLLEAQIA TGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKERCIKDEETGLCLLPLKEKKKQVQTSQKNTLRK RRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDRKTGSQYDIQDAIDKGLVDRKFFDQYRSGSLS LTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDTLEESSPIAAIFDTENLEKISITEGIERGIVD SITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVKGKKKMSAAEAVKEKWLPYEAGQRFLEFQYLT GGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRSMVEDITGLRLLEAASVSSKGLPSPYNMSSAP -------------------------------------------------------------- >44707_44707_2_LIMD1-DSP_LIMD1_chr3_45718426_ENST00000273317_DSP_chr6_7579755_ENST00000418664_length(amino acids)=1159AA_BP= MTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKASNRIQESK NQCTQVVQERESLLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRLECEKQQIQNDLNQWKTQYSRKEEAIRKIESEREKSEREK NSLRSEIERLQAEIKRIEERCRRKLEDSTRETQSQLETERSRYQREIDKLRQRPYGSHRETQTECEWTVDTSKLVFDGLRKKVTAMQLYE CQLIDKTTLDKLLKGKKSVEEVASEIQPFLRGAGSIAGASASPKEKYSLVEAKRKKLISPESTVMLLEAQAATGGIIDPHRNEKLTVDSA IARDLIDFDDRQQIYAAEKAITGFDDPFSGKTVSVSEAIKKNLIDRETGMRLLEAQIASGGVVDPVNSVFLPKDVALARGLIDRDLYRSL NDPRDSQKNFVDPVTKKKVSYVQLKERCRIEPHTGLLLLSVQKRSMSFQGIRQPVTVTELVDSGILRPSTVNELESGQISYDEVGERIKD FLQGSSCIAGIYNETTKQKLGIYEAMKIGLVRPGTALELLEAQAATGFIVDPVSNLRLPVEEAYKRGLVGIEFKEKLLSAERAVTGYNDP ETGNIISLFQAMNKELIEKGHGIRLLEAQIATGGIIDPKESHRLPVDIAYKRGYFNEELSEILSDPSDDTKGFFDPNTEENLTYLQLKER CIKDEETGLCLLPLKEKKKQVQTSQKNTLRKRRVVIVDPETNKEMSVQEAYKKGLIDYETFKELCEQECEWEEITITGSDGSTRVVLVDR KTGSQYDIQDAIDKGLVDRKFFDQYRSGSLSLTQFADMISLKNGVGTSSSMGSGVSDDVFSSSRHESVSKISTISSVRNLTIRSSSFSDT LEESSPIAAIFDTENLEKISITEGIERGIVDSITGQRLLEAQACTGGIIHPTTGQKLSLQDAVSQGVIDQDMATRLKPAQKAFIGFEGVK GKKKMSAAEAVKEKWLPYEAGQRFLEFQYLTGGLVDPEVHGRISTEEAIRKGFIDGRAAQRLQDTSSYAKILTCPKTKLKISYKDAINRS -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:45718426/chr6:7579755) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LIMD1 | DSP |
| FUNCTION: Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing and is essential for P-body formation and integrity. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. Acts as a transcriptional corepressor for SNAI1- and SNAI2/SLUG-dependent repression of E-cadherin transcription. Negatively regulates the Hippo signaling pathway and antagonizes phosphorylation of YAP1. Inhibits E2F-mediated transcription, and suppresses the expression of the majority of genes with E2F1-responsive elements. Regulates osteoblast development, function, differentiation and stress osteoclastogenesis. Enhances the ability of TRAF6 to activate adapter protein complex 1 (AP-1) and negatively regulates the canonical Wnt receptor signaling pathway in osteoblasts. May act as a tumor suppressor by inhibiting cell proliferation. {ECO:0000269|PubMed:15542589, ECO:0000269|PubMed:20303269, ECO:0000269|PubMed:20616046, ECO:0000269|PubMed:21834987, ECO:0000269|PubMed:22286099}. | FUNCTION: Major high molecular weight protein of desmosomes. Involved in the organization of the desmosomal cadherin-plakoglobin complexes into discrete plasma membrane domains and in the anchoring of intermediate filaments to the desmosomes. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 1018_1945 | 0 | 2872.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 1018_1945 | 0 | 2273.0 | Coiled coil | Ontology_term=ECO:0000255 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 458_515 | 0 | 2872.0 | Domain | SH3 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 458_515 | 0 | 2273.0 | Domain | SH3 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 1057_1945 | 0 | 2872.0 | Region | Note=Central fibrous rod domain | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 1946_2871 | 0 | 2872.0 | Region | Note=Globular 2 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 1960_2208 | 0 | 2872.0 | Region | Note=4.5 X 38 AA tandem repeats (Domain A) | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 1_1056 | 0 | 2872.0 | Region | Note=Globular 1 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2244_2446 | 0 | 2872.0 | Region | Note=4.5 X 38 AA tandem repeats (Domain B) | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2609_2822 | 0 | 2872.0 | Region | Note=4.5 X 38 AA tandem repeats (Domain C) | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2824_2847 | 0 | 2872.0 | Region | Note=6 X 4 AA tandem repeats of G-S-R-[SR] | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 1057_1945 | 0 | 2273.0 | Region | Note=Central fibrous rod domain | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 1946_2871 | 0 | 2273.0 | Region | Note=Globular 2 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 1960_2208 | 0 | 2273.0 | Region | Note=4.5 X 38 AA tandem repeats (Domain A) | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 1_1056 | 0 | 2273.0 | Region | Note=Globular 1 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2244_2446 | 0 | 2273.0 | Region | Note=4.5 X 38 AA tandem repeats (Domain B) | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2609_2822 | 0 | 2273.0 | Region | Note=4.5 X 38 AA tandem repeats (Domain C) | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2824_2847 | 0 | 2273.0 | Region | Note=6 X 4 AA tandem repeats of G-S-R-[SR] | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 178_271 | 0 | 2872.0 | Repeat | Note=Spectrin 1 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2009_2045 | 0 | 2872.0 | Repeat | Note=Plectin 1 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2046_2083 | 0 | 2872.0 | Repeat | Note=Plectin 2 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2084_2121 | 0 | 2872.0 | Repeat | Note=Plectin 3 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2122_2159 | 0 | 2872.0 | Repeat | Note=Plectin 4 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2163_2197 | 0 | 2872.0 | Repeat | Note=Plectin 5 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2198_2233 | 0 | 2872.0 | Repeat | Note=Plectin 6 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2251_2288 | 0 | 2872.0 | Repeat | Note=Plectin 7 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2289_2326 | 0 | 2872.0 | Repeat | Note=Plectin 8 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2327_2364 | 0 | 2872.0 | Repeat | Note=Plectin 9 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2365_2402 | 0 | 2872.0 | Repeat | Note=Plectin 10 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2406_2440 | 0 | 2872.0 | Repeat | Note=Plectin 11 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2456_2493 | 0 | 2872.0 | Repeat | Note=Plectin 12 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2507_2544 | 0 | 2872.0 | Repeat | Note=Plectin 13 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2610_2647 | 0 | 2872.0 | Repeat | Note=Plectin 14 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2648_2685 | 0 | 2872.0 | Repeat | Note=Plectin 15 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2724_2761 | 0 | 2872.0 | Repeat | Note=Plectin 16 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 272_375 | 0 | 2872.0 | Repeat | Note=Spectrin 2 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 2762_2799 | 0 | 2872.0 | Repeat | Note=Plectin 17 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 376_446 | 0 | 2872.0 | Repeat | Note=Spectrin 3a | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 516_545 | 0 | 2872.0 | Repeat | Note=Spectrin 3b | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 546_627 | 0 | 2872.0 | Repeat | Note=Spectrin 4 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 654_769 | 0 | 2872.0 | Repeat | Note=Spectrin 5 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000379802 | 0 | 24 | 770_883 | 0 | 2872.0 | Repeat | Note=Spectrin 6 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 178_271 | 0 | 2273.0 | Repeat | Note=Spectrin 1 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2009_2045 | 0 | 2273.0 | Repeat | Note=Plectin 1 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2046_2083 | 0 | 2273.0 | Repeat | Note=Plectin 2 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2084_2121 | 0 | 2273.0 | Repeat | Note=Plectin 3 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2122_2159 | 0 | 2273.0 | Repeat | Note=Plectin 4 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2163_2197 | 0 | 2273.0 | Repeat | Note=Plectin 5 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2198_2233 | 0 | 2273.0 | Repeat | Note=Plectin 6 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2251_2288 | 0 | 2273.0 | Repeat | Note=Plectin 7 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2289_2326 | 0 | 2273.0 | Repeat | Note=Plectin 8 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2327_2364 | 0 | 2273.0 | Repeat | Note=Plectin 9 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2365_2402 | 0 | 2273.0 | Repeat | Note=Plectin 10 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2406_2440 | 0 | 2273.0 | Repeat | Note=Plectin 11 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2456_2493 | 0 | 2273.0 | Repeat | Note=Plectin 12 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2507_2544 | 0 | 2273.0 | Repeat | Note=Plectin 13 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2610_2647 | 0 | 2273.0 | Repeat | Note=Plectin 14 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2648_2685 | 0 | 2273.0 | Repeat | Note=Plectin 15 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2724_2761 | 0 | 2273.0 | Repeat | Note=Plectin 16 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 272_375 | 0 | 2273.0 | Repeat | Note=Spectrin 2 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 2762_2799 | 0 | 2273.0 | Repeat | Note=Plectin 17 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 376_446 | 0 | 2273.0 | Repeat | Note=Spectrin 3a | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 516_545 | 0 | 2273.0 | Repeat | Note=Spectrin 3b | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 546_627 | 0 | 2273.0 | Repeat | Note=Spectrin 4 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 654_769 | 0 | 2273.0 | Repeat | Note=Spectrin 5 | |
| Tgene | DSP | chr3:45718426 | chr6:7579755 | ENST00000418664 | 0 | 24 | 770_883 | 0 | 2273.0 | Repeat | Note=Spectrin 6 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 470_531 | 0 | 677.0 | Domain | LIM zinc-binding 1 |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 535_595 | 0 | 677.0 | Domain | LIM zinc-binding 2 |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 595_664 | 0 | 677.0 | Domain | LIM zinc-binding 3 |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 472_676 | 0 | 677.0 | Region | Note=Necessary for nuclear localization |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 54_134 | 0 | 677.0 | Region | Note=Mediates nuclear export |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| LIMD1 | |
| DSP |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 186_260 | 0 | 677.0 | EGLN1/PHD2 |
| Hgene | LIMD1 | chr3:45718426 | chr6:7579755 | ENST00000273317 | - | 1 | 8 | 404_442 | 0 | 677.0 | RB1 |
Top |
Related Drugs to LIMD1-DSP |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to LIMD1-DSP |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2021-Present -The University of Texas Health Science Center at Houston (UTHealth)
Web File Viewing | Emergency Information |Campus Carry|Site Policies