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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LIMK2-CDC45

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LIMK2-CDC45
FusionPDB ID: 44720
FusionGDB2.0 ID: 44720
HgeneTgene
Gene symbol

LIMK2

CDC45

Gene ID

3985

8318

Gene nameLIM domain kinase 2cell division cycle 45
Synonyms-CDC45L|CDC45L2|MGORS7|PORC-PI-1
Cytomap

22q12.2

22q11.21

Type of geneprotein-codingprotein-coding
DescriptionLIM domain kinase 2cell division control protein 45 homologCDC45 cell division cycle 45 homologCDC45 cell division cycle 45-likeCDC45-related proteincell division cycle 45 homologcell division cycle 45-like 2human CDC45
Modification date2020031320200313
UniProtAcc

P53671

O75419

Ensembl transtripts involved in fusion geneENST idsENST00000331728, ENST00000333611, 
ENST00000340552, ENST00000406516, 
ENST00000444929, ENST00000467301, 
ENST00000404724, ENST00000483431, 
ENST00000263201, ENST00000407835, 
ENST00000437685, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 7 X 7=5393 X 4 X 3=36
# samples 135
** MAII scorelog2(13/539*10)=-2.05177364972405
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/36*10)=0.473931188332412
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LIMK2 [Title/Abstract] AND CDC45 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LIMK2(31664186)-CDC45(19504050), # samples:3
Anticipated loss of major functional domain due to fusion event.LIMK2-CDC45 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIMK2-CDC45 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LIMK2-CDC45 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LIMK2-CDC45 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLIMK2

GO:0006468

protein phosphorylation

22328514

HgeneLIMK2

GO:0030953

astral microtubule organization

22328514


check buttonFusion gene breakpoints across LIMK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDC45 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-DK-A3IN-01ALIMK2chr22

31664186

-CDC45chr22

19504050

+
ChimerDB4BLCATCGA-DK-A3IN-01ALIMK2chr22

31664186

+CDC45chr22

19504050

+
ChimerDB4BLCATCGA-DK-A3INLIMK2chr22

31664186

+CDC45chr22

19504049

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000406516LIMK2chr2231664186+ENST00000407835CDC45chr2219504050+17461352771612511
ENST00000406516LIMK2chr2231664186+ENST00000437685CDC45chr2219504050+17451352771612511
ENST00000406516LIMK2chr2231664186+ENST00000263201CDC45chr2219504050+17451352771612511
ENST00000444929LIMK2chr2231664186+ENST00000407835CDC45chr2219504050+110370982969295
ENST00000444929LIMK2chr2231664186+ENST00000437685CDC45chr2219504050+110270982969295
ENST00000444929LIMK2chr2231664186+ENST00000263201CDC45chr2219504050+110270982969295
ENST00000331728LIMK2chr2231664186+ENST00000407835CDC45chr2219504050+18251431661691541
ENST00000331728LIMK2chr2231664186+ENST00000437685CDC45chr2219504050+18241431661691541
ENST00000331728LIMK2chr2231664186+ENST00000263201CDC45chr2219504050+18241431661691541
ENST00000333611LIMK2chr2231664186+ENST00000407835CDC45chr2219504050+196315691411829562
ENST00000333611LIMK2chr2231664186+ENST00000437685CDC45chr2219504050+196215691411829562
ENST00000333611LIMK2chr2231664186+ENST00000263201CDC45chr2219504050+196215691411829562
ENST00000340552LIMK2chr2231664186+ENST00000407835CDC45chr2219504050+18781484561744562
ENST00000340552LIMK2chr2231664186+ENST00000437685CDC45chr2219504050+18771484561744562
ENST00000340552LIMK2chr2231664186+ENST00000263201CDC45chr2219504050+18771484561744562
ENST00000406516LIMK2chr2231664186+ENST00000407835CDC45chr2219504049+17461352771612511
ENST00000406516LIMK2chr2231664186+ENST00000437685CDC45chr2219504049+17451352771612511
ENST00000406516LIMK2chr2231664186+ENST00000263201CDC45chr2219504049+17451352771612511
ENST00000444929LIMK2chr2231664186+ENST00000407835CDC45chr2219504049+110370982969295
ENST00000444929LIMK2chr2231664186+ENST00000437685CDC45chr2219504049+110270982969295
ENST00000444929LIMK2chr2231664186+ENST00000263201CDC45chr2219504049+110270982969295
ENST00000331728LIMK2chr2231664186+ENST00000407835CDC45chr2219504049+18251431661691541
ENST00000331728LIMK2chr2231664186+ENST00000437685CDC45chr2219504049+18241431661691541
ENST00000331728LIMK2chr2231664186+ENST00000263201CDC45chr2219504049+18241431661691541
ENST00000333611LIMK2chr2231664186+ENST00000407835CDC45chr2219504049+196315691411829562
ENST00000333611LIMK2chr2231664186+ENST00000437685CDC45chr2219504049+196215691411829562
ENST00000333611LIMK2chr2231664186+ENST00000263201CDC45chr2219504049+196215691411829562
ENST00000340552LIMK2chr2231664186+ENST00000407835CDC45chr2219504049+18781484561744562
ENST00000340552LIMK2chr2231664186+ENST00000437685CDC45chr2219504049+18771484561744562
ENST00000340552LIMK2chr2231664186+ENST00000263201CDC45chr2219504049+18771484561744562

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000406516ENST00000407835LIMK2chr2231664186+CDC45chr2219504050+0.0101634810.9898365
ENST00000406516ENST00000437685LIMK2chr2231664186+CDC45chr2219504050+0.0103579360.9896421
ENST00000406516ENST00000263201LIMK2chr2231664186+CDC45chr2219504050+0.0103579360.9896421
ENST00000444929ENST00000407835LIMK2chr2231664186+CDC45chr2219504050+0.029879630.97012043
ENST00000444929ENST00000437685LIMK2chr2231664186+CDC45chr2219504050+0.0304418450.9695581
ENST00000444929ENST00000263201LIMK2chr2231664186+CDC45chr2219504050+0.0304418450.9695581
ENST00000331728ENST00000407835LIMK2chr2231664186+CDC45chr2219504050+0.0103591050.9896409
ENST00000331728ENST00000437685LIMK2chr2231664186+CDC45chr2219504050+0.0105710820.98942894
ENST00000331728ENST00000263201LIMK2chr2231664186+CDC45chr2219504050+0.0105710820.98942894
ENST00000333611ENST00000407835LIMK2chr2231664186+CDC45chr2219504050+0.013666860.9863332
ENST00000333611ENST00000437685LIMK2chr2231664186+CDC45chr2219504050+0.0139072510.98609275
ENST00000333611ENST00000263201LIMK2chr2231664186+CDC45chr2219504050+0.0139072510.98609275
ENST00000340552ENST00000407835LIMK2chr2231664186+CDC45chr2219504050+0.0137790790.98622096
ENST00000340552ENST00000437685LIMK2chr2231664186+CDC45chr2219504050+0.0140221990.98597777
ENST00000340552ENST00000263201LIMK2chr2231664186+CDC45chr2219504050+0.0140221990.98597777
ENST00000406516ENST00000407835LIMK2chr2231664186+CDC45chr2219504049+0.0101634810.9898365
ENST00000406516ENST00000437685LIMK2chr2231664186+CDC45chr2219504049+0.0103579360.9896421
ENST00000406516ENST00000263201LIMK2chr2231664186+CDC45chr2219504049+0.0103579360.9896421
ENST00000444929ENST00000407835LIMK2chr2231664186+CDC45chr2219504049+0.029879630.97012043
ENST00000444929ENST00000437685LIMK2chr2231664186+CDC45chr2219504049+0.0304418450.9695581
ENST00000444929ENST00000263201LIMK2chr2231664186+CDC45chr2219504049+0.0304418450.9695581
ENST00000331728ENST00000407835LIMK2chr2231664186+CDC45chr2219504049+0.0103591050.9896409
ENST00000331728ENST00000437685LIMK2chr2231664186+CDC45chr2219504049+0.0105710820.98942894
ENST00000331728ENST00000263201LIMK2chr2231664186+CDC45chr2219504049+0.0105710820.98942894
ENST00000333611ENST00000407835LIMK2chr2231664186+CDC45chr2219504049+0.013666860.9863332
ENST00000333611ENST00000437685LIMK2chr2231664186+CDC45chr2219504049+0.0139072510.98609275
ENST00000333611ENST00000263201LIMK2chr2231664186+CDC45chr2219504049+0.0139072510.98609275
ENST00000340552ENST00000407835LIMK2chr2231664186+CDC45chr2219504049+0.0137790790.98622096
ENST00000340552ENST00000437685LIMK2chr2231664186+CDC45chr2219504049+0.0140221990.98597777
ENST00000340552ENST00000263201LIMK2chr2231664186+CDC45chr2219504049+0.0140221990.98597777

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>44720_44720_1_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000331728_CDC45_chr22_19504049_ENST00000263201_length(amino acids)=541AA_BP=455
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRG
FSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLA
PHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQ
AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG
IASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLL

--------------------------------------------------------------

>44720_44720_2_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000331728_CDC45_chr22_19504049_ENST00000407835_length(amino acids)=541AA_BP=455
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRG
FSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLA
PHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQ
AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG
IASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLL

--------------------------------------------------------------

>44720_44720_3_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000331728_CDC45_chr22_19504049_ENST00000437685_length(amino acids)=541AA_BP=455
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRG
FSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLA
PHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQ
AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG
IASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLL

--------------------------------------------------------------

>44720_44720_4_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000331728_CDC45_chr22_19504050_ENST00000263201_length(amino acids)=541AA_BP=455
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRG
FSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLA
PHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQ
AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG
IASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLL

--------------------------------------------------------------

>44720_44720_5_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000331728_CDC45_chr22_19504050_ENST00000407835_length(amino acids)=541AA_BP=455
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRG
FSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLA
PHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQ
AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG
IASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLL

--------------------------------------------------------------

>44720_44720_6_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000331728_CDC45_chr22_19504050_ENST00000437685_length(amino acids)=541AA_BP=455
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHG
CSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRG
FSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLA
PHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQ
AIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKG
IASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDLSVIELKAEDRSKFLDALISLL

--------------------------------------------------------------

>44720_44720_7_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000333611_CDC45_chr22_19504049_ENST00000263201_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_8_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000333611_CDC45_chr22_19504049_ENST00000407835_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_9_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000333611_CDC45_chr22_19504049_ENST00000437685_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_10_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000333611_CDC45_chr22_19504050_ENST00000263201_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_11_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000333611_CDC45_chr22_19504050_ENST00000407835_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_12_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000333611_CDC45_chr22_19504050_ENST00000437685_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_13_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000340552_CDC45_chr22_19504049_ENST00000263201_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_14_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000340552_CDC45_chr22_19504049_ENST00000407835_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_15_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000340552_CDC45_chr22_19504049_ENST00000437685_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_16_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000340552_CDC45_chr22_19504050_ENST00000263201_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_17_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000340552_CDC45_chr22_19504050_ENST00000407835_length(amino acids)=562AA_BP=476
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_18_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000340552_CDC45_chr22_19504050_ENST00000437685_length(amino acids)=562AA_BP=
MESSGSRSCSGGRGELRAACLQPEVPGAPGLSWWPSTAGLRQSQTDLQLSLSIWCGKKMGSYLSVPAYFTSRDLFRCSECQDSLTNWYYE
KDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVIIEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQ
EQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNNRNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQL
LIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSLRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQ
QIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTL
KDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNHFDL

--------------------------------------------------------------

>44720_44720_19_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000406516_CDC45_chr22_19504049_ENST00000263201_length(amino acids)=511AA_BP=425
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVI
IEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNN
RNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSL
RRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFL
TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVT

--------------------------------------------------------------

>44720_44720_20_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000406516_CDC45_chr22_19504049_ENST00000407835_length(amino acids)=511AA_BP=425
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVI
IEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNN
RNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSL
RRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFL
TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVT

--------------------------------------------------------------

>44720_44720_21_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000406516_CDC45_chr22_19504049_ENST00000437685_length(amino acids)=511AA_BP=425
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVI
IEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNN
RNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSL
RRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFL
TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVT

--------------------------------------------------------------

>44720_44720_22_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000406516_CDC45_chr22_19504050_ENST00000263201_length(amino acids)=511AA_BP=425
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVI
IEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNN
RNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSL
RRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFL
TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVT

--------------------------------------------------------------

>44720_44720_23_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000406516_CDC45_chr22_19504050_ENST00000407835_length(amino acids)=511AA_BP=425
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVI
IEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNN
RNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSL
RRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFL
TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVT

--------------------------------------------------------------

>44720_44720_24_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000406516_CDC45_chr22_19504050_ENST00000437685_length(amino acids)=511AA_BP=425
MRGAAVSPASSSPFPRSRDHVRAGGCSECQDSLTNWYYEKDGKLYCPKDYWGKFGEFCHGCSLLMTGPFMVAGEFKYHPECFACMSCKVI
IEDGDAYALVQHATLYCGKCHNEVVLAPMFERLSTESVQEQLPYSVTLISMPATTEGRRGFSVSVESACSNYATTVQVKEVNRMHISPNN
RNAIHPGDRILEINGTPVRTLRVEEVEDAISQTSQTLQLLIEHDPVSQRLDQLRLEARLAPHMQNAGHPHALSTLDTKENLEGTLRRRSL
RRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSSYSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFL
TEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEGGTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVT

--------------------------------------------------------------

>44720_44720_25_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000444929_CDC45_chr22_19504049_ENST00000263201_length(amino acids)=295AA_BP=209
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS
YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG
GTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNH

--------------------------------------------------------------

>44720_44720_26_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000444929_CDC45_chr22_19504049_ENST00000407835_length(amino acids)=295AA_BP=209
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS
YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG
GTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNH

--------------------------------------------------------------

>44720_44720_27_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000444929_CDC45_chr22_19504049_ENST00000437685_length(amino acids)=295AA_BP=209
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS
YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG
GTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNH

--------------------------------------------------------------

>44720_44720_28_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000444929_CDC45_chr22_19504050_ENST00000263201_length(amino acids)=295AA_BP=209
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS
YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG
GTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNH

--------------------------------------------------------------

>44720_44720_29_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000444929_CDC45_chr22_19504050_ENST00000407835_length(amino acids)=295AA_BP=209
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS
YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG
GTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNH

--------------------------------------------------------------

>44720_44720_30_LIMK2-CDC45_LIMK2_chr22_31664186_ENST00000444929_CDC45_chr22_19504050_ENST00000437685_length(amino acids)=295AA_BP=209
MLCPPPPPPHFRAPGTMSALAGEDVWRCPGCGDHIAPSQIWYRTVNETWHGSCFRRSNSISKSPGPSSPKEPLLFSRDISRSESLRCSSS
YSQQIFRPCDLIHGEVLGKGFFGQAIKVTHKATGKVMVMKELIRCDEETQKTFLTEVKVMRSLDHPNVLKFIGVLYKDKKLNLLTEYIEG
GTLKDFLRSMDPFPWQQKVRFAKGIASGMTKNRRCKLLPLVMAAPLSMEHGTVTVVGIPPETDSSDRKNFFGRAFEKAAESTSSRMLHNH

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:31664186/chr22:19504050)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LIMK2

P53671

CDC45

O75419

FUNCTION: Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042). Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042). Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514). Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro (PubMed:8537403). Suppresses ciliogenesis via multiple pathways; phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1 (PubMed:25849865). {ECO:0000269|PubMed:10436159, ECO:0000269|PubMed:11018042, ECO:0000269|PubMed:22328514, ECO:0000269|PubMed:25849865, ECO:0000269|PubMed:8537403}.FUNCTION: Required for initiation of chromosomal DNA replication.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMK2chr22:31664186chr22:19504049ENST00000331728+111612_63439.0639.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31664186chr22:19504049ENST00000331728+1116152_239439.0639.0DomainPDZ
HgeneLIMK2chr22:31664186chr22:19504049ENST00000331728+111672_124439.0639.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31664186chr22:19504049ENST00000333611+101512_63418.0618.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31664186chr22:19504049ENST00000333611+1015152_239418.0618.0DomainPDZ
HgeneLIMK2chr22:31664186chr22:19504049ENST00000333611+101572_124418.0618.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31664186chr22:19504049ENST00000340552+101512_63418.0687.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31664186chr22:19504049ENST00000340552+1015152_239418.0687.0DomainPDZ
HgeneLIMK2chr22:31664186chr22:19504049ENST00000340552+101572_124418.0687.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31664186chr22:19504050ENST00000331728+111612_63439.0639.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31664186chr22:19504050ENST00000331728+1116152_239439.0639.0DomainPDZ
HgeneLIMK2chr22:31664186chr22:19504050ENST00000331728+111672_124439.0639.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31664186chr22:19504050ENST00000333611+101512_63418.0618.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31664186chr22:19504050ENST00000333611+1015152_239418.0618.0DomainPDZ
HgeneLIMK2chr22:31664186chr22:19504050ENST00000333611+101572_124418.0618.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31664186chr22:19504050ENST00000340552+101512_63418.0687.0DomainLIM zinc-binding 1
HgeneLIMK2chr22:31664186chr22:19504050ENST00000340552+1015152_239418.0687.0DomainPDZ
HgeneLIMK2chr22:31664186chr22:19504050ENST00000340552+101572_124418.0687.0DomainLIM zinc-binding 2
HgeneLIMK2chr22:31664186chr22:19504049ENST00000331728+1116337_345439.0639.0Nucleotide bindingATP
HgeneLIMK2chr22:31664186chr22:19504049ENST00000333611+1015337_345418.0618.0Nucleotide bindingATP
HgeneLIMK2chr22:31664186chr22:19504049ENST00000340552+1015337_345418.0687.0Nucleotide bindingATP
HgeneLIMK2chr22:31664186chr22:19504050ENST00000331728+1116337_345439.0639.0Nucleotide bindingATP
HgeneLIMK2chr22:31664186chr22:19504050ENST00000333611+1015337_345418.0618.0Nucleotide bindingATP
HgeneLIMK2chr22:31664186chr22:19504050ENST00000340552+1015337_345418.0687.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLIMK2chr22:31664186chr22:19504049ENST00000331728+1116331_608439.0639.0DomainProtein kinase
HgeneLIMK2chr22:31664186chr22:19504049ENST00000333611+1015331_608418.0618.0DomainProtein kinase
HgeneLIMK2chr22:31664186chr22:19504049ENST00000340552+1015331_608418.0687.0DomainProtein kinase
HgeneLIMK2chr22:31664186chr22:19504050ENST00000331728+1116331_608439.0639.0DomainProtein kinase
HgeneLIMK2chr22:31664186chr22:19504050ENST00000333611+1015331_608418.0618.0DomainProtein kinase
HgeneLIMK2chr22:31664186chr22:19504050ENST00000340552+1015331_608418.0687.0DomainProtein kinase


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LIMK2
CDC45


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LIMK2-CDC45


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LIMK2-CDC45


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource