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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LIPC-TCF12

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LIPC-TCF12
	FusionPDB ID: 45627
	FusionGDB2.0 ID: 45627
		Hgene	Tgene
	Gene symbol	LIPC	TCF12
	Gene ID	3990	6938
	Gene name	lipase C, hepatic type	transcription factor 12
	Synonyms	HDLCQ12\|HL\|HTGL\|LIPH	CRS3\|HEB\|HTF4\|HsT17266\|TCF-12\|bHLHb20\|p64
	Cytomap	15q21.3	15q21.3
	Type of gene	protein-coding	protein-coding
	Description	hepatic triacylglycerol lipaseTriacylglycerol lipasehepatic lipaselipase member Clipase, hepatic	transcription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4
	Modification date	20200322	20200313
	UniProtAcc	P11150	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000299022, ENST00000356113, ENST00000414170, ENST00000433326,	ENST00000343827, ENST00000537840, ENST00000543579, ENST00000559703, ENST00000559710, ENST00000560764, ENST00000267811, ENST00000333725, ENST00000438423, ENST00000452095, ENST00000557843,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 3 X 3=36	21 X 22 X 8=3696
	# samples	4	26
	** MAII score	log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(26/3696*10)=-3.8293812283876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LIPC [Title/Abstract] AND TCF12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LIPC(58724319)-TCF12(57458600), # samples:2
Anticipated loss of major functional domain due to fusion event.	LIPC-TCF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIPC-TCF12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LIPC-TCF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LIPC-TCF12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LIPC	GO:0006633	fatty acid biosynthetic process	182536
Hgene	LIPC	GO:0019433	triglyceride catabolic process	182536\|2839510\|8640403
Hgene	LIPC	GO:0034372	very-low-density lipoprotein particle remodeling	8640403
Tgene	TCF12	GO:0045944	positive regulation of transcription by RNA polymerase II	11802795

Fusion gene breakpoints across LIPC (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TCF12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-BD-A3ER-01A	LIPC	chr15	58724319	-	TCF12	chr15	57458600	+
ChimerDB4	LIHC	TCGA-BD-A3ER-01A	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000356113	LIPC	chr15	58724319	+	ENST00000438423	TCF12	chr15	57458600	+	4868	703	615	2498	627
ENST00000356113	LIPC	chr15	58724319	+	ENST00000267811	TCF12	chr15	57458600	+	6135	703	615	2426	603
ENST00000356113	LIPC	chr15	58724319	+	ENST00000452095	TCF12	chr15	57458600	+	4868	703	615	2498	627
ENST00000356113	LIPC	chr15	58724319	+	ENST00000333725	TCF12	chr15	57458600	+	4862	703	615	2498	627
ENST00000356113	LIPC	chr15	58724319	+	ENST00000557843	TCF12	chr15	57458600	+	4367	703	615	2426	603
ENST00000414170	LIPC	chr15	58724319	+	ENST00000438423	TCF12	chr15	57458600	+	4540	375	287	2170	627
ENST00000414170	LIPC	chr15	58724319	+	ENST00000267811	TCF12	chr15	57458600	+	5807	375	287	2098	603
ENST00000414170	LIPC	chr15	58724319	+	ENST00000452095	TCF12	chr15	57458600	+	4540	375	287	2170	627
ENST00000414170	LIPC	chr15	58724319	+	ENST00000333725	TCF12	chr15	57458600	+	4534	375	287	2170	627
ENST00000414170	LIPC	chr15	58724319	+	ENST00000557843	TCF12	chr15	57458600	+	4039	375	287	2098	603
ENST00000299022	LIPC	chr15	58724319	+	ENST00000438423	TCF12	chr15	57458600	+	4488	323	235	2118	627
ENST00000299022	LIPC	chr15	58724319	+	ENST00000267811	TCF12	chr15	57458600	+	5755	323	235	2046	603
ENST00000299022	LIPC	chr15	58724319	+	ENST00000452095	TCF12	chr15	57458600	+	4488	323	235	2118	627
ENST00000299022	LIPC	chr15	58724319	+	ENST00000333725	TCF12	chr15	57458600	+	4482	323	235	2118	627
ENST00000299022	LIPC	chr15	58724319	+	ENST00000557843	TCF12	chr15	57458600	+	3987	323	235	2046	603
ENST00000433326	LIPC	chr15	58724319	+	ENST00000438423	TCF12	chr15	57458600	+	4295	130	42	1925	627
ENST00000433326	LIPC	chr15	58724319	+	ENST00000267811	TCF12	chr15	57458600	+	5562	130	42	1853	603
ENST00000433326	LIPC	chr15	58724319	+	ENST00000452095	TCF12	chr15	57458600	+	4295	130	42	1925	627
ENST00000433326	LIPC	chr15	58724319	+	ENST00000333725	TCF12	chr15	57458600	+	4289	130	42	1925	627
ENST00000433326	LIPC	chr15	58724319	+	ENST00000557843	TCF12	chr15	57458600	+	3794	130	42	1853	603

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000356113	ENST00000438423	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001697555	0.99830246
ENST00000356113	ENST00000267811	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.0008446	0.9991554
ENST00000356113	ENST00000452095	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001697555	0.99830246
ENST00000356113	ENST00000333725	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001722691	0.9982773
ENST00000356113	ENST00000557843	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.003280105	0.9967199
ENST00000414170	ENST00000438423	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001687518	0.9983125
ENST00000414170	ENST00000267811	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.00085818	0.9991418
ENST00000414170	ENST00000452095	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001687518	0.9983125
ENST00000414170	ENST00000333725	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001713637	0.9982863
ENST00000414170	ENST00000557843	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.003119308	0.99688065
ENST00000299022	ENST00000438423	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001173409	0.99882656
ENST00000299022	ENST00000267811	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.000663848	0.9993362
ENST00000299022	ENST00000452095	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001173409	0.99882656
ENST00000299022	ENST00000333725	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001190824	0.9988092
ENST00000299022	ENST00000557843	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.002165583	0.9978344
ENST00000433326	ENST00000438423	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001466449	0.9985335
ENST00000433326	ENST00000267811	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.000739159	0.99926084
ENST00000433326	ENST00000452095	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001466449	0.9985335
ENST00000433326	ENST00000333725	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.001489868	0.99851006
ENST00000433326	ENST00000557843	LIPC	chr15	58724319	+	TCF12	chr15	57458600	+	0.002680139	0.9973199

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>45627_45627_1_LIPC-TCF12_LIPC_chr15_58724319_ENST00000299022_TCF12_chr15_57458600_ENST00000267811_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_2_LIPC-TCF12_LIPC_chr15_58724319_ENST00000299022_TCF12_chr15_57458600_ENST00000333725_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_3_LIPC-TCF12_LIPC_chr15_58724319_ENST00000299022_TCF12_chr15_57458600_ENST00000438423_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_4_LIPC-TCF12_LIPC_chr15_58724319_ENST00000299022_TCF12_chr15_57458600_ENST00000452095_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_5_LIPC-TCF12_LIPC_chr15_58724319_ENST00000299022_TCF12_chr15_57458600_ENST00000557843_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_6_LIPC-TCF12_LIPC_chr15_58724319_ENST00000356113_TCF12_chr15_57458600_ENST00000267811_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_7_LIPC-TCF12_LIPC_chr15_58724319_ENST00000356113_TCF12_chr15_57458600_ENST00000333725_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_8_LIPC-TCF12_LIPC_chr15_58724319_ENST00000356113_TCF12_chr15_57458600_ENST00000438423_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_9_LIPC-TCF12_LIPC_chr15_58724319_ENST00000356113_TCF12_chr15_57458600_ENST00000452095_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_10_LIPC-TCF12_LIPC_chr15_58724319_ENST00000356113_TCF12_chr15_57458600_ENST00000557843_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_11_LIPC-TCF12_LIPC_chr15_58724319_ENST00000414170_TCF12_chr15_57458600_ENST00000267811_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_12_LIPC-TCF12_LIPC_chr15_58724319_ENST00000414170_TCF12_chr15_57458600_ENST00000333725_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_13_LIPC-TCF12_LIPC_chr15_58724319_ENST00000414170_TCF12_chr15_57458600_ENST00000438423_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_14_LIPC-TCF12_LIPC_chr15_58724319_ENST00000414170_TCF12_chr15_57458600_ENST00000452095_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_15_LIPC-TCF12_LIPC_chr15_58724319_ENST00000414170_TCF12_chr15_57458600_ENST00000557843_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_16_LIPC-TCF12_LIPC_chr15_58724319_ENST00000433326_TCF12_chr15_57458600_ENST00000267811_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

>45627_45627_17_LIPC-TCF12_LIPC_chr15_58724319_ENST00000433326_TCF12_chr15_57458600_ENST00000333725_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_18_LIPC-TCF12_LIPC_chr15_58724319_ENST00000433326_TCF12_chr15_57458600_ENST00000438423_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_19_LIPC-TCF12_LIPC_chr15_58724319_ENST00000433326_TCF12_chr15_57458600_ENST00000452095_length(amino acids)=627AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLKNRVEQQLHEHLQDAMSFLKDVCEQSRMEDRLDRLDDAIHVLR
NHAVGPSTSLPAGHSDIHSLLGPSHNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGG
LQSQSGTVVTTEIKTENKEKDENLHEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINE

--------------------------------------------------------------

>45627_45627_20_LIPC-TCF12_LIPC_chr15_58724319_ENST00000433326_TCF12_chr15_57458600_ENST00000557843_length(amino acids)=603AA_BP=29
MDTSPLCFSILLVLCIFIQSSALGQSLKPGKTSERGSFSLYSRDTGLPGCQSSLLRQDLGLGSPAQLSSSGKPGTAYYSFSATSSRRRPL
HDSAALDPLQAKKVRKVPPGLPSSVYAPSPNSDDFNRESPSYPSPKPPTSMFASTFFMQDGTHNSSDLWSSSNGMSQPGFGGILGTSTSH
MSQSSSYGNLHSHDRLSYPPHSVSPTDINTSLPPMSSFHRGSTSSSPYVAASHTPPINGSDSILGTRGNAAGSSQTGDALGKALASIYSP
DHTSSSFPSNPSTPVGSPSPLTGTSQWPRPGGQAPSSPSYENSLHSLQSRMEDRLDRLDDAIHVLRNHAVGPSTSLPAGHSDIHSLLGPS
HNAPIGSLNSNYGGSSLVASSRSASMVGTHREDSVSLNGNHSVLSSTVTTSSTDLNHKTQENYRGGLQSQSGTVVTTEIKTENKEKDENL
HEPPSSDDMKSDDESSQKDIKVSSRGRTSSTNEDEDLNPEQKIEREKERRMANNARERLRVRDINEAFKELGRMCQLHLKSEKPQTKLLI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:58724319/chr15:57458600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LIPC P11150	.
FUNCTION: Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles (PubMed:7592706, PubMed:8798474, PubMed:12032167, PubMed:26193433). Also exhibits lysophospholipase activity (By similarity). Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates (By similarity). In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position (PubMed:26193433). {ECO:0000250\|UniProtKB:P07867, ECO:0000269\|PubMed:12032167, ECO:0000269\|PubMed:26193433, ECO:0000269\|PubMed:7592706, ECO:0000269\|PubMed:8798474}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000267811

577_630

108.33333333333333

1821.3333333333333

Domain

bHLH

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000333725

577_630

108.33333333333333

1420.0

Domain

bHLH

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000343827

577_630

1254.6666666666667

Domain

bHLH

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000438423

577_630

108.33333333333333

1398.3333333333333

Domain

bHLH

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000557843

577_630

108.33333333333333

1301.0

Domain

bHLH

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000343827

19_27

1254.6666666666667

Motif

Note=9aaTAD

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000267811

119_140

108.33333333333333

1821.3333333333333

Region

Note=Leucine-zipper

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000267811

632_655

108.33333333333333

1821.3333333333333

Region

Note=Class A specific domain

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000333725

119_140

108.33333333333333

1420.0

Region

Note=Leucine-zipper

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000333725

632_655

108.33333333333333

1420.0

Region

Note=Class A specific domain

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000343827

119_140

1254.6666666666667

Region

Note=Leucine-zipper

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000343827

632_655

1254.6666666666667

Region

Note=Class A specific domain

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000438423

119_140

108.33333333333333

1398.3333333333333

Region

Note=Leucine-zipper

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000438423

632_655

108.33333333333333

1398.3333333333333

Region

Note=Class A specific domain

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000557843

119_140

108.33333333333333

1301.0

Region

Note=Leucine-zipper

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000557843

632_655

108.33333333333333

1301.0

Region

Note=Class A specific domain

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LIPC

chr15:58724319

chr15:57458600

ENST00000299022

352_486

29.333333333333332

500.0

Domain

PLAT

Hgene

LIPC

chr15:58724319

chr15:57458600

ENST00000356113

352_486

29.333333333333332

500.0

Domain

PLAT

Hgene

LIPC

chr15:58724319

chr15:57458600

ENST00000299022

254_277

29.333333333333332

500.0

Region

Essential for determining substrate specificity

Hgene

LIPC

chr15:58724319

chr15:57458600

ENST00000356113

254_277

29.333333333333332

500.0

Region

Essential for determining substrate specificity

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000267811

19_27

108.33333333333333

1821.3333333333333

Motif

Note=9aaTAD

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000333725

19_27

108.33333333333333

1420.0

Motif

Note=9aaTAD

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000438423

19_27

108.33333333333333

1398.3333333333333

Motif

Note=9aaTAD

Tgene

TCF12

chr15:58724319

chr15:57458600

ENST00000557843

19_27

108.33333333333333

1301.0

Motif

Note=9aaTAD

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LIPC
TCF12

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to LIPC-TCF12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LIPC-TCF12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source