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Fusion Protein:LMNA-IGFBP2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: LMNA-IGFBP2 | FusionPDB ID: 45788 | FusionGDB2.0 ID: 45788 | Hgene | Tgene | Gene symbol | LMNA | IGFBP2 | Gene ID | 4000 | 3485 |
| Gene name | lamin A/C | insulin like growth factor binding protein 2 | |
| Synonyms | CDCD1|CDDC|CMD1A|CMT2B1|EMD2|FPL|FPLD|FPLD2|HGPS|IDC|LDP1|LFP|LGMD1B|LMN1|LMNC|LMNL1|MADA|PRO1 | IBP2|IGF-BP53 | |
| Cytomap | 1q22 | 2q35 | |
| Type of gene | protein-coding | protein-coding | |
| Description | lamin70 kDa laminepididymis secretory sperm binding proteinlamin A/C-like 1mandibuloacral dysplasia type Aprelamin-A/Crenal carcinoma antigen NY-REN-32 | insulin-like growth factor-binding protein 2IGF-binding protein 2insulin-like growth factor binding protein 2, 36kDa | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P02545 | P18065 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000347559, ENST00000368300, ENST00000368299, ENST00000361308, ENST00000368297, ENST00000368301, ENST00000392353, ENST00000448611, ENST00000473598, ENST00000496738, | ENST00000233809, ENST00000456764, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 16 X 16 X 9=2304 | 4 X 4 X 4=64 |
| # samples | 21 | 5 | |
| ** MAII score | log2(21/2304*10)=-3.45567948377619 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/64*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: LMNA [Title/Abstract] AND IGFBP2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LMNA(156109108)-IGFBP2(217525456), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LMNA-IGFBP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | LMNA | GO:0090343 | positive regulation of cell aging | 20458013 |
| Tgene | IGFBP2 | GO:0042104 | positive regulation of activated T cell proliferation | 15694994 |
| Fusion gene breakpoints across LMNA (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across IGFBP2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-EO-A3AY-01A | LMNA | chr1 | 156109108 | - | IGFBP2 | chr2 | 217525456 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000368299 | LMNA | chr1 | 156109108 | - | ENST00000233809 | IGFBP2 | chr2 | 217525456 | + | 2944 | 2253 | 68 | 2041 | 657 |
| ENST00000368299 | LMNA | chr1 | 156109108 | - | ENST00000456764 | IGFBP2 | chr2 | 217525456 | + | 2793 | 2253 | 68 | 2041 | 657 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000368299 | ENST00000233809 | LMNA | chr1 | 156109108 | - | IGFBP2 | chr2 | 217525456 | + | 0.020472037 | 0.97952795 |
| ENST00000368299 | ENST00000456764 | LMNA | chr1 | 156109108 | - | IGFBP2 | chr2 | 217525456 | + | 0.026049227 | 0.9739508 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >45788_45788_1_LMNA-IGFBP2_LMNA_chr1_156109108_ENST00000368299_IGFBP2_chr2_217525456_ENST00000233809_length(amino acids)=657AA_BP= MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS QTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTI WAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVL -------------------------------------------------------------- >45788_45788_2_LMNA-IGFBP2_LMNA_chr1_156109108_ENST00000368299_IGFBP2_chr2_217525456_ENST00000456764_length(amino acids)=657AA_BP= MPGASREPAGRRTPTPSSLCPSTRAPRPFRDPCPAGSAANLPAMETPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYID RVRSLETENAGLRLRITESEEVVSREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDL EALLNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNIYSEELRETKRRHETRLV EIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAERNSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKE AKLRDLEDSLARERDTSRRLLAEKEREMAEMRARMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSS QTQGGGSVTKKRKLESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLKAGQVVTI WAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDDLLHHHHGSHCSSSGDPAEYNLRSRTVL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:156109108/chr2:217525456) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| LMNA | IGFBP2 |
| FUNCTION: Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin. Lamin A and C are present in equal amounts in the lamina of mammals. Recruited by DNA repair proteins XRCC4 and IFFO1 to the DNA double-strand breaks (DSBs) to prevent chromosome translocation by immobilizing broken DNA ends (PubMed:31548606). Plays an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. Required for normal development of peripheral nervous system and skeletal muscle and for muscle satellite cell proliferation (PubMed:10080180, PubMed:22431096, PubMed:10814726, PubMed:11799477, PubMed:18551513). Required for osteoblastogenesis and bone formation (PubMed:12075506, PubMed:15317753, PubMed:18611980). Also prevents fat infiltration of muscle and bone marrow, helping to maintain the volume and strength of skeletal muscle and bone (PubMed:10587585). Required for cardiac homeostasis (PubMed:10580070, PubMed:12927431, PubMed:18611980, PubMed:23666920). {ECO:0000269|PubMed:10080180, ECO:0000269|PubMed:10580070, ECO:0000269|PubMed:10587585, ECO:0000269|PubMed:10814726, ECO:0000269|PubMed:11799477, ECO:0000269|PubMed:12075506, ECO:0000269|PubMed:12927431, ECO:0000269|PubMed:15317753, ECO:0000269|PubMed:18551513, ECO:0000269|PubMed:18611980, ECO:0000269|PubMed:22431096, ECO:0000269|PubMed:23666920, ECO:0000269|PubMed:31548606}.; FUNCTION: Prelamin-A/C can accelerate smooth muscle cell senescence. It acts to disrupt mitosis and induce DNA damage in vascular smooth muscle cells (VSMCs), leading to mitotic failure, genomic instability, and premature senescence. | FUNCTION: Inhibits IGF-mediated growth and developmental rates. IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. {ECO:0000269|PubMed:19081843}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | IGFBP2 | chr1:156109108 | chr2:217525456 | ENST00000233809 | 0 | 4 | 224_306 | 0 | 326.0 | Domain | Thyroglobulin type-1 | |
| Tgene | IGFBP2 | chr1:156109108 | chr2:217525456 | ENST00000233809 | 0 | 4 | 38_134 | 0 | 326.0 | Domain | IGFBP N-terminal | |
| Tgene | IGFBP2 | chr1:156109108 | chr2:217525456 | ENST00000233809 | 0 | 4 | 301_303 | 0 | 326.0 | Motif | Note=Cell attachment site |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 31_387 | 0 | 635.0 | Domain | IF rod |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 428_545 | 0 | 635.0 | Domain | LTD |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 31_387 | 0 | 573.0 | Domain | IF rod |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 428_545 | 0 | 573.0 | Domain | LTD |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 31_387 | 0 | 665.0 | Domain | IF rod |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 428_545 | 0 | 665.0 | Domain | LTD |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 31_387 | 0 | 573.0 | Domain | IF rod |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 428_545 | 0 | 573.0 | Domain | LTD |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 31_387 | 0 | 575.0 | Domain | IF rod |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 428_545 | 0 | 575.0 | Domain | LTD |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 417_422 | 0 | 635.0 | Motif | Nuclear localization signal |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 417_422 | 0 | 573.0 | Motif | Nuclear localization signal |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 417_422 | 0 | 665.0 | Motif | Nuclear localization signal |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 417_422 | 0 | 573.0 | Motif | Nuclear localization signal |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 417_422 | 0 | 575.0 | Motif | Nuclear localization signal |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 1_33 | 0 | 635.0 | Region | Note=Head |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 219_242 | 0 | 635.0 | Region | Note=Linker 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 243_383 | 0 | 635.0 | Region | Note=Coil 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 34_70 | 0 | 635.0 | Region | Note=Coil 1A |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 384_664 | 0 | 635.0 | Region | Note=Tail |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 71_80 | 0 | 635.0 | Region | Note=Linker 1 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 81_218 | 0 | 635.0 | Region | Note=Coil 1B |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 1_33 | 0 | 573.0 | Region | Note=Head |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 219_242 | 0 | 573.0 | Region | Note=Linker 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 243_383 | 0 | 573.0 | Region | Note=Coil 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 34_70 | 0 | 573.0 | Region | Note=Coil 1A |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 384_664 | 0 | 573.0 | Region | Note=Tail |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 71_80 | 0 | 573.0 | Region | Note=Linker 1 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 81_218 | 0 | 573.0 | Region | Note=Coil 1B |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 1_33 | 0 | 665.0 | Region | Note=Head |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 219_242 | 0 | 665.0 | Region | Note=Linker 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 243_383 | 0 | 665.0 | Region | Note=Coil 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 34_70 | 0 | 665.0 | Region | Note=Coil 1A |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 384_664 | 0 | 665.0 | Region | Note=Tail |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 71_80 | 0 | 665.0 | Region | Note=Linker 1 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 81_218 | 0 | 665.0 | Region | Note=Coil 1B |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 1_33 | 0 | 573.0 | Region | Note=Head |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 219_242 | 0 | 573.0 | Region | Note=Linker 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 243_383 | 0 | 573.0 | Region | Note=Coil 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 34_70 | 0 | 573.0 | Region | Note=Coil 1A |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 384_664 | 0 | 573.0 | Region | Note=Tail |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 71_80 | 0 | 573.0 | Region | Note=Linker 1 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 81_218 | 0 | 573.0 | Region | Note=Coil 1B |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 1_33 | 0 | 575.0 | Region | Note=Head |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 219_242 | 0 | 575.0 | Region | Note=Linker 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 243_383 | 0 | 575.0 | Region | Note=Coil 2 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 34_70 | 0 | 575.0 | Region | Note=Coil 1A |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 384_664 | 0 | 575.0 | Region | Note=Tail |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 71_80 | 0 | 575.0 | Region | Note=Linker 1 |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 81_218 | 0 | 575.0 | Region | Note=Coil 1B |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| LMNA | |
| IGFBP2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000347559 | - | 1 | 11 | 1_130 | 0 | 635.0 | MLIP |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000361308 | - | 1 | 10 | 1_130 | 0 | 573.0 | MLIP |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368300 | - | 1 | 12 | 1_130 | 0 | 665.0 | MLIP |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000368301 | - | 1 | 13 | 1_130 | 0 | 573.0 | MLIP |
| Hgene | LMNA | chr1:156109108 | chr2:217525456 | ENST00000448611 | - | 1 | 13 | 1_130 | 0 | 575.0 | MLIP |
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Related Drugs to LMNA-IGFBP2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to LMNA-IGFBP2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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