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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANKRD28-COLQ

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANKRD28-COLQ
FusionPDB ID: 4659
FusionGDB2.0 ID: 4659
HgeneTgene
Gene symbol

ANKRD28

COLQ

Gene ID

23243

8292

Gene nameankyrin repeat domain 28collagen like tail subunit of asymmetric acetylcholinesterase
SynonymsCFAP79|FAP79|PITK|PPP1R65CMS5|EAD
Cytomap

3p25.1

3p25.1

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit APP6-ARS-Aankyrin repeat domain-containing protein 28phosphatase interactor targeting K proteinphosphatase interactor targeting protein hnRNP Kprotein phosphatase 1, regulatory acetylcholinesterase collagenic tail peptideAChE Q subunitacetylcholinesterase-associated collagencollagen-like tail subunit (single strand of homotrimer) of asymmetric acetylcholinesterasecollagenic tail of endplate acetylcholinesterasesingle strand
Modification date2020032020200313
UniProtAcc

O15084

Q9Y215

Ensembl transtripts involved in fusion geneENST idsENST00000383777, ENST00000399451, 
ENST00000497037, 		ENST00000383781, 
ENST00000383786, ENST00000603752, 
ENST00000603808, ENST00000383785, 
ENST00000383787, ENST00000383788, 
ENST00000435459, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 13 X 13=30425 X 4 X 6=120
# samples 217
** MAII scorelog2(21/3042*10)=-3.85655892005837
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANKRD28 [Title/Abstract] AND COLQ [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANKRD28(15900884)-COLQ(15531144), # samples:3
ANKRD28(15900883)-COLQ(15531144), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD28-COLQ seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD28-COLQ seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD28-COLQ seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD28-COLQ seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD28-COLQ seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ANKRD28 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across COLQ (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-R6-A8W5-01BANKRD28chr3

15900884

-COLQchr3

15531144

-
ChimerDB4ESCATCGA-R6-A8W5ANKRD28chr3

15900883

-COLQchr3

15531144

-
ChimerDB4ESCATCGA-R6-A8W5ANKRD28chr3

15900884

-COLQchr3

15531144

-
ChimerDB4LIHCTCGA-DD-AAEE-01AANKRD28chr3

15793257

-COLQchr3

15507944

-
ChimerDB4LIHCTCGA-DD-AAEEANKRD28chr3

15793257

-COLQchr3

15507944

-
ChimerDB4UCECTCGA-AX-A2H2-01AANKRD28chr3

15900884

-COLQchr3

15531144

-
ChimerDB4UCECTCGA-AX-A2H2ANKRD28chr3

15900883

-COLQchr3

15531144

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000399451ANKRD28chr315900884-ENST00000383785COLQchr315531144-33103954061164252
ENST00000383777ANKRD28chr315793257-ENST00000435459COLQchr315507944-252236001010336
ENST00000383777ANKRD28chr315793257-ENST00000383787COLQchr315507944-252236001010336
ENST00000383777ANKRD28chr315793257-ENST00000383788COLQchr315507944-250836001010336
ENST00000399451ANKRD28chr315793257-ENST00000435459COLQchr315507944-27916293681279303
ENST00000399451ANKRD28chr315793257-ENST00000383787COLQchr315507944-27916293681279303
ENST00000399451ANKRD28chr315793257-ENST00000383788COLQchr315507944-27776293681279303
ENST00000399451ANKRD28chr315900883-ENST00000383785COLQchr315531144-33103954061164252

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000399451ENST00000383785ANKRD28chr315900884-COLQchr315531144-0.286861270.7131387
ENST00000383777ENST00000435459ANKRD28chr315793257-COLQchr315507944-0.0025593370.9974407
ENST00000383777ENST00000383787ANKRD28chr315793257-COLQchr315507944-0.0025593370.9974407
ENST00000383777ENST00000383788ANKRD28chr315793257-COLQchr315507944-0.0026218720.9973781
ENST00000399451ENST00000435459ANKRD28chr315793257-COLQchr315507944-0.0019011910.9980988
ENST00000399451ENST00000383787ANKRD28chr315793257-COLQchr315507944-0.0019011910.9980988
ENST00000399451ENST00000383788ANKRD28chr315793257-COLQchr315507944-0.0019431670.9980568
ENST00000399451ENST00000383785ANKRD28chr315900883-COLQchr315531144-0.286861270.7131387

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4659_4659_1_ANKRD28-COLQ_ANKRD28_chr3_15793257_ENST00000383777_COLQ_chr3_15507944_ENST00000383787_length(amino acids)=336AA_BP=0
MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEII
ELLILSGARVNAKDSKWLTPLHRAVASCSEGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNV
NNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDG

--------------------------------------------------------------

>4659_4659_2_ANKRD28-COLQ_ANKRD28_chr3_15793257_ENST00000383777_COLQ_chr3_15507944_ENST00000383788_length(amino acids)=336AA_BP=0
MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEII
ELLILSGARVNAKDSKWLTPLHRAVASCSEGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNV
NNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDG

--------------------------------------------------------------

>4659_4659_3_ANKRD28-COLQ_ANKRD28_chr3_15793257_ENST00000383777_COLQ_chr3_15507944_ENST00000435459_length(amino acids)=336AA_BP=0
MSRVCIVVLEEVEDESPAFISKLPQENKSLHSPPSGNVLVRYPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEII
ELLILSGARVNAKDSKWLTPLHRAVASCSEGQKGDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNV
NNPSYGESVYGPSSPRVPVIFVVNNQEELERLNTQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDG

--------------------------------------------------------------

>4659_4659_4_ANKRD28-COLQ_ANKRD28_chr3_15793257_ENST00000399451_COLQ_chr3_15507944_ENST00000383787_length(amino acids)=303AA_BP=0
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEGQK
GDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLN
TQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDF

--------------------------------------------------------------

>4659_4659_5_ANKRD28-COLQ_ANKRD28_chr3_15793257_ENST00000399451_COLQ_chr3_15507944_ENST00000383788_length(amino acids)=303AA_BP=0
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEGQK
GDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLN
TQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDF

--------------------------------------------------------------

>4659_4659_6_ANKRD28-COLQ_ANKRD28_chr3_15793257_ENST00000399451_COLQ_chr3_15507944_ENST00000435459_length(amino acids)=303AA_BP=0
MAFLKLRDQPSLVQAIFNGDPDEVRALIFKKEDVNFQDNEKRTPLHAAAYLGDAEIIELLILSGARVNAKDSKWLTPLHRAVASCSEGQK
GDSGVMGPPGKPGPSGQPGRPGPPGPPPAGQLIMGPKGERGFPGPPGRCLCGPTMNVNNPSYGESVYGPSSPRVPVIFVVNNQEELERLN
TQNAIAFRRDQRSLYFKDSLGWLPIQLTPFYPVDYTADQHGTCGDGLLQPGEECDDGNSDVGDDCIRCHRAYCGDGHRHEGVEDCDGSDF

--------------------------------------------------------------

>4659_4659_7_ANKRD28-COLQ_ANKRD28_chr3_15900883_ENST00000399451_COLQ_chr3_15531144_ENST00000383785_length(amino acids)=252AA_BP=
MDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPG
RKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKG

--------------------------------------------------------------

>4659_4659_8_ANKRD28-COLQ_ANKRD28_chr3_15900884_ENST00000399451_COLQ_chr3_15531144_ENST00000383785_length(amino acids)=252AA_BP=
MDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPG
RKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:15900884/chr3:15531144)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD28

O15084

COLQ

Q9Y215

FUNCTION: Putative regulatory subunit of protein phosphatase 6 (PP6) that may be involved in the recognition of phosphoprotein substrates. Involved in the PP6-mediated dephosphorylation of NFKBIE opposing its degradation in response to TNF-alpha. Selectively inhibits the phosphatase activity of PPP1C. Targets PPP1C to modulate HNRPK phosphorylation. {ECO:0000269|PubMed:16564677, ECO:0000269|PubMed:18186651}.FUNCTION: Anchors the catalytic subunits of asymmetric AChE to the synaptic basal lamina.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-42840_69120.01087.0RepeatNote=ANK 1
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-42873_102120.01087.0RepeatNote=ANK 2
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-42840_6987.01054.0RepeatNote=ANK 1
TgeneCOLQchr3:15793257chr3:15507944ENST000003837811017277_291229.0446.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15793257chr3:15507944ENST00000383786916277_291205.0422.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15793257chr3:15507944ENST00000383787916277_291230.0447.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15793257chr3:15507944ENST000003837881017277_291239.0456.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15793257chr3:15507944ENST000006038081017277_291239.0457.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900883chr3:15531144ENST00000383781017277_29125.333333333333332446.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378101796_26925.333333333333332446.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900883chr3:15531144ENST00000383786016277_29135.333333333333336422.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378601696_26935.333333333333336422.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900883chr3:15531144ENST00000383787016277_29135.333333333333336447.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378701696_26935.333333333333336447.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900883chr3:15531144ENST00000383788017277_29135.333333333333336456.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378801796_26935.333333333333336456.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900883chr3:15531144ENST00000603808017277_29135.333333333333336457.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900883chr3:15531144ENST0000060380801796_26935.333333333333336457.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900884chr3:15531144ENST00000383781017277_29125.333333333333332446.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378101796_26925.333333333333332446.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900884chr3:15531144ENST00000383786016277_29135.333333333333336422.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378601696_26935.333333333333336422.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900884chr3:15531144ENST00000383787016277_29135.333333333333336447.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378701696_26935.333333333333336447.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900884chr3:15531144ENST00000383788017277_29135.333333333333336456.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378801796_26935.333333333333336456.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15900884chr3:15531144ENST00000603808017277_29135.333333333333336457.0DomainNote=Collagen-like 2
TgeneCOLQchr3:15900884chr3:15531144ENST0000060380801796_26935.333333333333336457.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15793257chr3:15507944ENST000003837811017235_238229.0446.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST00000383786916235_238205.0422.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST00000383787916235_238230.0447.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST00000383781017130_13325.333333333333332446.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST00000383781017235_23825.333333333333332446.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378101751_6725.333333333333332446.0RegionNote=PRAD
TgeneCOLQchr3:15900883chr3:15531144ENST00000383786016130_13335.333333333333336422.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST00000383786016235_23835.333333333333336422.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378601651_6735.333333333333336422.0RegionNote=PRAD
TgeneCOLQchr3:15900883chr3:15531144ENST00000383787016130_13335.333333333333336447.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST00000383787016235_23835.333333333333336447.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378701651_6735.333333333333336447.0RegionNote=PRAD
TgeneCOLQchr3:15900883chr3:15531144ENST00000383788017130_13335.333333333333336456.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST00000383788017235_23835.333333333333336456.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST0000038378801751_6735.333333333333336456.0RegionNote=PRAD
TgeneCOLQchr3:15900883chr3:15531144ENST00000603808017130_13335.333333333333336457.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST00000603808017235_23835.333333333333336457.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900883chr3:15531144ENST0000060380801751_6735.333333333333336457.0RegionNote=PRAD
TgeneCOLQchr3:15900884chr3:15531144ENST00000383781017130_13325.333333333333332446.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST00000383781017235_23825.333333333333332446.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378101751_6725.333333333333332446.0RegionNote=PRAD
TgeneCOLQchr3:15900884chr3:15531144ENST00000383786016130_13335.333333333333336422.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST00000383786016235_23835.333333333333336422.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378601651_6735.333333333333336422.0RegionNote=PRAD
TgeneCOLQchr3:15900884chr3:15531144ENST00000383787016130_13335.333333333333336447.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST00000383787016235_23835.333333333333336447.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378701651_6735.333333333333336447.0RegionNote=PRAD
TgeneCOLQchr3:15900884chr3:15531144ENST00000383788017130_13335.333333333333336456.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST00000383788017235_23835.333333333333336456.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST0000038378801751_6735.333333333333336456.0RegionNote=PRAD
TgeneCOLQchr3:15900884chr3:15531144ENST00000603808017130_13335.333333333333336457.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST00000603808017235_23835.333333333333336457.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15900884chr3:15531144ENST0000060380801751_6735.333333333333336457.0RegionNote=PRAD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428106_135120.01087.0RepeatNote=ANK 3
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428139_168120.01087.0RepeatNote=ANK 4
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428172_201120.01087.0RepeatNote=ANK 5
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428205_234120.01087.0RepeatNote=ANK 6
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428238_267120.01087.0RepeatNote=ANK 7
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428271_301120.01087.0RepeatNote=ANK 8
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428305_334120.01087.0RepeatNote=ANK 9
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428338_367120.01087.0RepeatNote=ANK 10
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428371_400120.01087.0RepeatNote=ANK 11
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428404_433120.01087.0RepeatNote=ANK 12
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428437_466120.01087.0RepeatNote=ANK 13
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428470_500120.01087.0RepeatNote=ANK 14
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428504_534120.01087.0RepeatNote=ANK 15
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428549_578120.01087.0RepeatNote=ANK 16
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428582_611120.01087.0RepeatNote=ANK 17
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428616_645120.01087.0RepeatNote=ANK 18
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428652_681120.01087.0RepeatNote=ANK 19
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428685_714120.01087.0RepeatNote=ANK 20
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428718_747120.01087.0RepeatNote=ANK 21
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428755_784120.01087.0RepeatNote=ANK 22
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428787_817120.01087.0RepeatNote=ANK 23
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428822_851120.01087.0RepeatNote=ANK 24
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428855_885120.01087.0RepeatNote=ANK 25
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428889_918120.01087.0RepeatNote=ANK 26
HgeneANKRD28chr3:15793257chr3:15507944ENST00000383777-428925_954120.01087.0RepeatNote=ANK 27
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428106_13587.01054.0RepeatNote=ANK 3
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428139_16887.01054.0RepeatNote=ANK 4
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428172_20187.01054.0RepeatNote=ANK 5
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428205_23487.01054.0RepeatNote=ANK 6
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428238_26787.01054.0RepeatNote=ANK 7
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428271_30187.01054.0RepeatNote=ANK 8
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428305_33487.01054.0RepeatNote=ANK 9
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428338_36787.01054.0RepeatNote=ANK 10
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428371_40087.01054.0RepeatNote=ANK 11
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428404_43387.01054.0RepeatNote=ANK 12
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428437_46687.01054.0RepeatNote=ANK 13
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428470_50087.01054.0RepeatNote=ANK 14
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428504_53487.01054.0RepeatNote=ANK 15
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428549_57887.01054.0RepeatNote=ANK 16
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428582_61187.01054.0RepeatNote=ANK 17
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428616_64587.01054.0RepeatNote=ANK 18
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428652_68187.01054.0RepeatNote=ANK 19
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428685_71487.01054.0RepeatNote=ANK 20
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428718_74787.01054.0RepeatNote=ANK 21
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-42873_10287.01054.0RepeatNote=ANK 2
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428755_78487.01054.0RepeatNote=ANK 22
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428787_81787.01054.0RepeatNote=ANK 23
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428822_85187.01054.0RepeatNote=ANK 24
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428855_88587.01054.0RepeatNote=ANK 25
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428889_91887.01054.0RepeatNote=ANK 26
HgeneANKRD28chr3:15793257chr3:15507944ENST00000399451-428925_95487.01054.0RepeatNote=ANK 27
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128106_1350.01087.0RepeatNote=ANK 3
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128139_1680.01087.0RepeatNote=ANK 4
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128172_2010.01087.0RepeatNote=ANK 5
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128205_2340.01087.0RepeatNote=ANK 6
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128238_2670.01087.0RepeatNote=ANK 7
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128271_3010.01087.0RepeatNote=ANK 8
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128305_3340.01087.0RepeatNote=ANK 9
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128338_3670.01087.0RepeatNote=ANK 10
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128371_4000.01087.0RepeatNote=ANK 11
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128404_4330.01087.0RepeatNote=ANK 12
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-12840_690.01087.0RepeatNote=ANK 1
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128437_4660.01087.0RepeatNote=ANK 13
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128470_5000.01087.0RepeatNote=ANK 14
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128504_5340.01087.0RepeatNote=ANK 15
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128549_5780.01087.0RepeatNote=ANK 16
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128582_6110.01087.0RepeatNote=ANK 17
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128616_6450.01087.0RepeatNote=ANK 18
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128652_6810.01087.0RepeatNote=ANK 19
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128685_7140.01087.0RepeatNote=ANK 20
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128718_7470.01087.0RepeatNote=ANK 21
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-12873_1020.01087.0RepeatNote=ANK 2
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128755_7840.01087.0RepeatNote=ANK 22
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128787_8170.01087.0RepeatNote=ANK 23
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128822_8510.01087.0RepeatNote=ANK 24
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128855_8850.01087.0RepeatNote=ANK 25
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128889_9180.01087.0RepeatNote=ANK 26
HgeneANKRD28chr3:15900883chr3:15531144ENST00000383777-128925_9540.01087.0RepeatNote=ANK 27
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128106_1359.01054.0RepeatNote=ANK 3
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128139_1689.01054.0RepeatNote=ANK 4
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128172_2019.01054.0RepeatNote=ANK 5
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128205_2349.01054.0RepeatNote=ANK 6
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128238_2679.01054.0RepeatNote=ANK 7
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128271_3019.01054.0RepeatNote=ANK 8
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128305_3349.01054.0RepeatNote=ANK 9
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128338_3679.01054.0RepeatNote=ANK 10
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128371_4009.01054.0RepeatNote=ANK 11
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128404_4339.01054.0RepeatNote=ANK 12
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-12840_699.01054.0RepeatNote=ANK 1
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128437_4669.01054.0RepeatNote=ANK 13
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128470_5009.01054.0RepeatNote=ANK 14
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128504_5349.01054.0RepeatNote=ANK 15
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128549_5789.01054.0RepeatNote=ANK 16
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128582_6119.01054.0RepeatNote=ANK 17
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128616_6459.01054.0RepeatNote=ANK 18
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128652_6819.01054.0RepeatNote=ANK 19
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128685_7149.01054.0RepeatNote=ANK 20
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128718_7479.01054.0RepeatNote=ANK 21
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-12873_1029.01054.0RepeatNote=ANK 2
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128755_7849.01054.0RepeatNote=ANK 22
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128787_8179.01054.0RepeatNote=ANK 23
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128822_8519.01054.0RepeatNote=ANK 24
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128855_8859.01054.0RepeatNote=ANK 25
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128889_9189.01054.0RepeatNote=ANK 26
HgeneANKRD28chr3:15900883chr3:15531144ENST00000399451-128925_9549.01054.0RepeatNote=ANK 27
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128106_1350.01087.0RepeatNote=ANK 3
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128139_1680.01087.0RepeatNote=ANK 4
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128172_2010.01087.0RepeatNote=ANK 5
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128205_2340.01087.0RepeatNote=ANK 6
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128238_2670.01087.0RepeatNote=ANK 7
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128271_3010.01087.0RepeatNote=ANK 8
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128305_3340.01087.0RepeatNote=ANK 9
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128338_3670.01087.0RepeatNote=ANK 10
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128371_4000.01087.0RepeatNote=ANK 11
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128404_4330.01087.0RepeatNote=ANK 12
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-12840_690.01087.0RepeatNote=ANK 1
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128437_4660.01087.0RepeatNote=ANK 13
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128470_5000.01087.0RepeatNote=ANK 14
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128504_5340.01087.0RepeatNote=ANK 15
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128549_5780.01087.0RepeatNote=ANK 16
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128582_6110.01087.0RepeatNote=ANK 17
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128616_6450.01087.0RepeatNote=ANK 18
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128652_6810.01087.0RepeatNote=ANK 19
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128685_7140.01087.0RepeatNote=ANK 20
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128718_7470.01087.0RepeatNote=ANK 21
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-12873_1020.01087.0RepeatNote=ANK 2
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128755_7840.01087.0RepeatNote=ANK 22
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128787_8170.01087.0RepeatNote=ANK 23
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128822_8510.01087.0RepeatNote=ANK 24
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128855_8850.01087.0RepeatNote=ANK 25
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128889_9180.01087.0RepeatNote=ANK 26
HgeneANKRD28chr3:15900884chr3:15531144ENST00000383777-128925_9540.01087.0RepeatNote=ANK 27
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128106_1359.01054.0RepeatNote=ANK 3
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128139_1689.01054.0RepeatNote=ANK 4
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128172_2019.01054.0RepeatNote=ANK 5
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128205_2349.01054.0RepeatNote=ANK 6
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128238_2679.01054.0RepeatNote=ANK 7
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128271_3019.01054.0RepeatNote=ANK 8
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128305_3349.01054.0RepeatNote=ANK 9
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128338_3679.01054.0RepeatNote=ANK 10
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128371_4009.01054.0RepeatNote=ANK 11
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128404_4339.01054.0RepeatNote=ANK 12
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-12840_699.01054.0RepeatNote=ANK 1
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128437_4669.01054.0RepeatNote=ANK 13
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128470_5009.01054.0RepeatNote=ANK 14
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128504_5349.01054.0RepeatNote=ANK 15
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128549_5789.01054.0RepeatNote=ANK 16
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128582_6119.01054.0RepeatNote=ANK 17
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128616_6459.01054.0RepeatNote=ANK 18
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128652_6819.01054.0RepeatNote=ANK 19
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128685_7149.01054.0RepeatNote=ANK 20
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128718_7479.01054.0RepeatNote=ANK 21
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-12873_1029.01054.0RepeatNote=ANK 2
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128755_7849.01054.0RepeatNote=ANK 22
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128787_8179.01054.0RepeatNote=ANK 23
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128822_8519.01054.0RepeatNote=ANK 24
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128855_8859.01054.0RepeatNote=ANK 25
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128889_9189.01054.0RepeatNote=ANK 26
HgeneANKRD28chr3:15900884chr3:15531144ENST00000399451-128925_9549.01054.0RepeatNote=ANK 27
TgeneCOLQchr3:15793257chr3:15507944ENST00000383781101796_269229.0446.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15793257chr3:15507944ENST0000038378691696_269205.0422.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15793257chr3:15507944ENST0000038378791696_269230.0447.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15793257chr3:15507944ENST00000383788101796_269239.0456.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15793257chr3:15507944ENST00000603808101796_269239.0457.0DomainNote=Collagen-like 1
TgeneCOLQchr3:15793257chr3:15507944ENST000003837811017130_133229.0446.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST00000383781101751_67229.0446.0RegionNote=PRAD
TgeneCOLQchr3:15793257chr3:15507944ENST00000383786916130_133205.0422.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST0000038378691651_67205.0422.0RegionNote=PRAD
TgeneCOLQchr3:15793257chr3:15507944ENST00000383787916130_133230.0447.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST0000038378791651_67230.0447.0RegionNote=PRAD
TgeneCOLQchr3:15793257chr3:15507944ENST000003837881017130_133239.0456.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST000003837881017235_238239.0456.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST00000383788101751_67239.0456.0RegionNote=PRAD
TgeneCOLQchr3:15793257chr3:15507944ENST000006038081017130_133239.0457.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST000006038081017235_238239.0457.0RegionHeparan sulfate proteoglycan binding
TgeneCOLQchr3:15793257chr3:15507944ENST00000603808101751_67239.0457.0RegionNote=PRAD


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>420_ANKRD28_15900884_COLQ_15531144_ranked_0.pdbANKRD281590088315900884ENST00000383785COLQchr315531144-
MDQKKRGGHKACCLLTPPPPPLFPPPFFRGGRSPLLSPDMKNLMLELETSQSPCMQGSLGSPGPPGPQGPPGLPGKTGPKGEKGELGRPG
RKGRPGPPGVPGMPGPIGWPGPEGPRGEKGDLGMMGLPGSRGPMGSKGYPGSRGEKGSRGEKGDLGPKGEKGFPGFPGMLGQKGEMGPKG
252


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ANKRD28_pLDDT.png
all structure
all structure
COLQ_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANKRD28
COLQ


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ANKRD28-COLQ


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANKRD28-COLQ


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource