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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANKRD33B-NIPBL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANKRD33B-NIPBL
FusionPDB ID: 4704
FusionGDB2.0 ID: 4704
HgeneTgene
Gene symbol

ANKRD33B

NIPBL

Gene ID

651746

25836

Gene nameankyrin repeat domain 33BNIPBL cohesin loading factor
Synonyms-CDLS|CDLS1|IDN3|IDN3-B|Scc2
Cytomap

5p15.2

5p13.2

Type of geneprotein-codingprotein-coding
Descriptionankyrin repeat domain-containing protein 33BAnkyrin repeat domain-containing protein LOC651746nipped-B-like proteinNipped-B homologSCC2 homologdelanginsister chromatid cohesion 2 homolog
Modification date2020031320200313
UniProtAcc

A6NCL7

Q6KC79

Ensembl transtripts involved in fusion geneENST idsENST00000296657, ENST00000504430, 
ENST00000448238, ENST00000282516, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 3 X 6=1628 X 11 X 5=440
# samples 129
** MAII scorelog2(12/162*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/440*10)=-2.28950661719499
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANKRD33B [Title/Abstract] AND NIPBL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANKRD33B(10564945)-NIPBL(37058993), # samples:3
Anticipated loss of major functional domain due to fusion event.ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ANKRD33B-NIPBL seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNIPBL

GO:0000122

negative regulation of transcription by RNA polymerase II

18854353

TgeneNIPBL

GO:0031065

positive regulation of histone deacetylation

18854353

TgeneNIPBL

GO:0045892

negative regulation of transcription, DNA-templated

18854353

TgeneNIPBL

GO:0071921

cohesin loading

22628566


check buttonFusion gene breakpoints across ANKRD33B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NIPBL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4KIRPTCGA-B9-A5W9-01AANKRD33Bchr5

10564945

-NIPBLchr5

37058993

+
ChimerDB4KIRPTCGA-B9-A5W9-01AANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37058992

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37058993

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37063891

+
ChimerDB4KIRPTCGA-B9-A5W9ANKRD33Bchr5

10564945

+NIPBLchr5

37063892

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537058993+289236601370456
ENST00000296657ANKRD33Bchr510564945+ENST00000448238NIPBLchr537058993+121736601049349
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537058992+289236601370456
ENST00000296657ANKRD33Bchr510564945+ENST00000448238NIPBLchr537058992+121736601049349
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537063891+24423660920306
ENST00000296657ANKRD33Bchr510564945+ENST00000282516NIPBLchr537063892+24423660920306

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537058993+0.0007480650.9992519
ENST00000296657ENST00000448238ANKRD33Bchr510564945+NIPBLchr537058993+0.0038801760.99611986
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537058992+0.0007480650.9992519
ENST00000296657ENST00000448238ANKRD33Bchr510564945+NIPBLchr537058992+0.0038801760.99611986
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537063891+0.000616580.99938345
ENST00000296657ENST00000282516ANKRD33Bchr510564945+NIPBLchr537063892+0.000616580.99938345

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4704_4704_1_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058992_ENST00000282516_length(amino acids)=456AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY
LDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVM
DVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAA

--------------------------------------------------------------

>4704_4704_2_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058992_ENST00000448238_length(amino acids)=349AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY

--------------------------------------------------------------

>4704_4704_3_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058993_ENST00000282516_length(amino acids)=456AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY
LDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVM
DVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAA

--------------------------------------------------------------

>4704_4704_4_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37058993_ENST00000448238_length(amino acids)=349AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY

--------------------------------------------------------------

>4704_4704_5_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37063891_ENST00000282516_length(amino acids)=306AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRG
GGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKE

--------------------------------------------------------------

>4704_4704_6_ANKRD33B-NIPBL_ANKRD33B_chr5_10564945_ENST00000296657_NIPBL_chr5_37063892_ENST00000282516_length(amino acids)=306AA_BP=122
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRG
GGTSGSLRRSKRNSDSTELAAQMNESVDVMDVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:10564945/chr5:37058993)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANKRD33B

A6NCL7

NIPBL

Q6KC79

FUNCTION: Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity). {ECO:0000250|UniProtKB:Q6KCD5, ECO:0000269|PubMed:22628566, ECO:0000269|PubMed:28167679, ECO:0000269|PubMed:28914604}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+1419_25122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+1419_25122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+1419_25122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+1419_25122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+1484_113122.0495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+1484_113122.0495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+1484_113122.0495.0RepeatNote=ANK 1
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+1484_113122.0495.0RepeatNote=ANK 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14459_488122.0495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14459_488122.0495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14459_488122.0495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14459_488122.0495.0Coiled coilOntology_term=ECO:0000255
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14264_267122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14264_267122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14264_267122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14264_267122.0495.0Compositional biasNote=Poly-Pro
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14120_150122.0495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14154_183122.0495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14189_218122.0495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37058992ENST00000296657+14223_255122.0495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14120_150122.0495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14154_183122.0495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14189_218122.0495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37058993ENST00000296657+14223_255122.0495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14120_150122.0495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14154_183122.0495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14189_218122.0495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37063891ENST00000296657+14223_255122.0495.0RepeatNote=ANK 5
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14120_150122.0495.0RepeatNote=ANK 2
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14154_183122.0495.0RepeatNote=ANK 3
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14189_218122.0495.0RepeatNote=ANK 4
HgeneANKRD33Bchr5:10564945chr5:37063892ENST00000296657+14223_255122.0495.0RepeatNote=ANK 5
TgeneNIPBLchr5:10564945chr5:37058992ENST000002825164247418_4622470.02805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058992ENST000004482384246418_4622470.02698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058993ENST000002825164247418_4622470.02805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058993ENST000004482384246418_4622470.02698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063891ENST000002825164447418_4622620.02805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063891ENST000004482384446418_4622620.02698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063892ENST000002825164447418_4622620.02805.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37063892ENST000004482384446418_4622620.02698.0Compositional biasNote=Gln-rich
TgeneNIPBLchr5:10564945chr5:37058992ENST000002825164247996_10092470.02805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058992ENST000004482384246996_10092470.02698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058993ENST000002825164247996_10092470.02805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058993ENST000004482384246996_10092470.02698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063891ENST000002825164447996_10092620.02805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063891ENST000004482384446996_10092620.02698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063892ENST000002825164447996_10092620.02805.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37063892ENST000004482384446996_10092620.02698.0MotifPxVxL motif
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642471767_18052470.02805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642471843_18812470.02805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642471945_19842470.02805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642472227_22672470.02805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058992ENST0000028251642472313_23512470.02805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842461767_18052470.02698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842461843_18812470.02698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842461945_19842470.02698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842462227_22672470.02698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058992ENST0000044823842462313_23512470.02698.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642471767_18052470.02805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642471843_18812470.02805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642471945_19842470.02805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642472227_22672470.02805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058993ENST0000028251642472313_23512470.02805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842461767_18052470.02698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842461843_18812470.02698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842461945_19842470.02698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842462227_22672470.02698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37058993ENST0000044823842462313_23512470.02698.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644471767_18052620.02805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644471843_18812620.02805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644471945_19842620.02805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644472227_22672620.02805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063891ENST0000028251644472313_23512620.02805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844461767_18052620.02698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844461843_18812620.02698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844461945_19842620.02698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844462227_22672620.02698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063891ENST0000044823844462313_23512620.02698.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644471767_18052620.02805.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644471843_18812620.02805.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644471945_19842620.02805.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644472227_22672620.02805.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063892ENST0000028251644472313_23512620.02805.0RepeatNote=HEAT 5
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844461767_18052620.02698.0RepeatNote=HEAT 1
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844461843_18812620.02698.0RepeatNote=HEAT 2
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844461945_19842620.02698.0RepeatNote=HEAT 3
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844462227_22672620.02698.0RepeatNote=HEAT 4
TgeneNIPBLchr5:10564945chr5:37063892ENST0000044823844462313_23512620.02698.0RepeatNote=HEAT 5


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>953_ANKRD33B_10564945_NIPBL_37058993_953_ANKRD33B_10564945_NIPBL_37058993_ranked_0.pdbANKRD33B1056494510564945ENST00000282516NIPBLchr537058993+
MVLLAGTGPEGGGARCMTPPPPSPPRGAQVEEDPADYEEFEDFSSLPDTRSIASDDSFYPFEDEEEHGVESAESVPEGVPESVPETATLL
RAACANNVGLLRTLVRRGVSVEEAQETDRNGRSMVKDKRKERKSSPSKENESSDSEEEVSRPRKSRKRVDSDSDSDSEDDINSVMKCLPE
NSAPLIEFANVSQGILLLLMLKQHLKNLCGFSDSKIQKYSPSESAKVYDKAINRKTGVHFHPKQTLDFLRSDMANSKITEEVKRSIVKQY
LDFKLLMEHLDPDEEEEEGEVSASTNARNKAITSLLGGGSPKNNTAAETEDDESDGEDRGGGTSGSLRRSKRNSDSTELAAQMNESVDVM
DVIAICCPKYKDRPQIARVVQKTSSGFSVQWMAGSYSGSWTEAKRRDGRKLVPWVDTIKESDIIYKKIALTSANKLTNKVVQTLRSLYAA
456


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
ANKRD33B_pLDDT.png
all structure
all structure
NIPBL_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANKRD33B
NIPBL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ANKRD33B-NIPBL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANKRD33B-NIPBL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource