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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ANO1-CDC42BPG

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ANO1-CDC42BPG
FusionPDB ID: 4847
FusionGDB2.0 ID: 4847
HgeneTgene
Gene symbol

ANO1

CDC42BPG

Gene ID

55107

55561

Gene nameanoctamin 1CDC42 binding protein kinase gamma
SynonymsDOG1|ORAOV2|TAOS2|TMEM16ADMPK2|HSMDPKIN|KAPPA-200|MRCKG|MRCKgamma
Cytomap

11q13.3

11q13.1

Type of geneprotein-codingprotein-coding
Descriptionanoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spanninserine/threonine-protein kinase MRCK gammaCDC42 binding protein kinase gamma (DMPK-like)DMPK-like gammaMRCK gammamyotonic dystrophy kinase-related CDC42-binding kinase gammamyotonic dystrophy protein kinase like proteinmyotonic dystrophy protein kin
Modification date2020031320200313
UniProtAcc

Q9NW15

Q6DT37

Ensembl transtripts involved in fusion geneENST idsENST00000316296, ENST00000355303, 
ENST00000398543, ENST00000530676, 
ENST00000538023, ENST00000525494, 
ENST00000531349, 		ENST00000491280, 
ENST00000342711, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score20 X 18 X 9=32405 X 5 X 5=125
# samples 205
** MAII scorelog2(20/3240*10)=-4.01792190799726
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ANO1 [Title/Abstract] AND CDC42BPG [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ANO1(69951894)-CDC42BPG(64606374), # samples:1
Anticipated loss of major functional domain due to fusion event.ANO1-CDC42BPG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANO1-CDC42BPG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ANO1-CDC42BPG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ANO1-CDC42BPG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneANO1

GO:0006812

cation transport

22946059

TgeneCDC42BPG

GO:0006468

protein phosphorylation

15194684


check buttonFusion gene breakpoints across ANO1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDC42BPG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4TGCTTCGA-2G-AAGP-01AANO1chr11

69951894

-CDC42BPGchr11

64606374

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355303ANO1chr1169951894-ENST00000342711CDC42BPGchr1164606374-5918105222148311536
ENST00000398543ANO1chr1169951894-ENST00000342711CDC42BPGchr1164606374-56627964945751508
ENST00000538023ANO1chr1169951894-ENST00000342711CDC42BPGchr1164606374-56627964945751508
ENST00000316296ANO1chr1169951894-ENST00000342711CDC42BPGchr1164606374-563476810545471480
ENST00000530676ANO1chr1169951894-ENST00000342711CDC42BPGchr1164606374-575488824946671472

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355303ENST00000342711ANO1chr1169951894-CDC42BPGchr1164606374-0.0049332320.99506676
ENST00000398543ENST00000342711ANO1chr1169951894-CDC42BPGchr1164606374-0.0037838110.99621624
ENST00000538023ENST00000342711ANO1chr1169951894-CDC42BPGchr1164606374-0.0037838110.99621624
ENST00000316296ENST00000342711ANO1chr1169951894-CDC42BPGchr1164606374-0.0040742060.9959258
ENST00000530676ENST00000342711ANO1chr1169951894-CDC42BPGchr1164606374-0.005776660.9942233

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>4847_4847_1_ANO1-CDC42BPG_ANO1_chr11_69951894_ENST00000316296_CDC42BPG_chr11_64606374_ENST00000342711_length(amino acids)=1480AA_BP=221
MLTRPSQVLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMD
YHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPK
VAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVD
WERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSR
KHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEE
LLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRK
EVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQAL
ATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQEL
AMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTL
RPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFA
ALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVL
GELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGR
GPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVG
AAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTV
FSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQ
QRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWT

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>4847_4847_2_ANO1-CDC42BPG_ANO1_chr11_69951894_ENST00000355303_CDC42BPG_chr11_64606374_ENST00000342711_length(amino acids)=1536AA_BP=277
MRSPPAEAAGAVDGEGAPPGGPSAQAATMRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKV
DYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHG
VGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFD
SKTRSTIDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHP
GTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLR
DKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQR
ELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRL
SREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQ
KMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDS
AKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYF
CHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQ
FSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHT
LCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAG
SILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGG
LGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSL
FLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGR
PGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVSCPQGSLSPATSLMQVSERPRSLPLSP

--------------------------------------------------------------

>4847_4847_3_ANO1-CDC42BPG_ANO1_chr11_69951894_ENST00000398543_CDC42BPG_chr11_64606374_ENST00000342711_length(amino acids)=1508AA_BP=249
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPS
GARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIDHLQFPPDVPDVPASAQDLIR
QLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSH
SPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDR
LHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESS
QAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRET
ESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERL
TQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLR
MGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPE
TGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTS
QLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSND
IFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPG
PWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDG
AGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDL
TDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSF

--------------------------------------------------------------

>4847_4847_4_ANO1-CDC42BPG_ANO1_chr11_69951894_ENST00000530676_CDC42BPG_chr11_64606374_ENST00000342711_length(amino acids)=1472AA_BP=213
MLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRF
RREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQT
MKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIDHLQFPPDVPDVPASAQDLIRQLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASST
APYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSHSPESSSEAWAALERKLQCLEQEKVELSRKHQEALHA
PTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDRLHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEA
QEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESSQAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQ
LEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRETESNWEAQLADILSWVNDEKVSRGYLQALATKMAEEL
ESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERLTQVQEAQLQAERRLQEAEKQSQALQQELAMLREELR
ARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLRMGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSP
TKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPETGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLL
LFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTSQLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLL
DARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSNDIFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFA
LAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPGPWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALY
PLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDGAGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDV
FDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDLTDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKD
PFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSFSEALRRPASMGSEGLGGDADPMKRKPWTSLSSESVS

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>4847_4847_5_ANO1-CDC42BPG_ANO1_chr11_69951894_ENST00000538023_CDC42BPG_chr11_64606374_ENST00000342711_length(amino acids)=1508AA_BP=249
MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPS
GARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK
MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIDHLQFPPDVPDVPASAQDLIR
QLLCRQEERLGRGGLDDFRNHPFFEGVDWERLASSTAPYIPELRGPMDTSNFDVDDDTLNHPGTLPPPSHGAFSGHHLPFVGFTYTSGSH
SPESSSEAWAALERKLQCLEQEKVELSRKHQEALHAPTDHRELEQLRKEVQTLRDRLPEMLRDKASLSQTDGPPAGSPGQDSDLRQELDR
LHRELAEGRAGLQAQEQELCRAQGQQEELLQRLQEAQEREAATASQTRALSSQLEEARAAQRELEAQVSSLSRQVTQLQGQWEQRLEESS
QAKTIHTASETNGMGPPEGGPQEAQLRKEVAALREQLEQAHSHRPSGKEEALCQLQEENRRLSREQERLEAELAQEQESKQRLEGERRET
ESNWEAQLADILSWVNDEKVSRGYLQALATKMAEELESLRNVGTQTLPARPLDHQWKARRLQKMEASARLELQSALEAEIRAKQGLQERL
TQVQEAQLQAERRLQEAEKQSQALQQELAMLREELRARGPVDTKPSNSLIPFLSFRSSEKDSAKDPGISGEATRHGGEPDLRPEGRRSLR
MGAVFPRAPTANTASTEGLPAKPGSHTLRPRSFPSPTKCLRCTSLMLGLGRQGLGCDACGYFCHTTCAPQAPPCPVPPDLLRTALGVHPE
TGTGTAYEGFLSVPRPSGVRRGWQRVFAALSDSRLLLFDAPDLRLSPPSGALLQVLDLRDPQFSATPVLASDVIHAQSRDLPRIFRVTTS
QLAVPPTTCTVLLLAESEGERERWLQVLGELQRLLLDARPRPRPVYTLKEAYDNGLPLLPHTLCAAILDQDRLALGTEEGLFVIHLRSND
IFQVGECRRVQQLTLSPSAGLLVVLCGRGPSVRLFALAELENIEVAGAKIPESRGCQVLAAGSILQARTPVLCVAVKRQVLCYQLGPGPG
PWQRRIRELQAPATVQSLGLLGDRLCVGAAGGFALYPLLNEAAPLALGAGLVPEELPPSRGGLGEALGAVELSLSEFLLLFTTAGIYVDG
AGRKSRGHELLWPAAPMGWGYAAPYLTVFSENSIDVFDVRRAEWVQTVPLKKVRPLNPEGSLFLYGTEKVRLTYLRNQLAEKDEFDIPDL
TDNSRRQLFRTKSKRRFFFRVSEEQQKQQRREMLKDPFVRSKLISPPTNFNHLVHVGPANGRPGARDKSPAPEEKGRVARGSGPQRPHSF

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:69951894/chr11:64606374)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ANO1

Q9NW15

CDC42BPG

Q6DT37

FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}.FUNCTION: May act as a downstream effector of CDC42 in cytoskeletal reorganization. Contributes to the actomyosin contractility required for cell invasion, through the regulation of MYPT1 and thus MLC2 phosphorylation (By similarity). {ECO:0000250|UniProtKB:Q5VT25, ECO:0000269|PubMed:15194684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDC42BPGchr11:69951894chr11:64606374ENST00000342711637406_678292.01552.0Coiled coilOntology_term=ECO:0000255
TgeneCDC42BPGchr11:69951894chr11:64606374ENST00000342711637730_802292.01552.0Coiled coilOntology_term=ECO:0000255
TgeneCDC42BPGchr11:69951894chr11:64606374ENST000003427116371092_1366292.01552.0DomainCNH
TgeneCDC42BPGchr11:69951894chr11:64606374ENST000003427116371437_1450292.01552.0DomainCRIB
TgeneCDC42BPGchr11:69951894chr11:64606374ENST00000342711637338_408292.01552.0DomainAGC-kinase C-terminal
TgeneCDC42BPGchr11:69951894chr11:64606374ENST00000342711637947_1066292.01552.0DomainPH
TgeneCDC42BPGchr11:69951894chr11:64606374ENST00000342711637878_927292.01552.0Zinc fingerPhorbol-ester/DAG-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-5171_333221.0643.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517355_406221.0643.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517428_519221.0643.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517541_568221.0643.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517590_607221.0643.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517629_657221.0643.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517679_725221.0643.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517768_784221.0643.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517806_892221.0643.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517914_986221.0643.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-5261_333249.0987.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526355_406249.0987.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526428_519249.0987.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526541_568249.0987.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526590_607249.0987.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526629_657249.0987.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526679_725249.0987.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526768_784249.0987.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526806_892249.0987.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526914_986249.0987.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-5241_333133.0841.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524355_406133.0841.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524428_519133.0841.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524541_568133.0841.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524590_607133.0841.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524629_657133.0841.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524679_725133.0841.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524768_784133.0841.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524806_892133.0841.0Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524914_986133.0841.0Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-5251_333133.0819.3333333333334Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525355_406133.0819.3333333333334Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525428_519133.0819.3333333333334Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525541_568133.0819.3333333333334Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525590_607133.0819.3333333333334Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525629_657133.0819.3333333333334Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525679_725133.0819.3333333333334Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525768_784133.0819.3333333333334Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525806_892133.0819.3333333333334Topological domainExtracellular
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525914_986133.0819.3333333333334Topological domainCytoplasmic
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517334_354221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517407_427221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517520_540221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517569_589221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517608_628221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517658_678221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517726_746221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517747_767221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517785_805221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000316296-517893_913221.0643.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526334_354249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526407_427249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526520_540249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526569_589249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526608_628249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526658_678249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526726_746249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526747_767249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526785_805249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000355303-526893_913249.0987.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524334_354133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524407_427133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524520_540133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524569_589133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524608_628133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524658_678133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524726_746133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524747_767133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524785_805133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000398543-524893_913133.0841.0TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525334_354133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525407_427133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525520_540133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525569_589133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525608_628133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525658_678133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525726_746133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525747_767133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525785_805133.0819.3333333333334TransmembraneHelical
HgeneANO1chr11:69951894chr11:64606374ENST00000530676-525893_913133.0819.3333333333334TransmembraneHelical
TgeneCDC42BPGchr11:69951894chr11:64606374ENST0000034271163771_337292.01552.0DomainProtein kinase
TgeneCDC42BPGchr11:69951894chr11:64606374ENST0000034271163777_85292.01552.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ANO1
CDC42BPG


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ANO1-CDC42BPG


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ANO1-CDC42BPG


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource