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Fusion Protein:ANO1-SLC7A8 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ANO1-SLC7A8 | FusionPDB ID: 4864 | FusionGDB2.0 ID: 4864 | Hgene | Tgene | Gene symbol | ANO1 | SLC7A8 | Gene ID | 55107 | 23428 |
| Gene name | anoctamin 1 | solute carrier family 7 member 8 | |
| Synonyms | DOG1|ORAOV2|TAOS2|TMEM16A | LAT2|LPI-PC1 | |
| Cytomap | 11q13.3 | 14q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | anoctamin-1Ca2+-activated Cl- channelanoctamin 1, calcium activated chloride channelcalcium activated chloride channeldiscovered on gastrointestinal stromal tumors protein 1oral cancer overexpressed 2transmembrane protein 16A (eight membrane-spannin | large neutral amino acids transporter small subunit 2L-type amino acid transporter 2integral membrane protein E16Hsolute carrier family 7 (amino acid transporter light chain, L system), member 8solute carrier family 7 (amino acid transporter, L-type), | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | Q9NW15 | Q9UHI5 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000525494, ENST00000355303, ENST00000398543, ENST00000530676, ENST00000531349, ENST00000538023, ENST00000316296, | ENST00000316902, ENST00000469263, ENST00000422941, ENST00000453702, ENST00000529705, ENST00000532568, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 20 X 18 X 9=3240 | 4 X 4 X 4=64 |
| # samples | 20 | 4 | |
| ** MAII score | log2(20/3240*10)=-4.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ANO1 [Title/Abstract] AND SLC7A8 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ANO1(70017145)-SLC7A8(23635749), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ANO1 | GO:0006812 | cation transport | 22946059 |
| Tgene | SLC7A8 | GO:0006865 | amino acid transport | 10391915|10574970|15918515 |
| Fusion gene breakpoints across ANO1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across SLC7A8 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUSC | TCGA-68-A59J-01A | ANO1 | chr11 | 70017145 | - | SLC7A8 | chr14 | 23635749 | - |
| ChimerDB4 | LUSC | TCGA-68-A59J-01A | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - |
| ChimerDB4 | LUSC | TCGA-68-A59J | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000355303 | ANO1 | chr11 | 70017145 | + | ENST00000316902 | SLC7A8 | chr14 | 23635749 | - | 5994 | 2655 | 221 | 4111 | 1296 |
| ENST00000355303 | ANO1 | chr11 | 70017145 | + | ENST00000469263 | SLC7A8 | chr14 | 23635749 | - | 5334 | 2655 | 221 | 3373 | 1050 |
| ENST00000398543 | ANO1 | chr11 | 70017145 | + | ENST00000316902 | SLC7A8 | chr14 | 23635749 | - | 5648 | 2309 | 49 | 3765 | 1238 |
| ENST00000398543 | ANO1 | chr11 | 70017145 | + | ENST00000469263 | SLC7A8 | chr14 | 23635749 | - | 4988 | 2309 | 49 | 3027 | 992 |
| ENST00000538023 | ANO1 | chr11 | 70017145 | + | ENST00000316902 | SLC7A8 | chr14 | 23635749 | - | 5738 | 2399 | 49 | 3855 | 1268 |
| ENST00000538023 | ANO1 | chr11 | 70017145 | + | ENST00000469263 | SLC7A8 | chr14 | 23635749 | - | 5078 | 2399 | 49 | 3117 | 1022 |
| ENST00000530676 | ANO1 | chr11 | 70017145 | + | ENST00000316902 | SLC7A8 | chr14 | 23635749 | - | 5740 | 2401 | 249 | 3857 | 1202 |
| ENST00000530676 | ANO1 | chr11 | 70017145 | + | ENST00000469263 | SLC7A8 | chr14 | 23635749 | - | 5080 | 2401 | 249 | 3119 | 956 |
| ENST00000531349 | ANO1 | chr11 | 70017145 | + | ENST00000316902 | SLC7A8 | chr14 | 23635749 | - | 5032 | 1693 | 180 | 3149 | 989 |
| ENST00000531349 | ANO1 | chr11 | 70017145 | + | ENST00000469263 | SLC7A8 | chr14 | 23635749 | - | 4372 | 1693 | 180 | 2411 | 743 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000355303 | ENST00000316902 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.000580131 | 0.9994199 |
| ENST00000355303 | ENST00000469263 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.001910242 | 0.99808973 |
| ENST00000398543 | ENST00000316902 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.000723177 | 0.9992768 |
| ENST00000398543 | ENST00000469263 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.00061543 | 0.9993845 |
| ENST00000538023 | ENST00000316902 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.000370789 | 0.99962914 |
| ENST00000538023 | ENST00000469263 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.001285925 | 0.9987141 |
| ENST00000530676 | ENST00000316902 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.001234778 | 0.99876523 |
| ENST00000530676 | ENST00000469263 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.002308079 | 0.997692 |
| ENST00000531349 | ENST00000316902 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.000509756 | 0.99949026 |
| ENST00000531349 | ENST00000469263 | ANO1 | chr11 | 70017145 | + | SLC7A8 | chr14 | 23635749 | - | 0.001747985 | 0.998252 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >4864_4864_1_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000355303_SLC7A8_chr14_23635749_ENST00000316902_length(amino acids)=1296AA_BP=811 MRSPPAEAAGAVDGEGAPPGGPSAQAATMRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKV DYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHG VGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFD SKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYF AWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAAT FMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDR FPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSF EERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRY LKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKD IGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIA LTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEP DIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMP ISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVL RWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVE -------------------------------------------------------------- >4864_4864_2_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000355303_SLC7A8_chr14_23635749_ENST00000469263_length(amino acids)=1050AA_BP=811 MRSPPAEAAGAVDGEGAPPGGPSAQAATMRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKV DYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHG VGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFD SKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYF AWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAAT FMEHWKRKQMRLNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDR FPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSF EERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRY LKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKD IGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIA LTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEP -------------------------------------------------------------- >4864_4864_3_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000398543_SLC7A8_chr14_23635749_ENST00000316902_length(amino acids)=1238AA_BP=753 MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPS GARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITS LLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEDHP RAEYEARVLEKSLKKESRNKETDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVI INLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAP LFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDY SYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLA LALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAY VTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLL MLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGV -------------------------------------------------------------- >4864_4864_4_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000398543_SLC7A8_chr14_23635749_ENST00000469263_length(amino acids)=992AA_BP=753 MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPS GARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITS LLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEDHP RAEYEARVLEKSLKKESRNKETDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVI INLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMEL CIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAP LFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDY SYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLA LALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKAANPGEPEDVCGRVPRGGAGLRDR -------------------------------------------------------------- >4864_4864_5_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000530676_SLC7A8_chr14_23635749_ENST00000316902_length(amino acids)=1202AA_BP=717 MLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRF RREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQT MKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWA RYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACA TARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEDHPRAEYEARVLEKSLKKESRNKETDKVKLTWRDRFPAY LTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERL IFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLK QQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNI IGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS NYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGL VALAFLQGSFAYGGWNFLNYVTEELVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVA LSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKK PDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSG -------------------------------------------------------------- >4864_4864_6_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000530676_SLC7A8_chr14_23635749_ENST00000469263_length(amino acids)=956AA_BP=717 MLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPSGARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRF RREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKKMYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQT MKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWA RYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACA TARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEDHPRAEYEARVLEKSLKKESRNKETDKVKLTWRDRFPAY LTNLVSIIFMIAVTFAIVLGVIIYRISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERL IFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLK QQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNI IGSGIFVSPKGVLENAGSVGLALIVWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFS NYVLQPLFPTCFPPESGLRLLAAICLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGL -------------------------------------------------------------- >4864_4864_7_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000531349_SLC7A8_chr14_23635749_ENST00000316902_length(amino acids)=989AA_BP=504 MKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLI PASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMR LNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKETDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALA MNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDY VYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEY MEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFIT VVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVN CSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKNLP RAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGAREGHLPSVLAM IHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFLLVFSLWSEP -------------------------------------------------------------- >4864_4864_8_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000531349_SLC7A8_chr14_23635749_ENST00000469263_length(amino acids)=743AA_BP=504 MKRTTCTKAKYSMGITSLLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLI PASIVGIIVFLYGCATMDENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMR LNYRWDLTGFEEEEEAVKDHPRAEYEARVLEKSLKKESRNKETDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIYRISMAAALA MNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKGRFVGRPGDY VYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLEPFAGLTPEY MEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNIIGSGIFVSPKGVLENAGSVGLALIVWIVTGFIT VVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAICLLLLTWVN CSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEELVDPYKAAN -------------------------------------------------------------- >4864_4864_9_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000538023_SLC7A8_chr14_23635749_ENST00000316902_length(amino acids)=1268AA_BP=783 MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPS GARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITS LLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEKAL LDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKG RFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNIIGSGIFVSPKGVLENAGSVGLALI VWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAI CLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEE LVDPYKNLPRAIFISIPLVTFVYVFANVAYVTAMSPQELLASNAVAVTFGEKLLGVMAWIMPISVALSTFGGVNGSLFTSSRLFFAGARE GHLPSVLAMIHVKRCTPIPALLFTCISTLLMLVTSDMYTLINYVGFINYLFYGVTVAGQIVLRWKKPDIPRPIKINLLFPIIYLLFWAFL LVFSLWSEPVVCGIGLAIMLTGVPVYFLGVYWQHKPKCFSDFIELLTLVSQKMCVVVYPEVERGSGTEEANEDMEEQQQPMYQPTPTKDK -------------------------------------------------------------- >4864_4864_10_ANO1-SLC7A8_ANO1_chr11_70017145_ENST00000538023_SLC7A8_chr14_23635749_ENST00000469263_length(amino acids)=1022AA_BP=783 MRVNEKYSTLPAEDRSVHIINICAIEDIGYLPSEGTLLNSLSVDPDAECKYGLYFRDGRRKVDYILVYHHKRPSGNRTLVRRVQHSDTPS GARSVKQDHPLPGKGASLDAGSGEPPMDYHEDDKRFRREEYEGNLLEAGLELERDEDTKIHGVGFVKIHAPWNVLCREAEFLKLKMPTKK MYHINETRGLLKKINSVLQKITDPIQPKVAEHRPQTMKRLSYPFSREKQHLFDLSDKDSFFDSKTRSTIVYEILKRTTCTKAKYSMGITS LLANGVYAAAYPLHDGDYNGENVEFNDRKLLYEEWARYGVFYKYQPIDLVRKYFGEKIGLYFAWLGVYTQMLIPASIVGIIVFLYGCATM DENIPSMEMCDQRHNITMCPLCDKTCSYWKMSSACATARASHLFDNPATVFFSVFMALWAATFMEHWKRKQMRLNYRWDLTGFEEEEKAL LDHPRAEYEARVLEKSLKKESRNKEKRRHIPEESTNKWKQRVKTAMAGVKLTDKVKLTWRDRFPAYLTNLVSIIFMIAVTFAIVLGVIIY RISMAAALAMNSSPSVRSNIRVTVTATAVIINLVVIILLDEVYGCIARWLTKIEVPKTEKSFEERLIFKAFLLKFVNSYTPIFYVAFFKG RFVGRPGDYVYIFRSFRMEECAPGGCLMELCIQLSIIMLGKQLIQNNLFEIGIPKMKKLIRYLKLKQQSPPDHEECVKRKQRYEVDYNLE PFAGLTPEYMEMIIQFGFVTLFVASFPLAPLFALLNNIIEIRLDAKKFVTELRRPVAVRAKDIGNIIGSGIFVSPKGVLENAGSVGLALI VWIVTGFITVVGALCYAELGVTIPKSGGDYSYVKDIFGGLAGFLRLWIAVLVIYPTNQAVIALTFSNYVLQPLFPTCFPPESGLRLLAAI CLLLLTWVNCSSVRWATRVQDIFTAGKLLALALIIIMGIVQICKGEYFWLEPKNAFENFQEPDIGLVALAFLQGSFAYGGWNFLNYVTEE -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:70017145/chr14:23635749) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ANO1 | SLC7A8 |
| FUNCTION: Does not exhibit calcium-activated chloride channel (CaCC) activity. Can inhibit the activity of ANO1. {ECO:0000269|PubMed:20056604, ECO:0000269|PubMed:22946059}. | FUNCTION: Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine or D,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney. {ECO:0000269|PubMed:10391915, ECO:0000269|PubMed:10574970, ECO:0000269|PubMed:11311135, ECO:0000269|PubMed:12117417, ECO:0000269|PubMed:12716892, ECO:0000269|PubMed:15081149, ECO:0000269|PubMed:15769744, ECO:0000269|PubMed:15918515}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 1_333 | 783.3333333333334 | 987.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 355_406 | 783.3333333333334 | 987.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 428_519 | 783.3333333333334 | 987.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 541_568 | 783.3333333333334 | 987.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 590_607 | 783.3333333333334 | 987.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 629_657 | 783.3333333333334 | 987.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 679_725 | 783.3333333333334 | 987.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 768_784 | 783.3333333333334 | 987.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 1_333 | 637.3333333333334 | 841.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 355_406 | 637.3333333333334 | 841.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 428_519 | 637.3333333333334 | 841.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 541_568 | 637.3333333333334 | 841.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 590_607 | 637.3333333333334 | 841.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 1_333 | 637.3333333333334 | 819.3333333333334 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 355_406 | 637.3333333333334 | 819.3333333333334 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 428_519 | 637.3333333333334 | 819.3333333333334 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 541_568 | 637.3333333333334 | 819.3333333333334 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 590_607 | 637.3333333333334 | 819.3333333333334 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 334_354 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 407_427 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 520_540 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 569_589 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 608_628 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 658_678 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 726_746 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 747_767 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 334_354 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 407_427 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 520_540 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 569_589 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 608_628 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 334_354 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 407_427 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 520_540 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 569_589 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 608_628 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 113_133 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 155_175 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 189_209 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 231_251 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 268_288 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 310_330 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 362_382 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 388_408 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 424_444 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 447_467 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 72_92 | 50.333333333333336 | 536.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 113_133 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 155_175 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 189_209 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 231_251 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 268_288 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 310_330 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 362_382 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 388_408 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 40_60 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 424_444 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 447_467 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000422941 | 0 | 8 | 72_92 | 0 | 312.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 113_133 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 155_175 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 189_209 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 231_251 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 268_288 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 310_330 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 362_382 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 388_408 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 40_60 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 424_444 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 447_467 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000453702 | 0 | 9 | 72_92 | 0 | 333.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 113_133 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 155_175 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 189_209 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 231_251 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 268_288 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 310_330 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 362_382 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 388_408 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 40_60 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 424_444 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 447_467 | 0 | 431.0 | Transmembrane | Helical | |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000529705 | 0 | 9 | 72_92 | 0 | 431.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 1_333 | 0 | 643.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 355_406 | 0 | 643.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 428_519 | 0 | 643.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 541_568 | 0 | 643.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 590_607 | 0 | 643.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 629_657 | 0 | 643.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 679_725 | 0 | 643.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 768_784 | 0 | 643.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 806_892 | 0 | 643.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 914_986 | 0 | 643.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 806_892 | 783.3333333333334 | 987.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 914_986 | 783.3333333333334 | 987.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 629_657 | 637.3333333333334 | 841.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 679_725 | 637.3333333333334 | 841.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 768_784 | 637.3333333333334 | 841.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 806_892 | 637.3333333333334 | 841.0 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 914_986 | 637.3333333333334 | 841.0 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 629_657 | 637.3333333333334 | 819.3333333333334 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 679_725 | 637.3333333333334 | 819.3333333333334 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 768_784 | 637.3333333333334 | 819.3333333333334 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 806_892 | 637.3333333333334 | 819.3333333333334 | Topological domain | Extracellular |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 914_986 | 637.3333333333334 | 819.3333333333334 | Topological domain | Cytoplasmic |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 334_354 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 407_427 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 520_540 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 569_589 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 608_628 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 658_678 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 726_746 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 747_767 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 785_805 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000316296 | + | 1 | 17 | 893_913 | 0 | 643.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 785_805 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000355303 | + | 22 | 26 | 893_913 | 783.3333333333334 | 987.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 658_678 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 726_746 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 747_767 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 785_805 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000398543 | + | 20 | 24 | 893_913 | 637.3333333333334 | 841.0 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 658_678 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 726_746 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 747_767 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 785_805 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Hgene | ANO1 | chr11:70017145 | chr14:23635749 | ENST00000530676 | + | 20 | 25 | 893_913 | 637.3333333333334 | 819.3333333333334 | Transmembrane | Helical |
| Tgene | SLC7A8 | chr11:70017145 | chr14:23635749 | ENST00000316902 | 0 | 11 | 40_60 | 50.333333333333336 | 536.0 | Transmembrane | Helical |
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Fusion Protein Structures |
| PDB and CIF files of the predicted fusion proteins * Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format. |
| Fusion protein PDB link (fusion AA seq ID in FusionPDB) | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | AA seq | Len(AA seq) |
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pLDDT score distribution |
| pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
ANO1_pLDDT.png  |
SLC7A8_pLDDT.png  |
| pLDDT score distribution of the predicted fusion protein structures from AlphaFold2 * AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. |
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Ramachandran Plot of Fusion Protein Structure |
| Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide. |
| Fusion AA seq ID in FusionPDB and their Ramachandran plots |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ANO1 | |
| SLC7A8 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to ANO1-SLC7A8 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to ANO1-SLC7A8 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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