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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABL1-NTRK2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABL1-NTRK2
FusionPDB ID: 490
FusionGDB2.0 ID: 490
HgeneTgene
Gene symbol

ABL1

NTRK2

Gene ID

25

4915

Gene nameABL proto-oncogene 1, non-receptor tyrosine kinaseneurotrophic receptor tyrosine kinase 2
SynonymsABL|BCR-ABL|CHDSKM|JTK7|bcr/abl|c-ABL|c-ABL1|p150|v-ablEIEE58|GP145-TrkB|OBHD|TRKB|trk-B
Cytomap

9q34.12

9q21.33

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase ABL1ABL protooncogene 1 nonreceptor tyrosine kinaseAbelson tyrosine-protein kinase 1bcr/c-abl oncogene proteinc-abl oncogene 1, receptor tyrosine kinaseproto-oncogene c-Ablproto-oncogene tyrosine-protein kinase ABL1truncatedBDNF/NT-3 growth factors receptorBDNF-tropomyosine receptor kinase Bneurotrophic tyrosine kinase receptor type 2tropomyosin-related kinase Btyrosine kinase receptor B
Modification date2020032720200313
UniProtAcc

P00519

Q16620

Ensembl transtripts involved in fusion geneENST idsENST00000318560, ENST00000277120, 
ENST00000304053, ENST00000323115, 
ENST00000359847, ENST00000376208, 
ENST00000376213, ENST00000376214, 
ENST00000395866, ENST00000395882, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 55 X 13=1501510 X 9 X 7=630
# samples 6810
** MAII scorelog2(68/15015*10)=-4.46472591830681
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/630*10)=-2.65535182861255
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABL1 [Title/Abstract] AND NTRK2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABL1(133710912)-NTRK2(87338487), # samples:2
Anticipated loss of major functional domain due to fusion event.ABL1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL1-NTRK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABL1

GO:0006974

cellular response to DNA damage stimulus

15657060

HgeneABL1

GO:0006975

DNA damage induced protein phosphorylation

18280240

HgeneABL1

GO:0018108

peptidyl-tyrosine phosphorylation

7590236|9144171|10713049|11121037

HgeneABL1

GO:0038083

peptidyl-tyrosine autophosphorylation

10518561

HgeneABL1

GO:0042770

signal transduction in response to DNA damage

9037071|15657060

HgeneABL1

GO:0043065

positive regulation of apoptotic process

9037071

HgeneABL1

GO:0046777

protein autophosphorylation

10713049

HgeneABL1

GO:0050731

positive regulation of peptidyl-tyrosine phosphorylation

15657060

HgeneABL1

GO:0051353

positive regulation of oxidoreductase activity

12893824

HgeneABL1

GO:0051444

negative regulation of ubiquitin-protein transferase activity

20823226

HgeneABL1

GO:0070301

cellular response to hydrogen peroxide

10713049

HgeneABL1

GO:0071103

DNA conformation change

9558345

HgeneABL1

GO:0071901

negative regulation of protein serine/threonine kinase activity

11121037

HgeneABL1

GO:1990051

activation of protein kinase C activity

10713049

HgeneABL1

GO:2001020

regulation of response to DNA damage stimulus

9461559


check buttonFusion gene breakpoints across ABL1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NTRK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EWABL1chr9

133710912

+NTRK2chr9

87338487

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000318560ABL1chr9133710912+ENST00000376214NTRK2chr987338487+45474602702393707
ENST00000318560ABL1chr9133710912+ENST00000376213NTRK2chr987338487+44994602702345691
ENST00000318560ABL1chr9133710912+ENST00000395882NTRK2chr987338487+64384602701310346
ENST00000318560ABL1chr9133710912+ENST00000304053NTRK2chr987338487+76204602701538422
ENST00000318560ABL1chr9133710912+ENST00000376208NTRK2chr987338487+75724602701490406
ENST00000318560ABL1chr9133710912+ENST00000277120NTRK2chr987338487+34514602702393707
ENST00000318560ABL1chr9133710912+ENST00000323115NTRK2chr987338487+32324602702345691
ENST00000318560ABL1chr9133710912+ENST00000359847NTRK2chr987338487+64344602701310346
ENST00000318560ABL1chr9133710912+ENST00000395866NTRK2chr987338487+17954602701310346

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000318560ENST00000376214ABL1chr9133710912+NTRK2chr987338487+0.0013605440.9986394
ENST00000318560ENST00000376213ABL1chr9133710912+NTRK2chr987338487+0.0015985280.99840146
ENST00000318560ENST00000395882ABL1chr9133710912+NTRK2chr987338487+0.0008531470.9991468
ENST00000318560ENST00000304053ABL1chr9133710912+NTRK2chr987338487+0.0006861330.99931383
ENST00000318560ENST00000376208ABL1chr9133710912+NTRK2chr987338487+0.0007339110.9992661
ENST00000318560ENST00000277120ABL1chr9133710912+NTRK2chr987338487+0.0018912090.99810874
ENST00000318560ENST00000323115ABL1chr9133710912+NTRK2chr987338487+0.002284490.9977155
ENST00000318560ENST00000359847ABL1chr9133710912+NTRK2chr987338487+0.0008154420.99918455
ENST00000318560ENST00000395866ABL1chr9133710912+NTRK2chr987338487+0.0006708470.9993292

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>490_490_1_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000277120_length(amino acids)=707AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD
DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

--------------------------------------------------------------

>490_490_2_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000304053_length(amino acids)=422AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD

--------------------------------------------------------------

>490_490_3_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000323115_length(amino acids)=691AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP
SSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA
RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH
FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNE

--------------------------------------------------------------

>490_490_4_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000359847_length(amino acids)=346AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG

--------------------------------------------------------------

>490_490_5_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376208_length(amino acids)=406AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP

--------------------------------------------------------------

>490_490_6_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376213_length(amino acids)=691AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKGPASVISNDDDSASPLHHISNGSNTP
SSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA
RKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLHIAQQIAAGMVYLASQH
FVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNE

--------------------------------------------------------------

>490_490_7_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000376214_length(amino acids)=707AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG
TAANDIGDTTNRSNEIPSTDVTDKTGREHLSVYAVVVIASVVGFCLLVMLFLLKLARHSKFGMKDFSWFGFGKVKSRQGVGPASVISNDD
DSASPLHHISNGSNTPSSSEGGPDAVIIGMTKIPVIENPQYFGITNSQLKPDTFVQHIKRHNIVLKRELGEGAFGKVFLAECYNLCPEQD
KILVAVKTLKDASDNARKDFHREAELLTNLQHEHIVKFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPTELTQSQMLH
IAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSLGVVLWE

--------------------------------------------------------------

>490_490_8_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000395866_length(amino acids)=346AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG

--------------------------------------------------------------

>490_490_9_ABL1-NTRK2_ABL1_chr9_133710912_ENST00000318560_NTRK2_chr9_87338487_ENST00000395882_length(amino acids)=346AA_BP=63
MAGPGAPGGRAGRAGPEPGPRTELGEGFRPPTCWRGKMLEICLKLVGCKSKKGLSSSSSCYLEGLPSANLAAPNLTVEEGKSITLSCSVA
GDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNP
KPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:133710912/chr9:87338487)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABL1

P00519

NTRK2

Q16620

FUNCTION: Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins). Phosphorylation of WASF3 is critical for the stimulation of lamellipodia formation and cell migration. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as BCAR1, CRK, CRKL, DOK1, EFS or NEDD9. Phosphorylates multiple receptor tyrosine kinases and more particularly promotes endocytosis of EGFR, facilitates the formation of neuromuscular synapses through MUSK, inhibits PDGFRB-mediated chemotaxis and modulates the endocytosis of activated B-cell receptor complexes. Other substrates which are involved in endocytosis regulation are the caveolin (CAV1) and RIN1. Moreover, ABL1 regulates the CBL family of ubiquitin ligases that drive receptor down-regulation and actin remodeling. Phosphorylation of CBL leads to increased EGFR stability. Involved in late-stage autophagy by regulating positively the trafficking and function of lysosomal components. ABL1 targets to mitochondria in response to oxidative stress and thereby mediates mitochondrial dysfunction and cell death. In response to oxidative stress, phosphorylates serine/threonine kinase PRKD2 at 'Tyr-717' (PubMed:28428613). ABL1 is also translocated in the nucleus where it has DNA-binding activity and is involved in DNA-damage response and apoptosis. Many substrates are known mediators of DNA repair: DDB1, DDB2, ERCC3, ERCC6, RAD9A, RAD51, RAD52 or WRN. Activates the proapoptotic pathway when the DNA damage is too severe to be repaired. Phosphorylates TP73, a primary regulator for this type of damage-induced apoptosis. Phosphorylates the caspase CASP9 on 'Tyr-153' and regulates its processing in the apoptotic response to DNA damage. Phosphorylates PSMA7 that leads to an inhibition of proteasomal activity and cell cycle transition blocks. ABL1 acts also as a regulator of multiple pathological signaling cascades during infection. Several known tyrosine-phosphorylated microbial proteins have been identified as ABL1 substrates. This is the case of A36R of Vaccinia virus, Tir (translocated intimin receptor) of pathogenic E.coli and possibly Citrobacter, CagA (cytotoxin-associated gene A) of H.pylori, or AnkA (ankyrin repeat-containing protein A) of A.phagocytophilum. Pathogens can highjack ABL1 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Regulates T-cell differentiation in a TBX21-dependent manner. Phosphorylates TBX21 on tyrosine residues leading to an enhancement of its transcriptional activator activity (By similarity). {ECO:0000250|UniProtKB:P00520, ECO:0000269|PubMed:10391250, ECO:0000269|PubMed:11971963, ECO:0000269|PubMed:12379650, ECO:0000269|PubMed:12531427, ECO:0000269|PubMed:12672821, ECO:0000269|PubMed:15031292, ECO:0000269|PubMed:15556646, ECO:0000269|PubMed:15657060, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16424036, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:16943190, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:17623672, ECO:0000269|PubMed:18328268, ECO:0000269|PubMed:18945674, ECO:0000269|PubMed:19891780, ECO:0000269|PubMed:20357770, ECO:0000269|PubMed:20417104, ECO:0000269|PubMed:28428613, ECO:0000269|PubMed:9037071, ECO:0000269|PubMed:9144171, ECO:0000269|PubMed:9461559}.FUNCTION: Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity). Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:7574684, PubMed:15494731). Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731). Recruits, phosphorylates and/or activates several downstream effectors including SHC1, FRS2, SH2B1, SH2B2 and PLCG1 that regulate distinct overlapping signaling cascades. Through SHC1, FRS2, SH2B1, SH2B2 activates the GRB2-Ras-MAPK cascade that regulates for instance neuronal differentiation including neurite outgrowth. Through the same effectors controls the Ras-PI3 kinase-AKT1 signaling cascade that mainly regulates growth and survival. Through PLCG1 and the downstream protein kinase C-regulated pathways controls synaptic plasticity. Thereby, plays a role in learning and memory by regulating both short term synaptic function and long-term potentiation. PLCG1 also leads to NF-Kappa-B activation and the transcription of genes involved in cell survival. Hence, it is able to suppress anoikis, the apoptosis resulting from loss of cell-matrix interactions. May also play a role in neutrophin-dependent calcium signaling in glial cells and mediate communication between neurons and glia. {ECO:0000250|UniProtKB:P15209, ECO:0000269|PubMed:15494731, ECO:0000269|PubMed:7574684}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+11118_2226.3333333333333321131.0Compositional biasNote=Poly-Ser
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519197_282194.33333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519295_365194.33333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519538_807194.33333333333334839.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515197_282194.33333333333334554.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515295_365194.33333333333334554.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515538_807194.33333333333334554.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417197_282194.33333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417295_365194.33333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417538_807194.33333333333334823.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412197_282194.33333333333334478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412295_365194.33333333333334478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412538_807194.33333333333334478.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514197_282194.33333333333334538.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514295_365194.33333333333334538.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514538_807194.33333333333334538.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720197_282194.33333333333334823.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720295_365194.33333333333334823.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720538_807194.33333333333334823.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721197_282194.33333333333334839.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721295_365194.33333333333334839.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721538_807194.33333333333334839.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412148_19638.333333333333336322.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412197_28238.333333333333336322.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412295_36538.333333333333336322.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412538_80738.333333333333336322.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513197_282194.33333333333334478.0DomainNote=Ig-like C2-type 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513295_365194.33333333333334478.0DomainNote=Ig-like C2-type 2
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513538_807194.33333333333334478.0DomainProtein kinase
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519544_552194.33333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515544_552194.33333333333334554.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417544_552194.33333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412544_552194.33333333333334478.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514544_552194.33333333333334538.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720544_552194.33333333333334823.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721544_552194.33333333333334839.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412544_55238.333333333333336322.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513544_552194.33333333333334478.0Nucleotide bindingATP
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412116_13738.333333333333336322.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039586641292_11338.333333333333336322.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519455_822194.33333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515455_822194.33333333333334554.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417455_822194.33333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412455_822194.33333333333334478.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514455_822194.33333333333334538.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720455_822194.33333333333334823.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721455_822194.33333333333334839.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412455_82238.333333333333336322.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513455_822194.33333333333334478.0Topological domainCytoplasmic
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519431_454194.33333333333334839.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515431_454194.33333333333334554.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417431_454194.33333333333334823.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412431_454194.33333333333334478.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514431_454194.33333333333334538.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720431_454194.33333333333334823.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721431_454194.33333333333334839.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395866412431_45438.333333333333336322.0TransmembraneHelical
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513431_454194.33333333333334478.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111605_60926.3333333333333321131.0Compositional biasNote=Poly-Lys
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111782_101926.3333333333333321131.0Compositional biasNote=Pro-rich
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111897_90326.3333333333333321131.0Compositional biasNote=Poly-Pro
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111127_21726.3333333333333321131.0DomainSH2
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111242_49326.3333333333333321131.0DomainProtein kinase
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+11161_12126.3333333333333321131.0DomainSH3
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+1111090_110026.3333333333333321131.0MotifNuclear export signal
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111381_40526.3333333333333321131.0MotifNote=Kinase activation loop
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111709_71526.3333333333333321131.0MotifNuclear localization signal 2
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111762_76926.3333333333333321131.0MotifNuclear localization signal 3
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111248_25626.3333333333333321131.0Nucleotide bindingNote=ATP
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111316_32226.3333333333333321131.0Nucleotide bindingNote=ATP
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+1111_6026.3333333333333321131.0RegionNote=CAP
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111869_96826.3333333333333321131.0RegionDNA-binding
HgeneABL1chr9:133710912chr9:87338487ENST00000318560+111953_113026.3333333333333321131.0RegionNote=F-actin-binding
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519148_196194.33333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000027712051932_61194.33333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515148_196194.33333333333334554.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000030405351532_61194.33333333333334554.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417148_196194.33333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000032311541732_61194.33333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412148_196194.33333333333334478.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000035984741232_61194.33333333333334478.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514148_196194.33333333333334538.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037620851432_61194.33333333333334538.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720148_196194.33333333333334823.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621372032_61194.33333333333334823.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721148_196194.33333333333334839.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621472132_61194.33333333333334839.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039586641232_6138.333333333333336322.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513148_196194.33333333333334478.0DomainNote=LRRCT
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039588251332_61194.33333333333334478.0DomainNote=LRRNT
TgeneNTRK2chr9:133710912chr9:87338487ENST00000277120519116_137194.33333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000027712051992_113194.33333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000304053515116_137194.33333333333334554.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000030405351592_113194.33333333333334554.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000323115417116_137194.33333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000032311541792_113194.33333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000359847412116_137194.33333333333334478.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000035984741292_113194.33333333333334478.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376208514116_137194.33333333333334538.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037620851492_113194.33333333333334538.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376213720116_137194.33333333333334823.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621372092_113194.33333333333334823.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000376214721116_137194.33333333333334839.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621472192_113194.33333333333334839.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST00000395882513116_137194.33333333333334478.0RepeatNote=LRR 2
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039588251392_113194.33333333333334478.0RepeatNote=LRR 1
TgeneNTRK2chr9:133710912chr9:87338487ENST0000027712051932_430194.33333333333334839.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000030405351532_430194.33333333333334554.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000032311541732_430194.33333333333334823.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000035984741232_430194.33333333333334478.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037620851432_430194.33333333333334538.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621372032_430194.33333333333334823.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000037621472132_430194.33333333333334839.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039586641232_43038.333333333333336322.0Topological domainExtracellular
TgeneNTRK2chr9:133710912chr9:87338487ENST0000039588251332_430194.33333333333334478.0Topological domainExtracellular


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABL1all structure
NTRK2all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABL1-NTRK2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABL1-NTRK2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneABL1C0023473Myeloid Leukemia, Chronic3CGI;CTD_human;ORPHANET
HgeneABL1C0023452Childhood Acute Lymphoblastic Leukemia2CTD_human
HgeneABL1C0023453L2 Acute Lymphoblastic Leukemia2CTD_human
HgeneABL1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma2CGI;CTD_human
HgeneABL1C0001418Adenocarcinoma1CTD_human
HgeneABL1C0003706Arachnodactyly1GENOMICS_ENGLAND
HgeneABL1C0005941Bone Diseases, Developmental1CTD_human
HgeneABL1C0006142Malignant neoplasm of breast1CTD_human
HgeneABL1C0006413Burkitt Lymphoma1ORPHANET
HgeneABL1C0014859Esophageal Neoplasms1CTD_human
HgeneABL1C0015544Failure to Thrive1CTD_human
HgeneABL1C0018798Congenital Heart Defects1CTD_human
HgeneABL1C0023903Liver neoplasms1CTD_human
HgeneABL1C0027659Neoplasms, Experimental1CTD_human
HgeneABL1C0032927Precancerous Conditions1CTD_human
HgeneABL1C0039075Syndactyly1GENOMICS_ENGLAND
HgeneABL1C0151491Congenital musculoskeletal anomalies1CTD_human
HgeneABL1C0205641Adenocarcinoma, Basal Cell1CTD_human
HgeneABL1C0205642Adenocarcinoma, Oxyphilic1CTD_human
HgeneABL1C0205643Carcinoma, Cribriform1CTD_human
HgeneABL1C0205644Carcinoma, Granular Cell1CTD_human
HgeneABL1C0205645Adenocarcinoma, Tubular1CTD_human
HgeneABL1C0265610Clinodactyly of fingers1GENOMICS_ENGLAND
HgeneABL1C0282313Condition, Preneoplastic1CTD_human
HgeneABL1C0345904Malignant neoplasm of liver1CTD_human
HgeneABL1C0546837Malignant neoplasm of esophagus1CTD_human
HgeneABL1C0596263Carcinogenesis1CTD_human
HgeneABL1C0678222Breast Carcinoma1CTD_human
HgeneABL1C1257931Mammary Neoplasms, Human1CTD_human
HgeneABL1C1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
HgeneABL1C1458155Mammary Neoplasms1CTD_human
HgeneABL1C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1CGI;ORPHANET
HgeneABL1C4539857CONGENITAL HEART DEFECTS AND SKELETAL MALFORMATIONS SYNDROME1GENOMICS_ENGLAND;UNIPROT
HgeneABL1C4551485Clinodactyly1GENOMICS_ENGLAND
HgeneABL1C4704874Mammary Carcinoma, Human1CTD_human
TgeneNTRK2C0011570Mental Depression5PSYGENET
TgeneNTRK2C0011581Depressive disorder5PSYGENET
TgeneNTRK2C0041696Unipolar Depression5PSYGENET
TgeneNTRK2C0525045Mood Disorders5PSYGENET
TgeneNTRK2C1269683Major Depressive Disorder5PSYGENET
TgeneNTRK2C3151303Obesity, Hyperphagia, and Developmental Delay4CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0005586Bipolar Disorder3CTD_human;PSYGENET
TgeneNTRK2C4693367EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 583GENOMICS_ENGLAND;UNIPROT
TgeneNTRK2C0009171Cocaine Abuse2CTD_human
TgeneNTRK2C0036341Schizophrenia2PSYGENET
TgeneNTRK2C0038220Status Epilepticus2CTD_human
TgeneNTRK2C0236736Cocaine-Related Disorders2CTD_human
TgeneNTRK2C0270823Petit mal status2CTD_human
TgeneNTRK2C0311335Grand Mal Status Epilepticus2CTD_human
TgeneNTRK2C0393734Complex Partial Status Epilepticus2CTD_human
TgeneNTRK2C0600427Cocaine Dependence2CTD_human
TgeneNTRK2C0751217Hyperkinesia, Generalized2CTD_human
TgeneNTRK2C0751522Status Epilepticus, Subclinical2CTD_human
TgeneNTRK2C0751523Non-Convulsive Status Epilepticus2CTD_human
TgeneNTRK2C0751524Simple Partial Status Epilepticus2CTD_human
TgeneNTRK2C3887506Hyperkinesia2CTD_human
TgeneNTRK2C0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneNTRK2C0004114Astrocytoma1CTD_human
TgeneNTRK2C0004352Autistic Disorder1CTD_human
TgeneNTRK2C0005587Depression, Bipolar1CTD_human
TgeneNTRK2C0008073Developmental Disabilities1CTD_human
TgeneNTRK2C0013415Dysthymic Disorder1PSYGENET
TgeneNTRK2C0017638Glioma1CTD_human
TgeneNTRK2C0020505Hyperphagia1CTD_human
TgeneNTRK2C0024713Manic Disorder1CTD_human
TgeneNTRK2C0027819Neuroblastoma1CTD_human
TgeneNTRK2C0028754Obesity1CTD_human
TgeneNTRK2C0036349Paranoid Schizophrenia1PSYGENET
TgeneNTRK2C0037769West Syndrome1ORPHANET
TgeneNTRK2C0085996Child Development Deviations1CTD_human
TgeneNTRK2C0085997Child Development Disorders, Specific1CTD_human
TgeneNTRK2C0205768Subependymal Giant Cell Astrocytoma1CTD_human
TgeneNTRK2C0259783mixed gliomas1CTD_human
TgeneNTRK2C0280783Juvenile Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0280785Diffuse Astrocytoma1CTD_human
TgeneNTRK2C0334579Anaplastic astrocytoma1CTD_human
TgeneNTRK2C0334580Protoplasmic astrocytoma1CTD_human
TgeneNTRK2C0334581Gemistocytic astrocytoma1CTD_human
TgeneNTRK2C0334582Fibrillary Astrocytoma1CTD_human
TgeneNTRK2C0334583Pilocytic Astrocytoma1CTD_human
TgeneNTRK2C0338070Childhood Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0338831Manic1CTD_human
TgeneNTRK2C0547065Mixed oligoastrocytoma1CTD_human
TgeneNTRK2C0555198Malignant Glioma1CTD_human
TgeneNTRK2C0678807prenatal alcohol exposure1PSYGENET
TgeneNTRK2C0750935Cerebral Astrocytoma1CTD_human
TgeneNTRK2C0750936Intracranial Astrocytoma1CTD_human
TgeneNTRK2C0752347Lewy Body Disease1CTD_human
TgeneNTRK2C1519086Pilomyxoid astrocytoma1ORPHANET
TgeneNTRK2C1704230Grade I Astrocytoma1CTD_human
TgeneNTRK2C3146244Alcohol Related Birth Defect1PSYGENET