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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LPAR1-TMOD1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LPAR1-TMOD1
FusionPDB ID: 49476
FusionGDB2.0 ID: 49476
HgeneTgene
Gene symbol

LPAR1

TMOD1

Gene ID

1902

7111

Gene namelysophosphatidic acid receptor 1tropomodulin 1
SynonymsEDG2|GPR26|Gpcr26|LPA1|Mrec1.3|VZG1|edg-2|rec.1.3|vzg-1D9S57E|ETMOD|TMOD
Cytomap

9q31.3

9q22.33

Type of geneprotein-codingprotein-coding
Descriptionlysophosphatidic acid receptor 1LPA receptor 1LPA-1endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2lysophosphatidic acid receptor Edg-2ventricular zone gene 1tropomodulin-1E-Tmode-tropomodulinerythrocyte tropomodulin
Modification date2020031320200313
UniProtAcc

Q92633

.
Ensembl transtripts involved in fusion geneENST idsENST00000538760, ENST00000541779, 
ENST00000358883, ENST00000374430, 
ENST00000374431, 		ENST00000259365, 
ENST00000375175, ENST00000395211, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 3 X 3=366 X 6 X 3=108
# samples 46
** MAII scorelog2(4/36*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LPAR1 [Title/Abstract] AND TMOD1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LPAR1(113703701)-TMOD1(100353573), # samples:1
Anticipated loss of major functional domain due to fusion event.LPAR1-TMOD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LPAR1-TMOD1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LPAR1-TMOD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LPAR1-TMOD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LPAR1-TMOD1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
LPAR1-TMOD1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLPAR1

GO:0007202

activation of phospholipase C activity

19306925


check buttonFusion gene breakpoints across LPAR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMOD1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-06-0132-01ALPAR1chr9

113703701

-TMOD1chr9

100353573

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000374431LPAR1chr9113703701-ENST00000395211TMOD1chr9100353573+343011773841316310
ENST00000374431LPAR1chr9113703701-ENST00000259365TMOD1chr9100353573+343711773841316310
ENST00000374431LPAR1chr9113703701-ENST00000375175TMOD1chr9100353573+294311773841316310
ENST00000374430LPAR1chr9113703701-ENST00000395211TMOD1chr9100353573+330110482551187310
ENST00000374430LPAR1chr9113703701-ENST00000259365TMOD1chr9100353573+330810482551187310
ENST00000374430LPAR1chr9113703701-ENST00000375175TMOD1chr9100353573+281410482551187310
ENST00000358883LPAR1chr9113703701-ENST00000395211TMOD1chr9100353573+339411413481280310
ENST00000358883LPAR1chr9113703701-ENST00000259365TMOD1chr9100353573+340111413481280310
ENST00000358883LPAR1chr9113703701-ENST00000375175TMOD1chr9100353573+290711413481280310

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000374431ENST00000395211LPAR1chr9113703701-TMOD1chr9100353573+0.0008608720.9991391
ENST00000374431ENST00000259365LPAR1chr9113703701-TMOD1chr9100353573+0.0008396560.9991604
ENST00000374431ENST00000375175LPAR1chr9113703701-TMOD1chr9100353573+0.0006857530.9993143
ENST00000374430ENST00000395211LPAR1chr9113703701-TMOD1chr9100353573+0.0006857840.9993142
ENST00000374430ENST00000259365LPAR1chr9113703701-TMOD1chr9100353573+0.0006715720.9993285
ENST00000374430ENST00000375175LPAR1chr9113703701-TMOD1chr9100353573+0.0005805430.99941945
ENST00000358883ENST00000395211LPAR1chr9113703701-TMOD1chr9100353573+0.0008594260.9991405
ENST00000358883ENST00000259365LPAR1chr9113703701-TMOD1chr9100353573+0.0008476780.9991523
ENST00000358883ENST00000375175LPAR1chr9113703701-TMOD1chr9100353573+0.0007131980.99928683

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49476_49476_1_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000358883_TMOD1_chr9_100353573_ENST00000259365_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_2_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000358883_TMOD1_chr9_100353573_ENST00000375175_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_3_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000358883_TMOD1_chr9_100353573_ENST00000395211_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_4_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000374430_TMOD1_chr9_100353573_ENST00000259365_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_5_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000374430_TMOD1_chr9_100353573_ENST00000375175_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_6_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000374430_TMOD1_chr9_100353573_ENST00000395211_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_7_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000374431_TMOD1_chr9_100353573_ENST00000259365_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_8_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000374431_TMOD1_chr9_100353573_ENST00000375175_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

>49476_49476_9_LPAR1-TMOD1_LPAR1_chr9_113703701_ENST00000374431_TMOD1_chr9_100353573_ENST00000395211_length(amino acids)=310AA_BP=264
MAAISTSIPVISQPQFTAMNEPQCFYNESIAFFYNRSGKHLATEWNTVSKLVMGLGITVCIFIMLANLLVMVAIYVNRRFHFPIYYLMAN
LAAADFFAGLAYFYLMFNTGPNTRRLTVSTWLLRQGLIDTSLTASVANLLAIAIERHITVFRMQLHTRMSNRRVVVVIVVIWTMAIVMGA
IPSVGWNCICDIENCSNMAPLYSDSYLVFWAIFNLVTFVVMVVLYAHIFGYVRQRTMRMSRHSSGPRRNRDTMMSLLKTVVIVLEPAPGQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:113703701/chr9:100353573)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LPAR1

Q92633

.
FUNCTION: Receptor for lysophosphatidic acid (LPA) (PubMed:9070858, PubMed:19306925, PubMed:25025571, PubMed:26091040). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as lysophosphatidic acid receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to lysophosphatidic acid. Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity). {ECO:0000250|UniProtKB:P61793, ECO:0000269|PubMed:18066075, ECO:0000269|PubMed:19306925, ECO:0000269|PubMed:19656035, ECO:0000269|PubMed:19733258, ECO:0000269|PubMed:25025571, ECO:0000269|PubMed:26091040, ECO:0000269|PubMed:9070858, ECO:0000305|PubMed:11093753, ECO:0000305|PubMed:9069262}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34124_129264.3333333333333365.0RegionLysophosphatidic acid binding
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45124_129264.3333333333333365.0RegionLysophosphatidic acid binding
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45124_129264.3333333333333365.0RegionLysophosphatidic acid binding
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34108_121264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34145_163264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34185_204264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-341_50264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34226_255264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-3476_83264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45108_121264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45145_163264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45185_204264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-451_50264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45226_255264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-4576_83264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45108_121264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45145_163264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45185_204264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-451_50264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45226_255264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-4576_83264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34122_144264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D3
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34164_184264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D4
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34205_225264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D5
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-3451_75264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D1
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-3484_107264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D2
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45122_144264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D3
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45164_184264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D4
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45205_225264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D5
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-4551_75264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D1
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-4584_107264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D2
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45122_144264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D3
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45164_184264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D4
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45205_225264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D5
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-4551_75264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D1
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-4584_107264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34281_294264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34316_364264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45281_294264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45316_364264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45281_294264.3333333333333365.0Topological domainNote=Extracellular
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45316_364264.3333333333333365.0Topological domainNote=Cytoplasmic
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34256_280264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D6
HgeneLPAR1chr9:113703701chr9:100353573ENST00000358883-34295_315264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D7
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45256_280264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D6
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374430-45295_315264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D7
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45256_280264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D6
HgeneLPAR1chr9:113703701chr9:100353573ENST00000374431-45295_315264.3333333333333365.0TransmembraneNote=Helical%3B Name%3D7
TgeneTMOD1chr9:113703701chr9:100353573ENST0000025936571039_138290.0360.0RegionTropomyosin-binding
TgeneTMOD1chr9:113703701chr9:100353573ENST0000039521171039_138290.0360.0RegionTropomyosin-binding


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LPAR1
TMOD1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LPAR1-TMOD1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LPAR1-TMOD1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource