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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRBA-FBXW7

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRBA-FBXW7
FusionPDB ID: 49610
FusionGDB2.0 ID: 49610
HgeneTgene
Gene symbol

LRBA

FBXW7

Gene ID

987

55294

Gene nameLPS responsive beige-like anchor proteinF-box and WD repeat domain containing 7
SynonymsBGL|CDC4L|CVID8|LAB300|LBAAGO|CDC4|FBW6|FBW7|FBX30|FBXO30|FBXW6|SEL-10|SEL10|hAgo|hCdc4
Cytomap

4q31.3

4q31.3

Type of geneprotein-codingprotein-coding
Descriptionlipopolysaccharide-responsive and beige-like anchor proteinCDC4-like proteinLPS-responsive vesicle trafficking, beach and anchor containingvesicle trafficking, beach and anchor containingF-box/WD repeat-containing protein 7F-box and WD repeat domain containing 7, E3 ubiquitin protein ligaseF-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)F-box protein FBW7F-box protein FBX30F-box protein SEL-10archipelagohomolog of
Modification date2020032020200327
UniProtAcc

P50851

Q969H0

Ensembl transtripts involved in fusion geneENST idsENST00000357115, ENST00000507224, 
ENST00000510413, ENST00000535741, 
ENST00000503716, 		ENST00000263981, 
ENST00000296555, ENST00000393956, 
ENST00000603841, ENST00000604095, 
ENST00000604872, ENST00000281708, 
ENST00000603548, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 32 X 15=148806 X 6 X 4=144
# samples 417
** MAII scorelog2(41/14880*10)=-5.18160680648995
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRBA [Title/Abstract] AND FBXW7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRBA(151729472)-FBXW7(153271276), # samples:1
LRBA(151729471)-FBXW7(153271276), # samples:1
Anticipated loss of major functional domain due to fusion event.LRBA-FBXW7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRBA-FBXW7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRBA-FBXW7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRBA-FBXW7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRBA-FBXW7 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LRBA-FBXW7 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
LRBA-FBXW7 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneFBXW7

GO:0016567

protein ubiquitination

12354302|15103331

TgeneFBXW7

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

15103331|17434132

TgeneFBXW7

GO:0031398

positive regulation of protein ubiquitination

12628165

TgeneFBXW7

GO:0045741

positive regulation of epidermal growth factor-activated receptor activity

20208556

TgeneFBXW7

GO:0050821

protein stabilization

20208556

TgeneFBXW7

GO:0051443

positive regulation of ubiquitin-protein transferase activity

12628165

TgeneFBXW7

GO:1901800

positive regulation of proteasomal protein catabolic process

23858059

TgeneFBXW7

GO:1903378

positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

23858059

TgeneFBXW7

GO:2000060

positive regulation of ubiquitin-dependent protein catabolic process

20208556


check buttonFusion gene breakpoints across LRBA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FBXW7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-VQ-A92D-01ALRBAchr4

151729472

-FBXW7chr4

153271276

-
ChimerDB4STADTCGA-VQ-A92DLRBAchr4

151729471

-FBXW7chr4

153271276

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535741LRBAchr4151729472-ENST00000281708FBXW7chr4153271276-9104585847458611795
ENST00000535741LRBAchr4151729472-ENST00000603548FBXW7chr4153271276-7739585847458611795
ENST00000357115LRBAchr4151729472-ENST00000281708FBXW7chr4153271276-8874562824456311795
ENST00000357115LRBAchr4151729472-ENST00000603548FBXW7chr4153271276-7509562824456311795
ENST00000535741LRBAchr4151729471-ENST00000281708FBXW7chr4153271276-9104585847458611795
ENST00000535741LRBAchr4151729471-ENST00000603548FBXW7chr4153271276-7739585847458611795
ENST00000357115LRBAchr4151729471-ENST00000281708FBXW7chr4153271276-8874562824456311795
ENST00000357115LRBAchr4151729471-ENST00000603548FBXW7chr4153271276-7509562824456311795

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535741ENST00000281708LRBAchr4151729472-FBXW7chr4153271276-0.0005367370.99946326
ENST00000535741ENST00000603548LRBAchr4151729472-FBXW7chr4153271276-0.0009362690.9990638
ENST00000357115ENST00000281708LRBAchr4151729472-FBXW7chr4153271276-0.0003686910.9996313
ENST00000357115ENST00000603548LRBAchr4151729472-FBXW7chr4153271276-0.0006288210.99937123
ENST00000535741ENST00000281708LRBAchr4151729471-FBXW7chr4153271276-0.0005367370.99946326
ENST00000535741ENST00000603548LRBAchr4151729471-FBXW7chr4153271276-0.0009362690.9990638
ENST00000357115ENST00000281708LRBAchr4151729471-FBXW7chr4153271276-0.0003686910.9996313
ENST00000357115ENST00000603548LRBAchr4151729471-FBXW7chr4153271276-0.0006288210.99937123

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49610_49610_1_LRBA-FBXW7_LRBA_chr4_151729471_ENST00000357115_FBXW7_chr4_153271276_ENST00000281708_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

--------------------------------------------------------------

>49610_49610_2_LRBA-FBXW7_LRBA_chr4_151729471_ENST00000357115_FBXW7_chr4_153271276_ENST00000603548_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

--------------------------------------------------------------

>49610_49610_3_LRBA-FBXW7_LRBA_chr4_151729471_ENST00000535741_FBXW7_chr4_153271276_ENST00000281708_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

--------------------------------------------------------------

>49610_49610_4_LRBA-FBXW7_LRBA_chr4_151729471_ENST00000535741_FBXW7_chr4_153271276_ENST00000603548_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

--------------------------------------------------------------

>49610_49610_5_LRBA-FBXW7_LRBA_chr4_151729472_ENST00000357115_FBXW7_chr4_153271276_ENST00000281708_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

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>49610_49610_6_LRBA-FBXW7_LRBA_chr4_151729472_ENST00000357115_FBXW7_chr4_153271276_ENST00000603548_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

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>49610_49610_7_LRBA-FBXW7_LRBA_chr4_151729472_ENST00000535741_FBXW7_chr4_153271276_ENST00000281708_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

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>49610_49610_8_LRBA-FBXW7_LRBA_chr4_151729472_ENST00000535741_FBXW7_chr4_153271276_ENST00000603548_length(amino acids)=1795AA_BP=
MASEDNRVPSPPPTGDDGGGGGREETPTEGGALSLKPGLPIRGIRMKFAVLTGLVEVGEVSNRDIVETVFNLLVGGQFDLEMNFIIQEGE
SINCMVDLLEKCDITCQAEVWSMFTAILKKSIRNLQVCTEVGLVEKVLGKIEKVDNMIADLLVDMLGVLASYNLTVRELKLFFSKLQGDK
GRWPPHAGKLLSVLKHMPQKYGPDAFFNFPGKSAAAIALPPIAKWPYQNGFTFHTWLRMDPVNNINVDKDKPYLYCFRTSKGLGYSAHFV
GGCLIVTSIKSKGKGFQHCVKFDFKPQKWYMVTIVHIYNRWKNSELRCYVNGELASYGEITWFVNTSDTFDKCFLGSSETADANRVFCGQ
MTAVYLFSEALNAAQIFAIYQLGLGYKGTFKFKAESDLFLAEHHKLLLYDGKLSSAIAFTYNPRATDAQLCLESSPKDNPSIFVHSPHAL
MLQDVKAVLTHSIQSAMHSIGGVQVLFPLFAQLDYRQYLSDEIDLTICSTLLAFIMELLKNSIAMQEQMLACKGFLVIGYSLEKSSKSHV
SRAVLELCLAFSKYLSNLQNGMPLLKQLCDHVLLNPAIWIHTPAKVQLMLYTYLSTEFIGTVNIYNTIRRVGTVLLIMHTLKYYYWAVNP
QDRSGITPKGLDGPRPNQKEMLSLRAFLLMFIKQLVMKDSGVKEDELQAILNYLLTMHEDDNLMDVLQLLVALMSEHPNSMIPAFDQRNG
LRVIYKLLASKSEGIRVQALKAMGYFLKHLAPKRKAEVMLGHGLFSLLAERLMLQTNLITMTTYNVLFEILIEQIGTQVIHKQHPDPDSS
VKIQNPQILKVIATLLRNSPQCPESMEVRRAFLSDMIKLFNNSRENRRSLLQCSVWQEWMLSLCYFNPKNSDEQKITEMVYAIFRILLYH
AVKYEWGGWRVWVDTLSITHSKVTFEIHKENLANIFREQQGKVDEEIGLCSSTSVQAASGIRRDINVSVGSQQPDTKDSPVCPHFTTNGN
ENSSIEKTSSLESASNIELQTTNTSYEEMKAEQENQELPDEGTLEETLTNETRNADDLEVSSDIIEAVAISSNSFITTGKDSMTVSEVTA
SISSPSEEDASEMPEFLDKSIVEEEEDDDYVELKVEGSPTEEANLPTELQDNSLSPAASEAGEKLDMFGNDDKLIFQEGKPVTEKQTDTE
TQDSKDSGIQTMTASGSSAMSPETTVSQIAVESDLGQMLEEGKKATNLTRETKLINDCHGSVSEASSEQKIAKLDVSNVATDTERLELKA
SPNVEAPQPHRHVLEISRQHEQPGQGIAPDAVNGQRRDSRSTVFRIPEFNWSQMHQRLLTDLLFSIETDIQMWRSHSTKTVMDFVNSSDN
VIFVHNTIHLISQVMDNMVMACGGILPLLSAATSATHELENIEPTQGLSIEASVTFLQRLISLVDVLIFASSLGFTEIEAEKSMSSGGIL
RQCLRLVCAVAVRNCLECQQHSQLKTRGDKALKPMHSLIPLGKSAAKSPVDIVTGGISPVRDLDRLLQDMDINRLRAVVFRDIEDSKQAQ
FLALAVVYFISVLMVSKYRDILEPQNERHSQSCTETGSENENVSLSEITPAAFSTLTTASVEESESTSSARRRDSGIGEETATGLGSHVE
VTPHTAPPGVSAGPDAISEVLSTLSLEVNKSPETKNDRGNDLDTKATPSVSVSKNVNVKDILRSLVNIPADGVTVDPALLPPACLGALGD

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:151729472/chr4:153271276)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRBA

P50851

FBXW7

Q969H0

FUNCTION: May be involved in coupling signal transduction and vesicle trafficking to enable polarized secretion and/or membrane deposition of immune effector molecules. {ECO:0000250}.FUNCTION: Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds phosphorylated sites/phosphodegrons within target proteins and thereafter bring them to the SCF complex for ubiquitination (PubMed:22748924, PubMed:17434132, PubMed:26976582, PubMed:28727686). Identified substrates include cyclin-E (CCNE1 or CCNE2), DISC1, JUN, MYC, NOTCH1 released notch intracellular domain (NICD), NOTCH2, MCL1, and probably PSEN1 (PubMed:11565034, PubMed:12354302, PubMed:11585921, PubMed:15103331, PubMed:14739463, PubMed:17558397, PubMed:17873522, PubMed:22608923, PubMed:22748924, PubMed:29149593, PubMed:25775507, PubMed:28007894, PubMed:26976582, PubMed:28727686). Acts as a negative regulator of JNK signaling by binding to phosphorylated JUN and promoting its ubiquitination and subsequent degradation (PubMed:14739463). SCF(FBXW7) complex mediates the ubiquitination and subsequent degradation of NFE2L1 (By similarity). Involved in bone homeostasis and negative regulation of osteoclast differentiation (PubMed:29149593). Regulates the amplitude of the cyclic expression of hepatic core clock genes and genes involved in lipid and glucose metabolism via ubiquitination and proteasomal degradation of their transcriptional repressor NR1D1; CDK1-dependent phosphorylation of NR1D1 is necessary for SCF(FBXW7)-mediated ubiquitination (PubMed:27238018). {ECO:0000250|UniProtKB:Q8VBV4, ECO:0000269|PubMed:11565034, ECO:0000269|PubMed:11585921, ECO:0000269|PubMed:14739463, ECO:0000269|PubMed:15103331, ECO:0000269|PubMed:17434132, ECO:0000269|PubMed:17558397, ECO:0000269|PubMed:17873522, ECO:0000269|PubMed:22608923, ECO:0000269|PubMed:22748924, ECO:0000269|PubMed:25775507, ECO:0000269|PubMed:26976582, ECO:0000269|PubMed:27238018, ECO:0000269|PubMed:28007894, ECO:0000269|PubMed:28727686, ECO:0000269|PubMed:29149593, ECO:0000305|PubMed:12354302}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32581006_10531794.66666666666672864.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32571006_10531794.66666666666672852.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32581006_10531794.66666666666672864.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32571006_10531794.66666666666672852.0Coiled coilOntology_term=ECO:0000255
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32581301_13431794.66666666666672864.0RepeatNote=WD 1
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32571301_13431794.66666666666672852.0RepeatNote=WD 1
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32581301_13431794.66666666666672864.0RepeatNote=WD 1
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32571301_13431794.66666666666672852.0RepeatNote=WD 1
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32581531_15481794.66666666666672864.0TransmembraneHelical
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32571531_15481794.66666666666672852.0TransmembraneHelical
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32581531_15481794.66666666666672864.0TransmembraneHelical
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32571531_15481794.66666666666672852.0TransmembraneHelical
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011278_32487.0628.0DomainF-box
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112278_324167.0708.0DomainF-box
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011278_32449.0590.0DomainF-box
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213278_324167.0708.0DomainF-box
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011278_324167.0708.0DomainF-box
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011278_32487.0628.0DomainF-box
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112278_324167.0708.0DomainF-box
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011278_32449.0590.0DomainF-box
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213278_324167.0708.0DomainF-box
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011278_324167.0708.0DomainF-box
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011378_41887.0628.0RepeatNote=WD 1
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011420_45687.0628.0RepeatNote=WD 2
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011459_49887.0628.0RepeatNote=WD 3
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011500_53687.0628.0RepeatNote=WD 4
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011539_57887.0628.0RepeatNote=WD 5
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011580_61887.0628.0RepeatNote=WD 6
TgeneFBXW7chr4:151729471chr4:153271276ENST00000263981011622_65987.0628.0RepeatNote=WD 7
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112378_418167.0708.0RepeatNote=WD 1
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112420_456167.0708.0RepeatNote=WD 2
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112459_498167.0708.0RepeatNote=WD 3
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112500_536167.0708.0RepeatNote=WD 4
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112539_578167.0708.0RepeatNote=WD 5
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112580_618167.0708.0RepeatNote=WD 6
TgeneFBXW7chr4:151729471chr4:153271276ENST00000281708112622_659167.0708.0RepeatNote=WD 7
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011378_41849.0590.0RepeatNote=WD 1
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011420_45649.0590.0RepeatNote=WD 2
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011459_49849.0590.0RepeatNote=WD 3
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011500_53649.0590.0RepeatNote=WD 4
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011539_57849.0590.0RepeatNote=WD 5
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011580_61849.0590.0RepeatNote=WD 6
TgeneFBXW7chr4:151729471chr4:153271276ENST00000296555011622_65949.0590.0RepeatNote=WD 7
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213378_418167.0708.0RepeatNote=WD 1
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213420_456167.0708.0RepeatNote=WD 2
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213459_498167.0708.0RepeatNote=WD 3
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213500_536167.0708.0RepeatNote=WD 4
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213539_578167.0708.0RepeatNote=WD 5
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213580_618167.0708.0RepeatNote=WD 6
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603548213622_659167.0708.0RepeatNote=WD 7
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011378_418167.0708.0RepeatNote=WD 1
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011420_456167.0708.0RepeatNote=WD 2
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011459_498167.0708.0RepeatNote=WD 3
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011500_536167.0708.0RepeatNote=WD 4
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011539_578167.0708.0RepeatNote=WD 5
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011580_618167.0708.0RepeatNote=WD 6
TgeneFBXW7chr4:151729471chr4:153271276ENST00000603841011622_659167.0708.0RepeatNote=WD 7
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011378_41887.0628.0RepeatNote=WD 1
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011420_45687.0628.0RepeatNote=WD 2
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011459_49887.0628.0RepeatNote=WD 3
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011500_53687.0628.0RepeatNote=WD 4
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011539_57887.0628.0RepeatNote=WD 5
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011580_61887.0628.0RepeatNote=WD 6
TgeneFBXW7chr4:151729472chr4:153271276ENST00000263981011622_65987.0628.0RepeatNote=WD 7
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112378_418167.0708.0RepeatNote=WD 1
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112420_456167.0708.0RepeatNote=WD 2
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112459_498167.0708.0RepeatNote=WD 3
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112500_536167.0708.0RepeatNote=WD 4
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112539_578167.0708.0RepeatNote=WD 5
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112580_618167.0708.0RepeatNote=WD 6
TgeneFBXW7chr4:151729472chr4:153271276ENST00000281708112622_659167.0708.0RepeatNote=WD 7
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011378_41849.0590.0RepeatNote=WD 1
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011420_45649.0590.0RepeatNote=WD 2
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011459_49849.0590.0RepeatNote=WD 3
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011500_53649.0590.0RepeatNote=WD 4
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011539_57849.0590.0RepeatNote=WD 5
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011580_61849.0590.0RepeatNote=WD 6
TgeneFBXW7chr4:151729472chr4:153271276ENST00000296555011622_65949.0590.0RepeatNote=WD 7
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213378_418167.0708.0RepeatNote=WD 1
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213420_456167.0708.0RepeatNote=WD 2
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213459_498167.0708.0RepeatNote=WD 3
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213500_536167.0708.0RepeatNote=WD 4
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213539_578167.0708.0RepeatNote=WD 5
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213580_618167.0708.0RepeatNote=WD 6
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603548213622_659167.0708.0RepeatNote=WD 7
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011378_418167.0708.0RepeatNote=WD 1
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011420_456167.0708.0RepeatNote=WD 2
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011459_498167.0708.0RepeatNote=WD 3
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011500_536167.0708.0RepeatNote=WD 4
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011539_578167.0708.0RepeatNote=WD 5
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011580_618167.0708.0RepeatNote=WD 6
TgeneFBXW7chr4:151729472chr4:153271276ENST00000603841011622_659167.0708.0RepeatNote=WD 7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32581990_19941794.66666666666672864.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32571990_19941794.66666666666672852.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32581990_19941794.66666666666672864.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32571990_19941794.66666666666672852.0Compositional biasNote=Poly-Arg
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582073_21811794.66666666666672864.0DomainBEACH-type PH
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582200_24891794.66666666666672864.0DomainBEACH
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572073_21811794.66666666666672852.0DomainBEACH-type PH
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572200_24891794.66666666666672852.0DomainBEACH
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582073_21811794.66666666666672864.0DomainBEACH-type PH
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582200_24891794.66666666666672864.0DomainBEACH
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572073_21811794.66666666666672852.0DomainBEACH-type PH
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572200_24891794.66666666666672852.0DomainBEACH
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582591_26331794.66666666666672864.0RepeatNote=WD 2
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582636_26791794.66666666666672864.0RepeatNote=WD 3
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582695_27351794.66666666666672864.0RepeatNote=WD 4
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582777_28161794.66666666666672864.0RepeatNote=WD 5
HgeneLRBAchr4:151729471chr4:153271276ENST00000357115-32582819_28581794.66666666666672864.0RepeatNote=WD 6
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572591_26331794.66666666666672852.0RepeatNote=WD 2
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572636_26791794.66666666666672852.0RepeatNote=WD 3
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572695_27351794.66666666666672852.0RepeatNote=WD 4
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572777_28161794.66666666666672852.0RepeatNote=WD 5
HgeneLRBAchr4:151729471chr4:153271276ENST00000510413-32572819_28581794.66666666666672852.0RepeatNote=WD 6
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582591_26331794.66666666666672864.0RepeatNote=WD 2
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582636_26791794.66666666666672864.0RepeatNote=WD 3
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582695_27351794.66666666666672864.0RepeatNote=WD 4
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582777_28161794.66666666666672864.0RepeatNote=WD 5
HgeneLRBAchr4:151729472chr4:153271276ENST00000357115-32582819_28581794.66666666666672864.0RepeatNote=WD 6
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572591_26331794.66666666666672852.0RepeatNote=WD 2
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572636_26791794.66666666666672852.0RepeatNote=WD 3
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572695_27351794.66666666666672852.0RepeatNote=WD 4
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572777_28161794.66666666666672852.0RepeatNote=WD 5
HgeneLRBAchr4:151729472chr4:153271276ENST00000510413-32572819_28581794.66666666666672852.0RepeatNote=WD 6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRBA
FBXW7


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRBA-FBXW7


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRBA-FBXW7


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource