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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRIG1-BDH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRIG1-BDH1
FusionPDB ID: 49672
FusionGDB2.0 ID: 49672
HgeneTgene
Gene symbol

LRIG1

BDH1

Gene ID

26018

622

Gene nameleucine rich repeats and immunoglobulin like domains 13-hydroxybutyrate dehydrogenase 1
SynonymsLIG-1|LIG1BDH|SDR9C1
Cytomap

3p14.1

3q29

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 1leucine-rich repeat protein LRIG1ortholog of mouse integral membrane glycoprotein LIG-1D-beta-hydroxybutyrate dehydrogenase, mitochondrial(R)-3-hydroxybutyrate dehydrogenase3-hydroxybutyrate dehydrogenase (heart, mitochondrial)3-hydroxybutyrate dehydrogenase, type 1epididymis secretory sperm binding proteinshort chain dehydrogenase/red
Modification date2020032020200313
UniProtAcc

Q96JA1

Q02338

Ensembl transtripts involved in fusion geneENST idsENST00000273261, ENST00000383703, 
ENST00000496559, 		ENST00000441275, 
ENST00000476764, ENST00000358186, 
ENST00000392378, ENST00000392379, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 13 X 6=8588 X 8 X 8=512
# samples 1414
** MAII scorelog2(14/858*10)=-2.61555082055458
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/512*10)=-1.87071698305503
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRIG1 [Title/Abstract] AND BDH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRIG1(66501983)-BDH1(197260432), # samples:1
Anticipated loss of major functional domain due to fusion event.LRIG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG1-BDH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across LRIG1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BDH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A2CY-01ALRIG1chr3

66501983

-BDH1chr3

197260432

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000273261LRIG1chr366501983-ENST00000392379BDH1chr3197260432-39518901441838564
ENST00000273261LRIG1chr366501983-ENST00000392378BDH1chr3197260432-39518901441838564
ENST00000273261LRIG1chr366501983-ENST00000358186BDH1chr3197260432-39518901441838564
ENST00000383703LRIG1chr366501983-ENST00000392379BDH1chr3197260432-4030969101917635
ENST00000383703LRIG1chr366501983-ENST00000392378BDH1chr3197260432-4030969101917635
ENST00000383703LRIG1chr366501983-ENST00000358186BDH1chr3197260432-4030969101917635

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000273261ENST00000392379LRIG1chr366501983-BDH1chr3197260432-0.0030643220.9969357
ENST00000273261ENST00000392378LRIG1chr366501983-BDH1chr3197260432-0.0030643220.9969357
ENST00000273261ENST00000358186LRIG1chr366501983-BDH1chr3197260432-0.0030643220.9969357
ENST00000383703ENST00000392379LRIG1chr366501983-BDH1chr3197260432-0.003063890.9969361
ENST00000383703ENST00000392378LRIG1chr366501983-BDH1chr3197260432-0.003063890.9969361
ENST00000383703ENST00000358186LRIG1chr366501983-BDH1chr3197260432-0.003063890.9969361

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49672_49672_1_LRIG1-BDH1_LRIG1_chr3_66501983_ENST00000273261_BDH1_chr3_197260432_ENST00000358186_length(amino acids)=564AA_BP=249
MNACLPGAAAALPSAGVGSGTRRAPGGRRAQAGYTLPESAEFAASAGGPAGPDGRGVCGPRRVLRSGPGTGGTLSAGAAAAERTWGGGHA
PVRSLEPSGAPRGPARVCGRSGPHSPRARSSQRAPDKMARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLD
CGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLRPLLLGSTSFIPIGRRTYASA
AEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMW
GLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL
GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMD

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>49672_49672_2_LRIG1-BDH1_LRIG1_chr3_66501983_ENST00000273261_BDH1_chr3_197260432_ENST00000392378_length(amino acids)=564AA_BP=249
MNACLPGAAAALPSAGVGSGTRRAPGGRRAQAGYTLPESAEFAASAGGPAGPDGRGVCGPRRVLRSGPGTGGTLSAGAAAAERTWGGGHA
PVRSLEPSGAPRGPARVCGRSGPHSPRARSSQRAPDKMARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLD
CGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLRPLLLGSTSFIPIGRRTYASA
AEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMW
GLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL
GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMD

--------------------------------------------------------------

>49672_49672_3_LRIG1-BDH1_LRIG1_chr3_66501983_ENST00000273261_BDH1_chr3_197260432_ENST00000392379_length(amino acids)=564AA_BP=249
MNACLPGAAAALPSAGVGSGTRRAPGGRRAQAGYTLPESAEFAASAGGPAGPDGRGVCGPRRVLRSGPGTGGTLSAGAAAAERTWGGGHA
PVRSLEPSGAPRGPARVCGRSGPHSPRARSSQRAPDKMARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLD
CGGRGLAALPGDLPSWTRSLNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLRPLLLGSTSFIPIGRRTYASA
AEPVGSKAVLVTGCDSGFGFSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMW
GLVNNAGISTFGEVEFTSLETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPL
GVKVSVVEPGNFIAATSLYSPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMD

--------------------------------------------------------------

>49672_49672_4_LRIG1-BDH1_LRIG1_chr3_66501983_ENST00000383703_BDH1_chr3_197260432_ENST00000358186_length(amino acids)=635AA_BP=320
MRGRRDSCCAEEPCGTRGCARARALWPRRGDSEAHWGLPARGRPRRPARGLRLCAPSPEEDACRHRARAAGLNACLPGAAAALPSAGVGS
GTRRAPGGRRAQAGYTLPESAEFAASAGGPAGPDGRGVCGPRRVLRSGPGTGGTLSAGAAAAERTWGGGHAPVRSLEPSGAPRGPARVCG
RSGPHSPRARSSQRAPDKMARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRS
LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFG
FSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL
ETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY
SPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISD

--------------------------------------------------------------

>49672_49672_5_LRIG1-BDH1_LRIG1_chr3_66501983_ENST00000383703_BDH1_chr3_197260432_ENST00000392378_length(amino acids)=635AA_BP=320
MRGRRDSCCAEEPCGTRGCARARALWPRRGDSEAHWGLPARGRPRRPARGLRLCAPSPEEDACRHRARAAGLNACLPGAAAALPSAGVGS
GTRRAPGGRRAQAGYTLPESAEFAASAGGPAGPDGRGVCGPRRVLRSGPGTGGTLSAGAAAAERTWGGGHAPVRSLEPSGAPRGPARVCG
RSGPHSPRARSSQRAPDKMARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRS
LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFG
FSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL
ETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY
SPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISD

--------------------------------------------------------------

>49672_49672_6_LRIG1-BDH1_LRIG1_chr3_66501983_ENST00000383703_BDH1_chr3_197260432_ENST00000392379_length(amino acids)=635AA_BP=320
MRGRRDSCCAEEPCGTRGCARARALWPRRGDSEAHWGLPARGRPRRPARGLRLCAPSPEEDACRHRARAAGLNACLPGAAAALPSAGVGS
GTRRAPGGRRAQAGYTLPESAEFAASAGGPAGPDGRGVCGPRRVLRSGPGTGGTLSAGAAAAERTWGGGHAPVRSLEPSGAPRGPARVCG
RSGPHSPRARSSQRAPDKMARPVRGGLGAPRRSPCLLLLWLLLLRLEPVTAAAGPRAPCAAACTCAGDSLDCGGRGLAALPGDLPSWTRS
LNLSYNKLSEIDPAGFEDLPNLQEVYLNNNELTAVPSLGAASSHVVSLFLRPLLLGSTSFIPIGRRTYASAAEPVGSKAVLVTGCDSGFG
FSLAKHLHSKGFLVFAGCLMKDKGHDGVKELDSLNSDRLRTVQLNVCSSEEVEKVVEIVRSSLKDPEKGMWGLVNNAGISTFGEVEFTSL
ETYKQVAEVNLWGTVRMTKSFLPLIRRAKGRVVNISSMLGRMANPARSPYCITKFGVEAFSDCLRYEMYPLGVKVSVVEPGNFIAATSLY
SPESIQAIAKKMWEELPEVVRKDYGKKYFDEKIAKMETYCSSGSTDTSPVIDAVTHALTATTPYTRYHPMDYYWWLRMQIMTHLPGAISD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:66501983/chr3:197260432)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG1

Q96JA1

BDH1

Q02338

FUNCTION: Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation. {ECO:0000269|PubMed:15282549}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-31935_68121.666666666666671094.0DomainNote=LRRNT
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-32035_68121.666666666666671071.0DomainNote=LRRNT
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-31969_90121.666666666666671094.0RepeatNote=LRR 1
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-31993_114121.666666666666671094.0RepeatNote=LRR 2
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-32069_90121.666666666666671071.0RepeatNote=LRR 1
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-32093_114121.666666666666671071.0RepeatNote=LRR 2
TgeneBDH1chr3:66501983chr3:197260432ENST000003581861759_8327.666666666666668344.0Nucleotide bindingNAD
TgeneBDH1chr3:66501983chr3:197260432ENST000003923781759_8327.666666666666668344.0Nucleotide bindingNAD
TgeneBDH1chr3:66501983chr3:197260432ENST000003923792859_8327.666666666666668344.0Nucleotide bindingNAD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319520_524121.666666666666671094.0Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320520_524121.666666666666671071.0Compositional biasNote=Poly-Ser
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319440_491121.666666666666671094.0DomainNote=LRRCT
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319495_594121.666666666666671094.0DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319599_688121.666666666666671094.0DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319693_779121.666666666666671094.0DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320440_491121.666666666666671071.0DomainNote=LRRCT
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320495_594121.666666666666671071.0DomainNote=Ig-like C2-type 1
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320599_688121.666666666666671071.0DomainNote=Ig-like C2-type 2
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320693_779121.666666666666671071.0DomainNote=Ig-like C2-type 3
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319116_137121.666666666666671094.0RepeatNote=LRR 3
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319140_161121.666666666666671094.0RepeatNote=LRR 4
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319164_185121.666666666666671094.0RepeatNote=LRR 5
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319189_210121.666666666666671094.0RepeatNote=LRR 6
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319212_233121.666666666666671094.0RepeatNote=LRR 7
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319236_257121.666666666666671094.0RepeatNote=LRR 8
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319260_281121.666666666666671094.0RepeatNote=LRR 9
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319284_305121.666666666666671094.0RepeatNote=LRR 10
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319308_329121.666666666666671094.0RepeatNote=LRR 11
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319332_353121.666666666666671094.0RepeatNote=LRR 12
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319356_378121.666666666666671094.0RepeatNote=LRR 13
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319383_404121.666666666666671094.0RepeatNote=LRR 14
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319407_428121.666666666666671094.0RepeatNote=LRR 15
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320116_137121.666666666666671071.0RepeatNote=LRR 3
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320140_161121.666666666666671071.0RepeatNote=LRR 4
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320164_185121.666666666666671071.0RepeatNote=LRR 5
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320189_210121.666666666666671071.0RepeatNote=LRR 6
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320212_233121.666666666666671071.0RepeatNote=LRR 7
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320236_257121.666666666666671071.0RepeatNote=LRR 8
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320260_281121.666666666666671071.0RepeatNote=LRR 9
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320284_305121.666666666666671071.0RepeatNote=LRR 10
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320308_329121.666666666666671071.0RepeatNote=LRR 11
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320332_353121.666666666666671071.0RepeatNote=LRR 12
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320356_378121.666666666666671071.0RepeatNote=LRR 13
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320383_404121.666666666666671071.0RepeatNote=LRR 14
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320407_428121.666666666666671071.0RepeatNote=LRR 15
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-31935_794121.666666666666671094.0Topological domainExtracellular
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319816_1093121.666666666666671094.0Topological domainCytoplasmic
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-32035_794121.666666666666671071.0Topological domainExtracellular
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320816_1093121.666666666666671071.0Topological domainCytoplasmic
HgeneLRIG1chr3:66501983chr3:197260432ENST00000273261-319795_815121.666666666666671094.0TransmembraneHelical
HgeneLRIG1chr3:66501983chr3:197260432ENST00000383703-320795_815121.666666666666671071.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRIG1
BDH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRIG1-BDH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRIG1-BDH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource