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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRIG3-ATP5B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRIG3-ATP5B
FusionPDB ID: 49692
FusionGDB2.0 ID: 49692
HgeneTgene
Gene symbol

LRIG3

ATP5B

Gene ID

121227

506

Gene nameleucine rich repeats and immunoglobulin like domains 3ATP synthase F1 subunit beta
SynonymsLIG3ATP5B|ATPMB|ATPSB|HEL-S-271
Cytomap

12q14.1

12q13.3

Type of geneprotein-codingprotein-coding
Descriptionleucine-rich repeats and immunoglobulin-like domains protein 3LIG-3ATP synthase subunit beta, mitochondrialATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptideepididymis secretory protein Li 271mitochondrial ATP synthase beta subunitmitochondrial ATP synthetase, beta subunit
Modification date2020031320200327
UniProtAcc

Q6UXM1

.
Ensembl transtripts involved in fusion geneENST idsENST00000320743, ENST00000379141, 
ENST00000550162, ENST00000262030, 
ENST00000552919, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 8=6409 X 10 X 4=360
# samples 1211
** MAII scorelog2(12/640*10)=-2.41503749927884
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/360*10)=-1.71049338280502
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRIG3 [Title/Abstract] AND ATP5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRIG3(59270227)-ATP5B(57039137), # samples:2
Anticipated loss of major functional domain due to fusion event.LRIG3-ATP5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRIG3-ATP5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneATP5B

GO:0042776

mitochondrial ATP synthesis coupled proton transport

12110673


check buttonFusion gene breakpoints across LRIG3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-GN-A26D-06ALRIG3chr12

59270227

-ATP5Bchr12

57039137

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379141LRIG3chr1259270227-ENST00000262030ATP5Bchr1257039137-41902579440411345
ENST00000379141LRIG3chr1259270227-ENST00000552919ATP5Bchr1257039137-41282579440081334
ENST00000320743LRIG3chr1259270227-ENST00000262030ATP5Bchr1257039137-4593298222144441407
ENST00000320743LRIG3chr1259270227-ENST00000552919ATP5Bchr1257039137-4531298222144111396

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379141ENST00000262030LRIG3chr1259270227-ATP5Bchr1257039137-0.0011736540.9988263
ENST00000379141ENST00000552919LRIG3chr1259270227-ATP5Bchr1257039137-0.0008612870.9991387
ENST00000320743ENST00000262030LRIG3chr1259270227-ATP5Bchr1257039137-0.0015938750.9984061
ENST00000320743ENST00000552919LRIG3chr1259270227-ATP5Bchr1257039137-0.0011482910.99885166

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49692_49692_1_LRIG3-ATP5B_LRIG3_chr12_59270227_ENST00000320743_ATP5B_chr12_57039137_ENST00000262030_length(amino acids)=1407AA_BP=1
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARL
PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS
ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR
NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN
TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF
ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT
PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS
FLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP
TCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIA
MDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKI
GLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEY
FRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDAT
TVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAE

--------------------------------------------------------------

>49692_49692_2_LRIG3-ATP5B_LRIG3_chr12_59270227_ENST00000320743_ATP5B_chr12_57039137_ENST00000552919_length(amino acids)=1396AA_BP=1
MCRAPSARRLGASGRDLGRWTAMSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRLARL
PEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNIS
ELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQR
NGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSRLDDSSFLGLSLLN
TLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGN
AFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSF
ICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKT
PMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPS
FLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRLSVIPTP
TCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNLPADIPSYLSSQGTLADRQDGYVSSESGS
HHQFVTSSGAGFFLPQHDSSVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILNALEVQGRETRLVLEVAQHLGESTVRTIA
MDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFMEMSVEQEILVTGIKVVDLLAPYAKGGKI
GLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSKVALVYGQMNEPPGARARVALTGLTVAEY
FRDQEGQDVLLFIDVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELG
IYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVSRARKIQRFLSQPFQVAEVFTGHMGKLVP

--------------------------------------------------------------

>49692_49692_3_LRIG3-ATP5B_LRIG3_chr12_59270227_ENST00000379141_ATP5B_chr12_57039137_ENST00000262030_length(amino acids)=1345AA_BP=1
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG
NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL
ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC
QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS
ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ
CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIED
IGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS
DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNL
PADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILN
ALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFM
EMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSK
VALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDNIFRFTQAGSEVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSI
TSVQAIYVPADDLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMD

--------------------------------------------------------------

>49692_49692_4_LRIG3-ATP5B_LRIG3_chr12_59270227_ENST00000379141_ATP5B_chr12_57039137_ENST00000552919_length(amino acids)=1334AA_BP=1
MKSGFSFGKPPQQNSVILQVMVDVLLLFSLCLLFHISRPDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG
NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLNRNRISAIPPKMFKLPQLQHL
ELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFC
QKLSELDLTFNHLSRLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRS
ITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDG
FVCDDFPKPQITVQPETQSAIKGSNLSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQ
CVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARERRMHVMPEDDVFFIVDVKIED
IGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAVLQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVS
DAGKYTCEMSNTLGTERGNVRLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNTDETNL
PADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSVRDYAAQTSPSPKAGAATGRIVAVIGAVVDVQFDEGLPPILN
ALEVQGRETRLVLEVAQHLGESTVRTIAMDGTEGLVRGQKVLDSGAPIKIPVGPETLGRIMNVIGEPIDERGPIKTKQFAPIHAEAPEFM
EMSVEQEILVTGIKVVDLLAPYAKGGKIGLFGGAGVGKTVLIMELINNVAKAHGGYSVFAGVGERTREGNDLYHEMIESGVINLKDATSK
VALVYGQMNEPPGARARVALTGLTVAEYFRDQEGQDVLLFIDVSALLGRIPSAVGYQPTLATDMGTMQERITTTKKGSITSVQAIYVPAD
DLTDPAPATTFAHLDATTVLSRAIAELGIYPAVDPLDSTSRIMDPNIVGSEHYDVARGVQKILQDYKSLQDIIAILGMDELSEEDKLTVS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:59270227/chr12:57039137)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRIG3

Q6UXM1

.
FUNCTION: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-161938_74898.33333333333341120.0DomainNote=LRRNT
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619444_495898.33333333333341120.0DomainNote=LRRCT
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619499_598898.33333333333341120.0DomainNote=Ig-like C2-type 1
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619603_692898.33333333333341120.0DomainNote=Ig-like C2-type 2
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619697_783898.33333333333341120.0DomainNote=Ig-like C2-type 3
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-161938_74838.33333333333341060.0DomainNote=LRRNT
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619444_495838.33333333333341060.0DomainNote=LRRCT
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619499_598838.33333333333341060.0DomainNote=Ig-like C2-type 1
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619603_692838.33333333333341060.0DomainNote=Ig-like C2-type 2
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619697_783838.33333333333341060.0DomainNote=Ig-like C2-type 3
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619122_142898.33333333333341120.0RepeatNote=LRR 3
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619146_167898.33333333333341120.0RepeatNote=LRR 4
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619168_189898.33333333333341120.0RepeatNote=LRR 5
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619193_214898.33333333333341120.0RepeatNote=LRR 6
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619216_237898.33333333333341120.0RepeatNote=LRR 7
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619240_261898.33333333333341120.0RepeatNote=LRR 8
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619264_285898.33333333333341120.0RepeatNote=LRR 9
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619288_309898.33333333333341120.0RepeatNote=LRR 10
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619312_333898.33333333333341120.0RepeatNote=LRR 11
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619336_357898.33333333333341120.0RepeatNote=LRR 12
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619360_382898.33333333333341120.0RepeatNote=LRR 13
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619387_408898.33333333333341120.0RepeatNote=LRR 14
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619411_432898.33333333333341120.0RepeatNote=LRR 15
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-161975_96898.33333333333341120.0RepeatNote=LRR 1
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-161999_120898.33333333333341120.0RepeatNote=LRR 2
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619122_142838.33333333333341060.0RepeatNote=LRR 3
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619146_167838.33333333333341060.0RepeatNote=LRR 4
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619168_189838.33333333333341060.0RepeatNote=LRR 5
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619193_214838.33333333333341060.0RepeatNote=LRR 6
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619216_237838.33333333333341060.0RepeatNote=LRR 7
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619240_261838.33333333333341060.0RepeatNote=LRR 8
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619264_285838.33333333333341060.0RepeatNote=LRR 9
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619288_309838.33333333333341060.0RepeatNote=LRR 10
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619312_333838.33333333333341060.0RepeatNote=LRR 11
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619336_357838.33333333333341060.0RepeatNote=LRR 12
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619360_382838.33333333333341060.0RepeatNote=LRR 13
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619387_408838.33333333333341060.0RepeatNote=LRR 14
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619411_432838.33333333333341060.0RepeatNote=LRR 15
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-161975_96838.33333333333341060.0RepeatNote=LRR 1
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-161999_120838.33333333333341060.0RepeatNote=LRR 2
HgeneLRIG3chr12:59270227chr12:57039137ENST00000320743-1619810_830898.33333333333341120.0TransmembraneHelical
HgeneLRIG3chr12:59270227chr12:57039137ENST00000379141-1619810_830838.33333333333341060.0TransmembraneHelical
TgeneATP5Bchr12:59270227chr12:57039137ENST00000262030010207_21442.333333333333336530.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
LRIG3CAND1, TAZ, TNFSF13B, PVRIG, GINM1, LPAR6, PTPRK, PTGER3, GAL3ST1, LRIG1, LRRN2, TMPRSS3, EGFR, ERBB2, ERBB4, KIAA1429, MTDH, PSMD14, ORF3a, E, M, nsp4, nsp6, nsp9, ORF6, ORF7a, ORF7b, TRIM66, LMO7, LIMCH1, ELOVL5, GJA1, HSD17B11, METTL7A, STX4, PDE3A, CLEC12B, SPSB4, OR10H1, CLGN, FBXO2, TMPRSS13, NRSN1, RLN1, RARRES1, LRRC4C, CLEC4A, SPSB2, ANPEP, DPP4, TMPRSS4,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRIG3all structure
ATP5B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRIG3-ATP5B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRIG3-ATP5B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource