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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRP1-OS9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRP1-OS9
FusionPDB ID: 49752
FusionGDB2.0 ID: 49752
HgeneTgene
Gene symbol

LRP1

OS9

Gene ID

10438

10956

Gene nameC1D nuclear receptor corepressorOS9 endoplasmic reticulum lectin
SynonymsLRP1|Rrp47|SUN-CoR|SUNCOR|hC1DERLEC2|OS-9
Cytomap

2p14

12q13.3-q14.1

Type of geneprotein-codingprotein-coding
Descriptionnuclear nucleic acid-binding protein C1DC1D DNA-binding proteinC1D nuclear receptor co-repressornuclear DNA-binding proteinsmall unique nuclear receptor co-repressorsmall unique nuclear receptor corepressorprotein OS-9amplified in osteosarcoma 9endoplasmic reticulum lectin 2erlectin 2osteosarcoma amplified 9, endoplasmic reticulum associated proteinosteosarcoma amplified 9, endoplasmic reticulum lectin
Modification date2020031320200313
UniProtAcc

Q9NZR2

.
Ensembl transtripts involved in fusion geneENST idsENST00000243077, ENST00000338962, 
ENST00000553277, ENST00000554174, 
ENST00000553446, 		ENST00000257966, 
ENST00000315970, ENST00000389142, 
ENST00000389146, ENST00000413095, 
ENST00000435406, ENST00000439210, 
ENST00000551035, ENST00000552285, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score23 X 27 X 12=745228 X 16 X 12=5376
# samples 2638
** MAII scorelog2(26/7452*10)=-4.84104414591318
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(38/5376*10)=-3.82246181444781
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRP1 [Title/Abstract] AND OS9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRP1(57522814)-OS9(58088533), # samples:2
LRP1(57552421)-OS9(58114189), # samples:2
LRP1(57552421)-OS9(58114188), # samples:2
LRP1(57552421)-OS9(58113881), # samples:2
Anticipated loss of major functional domain due to fusion event.LRP1-OS9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP1-OS9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP1-OS9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP1-OS9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneOS9

GO:0006621

protein retention in ER lumen

18417469

TgeneOS9

GO:0034976

response to endoplasmic reticulum stress

19084021


check buttonFusion gene breakpoints across LRP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across OS9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-FC-7708-01ALRP1chr12

57522814

+OS9chr12

58088533

+
ChimerDB4PRADTCGA-FC-7708LRP1chr12

57522814

+OS9chr12

58088533

+
ChimerDB4PRADTCGA-H9-A6BY-01ALRP1chr12

57552420

+OS9chr12

58113881

+
ChimerDB4PRADTCGA-H9-A6BY-01ALRP1chr12

57552420

+OS9chr12

58114188

+
ChimerDB4PRADTCGA-H9-A6BY-01ALRP1chr12

57552421

+OS9chr12

58114189

+
ChimerDB4PRADTCGA-H9-A6BYLRP1chr12

57552421

+OS9chr12

58113881

+
ChimerDB4PRADTCGA-H9-A6BYLRP1chr12

57552421

+OS9chr12

58113882

+
ChimerDB4PRADTCGA-H9-A6BYLRP1chr12

57552421

+OS9chr12

58114188

+
ChimerDB4PRADTCGA-H9-A6BYLRP1chr12

57552421

+OS9chr12

58114189

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000243077LRP1chr1257552421+ENST00000552285OS9chr1258114189+259222644422502686
ENST00000243077LRP1chr1257552421+ENST00000315970OS9chr1258114189+314922644422502686
ENST00000243077LRP1chr1257552421+ENST00000439210OS9chr1258114189+281322644422502686
ENST00000243077LRP1chr1257552421+ENST00000389146OS9chr1258114189+261822644422502686
ENST00000243077LRP1chr1257552421+ENST00000413095OS9chr1258114189+292522644422502686
ENST00000243077LRP1chr1257552421+ENST00000551035OS9chr1258114189+298922644422502686
ENST00000243077LRP1chr1257552421+ENST00000435406OS9chr1258114189+314922644422502686
ENST00000243077LRP1chr1257552421+ENST00000257966OS9chr1258114189+314922644422502686
ENST00000243077LRP1chr1257552421+ENST00000389142OS9chr1258114189+315122644422502686
ENST00000243077LRP1chr1257552421+ENST00000552285OS9chr1258114188+259222644422502686
ENST00000243077LRP1chr1257552421+ENST00000315970OS9chr1258114188+314922644422502686
ENST00000243077LRP1chr1257552421+ENST00000439210OS9chr1258114188+281322644422502686
ENST00000243077LRP1chr1257552421+ENST00000389146OS9chr1258114188+261822644422502686
ENST00000243077LRP1chr1257552421+ENST00000413095OS9chr1258114188+292522644422502686
ENST00000243077LRP1chr1257552421+ENST00000551035OS9chr1258114188+298922644422502686
ENST00000243077LRP1chr1257552421+ENST00000435406OS9chr1258114188+314922644422502686
ENST00000243077LRP1chr1257552421+ENST00000257966OS9chr1258114188+314922644422502686
ENST00000243077LRP1chr1257552421+ENST00000389142OS9chr1258114188+315122644422502686
ENST00000243077LRP1chr1257552420+ENST00000552285OS9chr1258114188+259222644422502686
ENST00000243077LRP1chr1257552420+ENST00000315970OS9chr1258114188+314922644422502686
ENST00000243077LRP1chr1257552420+ENST00000439210OS9chr1258114188+281322644422502686
ENST00000243077LRP1chr1257552420+ENST00000389146OS9chr1258114188+261822644422502686
ENST00000243077LRP1chr1257552420+ENST00000413095OS9chr1258114188+292522644422502686
ENST00000243077LRP1chr1257552420+ENST00000551035OS9chr1258114188+298922644422502686
ENST00000243077LRP1chr1257552420+ENST00000435406OS9chr1258114188+314922644422502686
ENST00000243077LRP1chr1257552420+ENST00000257966OS9chr1258114188+314922644422502686
ENST00000243077LRP1chr1257552420+ENST00000389142OS9chr1258114188+315122644422502686

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000243077ENST00000552285LRP1chr1257552421+OS9chr1258114189+0.0097366470.99026334
ENST00000243077ENST00000315970LRP1chr1257552421+OS9chr1258114189+0.0079175840.99208236
ENST00000243077ENST00000439210LRP1chr1257552421+OS9chr1258114189+0.0091783130.9908217
ENST00000243077ENST00000389146LRP1chr1257552421+OS9chr1258114189+0.0099534140.99004656
ENST00000243077ENST00000413095LRP1chr1257552421+OS9chr1258114189+0.0092925860.9907074
ENST00000243077ENST00000551035LRP1chr1257552421+OS9chr1258114189+0.0087294890.99127054
ENST00000243077ENST00000435406LRP1chr1257552421+OS9chr1258114189+0.0079175840.99208236
ENST00000243077ENST00000257966LRP1chr1257552421+OS9chr1258114189+0.0079175840.99208236
ENST00000243077ENST00000389142LRP1chr1257552421+OS9chr1258114189+0.0079341320.99206585
ENST00000243077ENST00000552285LRP1chr1257552421+OS9chr1258114188+0.0097366470.99026334
ENST00000243077ENST00000315970LRP1chr1257552421+OS9chr1258114188+0.0079175840.99208236
ENST00000243077ENST00000439210LRP1chr1257552421+OS9chr1258114188+0.0091783130.9908217
ENST00000243077ENST00000389146LRP1chr1257552421+OS9chr1258114188+0.0099534140.99004656
ENST00000243077ENST00000413095LRP1chr1257552421+OS9chr1258114188+0.0092925860.9907074
ENST00000243077ENST00000551035LRP1chr1257552421+OS9chr1258114188+0.0087294890.99127054
ENST00000243077ENST00000435406LRP1chr1257552421+OS9chr1258114188+0.0079175840.99208236
ENST00000243077ENST00000257966LRP1chr1257552421+OS9chr1258114188+0.0079175840.99208236
ENST00000243077ENST00000389142LRP1chr1257552421+OS9chr1258114188+0.0079341320.99206585
ENST00000243077ENST00000552285LRP1chr1257552420+OS9chr1258114188+0.0097366470.99026334
ENST00000243077ENST00000315970LRP1chr1257552420+OS9chr1258114188+0.0079175840.99208236
ENST00000243077ENST00000439210LRP1chr1257552420+OS9chr1258114188+0.0091783130.9908217
ENST00000243077ENST00000389146LRP1chr1257552420+OS9chr1258114188+0.0099534140.99004656
ENST00000243077ENST00000413095LRP1chr1257552420+OS9chr1258114188+0.0092925860.9907074
ENST00000243077ENST00000551035LRP1chr1257552420+OS9chr1258114188+0.0087294890.99127054
ENST00000243077ENST00000435406LRP1chr1257552420+OS9chr1258114188+0.0079175840.99208236
ENST00000243077ENST00000257966LRP1chr1257552420+OS9chr1258114188+0.0079175840.99208236
ENST00000243077ENST00000389142LRP1chr1257552420+OS9chr1258114188+0.0079341320.99206585

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49752_49752_1_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000257966_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_2_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000315970_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_3_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000389142_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_4_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000389146_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_5_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000413095_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_6_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000435406_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_7_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000439210_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_8_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000551035_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_9_LRP1-OS9_LRP1_chr12_57552420_ENST00000243077_OS9_chr12_58114188_ENST00000552285_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_10_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000257966_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_11_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000315970_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_12_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000389142_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_13_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000389146_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_14_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000413095_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_15_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000435406_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_16_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000439210_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_17_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000551035_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_18_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114188_ENST00000552285_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_19_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000257966_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_20_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000315970_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_21_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000389142_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_22_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000389146_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_23_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000413095_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_24_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000435406_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_25_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000439210_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_26_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000551035_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

--------------------------------------------------------------

>49752_49752_27_LRP1-OS9_LRP1_chr12_57552421_ENST00000243077_OS9_chr12_58114189_ENST00000552285_length(amino acids)=686AA_BP=1
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:57522814/chr12:58088533)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP1

Q9NZR2

.
FUNCTION: Potential cell surface proteins that bind and internalize ligands in the process of receptor-mediated endocytosis.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189111_149599.33333333333344545.0DomainEGF-like 1
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189150_189599.33333333333344545.0DomainEGF-like 2%3B calcium-binding
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+118925_66599.33333333333344545.0DomainLDL-receptor class A 1
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189474_520599.33333333333344545.0DomainEGF-like 3
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+118970_110599.33333333333344545.0DomainLDL-receptor class A 2
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189111_149599.33333333333344545.0DomainEGF-like 1
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189150_189599.33333333333344545.0DomainEGF-like 2%3B calcium-binding
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+118925_66599.33333333333344545.0DomainLDL-receptor class A 1
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189474_520599.33333333333344545.0DomainEGF-like 3
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+118970_110599.33333333333344545.0DomainLDL-receptor class A 2
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189111_149599.33333333333344545.0DomainEGF-like 1
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189150_189599.33333333333344545.0DomainEGF-like 2%3B calcium-binding
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+118925_66599.33333333333344545.0DomainLDL-receptor class A 1
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189474_520599.33333333333344545.0DomainEGF-like 3
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+118970_110599.33333333333344545.0DomainLDL-receptor class A 2
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189292_334599.33333333333344545.0RepeatNote=LDL-receptor class B 1
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189335_378599.33333333333344545.0RepeatNote=LDL-receptor class B 2
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189379_422599.33333333333344545.0RepeatNote=LDL-receptor class B 3
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189292_334599.33333333333344545.0RepeatNote=LDL-receptor class B 1
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189335_378599.33333333333344545.0RepeatNote=LDL-receptor class B 2
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189379_422599.33333333333344545.0RepeatNote=LDL-receptor class B 3
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189292_334599.33333333333344545.0RepeatNote=LDL-receptor class B 1
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189335_378599.33333333333344545.0RepeatNote=LDL-receptor class B 2
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189379_422599.33333333333344545.0RepeatNote=LDL-receptor class B 3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891013_1053599.33333333333344545.0DomainLDL-receptor class A 7
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891060_1099599.33333333333344545.0DomainLDL-receptor class A 8
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891102_1142599.33333333333344545.0DomainLDL-receptor class A 9
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891143_1182599.33333333333344545.0DomainLDL-receptor class A 10
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891183_1222599.33333333333344545.0DomainEGF-like 5
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891223_1262599.33333333333344545.0DomainEGF-like 6
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891536_1579599.33333333333344545.0DomainEGF-like 7
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891846_1887599.33333333333344545.0DomainEGF-like 8
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892155_2195599.33333333333344545.0DomainEGF-like 9
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892478_2518599.33333333333344545.0DomainEGF-like 10
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892522_2563599.33333333333344545.0DomainLDL-receptor class A 11
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892564_2602599.33333333333344545.0DomainLDL-receptor class A 12
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892603_2641599.33333333333344545.0DomainLDL-receptor class A 13
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892642_2690599.33333333333344545.0DomainLDL-receptor class A 14
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892694_2732599.33333333333344545.0DomainLDL-receptor class A 15
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892732_2771599.33333333333344545.0DomainLDL-receptor class A 16
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892772_2814599.33333333333344545.0DomainLDL-receptor class A 17
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892816_2855599.33333333333344545.0DomainLDL-receptor class A 18
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892856_2899599.33333333333344545.0DomainLDL-receptor class A 19
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892902_2940599.33333333333344545.0DomainLDL-receptor class A 20
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892941_2981599.33333333333344545.0DomainEGF-like 11
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892982_3022599.33333333333344545.0DomainEGF-like 12%3B calcium-binding
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893290_3331599.33333333333344545.0DomainEGF-like 13
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893332_3371599.33333333333344545.0DomainLDL-receptor class A 21
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893372_3410599.33333333333344545.0DomainLDL-receptor class A 22
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893411_3450599.33333333333344545.0DomainLDL-receptor class A 23
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893451_3491599.33333333333344545.0DomainLDL-receptor class A 24
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893492_3533599.33333333333344545.0DomainLDL-receptor class A 25
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893534_3572599.33333333333344545.0DomainLDL-receptor class A 26
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893573_3611599.33333333333344545.0DomainLDL-receptor class A 27
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893611_3649599.33333333333344545.0DomainLDL-receptor class A 28
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893652_3692599.33333333333344545.0DomainLDL-receptor class A 29
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893693_3733599.33333333333344545.0DomainLDL-receptor class A 30
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893739_3778599.33333333333344545.0DomainLDL-receptor class A 31
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893781_3823599.33333333333344545.0DomainEGF-like 14
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893824_3861599.33333333333344545.0DomainEGF-like 15
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894147_4183599.33333333333344545.0DomainEGF-like 16
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894196_4232599.33333333333344545.0DomainEGF-like 17
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894232_4268599.33333333333344545.0DomainEGF-like 18
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894268_4304599.33333333333344545.0DomainEGF-like 19
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894304_4340599.33333333333344545.0DomainEGF-like 20
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894340_4375599.33333333333344545.0DomainEGF-like 21
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894373_4409599.33333333333344545.0DomainEGF-like 22
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189803_843599.33333333333344545.0DomainEGF-like 4
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189852_892599.33333333333344545.0DomainLDL-receptor class A 3
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189893_933599.33333333333344545.0DomainLDL-receptor class A 4
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189934_973599.33333333333344545.0DomainLDL-receptor class A 5
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189974_1013599.33333333333344545.0DomainLDL-receptor class A 6
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891013_1053599.33333333333344545.0DomainLDL-receptor class A 7
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891060_1099599.33333333333344545.0DomainLDL-receptor class A 8
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891102_1142599.33333333333344545.0DomainLDL-receptor class A 9
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891143_1182599.33333333333344545.0DomainLDL-receptor class A 10
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891183_1222599.33333333333344545.0DomainEGF-like 5
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891223_1262599.33333333333344545.0DomainEGF-like 6
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891536_1579599.33333333333344545.0DomainEGF-like 7
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891846_1887599.33333333333344545.0DomainEGF-like 8
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892155_2195599.33333333333344545.0DomainEGF-like 9
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892478_2518599.33333333333344545.0DomainEGF-like 10
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892522_2563599.33333333333344545.0DomainLDL-receptor class A 11
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892564_2602599.33333333333344545.0DomainLDL-receptor class A 12
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892603_2641599.33333333333344545.0DomainLDL-receptor class A 13
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892642_2690599.33333333333344545.0DomainLDL-receptor class A 14
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892694_2732599.33333333333344545.0DomainLDL-receptor class A 15
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892732_2771599.33333333333344545.0DomainLDL-receptor class A 16
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892772_2814599.33333333333344545.0DomainLDL-receptor class A 17
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892816_2855599.33333333333344545.0DomainLDL-receptor class A 18
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892856_2899599.33333333333344545.0DomainLDL-receptor class A 19
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892902_2940599.33333333333344545.0DomainLDL-receptor class A 20
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892941_2981599.33333333333344545.0DomainEGF-like 11
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892982_3022599.33333333333344545.0DomainEGF-like 12%3B calcium-binding
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893290_3331599.33333333333344545.0DomainEGF-like 13
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893332_3371599.33333333333344545.0DomainLDL-receptor class A 21
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893372_3410599.33333333333344545.0DomainLDL-receptor class A 22
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893411_3450599.33333333333344545.0DomainLDL-receptor class A 23
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893451_3491599.33333333333344545.0DomainLDL-receptor class A 24
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893492_3533599.33333333333344545.0DomainLDL-receptor class A 25
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893534_3572599.33333333333344545.0DomainLDL-receptor class A 26
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893573_3611599.33333333333344545.0DomainLDL-receptor class A 27
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893611_3649599.33333333333344545.0DomainLDL-receptor class A 28
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893652_3692599.33333333333344545.0DomainLDL-receptor class A 29
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893693_3733599.33333333333344545.0DomainLDL-receptor class A 30
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893739_3778599.33333333333344545.0DomainLDL-receptor class A 31
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893781_3823599.33333333333344545.0DomainEGF-like 14
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893824_3861599.33333333333344545.0DomainEGF-like 15
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894147_4183599.33333333333344545.0DomainEGF-like 16
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894196_4232599.33333333333344545.0DomainEGF-like 17
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894232_4268599.33333333333344545.0DomainEGF-like 18
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894268_4304599.33333333333344545.0DomainEGF-like 19
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894304_4340599.33333333333344545.0DomainEGF-like 20
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894340_4375599.33333333333344545.0DomainEGF-like 21
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894373_4409599.33333333333344545.0DomainEGF-like 22
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189803_843599.33333333333344545.0DomainEGF-like 4
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189852_892599.33333333333344545.0DomainLDL-receptor class A 3
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189893_933599.33333333333344545.0DomainLDL-receptor class A 4
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189934_973599.33333333333344545.0DomainLDL-receptor class A 5
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189974_1013599.33333333333344545.0DomainLDL-receptor class A 6
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891013_1053599.33333333333344545.0DomainLDL-receptor class A 7
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891060_1099599.33333333333344545.0DomainLDL-receptor class A 8
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891102_1142599.33333333333344545.0DomainLDL-receptor class A 9
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891143_1182599.33333333333344545.0DomainLDL-receptor class A 10
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891183_1222599.33333333333344545.0DomainEGF-like 5
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891223_1262599.33333333333344545.0DomainEGF-like 6
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891536_1579599.33333333333344545.0DomainEGF-like 7
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891846_1887599.33333333333344545.0DomainEGF-like 8
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892155_2195599.33333333333344545.0DomainEGF-like 9
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892478_2518599.33333333333344545.0DomainEGF-like 10
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892522_2563599.33333333333344545.0DomainLDL-receptor class A 11
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892564_2602599.33333333333344545.0DomainLDL-receptor class A 12
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892603_2641599.33333333333344545.0DomainLDL-receptor class A 13
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892642_2690599.33333333333344545.0DomainLDL-receptor class A 14
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892694_2732599.33333333333344545.0DomainLDL-receptor class A 15
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892732_2771599.33333333333344545.0DomainLDL-receptor class A 16
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892772_2814599.33333333333344545.0DomainLDL-receptor class A 17
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892816_2855599.33333333333344545.0DomainLDL-receptor class A 18
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892856_2899599.33333333333344545.0DomainLDL-receptor class A 19
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892902_2940599.33333333333344545.0DomainLDL-receptor class A 20
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892941_2981599.33333333333344545.0DomainEGF-like 11
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892982_3022599.33333333333344545.0DomainEGF-like 12%3B calcium-binding
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893290_3331599.33333333333344545.0DomainEGF-like 13
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893332_3371599.33333333333344545.0DomainLDL-receptor class A 21
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893372_3410599.33333333333344545.0DomainLDL-receptor class A 22
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893411_3450599.33333333333344545.0DomainLDL-receptor class A 23
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893451_3491599.33333333333344545.0DomainLDL-receptor class A 24
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893492_3533599.33333333333344545.0DomainLDL-receptor class A 25
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893534_3572599.33333333333344545.0DomainLDL-receptor class A 26
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893573_3611599.33333333333344545.0DomainLDL-receptor class A 27
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893611_3649599.33333333333344545.0DomainLDL-receptor class A 28
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893652_3692599.33333333333344545.0DomainLDL-receptor class A 29
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893693_3733599.33333333333344545.0DomainLDL-receptor class A 30
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893739_3778599.33333333333344545.0DomainLDL-receptor class A 31
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893781_3823599.33333333333344545.0DomainEGF-like 14
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893824_3861599.33333333333344545.0DomainEGF-like 15
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894147_4183599.33333333333344545.0DomainEGF-like 16
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894196_4232599.33333333333344545.0DomainEGF-like 17
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894232_4268599.33333333333344545.0DomainEGF-like 18
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894268_4304599.33333333333344545.0DomainEGF-like 19
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894304_4340599.33333333333344545.0DomainEGF-like 20
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894340_4375599.33333333333344545.0DomainEGF-like 21
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894373_4409599.33333333333344545.0DomainEGF-like 22
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189803_843599.33333333333344545.0DomainEGF-like 4
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189852_892599.33333333333344545.0DomainLDL-receptor class A 3
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189893_933599.33333333333344545.0DomainLDL-receptor class A 4
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189934_973599.33333333333344545.0DomainLDL-receptor class A 5
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189974_1013599.33333333333344545.0DomainLDL-receptor class A 6
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893940_3943599.33333333333344545.0MotifRecognition site for proteolytical processing
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894502_4507599.33333333333344545.0MotifNote=NPXY motif
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893940_3943599.33333333333344545.0MotifRecognition site for proteolytical processing
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894502_4507599.33333333333344545.0MotifNote=NPXY motif
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893940_3943599.33333333333344545.0MotifRecognition site for proteolytical processing
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894502_4507599.33333333333344545.0MotifNote=NPXY motif
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891309_1355599.33333333333344545.0RepeatNote=LDL-receptor class B 8
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891356_1398599.33333333333344545.0RepeatNote=LDL-receptor class B 9
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891399_1445599.33333333333344545.0RepeatNote=LDL-receptor class B 10
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891446_1490599.33333333333344545.0RepeatNote=LDL-receptor class B 11
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891491_1531599.33333333333344545.0RepeatNote=LDL-receptor class B 12
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891627_1669599.33333333333344545.0RepeatNote=LDL-receptor class B 13
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891670_1713599.33333333333344545.0RepeatNote=LDL-receptor class B 14
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891714_1753599.33333333333344545.0RepeatNote=LDL-receptor class B 15
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891754_1798599.33333333333344545.0RepeatNote=LDL-receptor class B 16
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891934_1976599.33333333333344545.0RepeatNote=LDL-receptor class B 17
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11891977_2019599.33333333333344545.0RepeatNote=LDL-receptor class B 18
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892020_2063599.33333333333344545.0RepeatNote=LDL-receptor class B 19
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892064_2107599.33333333333344545.0RepeatNote=LDL-receptor class B 20
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892253_2294599.33333333333344545.0RepeatNote=LDL-receptor class B 21
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892295_2343599.33333333333344545.0RepeatNote=LDL-receptor class B 22
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892344_2388599.33333333333344545.0RepeatNote=LDL-receptor class B 23
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892389_2431599.33333333333344545.0RepeatNote=LDL-receptor class B 24
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11892432_2473599.33333333333344545.0RepeatNote=LDL-receptor class B 25
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893069_3113599.33333333333344545.0RepeatNote=LDL-receptor class B 26
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893114_3156599.33333333333344545.0RepeatNote=LDL-receptor class B 27
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893157_3200599.33333333333344545.0RepeatNote=LDL-receptor class B 28
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893201_3243599.33333333333344545.0RepeatNote=LDL-receptor class B 29
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893244_3284599.33333333333344545.0RepeatNote=LDL-receptor class B 30
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893912_3954599.33333333333344545.0RepeatNote=LDL-receptor class B 31
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11893970_4012599.33333333333344545.0RepeatNote=LDL-receptor class B 32
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894013_4056599.33333333333344545.0RepeatNote=LDL-receptor class B 33
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894057_4101599.33333333333344545.0RepeatNote=LDL-receptor class B 34
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189571_613599.33333333333344545.0RepeatNote=LDL-receptor class B 4
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189614_659599.33333333333344545.0RepeatNote=LDL-receptor class B 5
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189660_710599.33333333333344545.0RepeatNote=LDL-receptor class B 6
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+1189711_754599.33333333333344545.0RepeatNote=LDL-receptor class B 7
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891309_1355599.33333333333344545.0RepeatNote=LDL-receptor class B 8
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891356_1398599.33333333333344545.0RepeatNote=LDL-receptor class B 9
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891399_1445599.33333333333344545.0RepeatNote=LDL-receptor class B 10
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891446_1490599.33333333333344545.0RepeatNote=LDL-receptor class B 11
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891491_1531599.33333333333344545.0RepeatNote=LDL-receptor class B 12
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891627_1669599.33333333333344545.0RepeatNote=LDL-receptor class B 13
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891670_1713599.33333333333344545.0RepeatNote=LDL-receptor class B 14
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891714_1753599.33333333333344545.0RepeatNote=LDL-receptor class B 15
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891754_1798599.33333333333344545.0RepeatNote=LDL-receptor class B 16
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891934_1976599.33333333333344545.0RepeatNote=LDL-receptor class B 17
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11891977_2019599.33333333333344545.0RepeatNote=LDL-receptor class B 18
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892020_2063599.33333333333344545.0RepeatNote=LDL-receptor class B 19
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892064_2107599.33333333333344545.0RepeatNote=LDL-receptor class B 20
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892253_2294599.33333333333344545.0RepeatNote=LDL-receptor class B 21
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892295_2343599.33333333333344545.0RepeatNote=LDL-receptor class B 22
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892344_2388599.33333333333344545.0RepeatNote=LDL-receptor class B 23
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892389_2431599.33333333333344545.0RepeatNote=LDL-receptor class B 24
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11892432_2473599.33333333333344545.0RepeatNote=LDL-receptor class B 25
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893069_3113599.33333333333344545.0RepeatNote=LDL-receptor class B 26
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893114_3156599.33333333333344545.0RepeatNote=LDL-receptor class B 27
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893157_3200599.33333333333344545.0RepeatNote=LDL-receptor class B 28
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893201_3243599.33333333333344545.0RepeatNote=LDL-receptor class B 29
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893244_3284599.33333333333344545.0RepeatNote=LDL-receptor class B 30
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893912_3954599.33333333333344545.0RepeatNote=LDL-receptor class B 31
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11893970_4012599.33333333333344545.0RepeatNote=LDL-receptor class B 32
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894013_4056599.33333333333344545.0RepeatNote=LDL-receptor class B 33
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894057_4101599.33333333333344545.0RepeatNote=LDL-receptor class B 34
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189571_613599.33333333333344545.0RepeatNote=LDL-receptor class B 4
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189614_659599.33333333333344545.0RepeatNote=LDL-receptor class B 5
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189660_710599.33333333333344545.0RepeatNote=LDL-receptor class B 6
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+1189711_754599.33333333333344545.0RepeatNote=LDL-receptor class B 7
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891309_1355599.33333333333344545.0RepeatNote=LDL-receptor class B 8
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891356_1398599.33333333333344545.0RepeatNote=LDL-receptor class B 9
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891399_1445599.33333333333344545.0RepeatNote=LDL-receptor class B 10
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891446_1490599.33333333333344545.0RepeatNote=LDL-receptor class B 11
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891491_1531599.33333333333344545.0RepeatNote=LDL-receptor class B 12
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891627_1669599.33333333333344545.0RepeatNote=LDL-receptor class B 13
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891670_1713599.33333333333344545.0RepeatNote=LDL-receptor class B 14
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891714_1753599.33333333333344545.0RepeatNote=LDL-receptor class B 15
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891754_1798599.33333333333344545.0RepeatNote=LDL-receptor class B 16
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891934_1976599.33333333333344545.0RepeatNote=LDL-receptor class B 17
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11891977_2019599.33333333333344545.0RepeatNote=LDL-receptor class B 18
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892020_2063599.33333333333344545.0RepeatNote=LDL-receptor class B 19
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892064_2107599.33333333333344545.0RepeatNote=LDL-receptor class B 20
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892253_2294599.33333333333344545.0RepeatNote=LDL-receptor class B 21
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892295_2343599.33333333333344545.0RepeatNote=LDL-receptor class B 22
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892344_2388599.33333333333344545.0RepeatNote=LDL-receptor class B 23
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892389_2431599.33333333333344545.0RepeatNote=LDL-receptor class B 24
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11892432_2473599.33333333333344545.0RepeatNote=LDL-receptor class B 25
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893069_3113599.33333333333344545.0RepeatNote=LDL-receptor class B 26
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893114_3156599.33333333333344545.0RepeatNote=LDL-receptor class B 27
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893157_3200599.33333333333344545.0RepeatNote=LDL-receptor class B 28
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893201_3243599.33333333333344545.0RepeatNote=LDL-receptor class B 29
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893244_3284599.33333333333344545.0RepeatNote=LDL-receptor class B 30
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893912_3954599.33333333333344545.0RepeatNote=LDL-receptor class B 31
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11893970_4012599.33333333333344545.0RepeatNote=LDL-receptor class B 32
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894013_4056599.33333333333344545.0RepeatNote=LDL-receptor class B 33
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894057_4101599.33333333333344545.0RepeatNote=LDL-receptor class B 34
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189571_613599.33333333333344545.0RepeatNote=LDL-receptor class B 4
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189614_659599.33333333333344545.0RepeatNote=LDL-receptor class B 5
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189660_710599.33333333333344545.0RepeatNote=LDL-receptor class B 6
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+1189711_754599.33333333333344545.0RepeatNote=LDL-receptor class B 7
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+118920_4419599.33333333333344545.0Topological domainExtracellular
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+118920_4419599.33333333333344545.0Topological domainExtracellular
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+118920_4419599.33333333333344545.0Topological domainExtracellular
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894420_4444599.33333333333344545.0TransmembraneHelical
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894420_4444599.33333333333344545.0TransmembraneHelical
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894420_4444599.33333333333344545.0TransmembraneHelical
TgeneOS9chr12:57552420chr12:58114188ENST000002579661114414_429534.3333333333334614.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000003159701215414_429588.3333333333334668.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000003891421114414_429518.3333333333334598.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000003891461215414_429573.3333333333334653.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000004354061013414_429481.3333333333333561.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000004392101013414_429459.3333333333333539.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000005510351013414_429501.3333333333333581.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000005522851114414_429533.3333333333334613.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000002579661114414_429534.3333333333334614.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000003159701215414_429588.3333333333334668.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000003891421114414_429518.3333333333334598.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000003891461215414_429573.3333333333334653.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000004354061013414_429481.3333333333333561.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000004392101013414_429459.3333333333333539.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000005510351013414_429501.3333333333333581.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114188ENST000005522851114414_429533.3333333333334613.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000002579661114414_429534.3333333333334614.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000003159701215414_429588.3333333333334668.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000003891421114414_429518.3333333333334598.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000003891461215414_429573.3333333333334653.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000004354061013414_429481.3333333333333561.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000004392101013414_429459.3333333333333539.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000005510351013414_429501.3333333333333581.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552421chr12:58114189ENST000005522851114414_429533.3333333333334613.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneOS9chr12:57552420chr12:58114188ENST000002579661114108_230534.3333333333334614.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000003159701215108_230588.3333333333334668.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000003891421114108_230518.3333333333334598.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000003891461215108_230573.3333333333334653.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000004354061013108_230481.3333333333333561.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000004392101013108_230459.3333333333333539.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000005510351013108_230501.3333333333333581.0DomainMRH
TgeneOS9chr12:57552420chr12:58114188ENST000005522851114108_230533.3333333333334613.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000002579661114108_230534.3333333333334614.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000003159701215108_230588.3333333333334668.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000003891421114108_230518.3333333333334598.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000003891461215108_230573.3333333333334653.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000004354061013108_230481.3333333333333561.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000004392101013108_230459.3333333333333539.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000005510351013108_230501.3333333333333581.0DomainMRH
TgeneOS9chr12:57552421chr12:58114188ENST000005522851114108_230533.3333333333334613.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000002579661114108_230534.3333333333334614.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000003159701215108_230588.3333333333334668.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000003891421114108_230518.3333333333334598.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000003891461215108_230573.3333333333334653.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000004354061013108_230481.3333333333333561.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000004392101013108_230459.3333333333333539.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000005510351013108_230501.3333333333333581.0DomainMRH
TgeneOS9chr12:57552421chr12:58114189ENST000005522851114108_230533.3333333333334613.0DomainMRH


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1409_LRP1_57552421_OS9_58114189_ranked_0.pdbLRP15755242057552421ENST00000389142OS9chr1258114189+
MLLASAHTMLTPPLLLLLPLLSALVAAAIDAPKTCSPKQFACRDQITCISKGWRCDGERDCPDGSDEAPEICPQSKAQRCQPNEHNCLGT
ELCVPMSRLCNGVQDCMDGSDEGPHCRELQGNCSRLGCQHHCVPTLDGPTCYCNSSFQLQADGKTCKDFDECSVYGTCSQLCTNTDGSFI
CGCVEGYLLQPDNRSCKAKNEPVDRPPVLLIANSQNILATYLSGAQVSTITPTSTRQTTAMDFSYANETVCWVHVGDSAAQTQLKCARMP
GLKGFVDEHTINISLSLHHVEQMAIDWLTGNFYFVDDIDDRIFVCNRNGDTCVTLLDLELYNPKGIALDPAMGKVFFTDYGQIPKVERCD
MDGQNRTKLVDSKIVFPHGITLDLVSRLVYWADAYLDYIEVVDYEGKGRQTIIQGILIEHLYGLTVFENYLYATNSDNANAQQKTSVIRV
NRFNSTEYQVVTRVDKGGALHIYHQRRQPRVRSHACENDQYGKPGGCSDICLLANSHKARTCRCRSGFSLGSDGKSCKKPEHELFLVYGK
GRPGIIRGMDMGAKVPDEHMIPIENLMNPRALDFHAETGFIYFADTTSYLIGRQKIDGTERETILKDGKIEIKIVRPWAEGTEEGARWLT
686


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LRP1_pLDDT.png
all structure
all structure
OS9_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRP1
OS9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneLRP1chr12:57552420chr12:58114188ENST00000243077+11894445_4544599.33333333333344545.0MAFB
HgeneLRP1chr12:57552421chr12:58114188ENST00000243077+11894445_4544599.33333333333344545.0MAFB
HgeneLRP1chr12:57552421chr12:58114189ENST00000243077+11894445_4544599.33333333333344545.0MAFB


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Related Drugs to LRP1-OS9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRP1-OS9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource