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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LRP3-LSM14A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LRP3-LSM14A
	FusionPDB ID: 49770
	FusionGDB2.0 ID: 49770
		Hgene	Tgene
	Gene symbol	LRP3	LSM14A
	Gene ID	4037	26065
	Gene name	LDL receptor related protein 3	LSM14A mRNA processing body assembly factor
	Synonyms	-	C19orf13\|FAM61A\|RAP55\|RAP55A
	Cytomap	19q13.11	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 3105 kDa low-density lipoprotein receptor-related proteinCTD-2540B15.13LRP-3hLRp105	protein LSM14 homolog ALSM14 homolog ALSM14A, SCD6 homolog ARNA-associated protein 55RNA-associated protein 55AalphaSNBPfamily with sequence similarity 61, member AhRAP55hRAP55Aprotein SCD6 homologputative alpha-synuclein-binding protein
	Modification date	20200313	20200327
	UniProtAcc	O75074	Q8ND56
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000253193,	ENST00000433627, ENST00000540746, ENST00000544216,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 6 X 4=144	16 X 15 X 8=1920
	# samples	7	20
	** MAII score	log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(20/1920*10)=-3.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LRP3 [Title/Abstract] AND LSM14A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LRP3(33685764)-LSM14A(34685382), # samples:2
Anticipated loss of major functional domain due to fusion event.	LRP3-LSM14A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP3-LSM14A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP3-LSM14A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP3-LSM14A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	LSM14A	GO:0033962	cytoplasmic mRNA processing body assembly	16484376

Fusion gene breakpoints across LRP3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LSM14A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-J4-A83I-01A	LRP3	chr19	33685764	+	LSM14A	chr19	34685383	+
ChimerDB4	PRAD	TCGA-J4-A83I	LRP3	chr19	33685764	+	LSM14A	chr19	34685382	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000253193	LRP3	chr19	33685764	+	ENST00000540746	LSM14A	chr19	34685383	+	2188	275	202	1422	406
ENST00000253193	LRP3	chr19	33685764	+	ENST00000544216	LSM14A	chr19	34685383	+	3673	275	202	1545	447
ENST00000253193	LRP3	chr19	33685764	+	ENST00000433627	LSM14A	chr19	34685383	+	3503	275	202	1545	447
ENST00000253193	LRP3	chr19	33685764	+	ENST00000540746	LSM14A	chr19	34685382	+	2188	275	202	1422	406
ENST00000253193	LRP3	chr19	33685764	+	ENST00000544216	LSM14A	chr19	34685382	+	3673	275	202	1545	447
ENST00000253193	LRP3	chr19	33685764	+	ENST00000433627	LSM14A	chr19	34685382	+	3503	275	202	1545	447

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000253193	ENST00000540746	LRP3	chr19	33685764	+	LSM14A	chr19	34685383	+	0.000858011	0.99914193
ENST00000253193	ENST00000544216	LRP3	chr19	33685764	+	LSM14A	chr19	34685383	+	0.000383213	0.99961674
ENST00000253193	ENST00000433627	LRP3	chr19	33685764	+	LSM14A	chr19	34685383	+	0.000592472	0.99940753
ENST00000253193	ENST00000540746	LRP3	chr19	33685764	+	LSM14A	chr19	34685382	+	0.000858011	0.99914193
ENST00000253193	ENST00000544216	LRP3	chr19	33685764	+	LSM14A	chr19	34685382	+	0.000383213	0.99961674
ENST00000253193	ENST00000433627	LRP3	chr19	33685764	+	LSM14A	chr19	34685382	+	0.000592472	0.99940753

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49770_49770_1_LRP3-LSM14A_LRP3_chr19_33685764_ENST00000253193_LSM14A_chr19_34685382_ENST00000433627_length(amino acids)=447AA_BP=24
MEKRAAAGLEGAPGARAQLAVVCLVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQ
SMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTME
QAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRR
DGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCD

--------------------------------------------------------------

>49770_49770_2_LRP3-LSM14A_LRP3_chr19_33685764_ENST00000253193_LSM14A_chr19_34685382_ENST00000540746_length(amino acids)=406AA_BP=24
MEKRAAAGLEGAPGARAQLAVVCLVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQ
SMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHR
RAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEK
QEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGF

--------------------------------------------------------------

>49770_49770_3_LRP3-LSM14A_LRP3_chr19_33685764_ENST00000253193_LSM14A_chr19_34685382_ENST00000544216_length(amino acids)=447AA_BP=24
MEKRAAAGLEGAPGARAQLAVVCLVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQ
SMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTME
QAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRR
DGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCD

--------------------------------------------------------------

>49770_49770_4_LRP3-LSM14A_LRP3_chr19_33685764_ENST00000253193_LSM14A_chr19_34685383_ENST00000433627_length(amino acids)=447AA_BP=24
MEKRAAAGLEGAPGARAQLAVVCLVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQ
SMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTME
QAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRR
DGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCD

--------------------------------------------------------------

>49770_49770_5_LRP3-LSM14A_LRP3_chr19_33685764_ENST00000253193_LSM14A_chr19_34685383_ENST00000540746_length(amino acids)=406AA_BP=24
MEKRAAAGLEGAPGARAQLAVVCLVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQ
SMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHR
RAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRRDGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEK
QEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCDDNRERRPTWAEERRLNAETFGIPLRPNRGRGGYRGRGGLGF

--------------------------------------------------------------

>49770_49770_6_LRP3-LSM14A_LRP3_chr19_33685764_ENST00000253193_LSM14A_chr19_34685383_ENST00000544216_length(amino acids)=447AA_BP=24
MEKRAAAGLEGAPGARAQLAVVCLVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCEPPKPQCSLPQDPAIVQSSLGSSTSSFQ
SMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQDTRSLKTQLSQGRSSPQLDPLRKSPTME
QAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVAPGAPSAPRRGRGGHRGGRGRFGIRR
DGPMKFEKDFDFESANAQFNKEEIDREFHNKLKLKEDKLEKQEKPVNGEDKGDSGVDTQNSEGNADEEDPLGPNCYYDKTKSFFDNISCD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:33685764/chr19:34685382)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP3 O75074	LSM14A Q8ND56
FUNCTION: Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro.	FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269\|PubMed:16484376, ECO:0000269\|PubMed:17074753, ECO:0000269\|PubMed:26339800, ECO:0000269\|PubMed:29510985}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

LSM14A

chr19:33685764

chr19:34685382

ENST00000433627

284_320

40.333333333333336

1040.0

Domain

DFDF

Tgene

LSM14A

chr19:33685764

chr19:34685382

ENST00000544216

284_320

40.333333333333336

464.0

Domain

DFDF

Tgene

LSM14A

chr19:33685764

chr19:34685383

ENST00000433627

284_320

40.333333333333336

1040.0

Domain

DFDF

Tgene

LSM14A

chr19:33685764

chr19:34685383

ENST00000544216

284_320

40.333333333333336

464.0

Domain

DFDF

Tgene

LSM14A

chr19:33685764

chr19:34685382

ENST00000433627

361_377

40.333333333333336

1040.0

Motif

Note=FFD box

Tgene

LSM14A

chr19:33685764

chr19:34685382

ENST00000433627

380_400

40.333333333333336

1040.0

Motif

Note=TFG box

Tgene

LSM14A

chr19:33685764

chr19:34685382

ENST00000544216

361_377

40.333333333333336

464.0

Motif

Note=FFD box

Tgene

LSM14A

chr19:33685764

chr19:34685382

ENST00000544216

380_400

40.333333333333336

464.0

Motif

Note=TFG box

Tgene

LSM14A

chr19:33685764

chr19:34685383

ENST00000433627

361_377

40.333333333333336

1040.0

Motif

Note=FFD box

Tgene

LSM14A

chr19:33685764

chr19:34685383

ENST00000433627

380_400

40.333333333333336

1040.0

Motif

Note=TFG box

Tgene

LSM14A

chr19:33685764

chr19:34685383

ENST00000544216

361_377

40.333333333333336

464.0

Motif

Note=FFD box

Tgene

LSM14A

chr19:33685764

chr19:34685383

ENST00000544216

380_400

40.333333333333336

464.0

Motif

Note=TFG box

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

751_754

24.333333333333332

771.0

Compositional bias

Note=Poly-Pro

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

751_754

24.333333333333332

771.0

Compositional bias

Note=Poly-Pro

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

165_201

24.333333333333332

771.0

Domain

LDL-receptor class A 1

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

211_250

24.333333333333332

771.0

Domain

LDL-receptor class A 2

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

254_365

24.333333333333332

771.0

Domain

CUB 2

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

415_453

24.333333333333332

771.0

Domain

LDL-receptor class A 3

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

43_159

24.333333333333332

771.0

Domain

CUB 1

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

454_490

24.333333333333332

771.0

Domain

LDL-receptor class A 4

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

165_201

24.333333333333332

771.0

Domain

LDL-receptor class A 1

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

211_250

24.333333333333332

771.0

Domain

LDL-receptor class A 2

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

254_365

24.333333333333332

771.0

Domain

CUB 2

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

415_453

24.333333333333332

771.0

Domain

LDL-receptor class A 3

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

43_159

24.333333333333332

771.0

Domain

CUB 1

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

454_490

24.333333333333332

771.0

Domain

LDL-receptor class A 4

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

37_496

24.333333333333332

771.0

Topological domain

Extracellular

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

518_770

24.333333333333332

771.0

Topological domain

Cytoplasmic

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

37_496

24.333333333333332

771.0

Topological domain

Extracellular

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

518_770

24.333333333333332

771.0

Topological domain

Cytoplasmic

Hgene

LRP3

chr19:33685764

chr19:34685382

ENST00000253193

497_517

24.333333333333332

771.0

Transmembrane

Helical

Hgene

LRP3

chr19:33685764

chr19:34685383

ENST00000253193

497_517

24.333333333333332

771.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

LSM14A

Lsm14a, ELAVL1, RAE1, HNRNPDL, SYNCRIP, CIRBP, HNRNPH1, DDX1, HNRNPU, HNRNPL, CSNK2A1, HECW2, TP53, PRMT8, NTRK1, XPO1, AHSA1, SORT1, EGFR, SFPQ, STRAP, G3BP1, PHACTR3, PTCH1, ESR2, HEXIM1, MEPCE, LARP7, SNAI1, RECQL4, ATG16L1, ZC3H7A, EIF4ENIF1, DDX6, C1QBP, PRMT1, EDC4, PATL1, LSM1, LSM2, LSM3, LSM4, LSM6, LSM7, DCP1A, EDC3, UBQLN2, ZBTB10, HDAC2, APEX1, ITFG1, PLEKHA4, ORF9b, ENG, ZC3H18, N, nsp9, nsp3, ESR1, CELF1, DAZL, FAM120C, FMR1, FUBP3, FXR1, IGF2BP2, AGO1, AGO2, AGO3, ALG13, ANKRD17, ATXN2, CAPRIN1, CNOT1, CNOT10, CNOT3, CNOT4, RQCD1, CPEB4, DCP1B, FAM120A, G3BP2, GIGYF1, GTPBP1, HELZ, IGF2BP1, LSM12, LSM14B, KIAA0430, MEX3A, MKRN2, OTUD4, PRRC2A, PRRC2B, PRRC2C, PUM1, R3HDM1, RC3H1, RC3H2, SECISBP2, SMG1, SMG5, SMG7, SMG8, STAU2, TDRD3, TNRC6B, TOP3B, TRIM56, UBAP2L, UPF1, USP10, YTHDF1, YTHDF2, YTHDF3, ZC3HAV1, ZCCHC11, MEX3B, MOV10, DDX3X, FXR2, ANKHD1-EIF4EBP3, CNOT2, KIAA0355, LARP1B, PUM2, RBMS1, ZCCHC3, UNK, XRN1, CEP85, LARP4B, RNF214, UBAP2, RBM47, NUFIP2, TAF15, CNOT6, NUPL2, PARP12, SPATS2L, ARHGAP11B, ARHGAP23, CIC, FBP1, INSIG1, INSIG2, NUP37, DDX58, OGT, CD274, UFL1, FBL, MAPRE1, MYCBP2, NAA40, TMEM14B, IFI27L1, COL8A1, KIF2C, TMC4, GAGE2E, PEA15, SEPT9, CPEB1, KLF15, KLF16, KLF5, KLF8, SOX15, SOX5, SOX6, TLX2, TLX3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LRP3
LSM14A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to LRP3-LSM14A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to LRP3-LSM14A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source