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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRP5-CLPB

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRP5-CLPB
FusionPDB ID: 49791
FusionGDB2.0 ID: 49791
HgeneTgene
Gene symbol

LRP5

CLPB

Gene ID

4041

81570

Gene nameLDL receptor related protein 5caseinolytic mitochondrial matrix peptidase chaperone subunit B
SynonymsBMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP-7|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2ANKCLB|HSP78|MEGCANN|MGCA7|SKD3
Cytomap

11q13.2

11q13.4

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7caseinolytic peptidase B protein homologClpB caseinolytic peptidase B homologClpB homolog, mitochondrial AAA ATPase chaperoninankyrin-repeat containing bacterial clp fusionsuppressor of potassium transport defect 3testicular secretory protein Li 11
Modification date2020032920200313
UniProtAcc

A4QPB2

Q9H078

Ensembl transtripts involved in fusion geneENST idsENST00000294304, ENST00000529481, 
ENST00000340729, ENST00000437826, 
ENST00000445069, ENST00000538021, 
ENST00000538039, ENST00000542555, 
ENST00000543042, ENST00000294053, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score36 X 25 X 12=1080012 X 11 X 8=1056
# samples 4115
** MAII scorelog2(41/10800*10)=-4.71926359243275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/1056*10)=-2.81557542886257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRP5 [Title/Abstract] AND CLPB [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRP5(68080273)-CLPB(72070052), # samples:4
Anticipated loss of major functional domain due to fusion event.LRP5-CLPB seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP5-CLPB seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP5

GO:0008284

positive regulation of cell proliferation

9790987

HgeneLRP5

GO:0045840

positive regulation of mitotic nuclear division

9790987

HgeneLRP5

GO:0045893

positive regulation of transcription, DNA-templated

15035989|17955262

HgeneLRP5

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

HgeneLRP5

GO:0060070

canonical Wnt signaling pathway

11029007|12121999|12857724|15908424|24706814|25920554

TgeneCLPB

GO:0034605

cellular response to heat

2745427


check buttonFusion gene breakpoints across LRP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CLPB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7418-01ALRP5chr11

68080273

-CLPBchr11

72070052

-
ChimerDB4HNSCTCGA-CV-7418-01ALRP5chr11

68080273

+CLPBchr11

72070052

-
ChimerDB4HNSCTCGA-CV-7418LRP5chr11

68080273

+CLPBchr11

72070052

-
ChimerDB4HNSCTCGA-CV-7418LRP5chr11

68080273

+CLPBchr11

72084058

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000294304LRP5chr1168080273+ENST00000294053CLPBchr1172070052-25271971061584492
ENST00000294304LRP5chr1168080273+ENST00000538039CLPBchr1172070052-25061971061584492
ENST00000294304LRP5chr1168080273+ENST00000437826CLPBchr1172070052-16491971061584492
ENST00000294304LRP5chr1168080273+ENST00000340729CLPBchr1172070052-16491971061584492
ENST00000294304LRP5chr1168080273+ENST00000543042CLPBchr1172070052-16431971061584492
ENST00000294304LRP5chr1168080273+ENST00000445069CLPBchr1172070052-4491973631121
ENST00000294304LRP5chr1168080273+ENST00000294053CLPBchr1172084058-26171971061674522

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000294304ENST00000294053LRP5chr1168080273+CLPBchr1172070052-0.0026177150.9973822
ENST00000294304ENST00000538039LRP5chr1168080273+CLPBchr1172070052-0.0028338270.9971662
ENST00000294304ENST00000437826LRP5chr1168080273+CLPBchr1172070052-0.0014397410.99856025
ENST00000294304ENST00000340729LRP5chr1168080273+CLPBchr1172070052-0.0014397410.99856025
ENST00000294304ENST00000543042LRP5chr1168080273+CLPBchr1172070052-0.0015769530.9984231
ENST00000294304ENST00000445069LRP5chr1168080273+CLPBchr1172070052-0.0122274280.9877725
ENST00000294304ENST00000294053LRP5chr1168080273+CLPBchr1172084058-0.0039809640.99601907

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49791_49791_1_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72070052_ENST00000294053_length(amino acids)=492AA_BP=30
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY
AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA
KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID
CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE
LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE

--------------------------------------------------------------

>49791_49791_2_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72070052_ENST00000340729_length(amino acids)=492AA_BP=30
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY
AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA
KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID
CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE
LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE

--------------------------------------------------------------

>49791_49791_3_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72070052_ENST00000437826_length(amino acids)=492AA_BP=30
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY
AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA
KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID
CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE
LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE

--------------------------------------------------------------

>49791_49791_4_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72070052_ENST00000445069_length(amino acids)=121AA_BP=0
MPWRMRAQFSGGTSIKQLLDSAVVISKNSIVQGRAALETGAVVQPVVEVILSGDQDRGGGRAAAQRQQQQQQQQQRPRRPGRRCLHVVRR

--------------------------------------------------------------

>49791_49791_5_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72070052_ENST00000538039_length(amino acids)=492AA_BP=30
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY
AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA
KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID
CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE
LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE

--------------------------------------------------------------

>49791_49791_6_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72070052_ENST00000543042_length(amino acids)=492AA_BP=30
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY
AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA
KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID
CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE
LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE

--------------------------------------------------------------

>49791_49791_7_LRP5-CLPB_LRP5_chr11_68080273_ENST00000294304_CLPB_chr11_72084058_ENST00000294053_length(amino acids)=522AA_BP=30
MEAAPPGPPWPLLLLLLLLLALCGCPAPAADGGQDGASRHITNQWTSALEFRRWLGLPAGVLITREDDFNNRLNNRASFKGCTALHYAVL
ADDYRTVKELLDGGANPLQRNEMGHTPLDYAREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKE
NGWYDEEHPLVFLFLGSSGIGKTELAKQTAKYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDE
VDKAHPDVLTIMLQLFDEGRLTDGKGKTIDCKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVI
RPILKAHFRRDEFLGRINEIVYFLPFCHSELIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:68080273/chr11:72070052)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP5

A4QPB2

CLPB

Q9H078

FUNCTION: May function as a regulatory ATPase and be related to secretion/protein trafficking process. Involved in mitochondrial-mediated antiviral innate immunity, activates RIG-I-mediated signal transduction and production of IFNB1 and proinflammatory cytokine IL6 (PubMed:31522117). {ECO:0000269|PubMed:31522117}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCLPBchr11:68080273chr11:72070052ENST00000294053417381_388245.33333333333334708.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72070052ENST00000340729215381_388186.33333333333334649.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72070052ENST00000437826518381_388200.33333333333334663.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72070052ENST00000538039316381_388215.33333333333334678.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72084058ENST00000294053317381_388215.33333333333334708.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72084058ENST00000340729015381_3880649.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72084058ENST00000437826418381_388170.33333333333334663.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72084058ENST00000538039016381_3880678.0Nucleotide bindingATP
TgeneCLPBchr11:68080273chr11:72070052ENST00000294053417265_295245.33333333333334708.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72070052ENST00000294053417298_327245.33333333333334708.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72070052ENST00000340729215265_295186.33333333333334649.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72070052ENST00000340729215298_327186.33333333333334649.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72070052ENST00000437826518265_295200.33333333333334663.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72070052ENST00000437826518298_327200.33333333333334663.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72070052ENST00000538039316265_295215.33333333333334678.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72070052ENST00000538039316298_327215.33333333333334678.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72084058ENST00000294053317265_295215.33333333333334708.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72084058ENST00000294053317298_327215.33333333333334708.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72084058ENST00000340729015133_1620649.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72084058ENST00000340729015166_1950649.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72084058ENST00000340729015265_2950649.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72084058ENST00000340729015298_3270649.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72084058ENST00000437826418265_295170.33333333333334663.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72084058ENST00000437826418298_327170.33333333333334663.0RepeatNote=ANK 4
TgeneCLPBchr11:68080273chr11:72084058ENST00000538039016133_1620678.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72084058ENST00000538039016166_1950678.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72084058ENST00000538039016265_2950678.0RepeatNote=ANK 3
TgeneCLPBchr11:68080273chr11:72084058ENST00000538039016298_3270678.0RepeatNote=ANK 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231495_161030.3333333333333321616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231495_161030.3333333333333321616.0Compositional biasNote=Pro-rich
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231213_125430.3333333333333321616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231258_129630.3333333333333321616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231297_133330.3333333333333321616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231335_137130.3333333333333321616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123295_33730.3333333333333321616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123601_64130.3333333333333321616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123902_94230.3333333333333321616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231213_125430.3333333333333321616.0DomainNote=EGF-like 4
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231258_129630.3333333333333321616.0DomainLDL-receptor class A 1
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231297_133330.3333333333333321616.0DomainLDL-receptor class A 2
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231335_137130.3333333333333321616.0DomainLDL-receptor class A 3
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123295_33730.3333333333333321616.0DomainNote=EGF-like 1
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123601_64130.3333333333333321616.0DomainNote=EGF-like 2
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123902_94230.3333333333333321616.0DomainNote=EGF-like 3
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231500_150630.3333333333333321616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231538_154530.3333333333333321616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231574_158130.3333333333333321616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231591_159630.3333333333333321616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231605_161230.3333333333333321616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231500_150630.3333333333333321616.0MotifNote=PPPSP motif A
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231538_154530.3333333333333321616.0MotifNote=PPPSP motif B
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231574_158130.3333333333333321616.0MotifNote=PPPSP motif C
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231591_159630.3333333333333321616.0MotifNote=PPPSP motif D
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231605_161230.3333333333333321616.0MotifNote=PPPSP motif E
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+12332_28830.3333333333333321616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123341_60230.3333333333333321616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123644_90330.3333333333333321616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123945_121230.3333333333333321616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+12332_28830.3333333333333321616.0RegionNote=Beta-propeller 1
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123341_60230.3333333333333321616.0RegionNote=Beta-propeller 2
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123644_90330.3333333333333321616.0RegionNote=Beta-propeller 3
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123945_121230.3333333333333321616.0RegionNote=Beta-propeller 4
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231036_107830.3333333333333321616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231079_112330.3333333333333321616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231124_116430.3333333333333321616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231165_120730.3333333333333321616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123120_16230.3333333333333321616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123123_12630.3333333333333321616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123163_20630.3333333333333321616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123166_16930.3333333333333321616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123207_24730.3333333333333321616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123248_29030.3333333333333321616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123251_25430.3333333333333321616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123385_42730.3333333333333321616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123388_39130.3333333333333321616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123428_47030.3333333333333321616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123431_43430.3333333333333321616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123471_51430.3333333333333321616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123474_47730.3333333333333321616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123515_55730.3333333333333321616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123558_60030.3333333333333321616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123559_56230.3333333333333321616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123687_72930.3333333333333321616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123690_69330.3333333333333321616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123730_77230.3333333333333321616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+12375_11930.3333333333333321616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123773_81530.3333333333333321616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+12378_8130.3333333333333321616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123816_85530.3333333333333321616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123819_82230.3333333333333321616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123856_89830.3333333333333321616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123859_86230.3333333333333321616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+123989_103530.3333333333333321616.0RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231036_107830.3333333333333321616.0RepeatNote=LDL-receptor class B 17
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231079_112330.3333333333333321616.0RepeatNote=LDL-receptor class B 18
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231124_116430.3333333333333321616.0RepeatNote=LDL-receptor class B 19
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231165_120730.3333333333333321616.0RepeatNote=LDL-receptor class B 20
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123120_16230.3333333333333321616.0RepeatNote=LDL-receptor class B 2
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123123_12630.3333333333333321616.0RepeatNote=YWTD 2
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123163_20630.3333333333333321616.0RepeatNote=LDL-receptor class B 3
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123166_16930.3333333333333321616.0RepeatNote=YWTD 3
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123207_24730.3333333333333321616.0RepeatNote=LDL-receptor class B 4
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123248_29030.3333333333333321616.0RepeatNote=LDL-receptor class B 5
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123251_25430.3333333333333321616.0RepeatNote=YWTD 4
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123385_42730.3333333333333321616.0RepeatNote=LDL-receptor class B 6
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123388_39130.3333333333333321616.0RepeatNote=YWTD 5
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123428_47030.3333333333333321616.0RepeatNote=LDL-receptor class B 7
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123431_43430.3333333333333321616.0RepeatNote=YWTD 6
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123471_51430.3333333333333321616.0RepeatNote=LDL-receptor class B 8
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123474_47730.3333333333333321616.0RepeatNote=YWTD 7
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123515_55730.3333333333333321616.0RepeatNote=LDL-receptor class B 9
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123558_60030.3333333333333321616.0RepeatNote=LDL-receptor class B 10
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123559_56230.3333333333333321616.0RepeatNote=YWTD 8
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123687_72930.3333333333333321616.0RepeatNote=LDL-receptor class B 11
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123690_69330.3333333333333321616.0RepeatNote=YWTD 9
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123730_77230.3333333333333321616.0RepeatNote=LDL-receptor class B 12
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+12375_11930.3333333333333321616.0RepeatNote=LDL-receptor class B 1
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123773_81530.3333333333333321616.0RepeatNote=LDL-receptor class B 13
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+12378_8130.3333333333333321616.0RepeatNote=YWTD 1
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123816_85530.3333333333333321616.0RepeatNote=LDL-receptor class B 14
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123819_82230.3333333333333321616.0RepeatNote=YWTD 10
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123856_89830.3333333333333321616.0RepeatNote=LDL-receptor class B 15
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123859_86230.3333333333333321616.0RepeatNote=YWTD 11
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+123989_103530.3333333333333321616.0RepeatNote=LDL-receptor class B 16
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231408_161530.3333333333333321616.0Topological domainCytoplasmic
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+12332_138430.3333333333333321616.0Topological domainExtracellular
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231408_161530.3333333333333321616.0Topological domainCytoplasmic
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+12332_138430.3333333333333321616.0Topological domainExtracellular
HgeneLRP5chr11:68080273chr11:72070052ENST00000294304+1231385_140730.3333333333333321616.0TransmembraneHelical
HgeneLRP5chr11:68080273chr11:72084058ENST00000294304+1231385_140730.3333333333333321616.0TransmembraneHelical
TgeneCLPBchr11:68080273chr11:72070052ENST00000294053417133_162245.33333333333334708.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72070052ENST00000294053417166_195245.33333333333334708.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72070052ENST00000340729215133_162186.33333333333334649.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72070052ENST00000340729215166_195186.33333333333334649.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72070052ENST00000437826518133_162200.33333333333334663.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72070052ENST00000437826518166_195200.33333333333334663.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72070052ENST00000538039316133_162215.33333333333334678.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72070052ENST00000538039316166_195215.33333333333334678.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72084058ENST00000294053317133_162215.33333333333334708.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72084058ENST00000294053317166_195215.33333333333334708.0RepeatNote=ANK 2
TgeneCLPBchr11:68080273chr11:72084058ENST00000437826418133_162170.33333333333334663.0RepeatNote=ANK 1
TgeneCLPBchr11:68080273chr11:72084058ENST00000437826418166_195170.33333333333334663.0RepeatNote=ANK 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1035_LRP5_68080273_CLPB_72070052_1035_LRP5_68080273_CLPB_72070052_ranked_0.pdbLRP56808027368080273ENST00000294053CLPBchr1172070052-
MEAAPPGPPWPLLLLLLLLLALCGCPAPAAVLITREDDFNNRLNNRASFKGCTALHYAVLADDYRTVKELLDGGANPLQRNEMGHTPLDY
AREGEVMKLLRTSEAKYQEKQRKREAEERRRFPLEQRLKEHIIGQESAIATVGAAIRRKENGWYDEEHPLVFLFLGSSGIGKTELAKQTA
KYMHKDAKKGFIRLDMSEFQERHEVAKFIGSPPGYVGHEEGGQLTKKLKQCPNAVVLFDEVDKAHPDVLTIMLQLFDEGRLTDGKGKTID
CKDAIFIMTSNVASDEIAQHALQLRQEALEMSRNRIAENLGDVQISDKITISKNFKENVIRPILKAHFRRDEFLGRINEIVYFLPFCHSE
LIQLVNKELNFWAKRAKQRHNITLLWDREVADVLVDGYNVHYGARSIKHEVERRVVNQLAAAYEQDLLPGGCTLRITVEDSDKQLLKSPE
492


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LRP5_pLDDT.png
all structure
all structure
CLPB_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRP5
CLPB


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRP5-CLPB


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRP5-CLPB


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource