UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LRP6-NINJ2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LRP6-NINJ2
	FusionPDB ID: 49832
	FusionGDB2.0 ID: 49832
		Hgene	Tgene
	Gene symbol	LRP6	NINJ2
	Gene ID	4040	4815
	Gene name	LDL receptor related protein 6	ninjurin 2
	Synonyms	ADCAD2\|STHAG7	-
	Cytomap	12p13.2	12p13.33
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 6LRP-6	ninjurin-2nerve injury-induced protein 2
	Modification date	20200329	20200313
	UniProtAcc	O75581	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000261349, ENST00000543091, ENST00000540415,	ENST00000433832, ENST00000542920, ENST00000537416, ENST00000305108, ENST00000397265,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 12 X 8=1248	8 X 3 X 8=192
	# samples	18	15
	** MAII score	log2(18/1248*10)=-2.79354912253257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/192*10)=-0.356143810225275 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LRP6 [Title/Abstract] AND NINJ2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LRP6(12332744)-NINJ2(675344), # samples:3
Anticipated loss of major functional domain due to fusion event.	LRP6-NINJ2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP6-NINJ2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP6-NINJ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP6-NINJ2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LRP6	GO:0014029	neural crest formation	11029007
Hgene	LRP6	GO:0014033	neural crest cell differentiation	11029007
Hgene	LRP6	GO:0016055	Wnt signaling pathway	11357136
Hgene	LRP6	GO:0045944	positive regulation of transcription by RNA polymerase II	12857724
Hgene	LRP6	GO:0051091	positive regulation of DNA-binding transcription factor activity	14739301
Hgene	LRP6	GO:0060070	canonical Wnt signaling pathway	11448771\|11742004\|12121999\|14739301\|15271658\|15908424\|16263759\|16543246\|17239604\|19107203\|20059949\|20093106\|20137080
Hgene	LRP6	GO:0071901	negative regulation of protein serine/threonine kinase activity	19107203

Fusion gene breakpoints across LRP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NINJ2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LGG	TCGA-E1-5304-01A	LRP6	chr12	12332743	-	NINJ2	chr12	675343	-
ChimerDB4	LGG	TCGA-E1-5304-01A	LRP6	chr12	12332744	-	NINJ2	chr12	675344	-
ChimerDB4	LGG	TCGA-E1-5304	LRP6	chr12	12332743	-	NINJ2	chr12	675344	-
ChimerDB4	LGG	TCGA-E1-5304	LRP6	chr12	12332744	-	NINJ2	chr12	675344	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000261349	LRP6	chr12	12332744	-	ENST00000305108	NINJ2	chr12	675344	-	2422	1622	77	2017	646
ENST00000261349	LRP6	chr12	12332744	-	ENST00000397265	NINJ2	chr12	675344	-	2342	1622	77	2017	646
ENST00000543091	LRP6	chr12	12332744	-	ENST00000305108	NINJ2	chr12	675344	-	2379	1579	34	1974	646
ENST00000543091	LRP6	chr12	12332744	-	ENST00000397265	NINJ2	chr12	675344	-	2299	1579	34	1974	646
ENST00000261349	LRP6	chr12	12332743	-	ENST00000305108	NINJ2	chr12	675344	-	2422	1622	77	2017	646
ENST00000261349	LRP6	chr12	12332743	-	ENST00000397265	NINJ2	chr12	675344	-	2342	1622	77	2017	646
ENST00000543091	LRP6	chr12	12332743	-	ENST00000305108	NINJ2	chr12	675344	-	2379	1579	34	1974	646
ENST00000543091	LRP6	chr12	12332743	-	ENST00000397265	NINJ2	chr12	675344	-	2299	1579	34	1974	646
ENST00000261349	LRP6	chr12	12332743	-	ENST00000305108	NINJ2	chr12	675343	-	2422	1622	77	2017	646
ENST00000261349	LRP6	chr12	12332743	-	ENST00000397265	NINJ2	chr12	675343	-	2342	1622	77	2017	646
ENST00000543091	LRP6	chr12	12332743	-	ENST00000305108	NINJ2	chr12	675343	-	2379	1579	34	1974	646
ENST00000543091	LRP6	chr12	12332743	-	ENST00000397265	NINJ2	chr12	675343	-	2299	1579	34	1974	646

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000261349	ENST00000305108	LRP6	chr12	12332744	-	NINJ2	chr12	675344	-	0.001706313	0.9982937
ENST00000261349	ENST00000397265	LRP6	chr12	12332744	-	NINJ2	chr12	675344	-	0.001774627	0.9982254
ENST00000543091	ENST00000305108	LRP6	chr12	12332744	-	NINJ2	chr12	675344	-	0.001639717	0.9983602
ENST00000543091	ENST00000397265	LRP6	chr12	12332744	-	NINJ2	chr12	675344	-	0.001694185	0.9983058
ENST00000261349	ENST00000305108	LRP6	chr12	12332743	-	NINJ2	chr12	675344	-	0.001706313	0.9982937
ENST00000261349	ENST00000397265	LRP6	chr12	12332743	-	NINJ2	chr12	675344	-	0.001774627	0.9982254
ENST00000543091	ENST00000305108	LRP6	chr12	12332743	-	NINJ2	chr12	675344	-	0.001639717	0.9983602
ENST00000543091	ENST00000397265	LRP6	chr12	12332743	-	NINJ2	chr12	675344	-	0.001694185	0.9983058
ENST00000261349	ENST00000305108	LRP6	chr12	12332743	-	NINJ2	chr12	675343	-	0.001706313	0.9982937
ENST00000261349	ENST00000397265	LRP6	chr12	12332743	-	NINJ2	chr12	675343	-	0.001774627	0.9982254
ENST00000543091	ENST00000305108	LRP6	chr12	12332743	-	NINJ2	chr12	675343	-	0.001639717	0.9983602
ENST00000543091	ENST00000397265	LRP6	chr12	12332743	-	NINJ2	chr12	675343	-	0.001694185	0.9983058

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49832_49832_1_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000261349_NINJ2_chr12_675343_ENST00000305108_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_2_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000261349_NINJ2_chr12_675343_ENST00000397265_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_3_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000261349_NINJ2_chr12_675344_ENST00000305108_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_4_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000261349_NINJ2_chr12_675344_ENST00000397265_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_5_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000543091_NINJ2_chr12_675343_ENST00000305108_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_6_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000543091_NINJ2_chr12_675343_ENST00000397265_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_7_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000543091_NINJ2_chr12_675344_ENST00000305108_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_8_LRP6-NINJ2_LRP6_chr12_12332743_ENST00000543091_NINJ2_chr12_675344_ENST00000397265_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_9_LRP6-NINJ2_LRP6_chr12_12332744_ENST00000261349_NINJ2_chr12_675344_ENST00000305108_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_10_LRP6-NINJ2_LRP6_chr12_12332744_ENST00000261349_NINJ2_chr12_675344_ENST00000397265_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_11_LRP6-NINJ2_LRP6_chr12_12332744_ENST00000543091_NINJ2_chr12_675344_ENST00000305108_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

>49832_49832_12_LRP6-NINJ2_LRP6_chr12_12332744_ENST00000543091_NINJ2_chr12_675344_ENST00000397265_length(amino acids)=646AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES
MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12332744/chr12:675344)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP6 O75581	.
FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250, ECO:0000269\|PubMed:11357136, ECO:0000269\|PubMed:11448771, ECO:0000269\|PubMed:15778503, ECO:0000269\|PubMed:16341017, ECO:0000269\|PubMed:16513652, ECO:0000269\|PubMed:17326769, ECO:0000269\|PubMed:17400545, ECO:0000269\|PubMed:19107203, ECO:0000269\|PubMed:19293931, ECO:0000269\|PubMed:19801552}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

282_324

515.0

1614.0

Domain

Note=EGF-like 1

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

282_324

515.0

1614.0

Domain

Note=EGF-like 1

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

282_324

515.0

1614.0

Domain

Note=EGF-like 1

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

20_275

515.0

1614.0

Region

Note=Beta-propeller 1

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

20_275

515.0

1614.0

Region

Note=Beta-propeller 1

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

20_275

515.0

1614.0

Region

Note=Beta-propeller 1

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

107_149

515.0

1614.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

150_193

515.0

1614.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

194_236

515.0

1614.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

237_276

515.0

1614.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

372_414

515.0

1614.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

415_457

515.0

1614.0

Repeat

Note=LDL-receptor class B 7

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

458_501

515.0

1614.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

63_106

515.0

1614.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

107_149

515.0

1614.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

150_193

515.0

1614.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

194_236

515.0

1614.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

237_276

515.0

1614.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

372_414

515.0

1614.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

415_457

515.0

1614.0

Repeat

Note=LDL-receptor class B 7

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

458_501

515.0

1614.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

63_106

515.0

1614.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

107_149

515.0

1614.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

150_193

515.0

1614.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

194_236

515.0

1614.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

237_276

515.0

1614.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

372_414

515.0

1614.0

Repeat

Note=LDL-receptor class B 6

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

415_457

515.0

1614.0

Repeat

Note=LDL-receptor class B 7

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

458_501

515.0

1614.0

Repeat

Note=LDL-receptor class B 8

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

63_106

515.0

1614.0

Repeat

Note=LDL-receptor class B 1

Tgene

NINJ2

chr12:12332743

chr12:675343

ENST00000305108

128_142

57.0

152.33333333333334

Topological domain

Extracellular

Tgene

NINJ2

chr12:12332743

chr12:675343

ENST00000305108

89_106

57.0

152.33333333333334

Topological domain

Cytoplasmic

Tgene

NINJ2

chr12:12332743

chr12:675344

ENST00000305108

128_142

57.0

152.33333333333334

Topological domain

Extracellular

Tgene

NINJ2

chr12:12332743

chr12:675344

ENST00000305108

89_106

57.0

152.33333333333334

Topological domain

Cytoplasmic

Tgene

NINJ2

chr12:12332744

chr12:675344

ENST00000305108

128_142

57.0

152.33333333333334

Topological domain

Extracellular

Tgene

NINJ2

chr12:12332744

chr12:675344

ENST00000305108

89_106

57.0

152.33333333333334

Topological domain

Cytoplasmic

Tgene

NINJ2

chr12:12332743

chr12:675343

ENST00000305108

107_127

57.0

152.33333333333334

Transmembrane

Helical

Tgene

NINJ2

chr12:12332743

chr12:675343

ENST00000305108

66_88

57.0

152.33333333333334

Transmembrane

Helical

Tgene

NINJ2

chr12:12332743

chr12:675344

ENST00000305108

107_127

57.0

152.33333333333334

Transmembrane

Helical

Tgene

NINJ2

chr12:12332743

chr12:675344

ENST00000305108

66_88

57.0

152.33333333333334

Transmembrane

Helical

Tgene

NINJ2

chr12:12332744

chr12:675344

ENST00000305108

107_127

57.0

152.33333333333334

Transmembrane

Helical

Tgene

NINJ2

chr12:12332744

chr12:675344

ENST00000305108

66_88

57.0

152.33333333333334

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1203_1244

515.0

1614.0

Domain

Note=EGF-like 4

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1248_1286

515.0

1614.0

Domain

LDL-receptor class A 1

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1287_1323

515.0

1614.0

Domain

LDL-receptor class A 2

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1325_1361

515.0

1614.0

Domain

LDL-receptor class A 3

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

588_628

515.0

1614.0

Domain

Note=EGF-like 2

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

889_930

515.0

1614.0

Domain

Note=EGF-like 3

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1203_1244

515.0

1614.0

Domain

Note=EGF-like 4

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1248_1286

515.0

1614.0

Domain

LDL-receptor class A 1

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1287_1323

515.0

1614.0

Domain

LDL-receptor class A 2

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1325_1361

515.0

1614.0

Domain

LDL-receptor class A 3

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

588_628

515.0

1614.0

Domain

Note=EGF-like 2

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

889_930

515.0

1614.0

Domain

Note=EGF-like 3

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1203_1244

515.0

1614.0

Domain

Note=EGF-like 4

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1248_1286

515.0

1614.0

Domain

LDL-receptor class A 1

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1287_1323

515.0

1614.0

Domain

LDL-receptor class A 2

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1325_1361

515.0

1614.0

Domain

LDL-receptor class A 3

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

588_628

515.0

1614.0

Domain

Note=EGF-like 2

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

889_930

515.0

1614.0

Domain

Note=EGF-like 3

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1487_1493

515.0

1614.0

Motif

Note=PPPSP motif A

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1527_1534

515.0

1614.0

Motif

Note=PPPSP motif B

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1568_1575

515.0

1614.0

Motif

Note=PPPSP motif C

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1588_1593

515.0

1614.0

Motif

Note=PPPSP motif D

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1603_1610

515.0

1614.0

Motif

Note=PPPSP motif E

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1487_1493

515.0

1614.0

Motif

Note=PPPSP motif A

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1527_1534

515.0

1614.0

Motif

Note=PPPSP motif B

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1568_1575

515.0

1614.0

Motif

Note=PPPSP motif C

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1588_1593

515.0

1614.0

Motif

Note=PPPSP motif D

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1603_1610

515.0

1614.0

Motif

Note=PPPSP motif E

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1487_1493

515.0

1614.0

Motif

Note=PPPSP motif A

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1527_1534

515.0

1614.0

Motif

Note=PPPSP motif B

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1568_1575

515.0

1614.0

Motif

Note=PPPSP motif C

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1588_1593

515.0

1614.0

Motif

Note=PPPSP motif D

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1603_1610

515.0

1614.0

Motif

Note=PPPSP motif E

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

328_589

515.0

1614.0

Region

Note=Beta-propeller 2

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

631_890

515.0

1614.0

Region

Note=Beta-propeller 3

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

933_1202

515.0

1614.0

Region

Note=Beta-propeller 4

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

328_589

515.0

1614.0

Region

Note=Beta-propeller 2

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

631_890

515.0

1614.0

Region

Note=Beta-propeller 3

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

933_1202

515.0

1614.0

Region

Note=Beta-propeller 4

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

328_589

515.0

1614.0

Region

Note=Beta-propeller 2

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

631_890

515.0

1614.0

Region

Note=Beta-propeller 3

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

933_1202

515.0

1614.0

Region

Note=Beta-propeller 4

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1026_1068

515.0

1614.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1069_1113

515.0

1614.0

Repeat

Note=LDL-receptor class B 18

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1114_1156

515.0

1614.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1157_1198

515.0

1614.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

502_542

515.0

1614.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

543_584

515.0

1614.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

674_716

515.0

1614.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

717_759

515.0

1614.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

760_802

515.0

1614.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

803_842

515.0

1614.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

843_885

515.0

1614.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

977_1025

515.0

1614.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1026_1068

515.0

1614.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1069_1113

515.0

1614.0

Repeat

Note=LDL-receptor class B 18

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1114_1156

515.0

1614.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1157_1198

515.0

1614.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

502_542

515.0

1614.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

543_584

515.0

1614.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

674_716

515.0

1614.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

717_759

515.0

1614.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

760_802

515.0

1614.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

803_842

515.0

1614.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

843_885

515.0

1614.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

977_1025

515.0

1614.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1026_1068

515.0

1614.0

Repeat

Note=LDL-receptor class B 17

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1069_1113

515.0

1614.0

Repeat

Note=LDL-receptor class B 18

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1114_1156

515.0

1614.0

Repeat

Note=LDL-receptor class B 19

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1157_1198

515.0

1614.0

Repeat

Note=LDL-receptor class B 20

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

502_542

515.0

1614.0

Repeat

Note=LDL-receptor class B 9

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

543_584

515.0

1614.0

Repeat

Note=LDL-receptor class B 10

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

674_716

515.0

1614.0

Repeat

Note=LDL-receptor class B 11

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

717_759

515.0

1614.0

Repeat

Note=LDL-receptor class B 12

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

760_802

515.0

1614.0

Repeat

Note=LDL-receptor class B 13

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

803_842

515.0

1614.0

Repeat

Note=LDL-receptor class B 14

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

843_885

515.0

1614.0

Repeat

Note=LDL-receptor class B 15

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

977_1025

515.0

1614.0

Repeat

Note=LDL-receptor class B 16

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1394_1613

515.0

1614.0

Topological domain

Cytoplasmic

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

20_1370

515.0

1614.0

Topological domain

Extracellular

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1394_1613

515.0

1614.0

Topological domain

Cytoplasmic

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

20_1370

515.0

1614.0

Topological domain

Extracellular

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1394_1613

515.0

1614.0

Topological domain

Cytoplasmic

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

20_1370

515.0

1614.0

Topological domain

Extracellular

Hgene

LRP6

chr12:12332743

chr12:675343

ENST00000261349

1371_1393

515.0

1614.0

Transmembrane

Helical

Hgene

LRP6

chr12:12332743

chr12:675344

ENST00000261349

1371_1393

515.0

1614.0

Transmembrane

Helical

Hgene

LRP6

chr12:12332744

chr12:675344

ENST00000261349

1371_1393

515.0

1614.0

Transmembrane

Helical

Tgene

NINJ2

chr12:12332743

chr12:675343

ENST00000305108

1_65

57.0

152.33333333333334

Topological domain

Extracellular

Tgene

NINJ2

chr12:12332743

chr12:675344

ENST00000305108

1_65

57.0

152.33333333333334

Topological domain

Extracellular

Tgene

NINJ2

chr12:12332744

chr12:675344

ENST00000305108

1_65

57.0

152.33333333333334

Topological domain

Extracellular

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1347_LRP6_12332744_NINJ2_675344_1347_LRP6_12332744_NINJ2_675344_ranked_0.pdb	LRP6	12332743	12332744	ENST00000397265	NINJ2	chr12	675344	-	MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEPGSSDPRSQPINLNHYATKKSVAES MLDVALFMSNAMRLKAVLEQGPSSHYYTTLVTLISLSLLLQVVIGVLLVVIARLNLNEVEKQWRLNQLNNAATILVFFTVVINVFITAFG	646

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

LRP6_pLDDT.png

NINJ2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LRP6
NINJ2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to LRP6-NINJ2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LRP6-NINJ2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source