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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LRP8-RAD51C

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LRP8-RAD51C
	FusionPDB ID: 49838
	FusionGDB2.0 ID: 49838
		Hgene	Tgene
	Gene symbol	LRP8	RAD51C
	Gene ID	7804	5889
	Gene name	LDL receptor related protein 8	RAD51 paralog C
	Synonyms	APOER2\|HSZ75190\|LRP-8\|MCI1	BROVCA3\|FANCO\|R51H3\|RAD51L2
	Cytomap	1p32.3	17q22
	Type of gene	protein-coding	protein-coding
	Description	low-density lipoprotein receptor-related protein 8ApoE receptor 2low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	DNA repair protein RAD51 homolog 3RAD51-like protein 2yeast RAD51 homolog 3
	Modification date	20200313	20200313
	UniProtAcc	Q14114	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000306052, ENST00000347547, ENST00000354412, ENST00000371454, ENST00000465675, ENST00000460214,	ENST00000421782, ENST00000487921, ENST00000337432, ENST00000583539,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 12 X 6=576	12 X 11 X 4=528
	# samples	11	15
	** MAII score	log2(11/576*10)=-2.38856528791765 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/528*10)=-1.81557542886257 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LRP8 [Title/Abstract] AND RAD51C [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LRP8(53720789)-RAD51C(56772292), # samples:3
Anticipated loss of major functional domain due to fusion event.	LRP8-RAD51C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP8-RAD51C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LRP8-RAD51C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP8-RAD51C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LRP8-RAD51C seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. LRP8-RAD51C seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LRP8	GO:0006897	endocytosis	8626535
Tgene	RAD51C	GO:0006281	DNA repair	19451272
Tgene	RAD51C	GO:0006310	DNA recombination	19451272

Fusion gene breakpoints across LRP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51C (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-A8-A08F-01A	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000306052	LRP8	chr1	53720789	-	ENST00000583539	RAD51C	chr17	56772292	+	3708	2605	39	3500	1153
ENST00000306052	LRP8	chr1	53720789	-	ENST00000337432	RAD51C	chr17	56772292	+	3711	2605	39	3590	1183
ENST00000371454	LRP8	chr1	53720789	-	ENST00000583539	RAD51C	chr17	56772292	+	3748	2645	79	3540	1153
ENST00000371454	LRP8	chr1	53720789	-	ENST00000337432	RAD51C	chr17	56772292	+	3751	2645	79	3630	1183
ENST00000354412	LRP8	chr1	53720789	-	ENST00000583539	RAD51C	chr17	56772292	+	2994	1891	0	2786	928
ENST00000354412	LRP8	chr1	53720789	-	ENST00000337432	RAD51C	chr17	56772292	+	2997	1891	0	2876	958
ENST00000347547	LRP8	chr1	53720789	-	ENST00000583539	RAD51C	chr17	56772292	+	3096	1993	0	2888	962
ENST00000347547	LRP8	chr1	53720789	-	ENST00000337432	RAD51C	chr17	56772292	+	3099	1993	0	2978	992

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000306052	ENST00000583539	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.002104114	0.99789584
ENST00000306052	ENST00000337432	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.002367957	0.997632
ENST00000371454	ENST00000583539	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.002154159	0.9978459
ENST00000371454	ENST00000337432	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.002432903	0.9975672
ENST00000354412	ENST00000583539	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.001528378	0.99847156
ENST00000354412	ENST00000337432	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.001159542	0.9988405
ENST00000347547	ENST00000583539	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.001964751	0.99803525
ENST00000347547	ENST00000337432	LRP8	chr1	53720789	-	RAD51C	chr17	56772292	+	0.00150057	0.9984994

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49838_49838_1_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000306052_RAD51C_chr17_56772292_ENST00000337432_length(amino acids)=1183AA_BP=855
MRRGGGGAGSAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDED
DDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD
EAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG
PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE
CLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR
HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNK
TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS
SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGG
CEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVS
VPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQ
EHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLI
AEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLA
NNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKECTVLFQIKPQGFRDTVVTSACSLQTEGSL

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>49838_49838_2_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000306052_RAD51C_chr17_56772292_ENST00000583539_length(amino acids)=1153AA_BP=855
MRRGGGGAGSAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDED
DDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD
EAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG
PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE
CLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR
HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNK
TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS
SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGG
CEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVS
VPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQ
EHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLI
AEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLA

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>49838_49838_3_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000347547_RAD51C_chr17_56772292_ENST00000337432_length(amino acids)=992AA_BP=664
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD
FTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHI
CTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR
NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR
RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKT
LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQI
SSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPST
LSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFC
SALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRK
ALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTN
QMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKECTVLFQIKPQGFRDTVVTSACSLQTEGSLSTRKRSRDPEE

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>49838_49838_4_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000347547_RAD51C_chr17_56772292_ENST00000583539_length(amino acids)=962AA_BP=664
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD
FTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATWLNECLHNNGGCSHI
CTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKR
NYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGR
RRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKT
LISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQI
SSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVSVPRAPSISPST
LSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFC
SALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRK
ALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTN

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>49838_49838_5_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000354412_RAD51C_chr17_56772292_ENST00000337432_length(amino acids)=958AA_BP=630
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD
FTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG
TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC
ECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE
VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLV
SDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL
NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGSTVTAAVIGIIVPI
EVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQL
AVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPD
FLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWD

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>49838_49838_6_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000354412_RAD51C_chr17_56772292_ENST00000583539_length(amino acids)=928AA_BP=630
MGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDEDDDCLDHSDEDDCPKKTCADSD
FTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGADEAGCATSLGTCRGDEFQCGDG
TCVLAIKHCNQEQDCPDGSDEAGCLQGLNECLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKC
ECYPGYEMDLLTKNCKAAAGKSPSLIFTNRHEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQE
VLIDEQLHSPEGLAVDWVHKHIYWTDSGNKTISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLV
SDNIEWPNGITLDLLSQRLYWVDSKLHQLSSIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENL
NNPHDIVIFHELKQPRAPDACELSVQPNGGCEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRDANEDSKMGSTVTAAVIGIIVPI
EVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQEHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQL
AVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLIAEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPD
FLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLANNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWD

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>49838_49838_7_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000371454_RAD51C_chr17_56772292_ENST00000337432_length(amino acids)=1183AA_BP=855
MRRGGGGAGSAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDED
DDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD
EAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG
PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE
CLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR
HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNK
TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS
SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGG
CEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVS
VPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQ
EHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLI
AEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLA
NNHRLAVILTNQMTTKIDRNQALLVPALGESWGHAATIRLIFHWDRKQRLATLYKSPSQKECTVLFQIKPQGFRDTVVTSACSLQTEGSL

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>49838_49838_8_LRP8-RAD51C_LRP8_chr1_53720789_ENST00000371454_RAD51C_chr17_56772292_ENST00000583539_length(amino acids)=1153AA_BP=855
MRRGGGGAGSAGRGGRSPGPAMGLPEPGPLRLLALLLLLLLLLLLQLQHLAAAAADPLLGGQGPAKDCEKDQFQCRNERCIPSVWRCDED
DDCLDHSDEDDCPKKTCADSDFTCDNGHCIHERWKCDGEEECPDGSDESEATCTKQVCPAEKLSCGPTSHKCVPASWRCDGEKDCEGGAD
EAGCATLCAPHEFQCGNRSCLAAVFVCDGDDDCGDGSDERGCADPACGPREFRCGGDGGGACIPERWVCDRQFDCEDRSDEAAELCGRPG
PGATSAPAACATASQFACRSGECVHLGWRCDGDRDCKDKSDEADCPLGTCRGDEFQCGDGTCVLAIKHCNQEQDCPDGSDEAGCLQGLNE
CLHNNGGCSHICTDLKIGFECTCPAGFQLLDQKTCGDIDECKDPDACSQICVNYKGYFKCECYPGYEMDLLTKNCKAAAGKSPSLIFTNR
HEVRRIDLVKRNYSRLIPMLKNVVALDVEVATNRIYWCDLSYRKIYSAYMDKASDPKEQEVLIDEQLHSPEGLAVDWVHKHIYWTDSGNK
TISVATVDGGRRRTLFSRNLSEPRAIAVDPLRGFMYWSDWGDQAKIEKSGLNGVDRQTLVSDNIEWPNGITLDLLSQRLYWVDSKLHQLS
SIDFSGGNRKTLISSTDFLSHPFGIAVFEDKVFWTDLENEAIFSANRLNGLEISILAENLNNPHDIVIFHELKQPRAPDACELSVQPNGG
CEYLCLPAPQISSHSPKYTCACPDTMWLGPDMKRCYRAPQSTSTTTLASTMTRTVPATTRAPGTTVHRSTYQNHSTETPSLTAAVPSSVS
VPRAPSISPSTLSPATSNHSQHYANEDSKMGSTVTAAVIGIIVPIEVGISKAEALETLQIIRRECLTNKPRYAGTSESHKKCTALELLEQ
EHTQGFIITFCSALDDILGGGVPLMKTTEICGAPGVGKTQLCMQLAVDVQIPECFGGVAGEAVFIDTEGSFMVDRVVDLATACIQHLQLI
AEKHKGEEHRKALEDFTLDNILSHIYYFRCRDYTELLAQVYLLPDFLSEHSKVRLVIVDGIAFPFRHDLDDLSLRTRLLNGLAQQMISLA

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:53720789/chr17:56772292)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LRP8 Q14114	.
FUNCTION: Cell surface receptor for Reelin (RELN) and apolipoprotein E (apoE)-containing ligands. LRP8 participates in transmitting the extracellular Reelin signal to intracellular signaling processes, by binding to DAB1 on its cytoplasmic tail. Reelin acts via both the VLDL receptor (VLDLR) and LRP8 to regulate DAB1 tyrosine phosphorylation and microtubule function in neurons. LRP8 has higher affinity for Reelin than VLDLR. LRP8 is thus a key component of the Reelin pathway which governs neuronal layering of the forebrain during embryonic brain development. Binds the endoplasmic reticulum resident receptor-associated protein (RAP). Binds dimers of beta 2-glycoprotein I and may be involved in the suppression of platelet aggregation in the vasculature. Highly expressed in the initial segment of the epididymis, where it affects the functional expression of clusterin and phospholipid hydroperoxide glutathione peroxidase (PHGPx), two proteins required for sperm maturation. May also function as an endocytic receptor. Not required for endocytic uptake of SEPP1 in the kidney which is mediated by LRP2 (By similarity). Together with its ligand, apolipoprotein E (apoE), may indirectly play a role in the suppression of the innate immune response by controlling the survival of myeloid-derived suppressor cells (By similarity). {ECO:0000250\|UniProtKB:Q924X6, ECO:0000269\|PubMed:12807892, ECO:0000269\|PubMed:12899622, ECO:0000269\|PubMed:12950167}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

126_164

834.3333333333334

964.0

Domain

LDL-receptor class A 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

166_202

834.3333333333334

964.0

Domain

LDL-receptor class A 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

205_246

834.3333333333334

964.0

Domain

LDL-receptor class A 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

258_295

834.3333333333334

964.0

Domain

LDL-receptor class A 6

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

298_334

834.3333333333334

964.0

Domain

LDL-receptor class A 7

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

336_375

834.3333333333334

964.0

Domain

EGF-like 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

376_415

834.3333333333334

964.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

46_82

834.3333333333334

964.0

Domain

LDL-receptor class A 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

85_123

834.3333333333334

964.0

Domain

LDL-receptor class A 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

126_164

664.3333333333334

794.0

Domain

LDL-receptor class A 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

166_202

664.3333333333334

794.0

Domain

LDL-receptor class A 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

205_246

664.3333333333334

794.0

Domain

LDL-receptor class A 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

258_295

664.3333333333334

794.0

Domain

LDL-receptor class A 6

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

298_334

664.3333333333334

794.0

Domain

LDL-receptor class A 7

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

336_375

664.3333333333334

794.0

Domain

EGF-like 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

376_415

664.3333333333334

794.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

46_82

664.3333333333334

794.0

Domain

LDL-receptor class A 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

85_123

664.3333333333334

794.0

Domain

LDL-receptor class A 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

126_164

630.3333333333334

701.0

Domain

LDL-receptor class A 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

166_202

630.3333333333334

701.0

Domain

LDL-receptor class A 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

205_246

630.3333333333334

701.0

Domain

LDL-receptor class A 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

258_295

630.3333333333334

701.0

Domain

LDL-receptor class A 6

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

298_334

630.3333333333334

701.0

Domain

LDL-receptor class A 7

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

336_375

630.3333333333334

701.0

Domain

EGF-like 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

376_415

630.3333333333334

701.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

46_82

630.3333333333334

701.0

Domain

LDL-receptor class A 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

85_123

630.3333333333334

701.0

Domain

LDL-receptor class A 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

126_164

834.3333333333334

905.0

Domain

LDL-receptor class A 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

166_202

834.3333333333334

905.0

Domain

LDL-receptor class A 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

205_246

834.3333333333334

905.0

Domain

LDL-receptor class A 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

258_295

834.3333333333334

905.0

Domain

LDL-receptor class A 6

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

298_334

834.3333333333334

905.0

Domain

LDL-receptor class A 7

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

336_375

834.3333333333334

905.0

Domain

EGF-like 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

376_415

834.3333333333334

905.0

Domain

EGF-like 2%3B calcium-binding

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

46_82

834.3333333333334

905.0

Domain

LDL-receptor class A 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

85_123

834.3333333333334

905.0

Domain

LDL-receptor class A 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

740_798

834.3333333333334

964.0

Region

Note=Clustered O-linked oligosaccharides

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

740_798

834.3333333333334

905.0

Region

Note=Clustered O-linked oligosaccharides

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

462_508

834.3333333333334

964.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

509_551

834.3333333333334

964.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

552_595

834.3333333333334

964.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

596_639

834.3333333333334

964.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

640_681

834.3333333333334

964.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

462_508

664.3333333333334

794.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

509_551

664.3333333333334

794.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

552_595

664.3333333333334

794.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

596_639

664.3333333333334

794.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

462_508

630.3333333333334

701.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

509_551

630.3333333333334

701.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

552_595

630.3333333333334

701.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

462_508

834.3333333333334

905.0

Repeat

Note=LDL-receptor class B 1

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

509_551

834.3333333333334

905.0

Repeat

Note=LDL-receptor class B 2

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

552_595

834.3333333333334

905.0

Repeat

Note=LDL-receptor class B 3

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

596_639

834.3333333333334

905.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

640_681

834.3333333333334

905.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

42_826

834.3333333333334

964.0

Topological domain

Extracellular

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

42_826

834.3333333333334

905.0

Topological domain

Extracellular

Tgene

RAD51C

chr1:53720789

chr17:56772292

ENST00000337432

366_370

48.333333333333336

377.0

Motif

Nuclear localization signal

Tgene

RAD51C

chr1:53720789

chr17:56772292

ENST00000421782

366_370

48.333333333333336

136.0

Motif

Nuclear localization signal

Tgene

RAD51C

chr1:53720789

chr17:56772292

ENST00000337432

125_132

48.333333333333336

377.0

Nucleotide binding

ATP

Tgene

RAD51C

chr1:53720789

chr17:56772292

ENST00000421782

125_132

48.333333333333336

136.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

740_798

664.3333333333334

794.0

Region

Note=Clustered O-linked oligosaccharides

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

740_798

630.3333333333334

701.0

Region

Note=Clustered O-linked oligosaccharides

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

640_681

664.3333333333334

794.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

596_639

630.3333333333334

701.0

Repeat

Note=LDL-receptor class B 4

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

640_681

630.3333333333334

701.0

Repeat

Note=LDL-receptor class B 5

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

848_963

834.3333333333334

964.0

Topological domain

Cytoplasmic

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

42_826

664.3333333333334

794.0

Topological domain

Extracellular

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

848_963

664.3333333333334

794.0

Topological domain

Cytoplasmic

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

42_826

630.3333333333334

701.0

Topological domain

Extracellular

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

848_963

630.3333333333334

701.0

Topological domain

Cytoplasmic

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

848_963

834.3333333333334

905.0

Topological domain

Cytoplasmic

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000306052

827_847

834.3333333333334

964.0

Transmembrane

Helical

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000347547

827_847

664.3333333333334

794.0

Transmembrane

Helical

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000354412

827_847

630.3333333333334

701.0

Transmembrane

Helical

Hgene

LRP8

chr1:53720789

chr17:56772292

ENST00000371454

827_847

834.3333333333334

905.0

Transmembrane

Helical

Tgene

RAD51C

chr1:53720789

chr17:56772292

ENST00000337432

1_126

48.333333333333336

377.0

Region

Note=Required for Holliday junction resolution activity

Tgene

RAD51C

chr1:53720789

chr17:56772292

ENST00000421782

1_126

48.333333333333336

136.0

Region

Note=Required for Holliday junction resolution activity

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LRP8
RAD51C

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to LRP8-RAD51C

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to LRP8-RAD51C

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source