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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:ABL2-KCNH1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABL2-KCNH1
FusionPDB ID: 501
FusionGDB2.0 ID: 501
HgeneTgene
Gene symbol

ABL2

KCNH1

Gene ID

27

3756

Gene nameABL proto-oncogene 2, non-receptor tyrosine kinasepotassium voltage-gated channel subfamily H member 1
SynonymsABLL|ARGEAG|EAG1|Kv10.1|TMBTS|ZLS1|h-eag|hEAG|hEAG1
Cytomap

1q25.2

1q32.2

Type of geneprotein-codingprotein-coding
Descriptiontyrosine-protein kinase ABL2Abelson tyrosine-protein kinase 2abelson-related gene proteinc-abl oncogene 2, non-receptor tyrosine kinasetyrosine-protein kinase ARGv-abl Abelson murine leukemia viral oncogene homolog 2potassium voltage-gated channel subfamily H member 1EAG channel 1ether-a-go-go 1ether-a-go-go potassium channel 1ether-a-go-go, Drosophila, homolog ofpotassium channel, voltage gated eag related subfamily H, member 1potassium voltage-gated channel,
Modification date2020032720200313
UniProtAcc

P42684

O95259

Ensembl transtripts involved in fusion geneENST idsENST00000367623, ENST00000392043, 
ENST00000502732, ENST00000507173, 
ENST00000511413, ENST00000344730, 
ENST00000408940, ENST00000504405, 
ENST00000512653, 		ENST00000367007, 
ENST00000271751, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 6 X 6=2886 X 5 X 6=180
# samples 86
** MAII scorelog2(8/288*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABL2 [Title/Abstract] AND KCNH1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABL2(179198376)-KCNH1(210857480), # samples:1
Anticipated loss of major functional domain due to fusion event.ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
ABL2-KCNH1 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABL2

GO:0018108

peptidyl-tyrosine phosphorylation

15886098

HgeneABL2

GO:0051353

positive regulation of oxidoreductase activity

12893824

TgeneKCNH1

GO:0071805

potassium ion transmembrane transport

22732247|27005320|27325704


check buttonFusion gene breakpoints across ABL2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KCNH1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LIHCTCGA-2Y-A9HA-01AABL2chr1

179198376

-KCNH1chr1

210857480

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000502732ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-12873611031218371
ENST00000367623ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-10831571541014286
ENST00000507173ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-10831571541014286
ENST00000511413ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-10831571541014286
ENST00000392043ABL2chr1179198376-ENST00000271751KCNH1chr1210857480-13704441861301371

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000502732ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0187127420.9812873
ENST00000367623ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0190217330.98097825
ENST00000507173ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0190217330.98097825
ENST00000511413ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0190217330.98097825
ENST00000392043ENST00000271751ABL2chr1179198376-KCNH1chr1210857480-0.0160923250.9839077

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>501_501_1_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000367623_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=286AA_BP=1
MIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRES
PATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEI

--------------------------------------------------------------

>501_501_2_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000392043_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=371AA_BP=86
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMIVFR
KISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPV
SFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSD
LRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQS

--------------------------------------------------------------

>501_501_3_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000502732_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=371AA_BP=86
MGGRDRSSARSPRPEPRRNVTRGRRGRGSTREQGWGSRWAASGKLRGSSSLSPAGSGAAVQPGPPAAGGTRRGAPQRPASISSPSMIVFR
KISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRESPATPV
SFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSGITKSD
LRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEISRPQS

--------------------------------------------------------------

>501_501_4_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000507173_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=286AA_BP=1
MIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRES
PATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEI

--------------------------------------------------------------

>501_501_5_ABL2-KCNH1_ABL2_chr1_179198376_ENST00000511413_KCNH1_chr1_210857480_ENST00000271751_length(amino acids)=286AA_BP=1
MIVFRKISDVKREEEERMKRKNEAPLILPPDHPVRRLFQRFRQQKEARLAAERGGRDLDDLDVEKGNVLTEHASANHSLVKASVVTVRES
PATPVSFQAASTSGVPDHAKLQAPGSECLGPKGGGGDCAKRKSWARFKDACGKSEDWNKVSKAESMETLPERTKASGEATLKKTDSCDSG
ITKSDLRLDNVGEARSPQDRSPILAEVKHSFYPIPEQTLQATVLEVRHELKEDIKALNAKMTNIEKQLSEILRILTSRRSSQSPQELFEI

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:179198376/chr1:210857480)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABL2

P42684

KCNH1

O95259

FUNCTION: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. {ECO:0000269|PubMed:15735735, ECO:0000269|PubMed:15886098, ECO:0000269|PubMed:16678104, ECO:0000269|PubMed:17306540, ECO:0000269|PubMed:18945674}.FUNCTION: Pore-forming (alpha) subunit of a voltage-gated delayed rectifier potassium channel (PubMed:9738473, PubMed:11943152, PubMed:10880439, PubMed:22732247, PubMed:25556795, PubMed:27325704, PubMed:27005320, PubMed:27618660). Channel properties are modulated by subunit assembly (PubMed:11943152). Mediates IK(NI) current in myoblasts (PubMed:9738473). Involved in the regulation of cell proliferation and differentiation, in particular adipogenic and osteogenic differentiation in bone marrow-derived mesenchymal stem cells (MSCs) (PubMed:23881642). {ECO:0000269|PubMed:10880439, ECO:0000269|PubMed:11943152, ECO:0000269|PubMed:22732247, ECO:0000269|PubMed:23881642, ECO:0000269|PubMed:25556795, ECO:0000269|PubMed:27005320, ECO:0000269|PubMed:27325704, ECO:0000269|PubMed:27618660, ECO:0000269|PubMed:9738473}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911924_964704.0990.0RegionCAD (involved in subunit assembly)
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911924_964677.0963.0RegionCAD (involved in subunit assembly)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113561_56401065.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113732_73901065.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113843_105501065.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113984_98801065.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111561_56452.3333333333333361162.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111732_73952.3333333333333361162.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111843_105552.3333333333333361162.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111984_98852.3333333333333361162.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110561_56452.333333333333336543.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110732_73952.333333333333336543.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110843_105552.333333333333336543.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110984_98852.333333333333336543.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111561_5640.01147.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111732_7390.01147.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111843_10550.01147.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111984_9880.01147.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112561_56452.3333333333333361183.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112732_73952.3333333333333361183.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112843_105552.3333333333333361183.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112984_98852.3333333333333361183.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112561_5640.01044.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112732_7390.01044.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112843_10550.01044.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112984_9880.01044.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112561_56452.3333333333333361059.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112732_73952.3333333333333361059.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112843_105552.3333333333333361059.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112984_98852.3333333333333361059.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113561_56452.3333333333333361080.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113732_73952.3333333333333361080.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113843_105552.3333333333333361080.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113984_98852.3333333333333361080.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112561_56401168.0Compositional biasNote=Poly-Ser
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112732_73901168.0Compositional biasNote=Poly-Gly
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112843_105501168.0Compositional biasNote=Pro-rich
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112984_98801168.0Compositional biasNote=Poly-Pro
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113107_16701065.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113173_26301065.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113288_53901065.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111107_16752.3333333333333361162.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111173_26352.3333333333333361162.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111288_53952.3333333333333361162.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110107_16752.333333333333336543.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110173_26352.333333333333336543.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110288_53952.333333333333336543.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111107_1670.01147.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111173_2630.01147.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111288_5390.01147.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112107_16752.3333333333333361183.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112173_26352.3333333333333361183.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112288_53952.3333333333333361183.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112107_1670.01044.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112173_2630.01044.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112288_5390.01044.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112107_16752.3333333333333361059.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112173_26352.3333333333333361059.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112288_53952.3333333333333361059.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113107_16752.3333333333333361080.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113173_26352.3333333333333361080.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113288_53952.3333333333333361080.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112107_16701168.0DomainSH3
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112173_26301168.0DomainSH2
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112288_53901168.0DomainProtein kinase
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113427_45101065.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113658_66001065.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111427_45152.3333333333333361162.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111658_66052.3333333333333361162.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110427_45152.333333333333336543.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110658_66052.333333333333336543.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111427_4510.01147.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111658_6600.01147.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112427_45152.3333333333333361183.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112658_66052.3333333333333361183.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112427_4510.01044.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112658_6600.01044.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112427_45152.3333333333333361059.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112658_66052.3333333333333361059.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113427_45152.3333333333333361080.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113658_66052.3333333333333361080.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112427_45101168.0MotifKinase activation loop
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112658_66001168.0MotifNuclear localization signal
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113294_30201065.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113362_36801065.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111294_30252.3333333333333361162.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111362_36852.3333333333333361162.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110294_30252.333333333333336543.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110362_36852.333333333333336543.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111294_3020.01147.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111362_3680.01147.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112294_30252.3333333333333361183.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112362_36852.3333333333333361183.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112294_3020.01044.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112362_3680.01044.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112294_30252.3333333333333361059.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112362_36852.3333333333333361059.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113294_30252.3333333333333361080.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113362_36852.3333333333333361080.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112294_30201168.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112362_36801168.0Nucleotide bindingATP
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-1131020_118201065.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-1132_10601065.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000344730-113694_93001065.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-1111020_118252.3333333333333361162.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-1112_10652.3333333333333361162.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000367623-111694_93052.3333333333333361162.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-1101020_118252.333333333333336543.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-1102_10652.333333333333336543.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000392043-110694_93052.333333333333336543.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-1111020_11820.01147.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-1112_1060.01147.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000408940-111694_9300.01147.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-1121020_118252.3333333333333361183.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-1122_10652.3333333333333361183.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000502732-112694_93052.3333333333333361183.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-1121020_11820.01044.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-1122_1060.01044.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000504405-112694_9300.01044.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-1121020_118252.3333333333333361059.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-1122_10652.3333333333333361059.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000507173-112694_93052.3333333333333361059.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-1131020_118252.3333333333333361080.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-1132_10652.3333333333333361080.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000511413-113694_93052.3333333333333361080.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-1121020_118201168.0RegionF-actin-binding
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-1122_10601168.0RegionNote=CAP
HgeneABL2chr1:179198376chr1:210857480ENST00000512653-112694_93001168.0RegionF-actin-binding
TgeneKCNH1chr1:179198376chr1:210857480ENST0000027175191114_94704.0990.0DomainPAS
TgeneKCNH1chr1:179198376chr1:210857480ENST0000027175191193_145704.0990.0DomainPAC
TgeneKCNH1chr1:179198376chr1:210857480ENST0000036700791114_94677.0963.0DomainPAS
TgeneKCNH1chr1:179198376chr1:210857480ENST0000036700791193_145677.0963.0DomainPAC
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911449_470704.0990.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911449_470677.0963.0IntramembranePore-forming%3B Name%3DSegment H5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911463_468704.0990.0MotifSelectivity filter
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911463_468677.0963.0MotifSelectivity filter
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911151_162704.0990.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911673_770704.0990.0RegionCalmodulin-binding
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911151_162677.0963.0RegionRequired for phosphatidylinositol bisphosphate binding
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911673_770677.0963.0RegionCalmodulin-binding
TgeneKCNH1chr1:179198376chr1:210857480ENST000002717519111_220704.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911242_248704.0990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911270_290704.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911310_345704.0990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911369_377704.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911400_448704.0990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911471_477704.0990.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911499_989704.0990.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST000003670079111_220677.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911242_248677.0963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911270_290677.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911310_345677.0963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911369_377677.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911400_448677.0963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911471_477677.0963.0Topological domainExtracellular
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911499_989677.0963.0Topological domainCytoplasmic
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911221_241704.0990.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911249_269704.0990.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911291_309704.0990.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911346_368704.0990.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911378_399704.0990.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000271751911478_498704.0990.0TransmembraneHelical%3B Name%3DSegment S6
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911221_241677.0963.0TransmembraneHelical%3B Name%3DSegment S1
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911249_269677.0963.0TransmembraneHelical%3B Name%3DSegment S2
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911291_309677.0963.0TransmembraneHelical%3B Name%3DSegment S3
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911346_368677.0963.0TransmembraneHelical%3B Voltage-sensor%3B Name%3DSegment S4
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911378_399677.0963.0TransmembraneHelical%3B Name%3DSegment S5
TgeneKCNH1chr1:179198376chr1:210857480ENST00000367007911478_498677.0963.0TransmembraneHelical%3B Name%3DSegment S6


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABL2all structure
KCNH1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to ABL2-KCNH1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to ABL2-KCNH1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource