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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:LSM14A-TDRD12

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: LSM14A-TDRD12
	FusionPDB ID: 50194
	FusionGDB2.0 ID: 50194
		Hgene	Tgene
	Gene symbol	LSM14A	TDRD12
	Gene ID	26065	91646
	Gene name	LSM14A mRNA processing body assembly factor	tudor domain containing 12
	Synonyms	C19orf13\|FAM61A\|RAP55\|RAP55A	ECAT8
	Cytomap	19q13.11	19q13.11
	Type of gene	protein-coding	protein-coding
	Description	protein LSM14 homolog ALSM14 homolog ALSM14A, SCD6 homolog ARNA-associated protein 55RNA-associated protein 55AalphaSNBPfamily with sequence similarity 61, member AhRAP55hRAP55Aprotein SCD6 homologputative alpha-synuclein-binding protein	putative ATP-dependent RNA helicase TDRD12ES cell associated transcript 8ES cell-associated transcript 8 proteintudor domain-containing protein 12
	Modification date	20200327	20200313
	UniProtAcc	Q8ND56	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000433627, ENST00000540746, ENST00000544216,	ENST00000421545, ENST00000444215,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 10 X 10=1800	13 X 12 X 8=1248
	# samples	24	16
	** MAII score	log2(24/1800*10)=-2.90689059560852 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1248*10)=-2.96347412397489 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: LSM14A [Title/Abstract] AND TDRD12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	LSM14A(34706566)-TDRD12(33263658), # samples:2
Anticipated loss of major functional domain due to fusion event.	LSM14A-TDRD12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LSM14A-TDRD12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LSM14A-TDRD12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LSM14A-TDRD12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	LSM14A	GO:0033962	cytoplasmic mRNA processing body assembly	16484376

Fusion gene breakpoints across LSM14A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TDRD12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-V1-A9O5-06A	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+
ChimerDB4	PRAD	TCGA-V1-A9O5	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000540746	LSM14A	chr19	34706566	+	ENST00000444215	TDRD12	chr19	33263658	+	3525	776	85	3444	1119
ENST00000540746	LSM14A	chr19	34706566	+	ENST00000421545	TDRD12	chr19	33263658	+	1228	776	85	1098	337
ENST00000544216	LSM14A	chr19	34706566	+	ENST00000444215	TDRD12	chr19	33263658	+	3607	858	44	3526	1160
ENST00000544216	LSM14A	chr19	34706566	+	ENST00000421545	TDRD12	chr19	33263658	+	1310	858	44	1180	378
ENST00000433627	LSM14A	chr19	34706566	+	ENST00000444215	TDRD12	chr19	33263658	+	3605	856	42	3524	1160
ENST00000433627	LSM14A	chr19	34706566	+	ENST00000421545	TDRD12	chr19	33263658	+	1308	856	42	1178	378
ENST00000540746	LSM14A	chr19	34706566	-	ENST00000444215	TDRD12	chr19	33263659	+	3525	776	85	3444	1119
ENST00000540746	LSM14A	chr19	34706566	-	ENST00000421545	TDRD12	chr19	33263659	+	1228	776	85	1098	337
ENST00000544216	LSM14A	chr19	34706566	-	ENST00000444215	TDRD12	chr19	33263659	+	3607	858	44	3526	1160
ENST00000544216	LSM14A	chr19	34706566	-	ENST00000421545	TDRD12	chr19	33263659	+	1310	858	44	1180	378
ENST00000433627	LSM14A	chr19	34706566	-	ENST00000444215	TDRD12	chr19	33263659	+	3605	856	42	3524	1160
ENST00000433627	LSM14A	chr19	34706566	-	ENST00000421545	TDRD12	chr19	33263659	+	1308	856	42	1178	378

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000540746	ENST00000444215	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+	0.000540695	0.9994593
ENST00000540746	ENST00000421545	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+	0.001435153	0.9985649
ENST00000544216	ENST00000444215	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+	0.000349324	0.9996507
ENST00000544216	ENST00000421545	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+	0.002521009	0.997479
ENST00000433627	ENST00000444215	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+	0.000349291	0.9996507
ENST00000433627	ENST00000421545	LSM14A	chr19	34706566	+	TDRD12	chr19	33263658	+	0.002471274	0.99752873
ENST00000540746	ENST00000444215	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+	0.000540695	0.9994593
ENST00000540746	ENST00000421545	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+	0.001435153	0.9985649
ENST00000544216	ENST00000444215	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+	0.000349324	0.9996507
ENST00000544216	ENST00000421545	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+	0.002521009	0.997479
ENST00000433627	ENST00000444215	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+	0.000349291	0.9996507
ENST00000433627	ENST00000421545	LSM14A	chr19	34706566	-	TDRD12	chr19	33263659	+	0.002471274	0.99752873

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50194_50194_1_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000433627_TDRD12_chr19_33263658_ENST00000421545_length(amino acids)=378AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ

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>50194_50194_2_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000433627_TDRD12_chr19_33263658_ENST00000444215_length(amino acids)=1160AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ
FLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPL
LYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRL
LACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGN
VQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDD
CVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGV
LEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNE
YFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPA
DNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPAC

--------------------------------------------------------------

>50194_50194_3_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000433627_TDRD12_chr19_33263659_ENST00000421545_length(amino acids)=378AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ

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>50194_50194_4_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000433627_TDRD12_chr19_33263659_ENST00000444215_length(amino acids)=1160AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ
FLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPL
LYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRL
LACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGN
VQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDD
CVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGV
LEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNE
YFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPA
DNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPAC

--------------------------------------------------------------

>50194_50194_5_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000540746_TDRD12_chr19_33263658_ENST00000421545_length(amino acids)=337AA_BP=230
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVY

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>50194_50194_6_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000540746_TDRD12_chr19_33263658_ENST00000444215_length(amino acids)=1119AA_BP=230
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVY
WPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQFLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTI
DSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPLLYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIF
ELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRLLACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNI
EVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGNVQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAET
EIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQG
SPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGVLEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDL
PRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNEYFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDA
WALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMV
HITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPACEESLSQTPPRVTGTSPAQDQDHPSEEQGGQGTPPAEDAACL

--------------------------------------------------------------

>50194_50194_7_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000540746_TDRD12_chr19_33263659_ENST00000421545_length(amino acids)=337AA_BP=230
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVY

--------------------------------------------------------------

>50194_50194_8_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000540746_TDRD12_chr19_33263659_ENST00000444215_length(amino acids)=1119AA_BP=230
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVGRSSPQLDPLRKSPTMEQAVQTASAHLPAPA
AVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQVDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVY
WPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQFLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTI
DSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPLLYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIF
ELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRLLACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNI
EVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGNVQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAET
EIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDDCVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQG
SPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGVLEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDL
PRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNEYFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDA
WALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPADNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMV
HITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPACEESLSQTPPRVTGTSPAQDQDHPSEEQGGQGTPPAEDAACL

--------------------------------------------------------------

>50194_50194_9_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000544216_TDRD12_chr19_33263658_ENST00000421545_length(amino acids)=378AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ

--------------------------------------------------------------

>50194_50194_10_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000544216_TDRD12_chr19_33263658_ENST00000444215_length(amino acids)=1160AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ
FLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPL
LYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRL
LACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGN
VQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDD
CVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGV
LEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNE
YFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPA
DNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPAC

--------------------------------------------------------------

>50194_50194_11_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000544216_TDRD12_chr19_33263659_ENST00000421545_length(amino acids)=378AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ

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>50194_50194_12_LSM14A-TDRD12_LSM14A_chr19_34706566_ENST00000544216_TDRD12_chr19_33263659_ENST00000444215_length(amino acids)=1160AA_BP=271
MRAAGSGGGGAMSGGTPYIGSKISLISKAEIRYEGILYTIDTENSTVALAKVRSFGTEDRPTDRPIPPRDEVFEYIIFRGSDIKDLTVCE
PPKPQCSLPQDPAIVQSSLGSSTSSFQSMGSYGPFGRMPTYSQFSPSSLVGQQFGAVGVAGSSLTSFGTETSNSGTLPQSSAVGSAFTQD
TRSLKTQLSQGRSSPQLDPLRKSPTMEQAVQTASAHLPAPAAVGRRSPVSTRPLPSASQKAGENQEHRRAEVHKVSRPENEQLRNDNKRQ
VDKAVKCNMDSLRDSPKDKSEKKHHCISLKDTNKRVESSVYWPAKRGITIYADPDVPEASALSQKSNEKPLRLTEKKEYDEKNSCVKLLQ
FLNPDPLRADGISDLQQLQKLKGLQPPVVVLRNKIKPCLTIDSSPLSADLKKALQRNKFPGPSHTESYSWPPIARGCDVVVISHCESNPL
LYLLPVLTVLQTGACYKSLPSRNGPLAVIVCPGWKKAQFIFELLGEYSMSSRPLHPVLLTIGLHKEEAKNTKLPRGCDVIVTTPYSLLRL
LACQSLLFLRLCHLILDEVEVLFLEANEQMFAILDNFKKNIEVEERESAPHQIVAVGVHWNKHIEHLIKEFMNDPYIVITAMEEAALYGN
VQQVVHLCLECEKTSSLLQALDFIPSQAQKTLIFTCSVAETEIVCKVVESSSIFCLKMHKEMIFNLQNVLEQWKKKLSSGSQIILALTDD
CVPLLAITDATCVIHFSFPASPKVFGGRLYCMSDHFHAEQGSPAEQGDKKAKSVLLLTEKDASHAVGVLRYLERADAKVPAELYEFTAGV
LEAKEDKKAGRPLCPYLKAFGFCKDKRICPDRHRINPETDLPRKLSSQALPSFGYIKIIPFYILNATNYFGRIVDKHMDLYATLNAEMNE
YFKDSNKTTVEKVEKFGLYGLAEKTLFHRVQVLEVNQKEDAWALDDILVEFIDEGRTGLVTRDQLLHLPEHFHTLPPQAVEFIVCRVKPA
DNEIEWNPKVTRYIHHKIVGKLHDAKVILALGNTVWIDPMVHITNLSSLKTSVIDYNVRAEILSMGMGIDNPEHIEQLKKLREDAKIPAC

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34706566/chr19:33263658)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
LSM14A Q8ND56	.
FUNCTION: Essential for formation of P-bodies, cytoplasmic structures that provide storage sites for translationally inactive mRNAs and protect them from degradation (PubMed:16484376, PubMed:17074753, PubMed:29510985). Acts as a repressor of mRNA translation (PubMed:29510985). May play a role in mitotic spindle assembly (PubMed:26339800). {ECO:0000269\|PubMed:16484376, ECO:0000269\|PubMed:17074753, ECO:0000269\|PubMed:26339800, ECO:0000269\|PubMed:29510985}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000421545

447_635

288.3333333333333

396.0

Domain

Note=Helicase ATP-binding

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000421545

900_999

288.3333333333333

396.0

Domain

Note=Tudor 2

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000444215

447_635

288.3333333333333

1178.0

Domain

Note=Helicase ATP-binding

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000444215

900_999

288.3333333333333

1178.0

Domain

Note=Tudor 2

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000421545

447_635

288.3333333333333

396.0

Domain

Note=Helicase ATP-binding

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000421545

900_999

288.3333333333333

396.0

Domain

Note=Tudor 2

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000444215

447_635

288.3333333333333

1178.0

Domain

Note=Helicase ATP-binding

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000444215

900_999

288.3333333333333

1178.0

Domain

Note=Tudor 2

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000421545

574_577

288.3333333333333

396.0

Motif

Note=DEAH box

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000444215

574_577

288.3333333333333

1178.0

Motif

Note=DEAH box

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000421545

574_577

288.3333333333333

396.0

Motif

Note=DEAH box

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000444215

574_577

288.3333333333333

1178.0

Motif

Note=DEAH box

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000421545

460_467

288.3333333333333

396.0

Nucleotide binding

ATP

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000444215

460_467

288.3333333333333

1178.0

Nucleotide binding

ATP

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000421545

460_467

288.3333333333333

396.0

Nucleotide binding

ATP

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000444215

460_467

288.3333333333333

1178.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

LSM14A

chr19:34706566

chr19:33263658

ENST00000433627

284_320

260.3333333333333

1040.0

Domain

DFDF

Hgene

LSM14A

chr19:34706566

chr19:33263658

ENST00000544216

284_320

260.3333333333333

464.0

Domain

DFDF

Hgene

LSM14A

chr19:34706566

chr19:33263659

ENST00000433627

284_320

260.3333333333333

1040.0

Domain

DFDF

Hgene

LSM14A

chr19:34706566

chr19:33263659

ENST00000544216

284_320

260.3333333333333

464.0

Domain

DFDF

Hgene

LSM14A

chr19:34706566

chr19:33263658

ENST00000433627

361_377

260.3333333333333

1040.0

Motif

Note=FFD box

Hgene

LSM14A

chr19:34706566

chr19:33263658

ENST00000433627

380_400

260.3333333333333

1040.0

Motif

Note=TFG box

Hgene

LSM14A

chr19:34706566

chr19:33263658

ENST00000544216

361_377

260.3333333333333

464.0

Motif

Note=FFD box

Hgene

LSM14A

chr19:34706566

chr19:33263658

ENST00000544216

380_400

260.3333333333333

464.0

Motif

Note=TFG box

Hgene

LSM14A

chr19:34706566

chr19:33263659

ENST00000433627

361_377

260.3333333333333

1040.0

Motif

Note=FFD box

Hgene

LSM14A

chr19:34706566

chr19:33263659

ENST00000433627

380_400

260.3333333333333

1040.0

Motif

Note=TFG box

Hgene

LSM14A

chr19:34706566

chr19:33263659

ENST00000544216

361_377

260.3333333333333

464.0

Motif

Note=FFD box

Hgene

LSM14A

chr19:34706566

chr19:33263659

ENST00000544216

380_400

260.3333333333333

464.0

Motif

Note=TFG box

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000421545

56_118

288.3333333333333

396.0

Domain

Note=Tudor 1

Tgene

TDRD12

chr19:34706566

chr19:33263658

ENST00000444215

56_118

288.3333333333333

1178.0

Domain

Note=Tudor 1

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000421545

56_118

288.3333333333333

396.0

Domain

Note=Tudor 1

Tgene

TDRD12

chr19:34706566

chr19:33263659

ENST00000444215

56_118

288.3333333333333

1178.0

Domain

Note=Tudor 1

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

LSM14A

Lsm14a, ELAVL1, RAE1, HNRNPDL, SYNCRIP, CIRBP, HNRNPH1, DDX1, HNRNPU, HNRNPL, CSNK2A1, HECW2, TP53, PRMT8, NTRK1, XPO1, AHSA1, SORT1, EGFR, SFPQ, STRAP, G3BP1, PHACTR3, PTCH1, ESR2, HEXIM1, MEPCE, LARP7, SNAI1, RECQL4, ATG16L1, ZC3H7A, EIF4ENIF1, DDX6, C1QBP, PRMT1, EDC4, PATL1, LSM1, LSM2, LSM3, LSM4, LSM6, LSM7, DCP1A, EDC3, UBQLN2, ZBTB10, HDAC2, APEX1, ITFG1, PLEKHA4, ORF9b, ENG, ZC3H18, N, nsp9, nsp3, ESR1, CELF1, DAZL, FAM120C, FMR1, FUBP3, FXR1, IGF2BP2, AGO1, AGO2, AGO3, ALG13, ANKRD17, ATXN2, CAPRIN1, CNOT1, CNOT10, CNOT3, CNOT4, RQCD1, CPEB4, DCP1B, FAM120A, G3BP2, GIGYF1, GTPBP1, HELZ, IGF2BP1, LSM12, LSM14B, KIAA0430, MEX3A, MKRN2, OTUD4, PRRC2A, PRRC2B, PRRC2C, PUM1, R3HDM1, RC3H1, RC3H2, SECISBP2, SMG1, SMG5, SMG7, SMG8, STAU2, TDRD3, TNRC6B, TOP3B, TRIM56, UBAP2L, UPF1, USP10, YTHDF1, YTHDF2, YTHDF3, ZC3HAV1, ZCCHC11, MEX3B, MOV10, DDX3X, FXR2, ANKHD1-EIF4EBP3, CNOT2, KIAA0355, LARP1B, PUM2, RBMS1, ZCCHC3, UNK, XRN1, CEP85, LARP4B, RNF214, UBAP2, RBM47, NUFIP2, TAF15, CNOT6, NUPL2, PARP12, SPATS2L, ARHGAP11B, ARHGAP23, CIC, FBP1, INSIG1, INSIG2, NUP37, DDX58, OGT, CD274, UFL1, FBL, MAPRE1, MYCBP2, NAA40, TMEM14B, IFI27L1, COL8A1, KIF2C, TMC4, GAGE2E, PEA15, SEPT9, CPEB1, KLF15, KLF16, KLF5, KLF8, SOX15, SOX5, SOX6, TLX2, TLX3,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
LSM14A
TDRD12

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to LSM14A-TDRD12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to LSM14A-TDRD12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source