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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LTA4H-SLC25A24

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LTA4H-SLC25A24
FusionPDB ID: 50256
FusionGDB2.0 ID: 50256
HgeneTgene
Gene symbol

LTA4H

SLC25A24

Gene ID

4048

29957

Gene nameleukotriene A4 hydrolasesolute carrier family 25 member 24
Synonyms-APC1|SCAMC-1|SCAMC1
Cytomap

12q23.1

1p13.3

Type of geneprotein-codingprotein-coding
Descriptionleukotriene A-4 hydrolaseLTA-4 hydrolasetesticular secretory protein Li 27calcium-binding mitochondrial carrier protein SCaMC-1calcium-binding transportermitochondrial ATP-Mg/Pi carrier protein 1mitochondrial Ca(2+)-dependent solute carrier protein 1short calcium-binding mitochondrial carrier 1small calcium-binding mitocho
Modification date2020031320200313
UniProtAcc

P09960

.
Ensembl transtripts involved in fusion geneENST idsENST00000228740, ENST00000413268, 
ENST00000552789, ENST00000548375, 
ENST00000569674, ENST00000370041, 
ENST00000565488, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 11 X 4=3964 X 3 X 4=48
# samples 115
** MAII scorelog2(11/396*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LTA4H [Title/Abstract] AND SLC25A24 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LTA4H(96402872)-SLC25A24(108686332), # samples:2
Anticipated loss of major functional domain due to fusion event.LTA4H-SLC25A24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LTA4H-SLC25A24 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLTA4H

GO:0019370

leukotriene biosynthetic process

9774412|15078870

HgeneLTA4H

GO:0043171

peptide catabolic process

9774412|15078870|18804029


check buttonFusion gene breakpoints across LTA4H (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SLC25A24 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-A4J6-01ALTA4Hchr12

96402872

-SLC25A24chr1

108686332

-
ChimerDB4STADTCGA-BR-A4J6LTA4Hchr12

96402871

-SLC25A24chr1

108686332

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000228740LTA4Hchr1296402872-ENST00000565488SLC25A24chr1108686332-469715761422079645
ENST00000228740LTA4Hchr1296402872-ENST00000370041SLC25A24chr1108686332-391015761422079645
ENST00000552789LTA4Hchr1296402872-ENST00000565488SLC25A24chr1108686332-45851464931967624
ENST00000552789LTA4Hchr1296402872-ENST00000370041SLC25A24chr1108686332-37981464931967624
ENST00000228740LTA4Hchr1296402871-ENST00000565488SLC25A24chr1108686332-469715761422079645
ENST00000228740LTA4Hchr1296402871-ENST00000370041SLC25A24chr1108686332-391015761422079645
ENST00000552789LTA4Hchr1296402871-ENST00000565488SLC25A24chr1108686332-45851464931967624
ENST00000552789LTA4Hchr1296402871-ENST00000370041SLC25A24chr1108686332-37981464931967624

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000228740ENST00000565488LTA4Hchr1296402872-SLC25A24chr1108686332-0.0002576940.9997423
ENST00000228740ENST00000370041LTA4Hchr1296402872-SLC25A24chr1108686332-0.0002395620.99976045
ENST00000552789ENST00000565488LTA4Hchr1296402872-SLC25A24chr1108686332-0.0002750830.9997249
ENST00000552789ENST00000370041LTA4Hchr1296402872-SLC25A24chr1108686332-0.0002648580.9997352
ENST00000228740ENST00000565488LTA4Hchr1296402871-SLC25A24chr1108686332-0.0002576940.9997423
ENST00000228740ENST00000370041LTA4Hchr1296402871-SLC25A24chr1108686332-0.0002395620.99976045
ENST00000552789ENST00000565488LTA4Hchr1296402871-SLC25A24chr1108686332-0.0002750830.9997249
ENST00000552789ENST00000370041LTA4Hchr1296402871-SLC25A24chr1108686332-0.0002648580.9997352

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50256_50256_1_LTA4H-SLC25A24_LTA4H_chr12_96402871_ENST00000228740_SLC25A24_chr1_108686332_ENST00000370041_length(amino acids)=645AA_BP=476
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEIS
LPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGG
MENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLY
SPGLPPIKPNYDMTLTNACIALSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYW
LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISY

--------------------------------------------------------------

>50256_50256_2_LTA4H-SLC25A24_LTA4H_chr12_96402871_ENST00000228740_SLC25A24_chr1_108686332_ENST00000565488_length(amino acids)=645AA_BP=476
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEIS
LPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGG
MENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLY
SPGLPPIKPNYDMTLTNACIALSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYW
LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISY

--------------------------------------------------------------

>50256_50256_3_LTA4H-SLC25A24_LTA4H_chr12_96402871_ENST00000552789_SLC25A24_chr1_108686332_ENST00000370041_length(amino acids)=624AA_BP=455
MSPMLPQRNLSKRQVPTMHIPVKTRRLLAALKVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSP
KSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCY
LIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLS
NVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSS
VPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIA
LSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA

--------------------------------------------------------------

>50256_50256_4_LTA4H-SLC25A24_LTA4H_chr12_96402871_ENST00000552789_SLC25A24_chr1_108686332_ENST00000565488_length(amino acids)=624AA_BP=455
MSPMLPQRNLSKRQVPTMHIPVKTRRLLAALKVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSP
KSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCY
LIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLS
NVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSS
VPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIA
LSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA

--------------------------------------------------------------

>50256_50256_5_LTA4H-SLC25A24_LTA4H_chr12_96402872_ENST00000228740_SLC25A24_chr1_108686332_ENST00000370041_length(amino acids)=645AA_BP=476
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEIS
LPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGG
MENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLY
SPGLPPIKPNYDMTLTNACIALSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYW
LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISY

--------------------------------------------------------------

>50256_50256_6_LTA4H-SLC25A24_LTA4H_chr12_96402872_ENST00000228740_SLC25A24_chr1_108686332_ENST00000565488_length(amino acids)=645AA_BP=476
MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEIS
LPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETP
DPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGG
MENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGET
HPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLY
SPGLPPIKPNYDMTLTNACIALSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYW
LDNFAKDSVNPGVMVLLGCGALSSTCGQLASYPLALVRTRMQAQAMLEGSPQLNMVGLFRRIISKEGIPGLYRGITPNFMKVLPAVGISY

--------------------------------------------------------------

>50256_50256_7_LTA4H-SLC25A24_LTA4H_chr12_96402872_ENST00000552789_SLC25A24_chr1_108686332_ENST00000370041_length(amino acids)=624AA_BP=455
MSPMLPQRNLSKRQVPTMHIPVKTRRLLAALKVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSP
KSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCY
LIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLS
NVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSS
VPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIA
LSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA

--------------------------------------------------------------

>50256_50256_8_LTA4H-SLC25A24_LTA4H_chr12_96402872_ENST00000552789_SLC25A24_chr1_108686332_ENST00000565488_length(amino acids)=624AA_BP=455
MSPMLPQRNLSKRQVPTMHIPVKTRRLLAALKVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSP
KSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCY
LIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLS
NVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSS
VPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIA
LSQRWITVMKTRLAVGKTGQYSGIYDCAKKILKHEGLGAFYKGYVPNLLGIIPYAGIDLAVYELLKSYWLDNFAKDSVNPGVMVLLGCGA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:96402872/chr1:108686332)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTA4H

P09960

.
FUNCTION: Bifunctional zinc metalloenzyme that comprises both epoxide hydrolase (EH) and aminopeptidase activities. Acts as an epoxide hydrolase to catalyze the conversion of LTA4 to the proinflammatory mediator leukotriene B4 (LTB4) (PubMed:11917124, PubMed:12207002, PubMed:15078870, PubMed:18804029, PubMed:1897988, PubMed:1975494, PubMed:2244921). Has also aminopeptidase activity, with high affinity for N-terminal arginines of various synthetic tripeptides (PubMed:20813919, PubMed:18804029). In addition to its proinflammatory EH activity, may also counteract inflammation by its aminopeptidase activity, which inactivates by cleavage another neutrophil attractant, the tripeptide Pro-Gly-Pro (PGP), a bioactive fragment of collagen generated by the action of matrix metalloproteinase-9 (MMP9) and prolylendopeptidase (PREPL) (PubMed:20813919, PubMed:24591641). Involved also in the biosynthesis of resolvin E1 and 18S-resolvin E1 from eicosapentaenoic acid, two lipid mediators that show potent anti-inflammatory and pro-resolving actions (PubMed:21206090). {ECO:0000269|PubMed:11917124, ECO:0000269|PubMed:12207002, ECO:0000269|PubMed:15078870, ECO:0000269|PubMed:18804029, ECO:0000269|PubMed:1897988, ECO:0000269|PubMed:1975494, ECO:0000269|PubMed:20813919, ECO:0000269|PubMed:21206090, ECO:0000269|PubMed:2244921, ECO:0000269|PubMed:24591641}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000228740-1519135_137478.0612.0RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000228740-1519267_272478.0612.0RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000228740-1519362_365478.0612.0RegionInhibitor ARM1 binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000413268-1518135_137454.0489.6666666666667RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000413268-1518267_272454.0489.6666666666667RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000413268-1518362_365454.0489.6666666666667RegionInhibitor ARM1 binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000552789-1519135_137454.0588.0RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000552789-1519267_272454.0588.0RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000552789-1519362_365454.0588.0RegionInhibitor ARM1 binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000228740-1519135_137478.0612.0RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000228740-1519267_272478.0612.0RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000228740-1519362_365478.0612.0RegionInhibitor ARM1 binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000413268-1518135_137454.0489.6666666666667RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000413268-1518267_272454.0489.6666666666667RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000413268-1518362_365454.0489.6666666666667RegionInhibitor ARM1 binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000552789-1519135_137454.0588.0RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000552789-1519267_272454.0588.0RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000552789-1519362_365454.0588.0RegionInhibitor ARM1 binding
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610383_471291.0459.0RepeatNote=Solcar 3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610383_471310.0478.0RepeatNote=Solcar 3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610383_471291.0459.0RepeatNote=Solcar 3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610383_471310.0478.0RepeatNote=Solcar 3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610310_345291.0459.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610366_388291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610407_445291.0459.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610466_477291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610310_345310.0478.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610366_388310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610407_445310.0478.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610466_477310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610310_345291.0459.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610366_388291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610407_445291.0459.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610466_477291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610310_345310.0478.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610366_388310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610407_445310.0478.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610466_477310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610296_309291.0459.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610346_365291.0459.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610389_406291.0459.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610446_465291.0459.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610346_365310.0478.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610389_406310.0478.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610446_465310.0478.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610296_309291.0459.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610346_365291.0459.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610389_406291.0459.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610446_465291.0459.0TransmembraneHelical%3B Name%3D6
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610346_365310.0478.0TransmembraneHelical%3B Name%3D4
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610389_406310.0478.0TransmembraneHelical%3B Name%3D5
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610446_465310.0478.0TransmembraneHelical%3B Name%3D6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000228740-1519564_566478.0612.0RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000413268-1518564_566454.0489.6666666666667RegionSubstrate binding
HgeneLTA4Hchr12:96402871chr1:108686332ENST00000552789-1519564_566454.0588.0RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000228740-1519564_566478.0612.0RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000413268-1518564_566454.0489.6666666666667RegionSubstrate binding
HgeneLTA4Hchr12:96402872chr1:108686332ENST00000552789-1519564_566454.0588.0RegionSubstrate binding
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610135_146291.0459.0Calcium bindingNote=4
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000037004161032_43291.0459.0Calcium bindingNote=1
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000037004161068_79291.0459.0Calcium bindingNote=2
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000037004161099_110291.0459.0Calcium bindingNote=3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610135_146310.0478.0Calcium bindingNote=4
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000056548861032_43310.0478.0Calcium bindingNote=1
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000056548861068_79310.0478.0Calcium bindingNote=2
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000056548861099_110310.0478.0Calcium bindingNote=3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610135_146291.0459.0Calcium bindingNote=4
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000037004161032_43291.0459.0Calcium bindingNote=1
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000037004161068_79291.0459.0Calcium bindingNote=2
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000037004161099_110291.0459.0Calcium bindingNote=3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610135_146310.0478.0Calcium bindingNote=4
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000056548861032_43310.0478.0Calcium bindingNote=1
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000056548861068_79310.0478.0Calcium bindingNote=2
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000056548861099_110310.0478.0Calcium bindingNote=3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610122_157291.0459.0DomainEF-hand 4
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000037004161019_54291.0459.0DomainEF-hand 1
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000037004161055_88291.0459.0DomainEF-hand 2
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000037004161086_121291.0459.0DomainEF-hand 3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610122_157310.0478.0DomainEF-hand 4
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000056548861019_54310.0478.0DomainEF-hand 1
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000056548861055_88310.0478.0DomainEF-hand 2
TgeneSLC25A24chr12:96402871chr1:108686332ENST0000056548861086_121310.0478.0DomainEF-hand 3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610122_157291.0459.0DomainEF-hand 4
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000037004161019_54291.0459.0DomainEF-hand 1
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000037004161055_88291.0459.0DomainEF-hand 2
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000037004161086_121291.0459.0DomainEF-hand 3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610122_157310.0478.0DomainEF-hand 4
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000056548861019_54310.0478.0DomainEF-hand 1
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000056548861055_88310.0478.0DomainEF-hand 2
TgeneSLC25A24chr12:96402872chr1:108686332ENST0000056548861086_121310.0478.0DomainEF-hand 3
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610192_278291.0459.0RepeatNote=Solcar 1
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610286_371291.0459.0RepeatNote=Solcar 2
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610192_278310.0478.0RepeatNote=Solcar 1
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610286_371310.0478.0RepeatNote=Solcar 2
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610192_278291.0459.0RepeatNote=Solcar 1
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610286_371291.0459.0RepeatNote=Solcar 2
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610192_278310.0478.0RepeatNote=Solcar 1
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610286_371310.0478.0RepeatNote=Solcar 2
TgeneSLC25A24chr12:96402871chr1:108686332ENST000003700416101_197291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610216_252291.0459.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610273_295291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST000005654886101_197310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610216_252310.0478.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610273_295310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST000003700416101_197291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610216_252291.0459.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610273_295291.0459.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST000005654886101_197310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610216_252310.0478.0Topological domainMitochondrial matrix
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610273_295310.0478.0Topological domainMitochondrial intermembrane
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610198_215291.0459.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000370041610253_272291.0459.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610198_215310.0478.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610253_272310.0478.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A24chr12:96402871chr1:108686332ENST00000565488610296_309310.0478.0TransmembraneHelical%3B Name%3D3
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610198_215291.0459.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000370041610253_272291.0459.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610198_215310.0478.0TransmembraneHelical%3B Name%3D1
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610253_272310.0478.0TransmembraneHelical%3B Name%3D2
TgeneSLC25A24chr12:96402872chr1:108686332ENST00000565488610296_309310.0478.0TransmembraneHelical%3B Name%3D3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LTA4H
SLC25A24


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LTA4H-SLC25A24


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LTA4H-SLC25A24


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource