UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:LTK-ITGB4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LTK-ITGB4
FusionPDB ID: 50316
FusionGDB2.0 ID: 50316
HgeneTgene
Gene symbol

LTK

ITGB4

Gene ID

4058

3691

Gene nameleukocyte receptor tyrosine kinaseintegrin subunit beta 4
SynonymsTYK1CD104|GP150
Cytomap

15q15.1

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionleukocyte tyrosine kinase receptorprotein tyrosine kinase 1integrin beta-4CD104 antigen
Modification date2020032020200329
UniProtAcc

P29376

P16144

Ensembl transtripts involved in fusion geneENST idsENST00000263800, ENST00000355166, 
ENST00000453182, ENST00000561619, 
ENST00000584558, ENST00000200181, 
ENST00000339591, ENST00000449880, 
ENST00000450894, ENST00000579662, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=18 X 8 X 7=448
# samples 19
** MAII scorelog2(1/1*10)=3.32192809488736log2(9/448*10)=-2.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LTK [Title/Abstract] AND ITGB4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LTK(41799292)-ITGB4(73746760), # samples:1
Anticipated loss of major functional domain due to fusion event.LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
LTK-ITGB4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
LTK-ITGB4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLTK

GO:0006468

protein phosphorylation

9223670

HgeneLTK

GO:0008283

cell proliferation

10445845

HgeneLTK

GO:0010666

positive regulation of cardiac muscle cell apoptotic process

10445845

TgeneITGB4

GO:0009611

response to wounding

19403692

TgeneITGB4

GO:0031581

hemidesmosome assembly

12482924


check buttonFusion gene breakpoints across LTK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ITGB4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer161NLTKchr15

41799292

-ITGB4chr17

73746760

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000453182LTKchr1541799292-ENST00000579662ITGB4chr1773746760+3254142017832041008
ENST00000453182LTKchr1541799292-ENST00000339591ITGB4chr1773746760+3626142017833631061
ENST00000453182LTKchr1541799292-ENST00000200181ITGB4chr1773746760+3678142017834141078
ENST00000453182LTKchr1541799292-ENST00000450894ITGB4chr1773746760+3465142017832041008
ENST00000453182LTKchr1541799292-ENST00000449880ITGB4chr1773746760+3627142017833631061

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000453182ENST00000579662LTKchr1541799292-ITGB4chr1773746760+0.0047244460.9952755
ENST00000453182ENST00000339591LTKchr1541799292-ITGB4chr1773746760+0.0075857160.9924143
ENST00000453182ENST00000200181LTKchr1541799292-ITGB4chr1773746760+0.0049205120.9950795
ENST00000453182ENST00000450894LTKchr1541799292-ITGB4chr1773746760+0.0044213850.9955786
ENST00000453182ENST00000449880LTKchr1541799292-ITGB4chr1773746760+0.0075989370.992401

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50316_50316_1_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000200181_length(amino acids)=1078AA_BP=414
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY
AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA
AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM
KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL
IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWK
FEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTT
SAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCE
RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAP
GPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITI

--------------------------------------------------------------

>50316_50316_2_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000339591_length(amino acids)=1061AA_BP=414
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY
AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA
AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM
KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL
IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN
GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPL
SWALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGE
LHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSW
ERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGL

--------------------------------------------------------------

>50316_50316_3_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000449880_length(amino acids)=1061AA_BP=414
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY
AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA
AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM
KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL
IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN
GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPL
SWALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGE
LHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSW
ERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGL

--------------------------------------------------------------

>50316_50316_4_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000450894_length(amino acids)=1008AA_BP=414
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY
AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA
AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM
KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL
IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN
GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRL
VFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHP
QSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKF
KVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRT

--------------------------------------------------------------

>50316_50316_5_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000579662_length(amino acids)=1008AA_BP=414
MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY
AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL
GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA
AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP
PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM
KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL
IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN
GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRL
VFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHP
QSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKF
KVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRT

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:41799292/chr17:73746760)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LTK

P29376

ITGB4

P16144

FUNCTION: Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. {ECO:0000269|PubMed:20548102}.FUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTKchr15:41799292chr17:73746760ENST00000263800-112017_424513.6666666666666865.0Topological domainExtracellular
HgeneLTKchr15:41799292chr17:73746760ENST00000355166-101917_424452.6666666666667804.0Topological domainExtracellular
HgeneLTKchr15:41799292chr17:73746760ENST00000263800-1120425_449513.6666666666666865.0TransmembraneHelical
HgeneLTKchr15:41799292chr17:73746760ENST00000355166-1019425_449452.6666666666667804.0TransmembraneHelical
TgeneITGB4chr15:41799292chr17:73746760ENST0000020018127401222_13211158.01823.0DomainFibronectin type-III 2
TgeneITGB4chr15:41799292chr17:73746760ENST0000020018127401530_16251158.01823.0DomainFibronectin type-III 3
TgeneITGB4chr15:41799292chr17:73746760ENST0000020018127401643_17391158.01823.0DomainFibronectin type-III 4
TgeneITGB4chr15:41799292chr17:73746760ENST0000033959127401222_13211158.01806.0DomainFibronectin type-III 2
TgeneITGB4chr15:41799292chr17:73746760ENST0000033959127401530_16251158.01806.0DomainFibronectin type-III 3
TgeneITGB4chr15:41799292chr17:73746760ENST0000033959127401643_17391158.01806.0DomainFibronectin type-III 4
TgeneITGB4chr15:41799292chr17:73746760ENST0000044988026391222_13211158.01806.0DomainFibronectin type-III 2
TgeneITGB4chr15:41799292chr17:73746760ENST0000044988026391530_16251158.01806.0DomainFibronectin type-III 3
TgeneITGB4chr15:41799292chr17:73746760ENST0000044988026391643_17391158.01806.0DomainFibronectin type-III 4
TgeneITGB4chr15:41799292chr17:73746760ENST0000045089427391222_13211158.01753.0DomainFibronectin type-III 2
TgeneITGB4chr15:41799292chr17:73746760ENST0000045089427391530_16251158.01753.0DomainFibronectin type-III 3
TgeneITGB4chr15:41799292chr17:73746760ENST0000045089427391643_17391158.01753.0DomainFibronectin type-III 4
TgeneITGB4chr15:41799292chr17:73746760ENST0000057966227391222_13211158.01753.0DomainFibronectin type-III 2
TgeneITGB4chr15:41799292chr17:73746760ENST0000057966227391530_16251158.01753.0DomainFibronectin type-III 3
TgeneITGB4chr15:41799292chr17:73746760ENST0000057966227391643_17391158.01753.0DomainFibronectin type-III 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLTKchr15:41799292chr17:73746760ENST00000263800-1120510_786513.6666666666666865.0DomainProtein kinase
HgeneLTKchr15:41799292chr17:73746760ENST00000355166-1019510_786452.6666666666667804.0DomainProtein kinase
HgeneLTKchr15:41799292chr17:73746760ENST00000453182-1018510_786414.0735.0DomainProtein kinase
HgeneLTKchr15:41799292chr17:73746760ENST00000263800-1120516_524513.6666666666666865.0Nucleotide bindingATP
HgeneLTKchr15:41799292chr17:73746760ENST00000355166-1019516_524452.6666666666667804.0Nucleotide bindingATP
HgeneLTKchr15:41799292chr17:73746760ENST00000453182-1018516_524414.0735.0Nucleotide bindingATP
HgeneLTKchr15:41799292chr17:73746760ENST00000263800-1120450_864513.6666666666666865.0Topological domainCytoplasmic
HgeneLTKchr15:41799292chr17:73746760ENST00000355166-1019450_864452.6666666666667804.0Topological domainCytoplasmic
HgeneLTKchr15:41799292chr17:73746760ENST00000453182-101817_424414.0735.0Topological domainExtracellular
HgeneLTKchr15:41799292chr17:73746760ENST00000453182-1018450_864414.0735.0Topological domainCytoplasmic
HgeneLTKchr15:41799292chr17:73746760ENST00000453182-1018425_449414.0735.0TransmembraneHelical
TgeneITGB4chr15:41799292chr17:73746760ENST0000020018127401129_12181158.01823.0DomainFibronectin type-III 1
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740131_3291158.01823.0DomainNote=VWFA
TgeneITGB4chr15:41799292chr17:73746760ENST00000200181274029_731158.01823.0DomainNote=PSI
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740979_10841158.01823.0DomainNote=Calx-beta
TgeneITGB4chr15:41799292chr17:73746760ENST0000033959127401129_12181158.01806.0DomainFibronectin type-III 1
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740131_3291158.01806.0DomainNote=VWFA
TgeneITGB4chr15:41799292chr17:73746760ENST00000339591274029_731158.01806.0DomainNote=PSI
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740979_10841158.01806.0DomainNote=Calx-beta
TgeneITGB4chr15:41799292chr17:73746760ENST0000044988026391129_12181158.01806.0DomainFibronectin type-III 1
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639131_3291158.01806.0DomainNote=VWFA
TgeneITGB4chr15:41799292chr17:73746760ENST00000449880263929_731158.01806.0DomainNote=PSI
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639979_10841158.01806.0DomainNote=Calx-beta
TgeneITGB4chr15:41799292chr17:73746760ENST0000045089427391129_12181158.01753.0DomainFibronectin type-III 1
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739131_3291158.01753.0DomainNote=VWFA
TgeneITGB4chr15:41799292chr17:73746760ENST00000450894273929_731158.01753.0DomainNote=PSI
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739979_10841158.01753.0DomainNote=Calx-beta
TgeneITGB4chr15:41799292chr17:73746760ENST0000057966227391129_12181158.01753.0DomainFibronectin type-III 1
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739131_3291158.01753.0DomainNote=VWFA
TgeneITGB4chr15:41799292chr17:73746760ENST00000579662273929_731158.01753.0DomainNote=PSI
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739979_10841158.01753.0DomainNote=Calx-beta
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740194_1991158.01823.0RegionInvolved in NRG1- and IGF1-binding
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740456_6191158.01823.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740732_7491158.01823.0RegionNote=Palmitoylated on several cysteines
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740194_1991158.01806.0RegionInvolved in NRG1- and IGF1-binding
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740456_6191158.01806.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740732_7491158.01806.0RegionNote=Palmitoylated on several cysteines
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639194_1991158.01806.0RegionInvolved in NRG1- and IGF1-binding
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639456_6191158.01806.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639732_7491158.01806.0RegionNote=Palmitoylated on several cysteines
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739194_1991158.01753.0RegionInvolved in NRG1- and IGF1-binding
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739456_6191158.01753.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739732_7491158.01753.0RegionNote=Palmitoylated on several cysteines
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739194_1991158.01753.0RegionInvolved in NRG1- and IGF1-binding
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739456_6191158.01753.0RegionNote=Cysteine-rich tandem repeats
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739732_7491158.01753.0RegionNote=Palmitoylated on several cysteines
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740456_5021158.01823.0RepeatNote=I
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740503_5421158.01823.0RepeatNote=II
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740543_5811158.01823.0RepeatNote=III
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740582_6191158.01823.0RepeatNote=IV
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740456_5021158.01806.0RepeatNote=I
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740503_5421158.01806.0RepeatNote=II
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740543_5811158.01806.0RepeatNote=III
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740582_6191158.01806.0RepeatNote=IV
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639456_5021158.01806.0RepeatNote=I
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639503_5421158.01806.0RepeatNote=II
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639543_5811158.01806.0RepeatNote=III
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639582_6191158.01806.0RepeatNote=IV
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739456_5021158.01753.0RepeatNote=I
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739503_5421158.01753.0RepeatNote=II
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739543_5811158.01753.0RepeatNote=III
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739582_6191158.01753.0RepeatNote=IV
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739456_5021158.01753.0RepeatNote=I
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739503_5421158.01753.0RepeatNote=II
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739543_5811158.01753.0RepeatNote=III
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739582_6191158.01753.0RepeatNote=IV
TgeneITGB4chr15:41799292chr17:73746760ENST00000200181274028_7101158.01823.0Topological domainExtracellular
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740734_18221158.01823.0Topological domainCytoplasmic
TgeneITGB4chr15:41799292chr17:73746760ENST00000339591274028_7101158.01806.0Topological domainExtracellular
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740734_18221158.01806.0Topological domainCytoplasmic
TgeneITGB4chr15:41799292chr17:73746760ENST00000449880263928_7101158.01806.0Topological domainExtracellular
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639734_18221158.01806.0Topological domainCytoplasmic
TgeneITGB4chr15:41799292chr17:73746760ENST00000450894273928_7101158.01753.0Topological domainExtracellular
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739734_18221158.01753.0Topological domainCytoplasmic
TgeneITGB4chr15:41799292chr17:73746760ENST00000579662273928_7101158.01753.0Topological domainExtracellular
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739734_18221158.01753.0Topological domainCytoplasmic
TgeneITGB4chr15:41799292chr17:73746760ENST000002001812740711_7331158.01823.0TransmembraneHelical
TgeneITGB4chr15:41799292chr17:73746760ENST000003395912740711_7331158.01806.0TransmembraneHelical
TgeneITGB4chr15:41799292chr17:73746760ENST000004498802639711_7331158.01806.0TransmembraneHelical
TgeneITGB4chr15:41799292chr17:73746760ENST000004508942739711_7331158.01753.0TransmembraneHelical
TgeneITGB4chr15:41799292chr17:73746760ENST000005796622739711_7331158.01753.0TransmembraneHelical


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LTK
ITGB4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to LTK-ITGB4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to LTK-ITGB4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource