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Fusion Protein:LTK-ITGB4 |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: LTK-ITGB4 | FusionPDB ID: 50316 | FusionGDB2.0 ID: 50316 | Hgene | Tgene | Gene symbol | LTK | ITGB4 | Gene ID | 4058 | 3691 |
Gene name | leukocyte receptor tyrosine kinase | integrin subunit beta 4 | |
Synonyms | TYK1 | CD104|GP150 | |
Cytomap | 15q15.1 | 17q25.1 | |
Type of gene | protein-coding | protein-coding | |
Description | leukocyte tyrosine kinase receptorprotein tyrosine kinase 1 | integrin beta-4CD104 antigen | |
Modification date | 20200320 | 20200329 | |
UniProtAcc | P29376 | P16144 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000263800, ENST00000355166, ENST00000453182, ENST00000561619, | ENST00000584558, ENST00000200181, ENST00000339591, ENST00000449880, ENST00000450894, ENST00000579662, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 1 X 1 X 1=1 | 8 X 8 X 7=448 |
# samples | 1 | 9 | |
** MAII score | log2(1/1*10)=3.32192809488736 | log2(9/448*10)=-2.31550182572793 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: LTK [Title/Abstract] AND ITGB4 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | LTK(41799292)-ITGB4(73746760), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. LTK-ITGB4 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. LTK-ITGB4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. LTK-ITGB4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | LTK | GO:0006468 | protein phosphorylation | 9223670 |
Hgene | LTK | GO:0008283 | cell proliferation | 10445845 |
Hgene | LTK | GO:0010666 | positive regulation of cardiac muscle cell apoptotic process | 10445845 |
Tgene | ITGB4 | GO:0009611 | response to wounding | 19403692 |
Tgene | ITGB4 | GO:0031581 | hemidesmosome assembly | 12482924 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | Non-Cancer | 161N | LTK | chr15 | 41799292 | - | ITGB4 | chr17 | 73746760 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000453182 | LTK | chr15 | 41799292 | - | ENST00000579662 | ITGB4 | chr17 | 73746760 | + | 3254 | 1420 | 178 | 3204 | 1008 |
ENST00000453182 | LTK | chr15 | 41799292 | - | ENST00000339591 | ITGB4 | chr17 | 73746760 | + | 3626 | 1420 | 178 | 3363 | 1061 |
ENST00000453182 | LTK | chr15 | 41799292 | - | ENST00000200181 | ITGB4 | chr17 | 73746760 | + | 3678 | 1420 | 178 | 3414 | 1078 |
ENST00000453182 | LTK | chr15 | 41799292 | - | ENST00000450894 | ITGB4 | chr17 | 73746760 | + | 3465 | 1420 | 178 | 3204 | 1008 |
ENST00000453182 | LTK | chr15 | 41799292 | - | ENST00000449880 | ITGB4 | chr17 | 73746760 | + | 3627 | 1420 | 178 | 3363 | 1061 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000453182 | ENST00000579662 | LTK | chr15 | 41799292 | - | ITGB4 | chr17 | 73746760 | + | 0.004724446 | 0.9952755 |
ENST00000453182 | ENST00000339591 | LTK | chr15 | 41799292 | - | ITGB4 | chr17 | 73746760 | + | 0.007585716 | 0.9924143 |
ENST00000453182 | ENST00000200181 | LTK | chr15 | 41799292 | - | ITGB4 | chr17 | 73746760 | + | 0.004920512 | 0.9950795 |
ENST00000453182 | ENST00000450894 | LTK | chr15 | 41799292 | - | ITGB4 | chr17 | 73746760 | + | 0.004421385 | 0.9955786 |
ENST00000453182 | ENST00000449880 | LTK | chr15 | 41799292 | - | ITGB4 | chr17 | 73746760 | + | 0.007598937 | 0.992401 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >50316_50316_1_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000200181_length(amino acids)=1078AA_BP=414 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTGCGWK FEPLLGEELDLRRVTWRLPPELIPRLSASSGRSSDAEAPHGPPDDGGAGGKGGSLPRSATPGPPGEHLVNGRMDFAFPGSTNSLHRMTTT SAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCE RPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAP GPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITI -------------------------------------------------------------- >50316_50316_2_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000339591_length(amino acids)=1061AA_BP=414 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPL SWALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGE LHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSW ERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGL -------------------------------------------------------------- >50316_50316_3_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000449880_length(amino acids)=1061AA_BP=414 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHGLPPIWEHGRSRLPL SWALGSRSRAQMKGFPPSRGPRDSIILAGRPAAPSWGPDSRLTAGVPDTPTRLVFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGE LHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHPQSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSW ERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKFKVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGL -------------------------------------------------------------- >50316_50316_4_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000450894_length(amino acids)=1008AA_BP=414 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRL VFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHP QSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKF KVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRT -------------------------------------------------------------- >50316_50316_5_LTK-ITGB4_LTK_chr15_41799292_ENST00000453182_ITGB4_chr17_73746760_ENST00000579662_length(amino acids)=1008AA_BP=414 MGCWGQLLVWFGAAGAILCSSPGSQETFLRSSPLPLASPSPRDPKVSAPPSILEPASPLNSPGTEGSWLFSTCGASGRHGPTQTQCDGAY AGTSVVVTVGAAGQLRGVQLWRVPGPGQYLISAYGAAGGKGAKNHLSRAHGVFVSAIFSLGLGESLYILVGQQGEDACPGGSPESQLVCL GESRAVEEHAAMDGSEGVPGSRRWAGGGGGGGGATYVFRVRAGELEPLLVAAGGGGRAYLRPRDRGRTQASPEKLENRSEAPGSGGRGGA AGGDASETDNLWADGEDGVSFIHPSSELFLQPLAVTENHGEVEIRRHLNCSHCPLRDCQWQAELQLAECLCPEGMELAVDNVTCMDLHKP PGPLVLMVAVVATSTLSLLMVCGVLILGGAWPGPVLASATRCHRGFPSQCYSAQVKYWIQGDSESEAHLLDSKVPSVELTNLYPYCDYEM KVCAYGAQGEGPYSSLVSCRTHQEVPSEPGRLAFNVVSSTVTQLSWAEPAETNGEITAYEVCYGLVNDDNRPIGPMKKVLVDNPKNRMLL IENLRESQPYRYTVKARNGAGWGPEREAIINLATQPKRPMSIPIIPDIPIVDAQSGEDYDSFLMYSDDVLRSPSGSQRPSVSDDTEHLVN GRMDFAFPGSTNSLHRMTTTSAAAYGTHLSPHVPHRVLSTSSTLTRDYNSLTRSEHSHSTTLPRDYSTLTSVSSHDSRLTAGVPDTPTRL VFSALGPTSLRVSWQEPRCERPLQGYSVEYQLLNGGELHRLNIPNPAQTSVVVEDLLPNHSYVFRVRAQSQEGWGREREGVITIESQVHP QSPLCPLPGSAFTLSTPSAPGPLVFTALSPDSLQLSWERPRRPNGDIVGYLVTCEMAQGGGPATAFRVDGDSPESRLTVPGLSENVPYKF KVQARTTEGFGPEREGIITIESQDGGPFPQLGSRAGLFQHPLQSEYSSITTTHTSATEPFLVDGLTLGAQHLEAGGSLTRHVTQEFVSRT -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:41799292/chr17:73746760) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
LTK | ITGB4 |
FUNCTION: Receptor with a tyrosine-protein kinase activity. The exact function of this protein is not known. Studies with chimeric proteins (replacing its extracellular region with that of several known growth factor receptors, such as EGFR and CSFIR) demonstrate its ability to promote growth and specifically neurite outgrowth, and cell survival. Signaling appears to involve the PI3 kinase pathway. Involved in regulation of the secretory pathway involving endoplasmic reticulum (ER) export sites (ERESs) and ER to Golgi transport. {ECO:0000269|PubMed:20548102}. | FUNCTION: Integrin alpha-6/beta-4 is a receptor for laminin. Plays a critical structural role in the hemidesmosome of epithelial cells. Is required for the regulation of keratinocyte polarity and motility. ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464). {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:19403692, ECO:0000269|PubMed:20682778, ECO:0000269|PubMed:22351760, ECO:0000269|PubMed:28873464}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000263800 | - | 11 | 20 | 17_424 | 513.6666666666666 | 865.0 | Topological domain | Extracellular |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000355166 | - | 10 | 19 | 17_424 | 452.6666666666667 | 804.0 | Topological domain | Extracellular |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000263800 | - | 11 | 20 | 425_449 | 513.6666666666666 | 865.0 | Transmembrane | Helical |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000355166 | - | 10 | 19 | 425_449 | 452.6666666666667 | 804.0 | Transmembrane | Helical |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 1222_1321 | 1158.0 | 1823.0 | Domain | Fibronectin type-III 2 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 1530_1625 | 1158.0 | 1823.0 | Domain | Fibronectin type-III 3 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 1643_1739 | 1158.0 | 1823.0 | Domain | Fibronectin type-III 4 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 1222_1321 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 2 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 1530_1625 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 3 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 1643_1739 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 4 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 1222_1321 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 2 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 1530_1625 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 3 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 1643_1739 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 4 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 1222_1321 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 2 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 1530_1625 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 3 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 1643_1739 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 4 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 1222_1321 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 2 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 1530_1625 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 3 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 1643_1739 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 4 |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000263800 | - | 11 | 20 | 510_786 | 513.6666666666666 | 865.0 | Domain | Protein kinase |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000355166 | - | 10 | 19 | 510_786 | 452.6666666666667 | 804.0 | Domain | Protein kinase |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000453182 | - | 10 | 18 | 510_786 | 414.0 | 735.0 | Domain | Protein kinase |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000263800 | - | 11 | 20 | 516_524 | 513.6666666666666 | 865.0 | Nucleotide binding | ATP |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000355166 | - | 10 | 19 | 516_524 | 452.6666666666667 | 804.0 | Nucleotide binding | ATP |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000453182 | - | 10 | 18 | 516_524 | 414.0 | 735.0 | Nucleotide binding | ATP |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000263800 | - | 11 | 20 | 450_864 | 513.6666666666666 | 865.0 | Topological domain | Cytoplasmic |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000355166 | - | 10 | 19 | 450_864 | 452.6666666666667 | 804.0 | Topological domain | Cytoplasmic |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000453182 | - | 10 | 18 | 17_424 | 414.0 | 735.0 | Topological domain | Extracellular |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000453182 | - | 10 | 18 | 450_864 | 414.0 | 735.0 | Topological domain | Cytoplasmic |
Hgene | LTK | chr15:41799292 | chr17:73746760 | ENST00000453182 | - | 10 | 18 | 425_449 | 414.0 | 735.0 | Transmembrane | Helical |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 1129_1218 | 1158.0 | 1823.0 | Domain | Fibronectin type-III 1 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 131_329 | 1158.0 | 1823.0 | Domain | Note=VWFA | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 29_73 | 1158.0 | 1823.0 | Domain | Note=PSI | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 979_1084 | 1158.0 | 1823.0 | Domain | Note=Calx-beta | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 1129_1218 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 1 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 131_329 | 1158.0 | 1806.0 | Domain | Note=VWFA | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 29_73 | 1158.0 | 1806.0 | Domain | Note=PSI | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 979_1084 | 1158.0 | 1806.0 | Domain | Note=Calx-beta | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 1129_1218 | 1158.0 | 1806.0 | Domain | Fibronectin type-III 1 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 131_329 | 1158.0 | 1806.0 | Domain | Note=VWFA | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 29_73 | 1158.0 | 1806.0 | Domain | Note=PSI | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 979_1084 | 1158.0 | 1806.0 | Domain | Note=Calx-beta | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 1129_1218 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 1 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 131_329 | 1158.0 | 1753.0 | Domain | Note=VWFA | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 29_73 | 1158.0 | 1753.0 | Domain | Note=PSI | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 979_1084 | 1158.0 | 1753.0 | Domain | Note=Calx-beta | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 1129_1218 | 1158.0 | 1753.0 | Domain | Fibronectin type-III 1 | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 131_329 | 1158.0 | 1753.0 | Domain | Note=VWFA | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 29_73 | 1158.0 | 1753.0 | Domain | Note=PSI | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 979_1084 | 1158.0 | 1753.0 | Domain | Note=Calx-beta | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 194_199 | 1158.0 | 1823.0 | Region | Involved in NRG1- and IGF1-binding | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 456_619 | 1158.0 | 1823.0 | Region | Note=Cysteine-rich tandem repeats | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 732_749 | 1158.0 | 1823.0 | Region | Note=Palmitoylated on several cysteines | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 194_199 | 1158.0 | 1806.0 | Region | Involved in NRG1- and IGF1-binding | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 456_619 | 1158.0 | 1806.0 | Region | Note=Cysteine-rich tandem repeats | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 732_749 | 1158.0 | 1806.0 | Region | Note=Palmitoylated on several cysteines | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 194_199 | 1158.0 | 1806.0 | Region | Involved in NRG1- and IGF1-binding | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 456_619 | 1158.0 | 1806.0 | Region | Note=Cysteine-rich tandem repeats | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 732_749 | 1158.0 | 1806.0 | Region | Note=Palmitoylated on several cysteines | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 194_199 | 1158.0 | 1753.0 | Region | Involved in NRG1- and IGF1-binding | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 456_619 | 1158.0 | 1753.0 | Region | Note=Cysteine-rich tandem repeats | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 732_749 | 1158.0 | 1753.0 | Region | Note=Palmitoylated on several cysteines | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 194_199 | 1158.0 | 1753.0 | Region | Involved in NRG1- and IGF1-binding | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 456_619 | 1158.0 | 1753.0 | Region | Note=Cysteine-rich tandem repeats | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 732_749 | 1158.0 | 1753.0 | Region | Note=Palmitoylated on several cysteines | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 456_502 | 1158.0 | 1823.0 | Repeat | Note=I | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 503_542 | 1158.0 | 1823.0 | Repeat | Note=II | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 543_581 | 1158.0 | 1823.0 | Repeat | Note=III | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 582_619 | 1158.0 | 1823.0 | Repeat | Note=IV | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 456_502 | 1158.0 | 1806.0 | Repeat | Note=I | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 503_542 | 1158.0 | 1806.0 | Repeat | Note=II | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 543_581 | 1158.0 | 1806.0 | Repeat | Note=III | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 582_619 | 1158.0 | 1806.0 | Repeat | Note=IV | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 456_502 | 1158.0 | 1806.0 | Repeat | Note=I | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 503_542 | 1158.0 | 1806.0 | Repeat | Note=II | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 543_581 | 1158.0 | 1806.0 | Repeat | Note=III | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 582_619 | 1158.0 | 1806.0 | Repeat | Note=IV | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 456_502 | 1158.0 | 1753.0 | Repeat | Note=I | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 503_542 | 1158.0 | 1753.0 | Repeat | Note=II | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 543_581 | 1158.0 | 1753.0 | Repeat | Note=III | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 582_619 | 1158.0 | 1753.0 | Repeat | Note=IV | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 456_502 | 1158.0 | 1753.0 | Repeat | Note=I | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 503_542 | 1158.0 | 1753.0 | Repeat | Note=II | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 543_581 | 1158.0 | 1753.0 | Repeat | Note=III | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 582_619 | 1158.0 | 1753.0 | Repeat | Note=IV | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 28_710 | 1158.0 | 1823.0 | Topological domain | Extracellular | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 734_1822 | 1158.0 | 1823.0 | Topological domain | Cytoplasmic | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 28_710 | 1158.0 | 1806.0 | Topological domain | Extracellular | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 734_1822 | 1158.0 | 1806.0 | Topological domain | Cytoplasmic | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 28_710 | 1158.0 | 1806.0 | Topological domain | Extracellular | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 734_1822 | 1158.0 | 1806.0 | Topological domain | Cytoplasmic | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 28_710 | 1158.0 | 1753.0 | Topological domain | Extracellular | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 734_1822 | 1158.0 | 1753.0 | Topological domain | Cytoplasmic | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 28_710 | 1158.0 | 1753.0 | Topological domain | Extracellular | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 734_1822 | 1158.0 | 1753.0 | Topological domain | Cytoplasmic | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000200181 | 27 | 40 | 711_733 | 1158.0 | 1823.0 | Transmembrane | Helical | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000339591 | 27 | 40 | 711_733 | 1158.0 | 1806.0 | Transmembrane | Helical | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000449880 | 26 | 39 | 711_733 | 1158.0 | 1806.0 | Transmembrane | Helical | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000450894 | 27 | 39 | 711_733 | 1158.0 | 1753.0 | Transmembrane | Helical | |
Tgene | ITGB4 | chr15:41799292 | chr17:73746760 | ENST00000579662 | 27 | 39 | 711_733 | 1158.0 | 1753.0 | Transmembrane | Helical |
Top |
Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
LTK | |
ITGB4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to LTK-ITGB4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to LTK-ITGB4 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |