UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:MACF1-GRIK3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MACF1-GRIK3
FusionPDB ID: 50602
FusionGDB2.0 ID: 50602
HgeneTgene
Gene symbol

MACF1

GRIK3

Gene ID

23499

2899

Gene namemicrotubule actin crosslinking factor 1glutamate ionotropic receptor kainate type subunit 3
SynonymsABP620|ACF7|LIS9|MACF|OFC4EAA5|GLR7|GLUR7|GluK3|GluR7a
Cytomap

1p34.3

1p34.3

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-actin cross-linking factor 1620 kDa actin binding proteinactin cross-linking family protein 7macrophin 1 isoformtrabeculin-alphaglutamate receptor ionotropic, kainate 3dJ1090M5.1 (glutamate receptor, ionotropic, kainate 3 (GLUR7))excitatory amino acid receptor 5gluR-7glutamate receptor 7
Modification date2020031320200313
UniProtAcc

Q9UPN3

.
Ensembl transtripts involved in fusion geneENST idsENST00000317713, ENST00000361689, 
ENST00000372915, ENST00000536367, 
ENST00000539005, ENST00000545844, 
ENST00000564288, ENST00000567887, 
ENST00000289893, ENST00000476350, 
ENST00000484793, ENST00000602421, 
ENST00000462621, ENST00000373091, 
ENST00000373093, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score46 X 37 X 13=221265 X 4 X 2=40
# samples 445
** MAII scorelog2(44/22126*10)=-5.65209532630239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/40*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MACF1 [Title/Abstract] AND GRIK3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MACF1(39696915)-GRIK3(37307540), # samples:1
Anticipated loss of major functional domain due to fusion event.MACF1-GRIK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-GRIK3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-GRIK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-GRIK3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACF1

GO:0030334

regulation of cell migration

27693509

HgeneMACF1

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneMACF1

GO:0045773

positive regulation of axon extension

22705394

HgeneMACF1

GO:0051893

regulation of focal adhesion assembly

27693509

TgeneGRIK3

GO:0007215

glutamate receptor signaling pathway

7719709

TgeneGRIK3

GO:0007216

G protein-coupled glutamate receptor signaling pathway

9144652

TgeneGRIK3

GO:0042391

regulation of membrane potential

11124978


check buttonFusion gene breakpoints across MACF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GRIK3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-OK-A5Q2-01AMACF1chr1

39696915

-GRIK3chr1

37307540

-


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545844MACF1chr139696915-ENST00000373091GRIK3chr137307540-81483901081823571
ENST00000545844MACF1chr139696915-ENST00000373093GRIK3chr137307540-19983901081682524
ENST00000567887MACF1chr139696915-ENST00000373091GRIK3chr137307540-8197439341872612
ENST00000567887MACF1chr139696915-ENST00000373093GRIK3chr137307540-2047439341731565
ENST00000372915MACF1chr139696915-ENST00000373091GRIK3chr137307540-812736961802598
ENST00000372915MACF1chr139696915-ENST00000373093GRIK3chr137307540-197736961661551
ENST00000361689MACF1chr139696915-ENST00000373091GRIK3chr137307540-8092334521767571
ENST00000361689MACF1chr139696915-ENST00000373093GRIK3chr137307540-1942334521626524
ENST00000539005MACF1chr139696915-ENST00000373091GRIK3chr137307540-8092334521767571
ENST00000539005MACF1chr139696915-ENST00000373093GRIK3chr137307540-1942334521626524
ENST00000317713MACF1chr139696915-ENST00000373091GRIK3chr137307540-8092334521767571
ENST00000317713MACF1chr139696915-ENST00000373093GRIK3chr137307540-1942334521626524
ENST00000564288MACF1chr139696915-ENST00000373091GRIK3chr137307540-87069487712381536
ENST00000564288MACF1chr139696915-ENST00000373093GRIK3chr137307540-25569487712240489
ENST00000536367MACF1chr139696915-ENST00000373091GRIK3chr137307540-82014432661876536
ENST00000536367MACF1chr139696915-ENST00000373093GRIK3chr137307540-20514432661735489

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545844ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0020966540.99790335
ENST00000545844ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0063923050.99360764
ENST00000567887ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0020486580.9979513
ENST00000567887ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.005495740.99450433
ENST00000372915ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0020851030.99791485
ENST00000372915ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0060700490.99393
ENST00000361689ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0020757480.9979242
ENST00000361689ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0061573270.9938427
ENST00000539005ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0020757480.9979242
ENST00000539005ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0061573270.9938427
ENST00000317713ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0020757480.9979242
ENST00000317713ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0061573270.9938427
ENST00000564288ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.0019077520.99809223
ENST00000564288ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0028835670.99711645
ENST00000536367ENST00000373091MACF1chr139696915-GRIK3chr137307540-0.001982080.9980179
ENST00000536367ENST00000373093MACF1chr139696915-GRIK3chr137307540-0.0035763290.99642366

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50602_50602_1_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000317713_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=571AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKT

--------------------------------------------------------------

>50602_50602_2_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000317713_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=524AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK

--------------------------------------------------------------

>50602_50602_3_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000361689_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=571AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKT

--------------------------------------------------------------

>50602_50602_4_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000361689_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=524AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK

--------------------------------------------------------------

>50602_50602_5_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000372915_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=598AA_BP=121
MLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLD
PAERAVVRVADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWN
GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEW
YDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK
IEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPM
GSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCST

--------------------------------------------------------------

>50602_50602_6_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000372915_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=551AA_BP=121
MLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLD
PAERAVVRVADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWN
GMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEW
YDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTK
IEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPM
GSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQVSLRAW

--------------------------------------------------------------

>50602_50602_7_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000536367_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=536AA_BP=59
MEMPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKEL
AHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSP
DIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSY
TANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTI
EYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLV

--------------------------------------------------------------

>50602_50602_8_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000536367_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=489AA_BP=59
MEMPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKEL
AHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSP
DIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSY
TANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTI
EYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLV

--------------------------------------------------------------

>50602_50602_9_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000539005_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=571AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKT

--------------------------------------------------------------

>50602_50602_10_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000539005_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=524AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK

--------------------------------------------------------------

>50602_50602_11_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000545844_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=571AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK
WWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKLRKTAEREQRSFCSTVADEIRFSLTCQRRVKHKPQPPMMVKT

--------------------------------------------------------------

>50602_50602_12_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000545844_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=524AA_BP=94
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKA
IDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGM
GSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMW
AFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEK

--------------------------------------------------------------

>50602_50602_13_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000564288_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=536AA_BP=59
MEMPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKEL
AHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSP
DIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSY
TANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTI
EYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLV

--------------------------------------------------------------

>50602_50602_14_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000564288_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=489AA_BP=59
MEMPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKEL
AHILGFSYEIRLVEDGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSP
DIWMYVLLAYLGVSCVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSY
TANLAAFLTVERMESPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTI
EYVTQRNCNLTQIGGLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLV

--------------------------------------------------------------

>50602_50602_15_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000567887_GRIK3_chr1_37307540_ENST00000373091_length(amino acids)=612AA_BP=135
MLPKSQCSLWDPFCLLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPL
HEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVE
DGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS
CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERME
SPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIG
GLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKL

--------------------------------------------------------------

>50602_50602_16_MACF1-GRIK3_MACF1_chr1_39696915_ENST00000567887_GRIK3_chr1_37307540_ENST00000373093_length(amino acids)=565AA_BP=135
MLPKSQCSLWDPFCLLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPL
HEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKEEPFVMFRKSDRTLYGNDRFEGYCIDLLKELAHILGFSYEIRLVE
DGKYGAQDDKGQWNGMVKELIDHKADLAVAPLTITHVREKAIDFSKPFMTLGVSILYRKPNGTNPSVFSFLNPLSPDIWMYVLLAYLGVS
CVLFVIARFSPYEWYDAHPCNPGSEVVENNFTLLNSFWFGMGSLMQQGSELMPKALSTRIIGGIWWFFTLIIISSYTANLAAFLTVERME
SPIDSADDLAKQTKIEYGAVKDGATMTFFKKSKISTFEKMWAFMSSKPSALVKNNEEGIQRALTADYALLMESTTIEYVTQRNCNLTQIG
GLIDSKGYGIGTPMGSPYRDKITIAILQLQEEDKLHIMKEKWWRGSGCPEEENKEASALGIQKIGGIFIVLAAGLVLSVLVAVGEFVYKL

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:39696915/chr1:37307540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACF1

Q9UPN3

.
FUNCTION: [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816690_692442.0920.0RegionGlutamate binding
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816585_636442.0920.0Topological domainCytoplasmic
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816658_820442.0920.0Topological domainExtracellular
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816842_919442.0920.0Topological domainCytoplasmic
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816564_584442.0920.0TransmembraneHelical
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816637_657442.0920.0TransmembraneHelical
TgeneGRIK3chr1:39696915chr1:37307540ENST00000373091816821_841442.0920.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647054_706505939.0Calcium binding1
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647090_710105939.0Calcium binding2
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937054_706594.05431.0Calcium binding1
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937090_710194.05431.0Calcium binding2
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977054_706594.07389.0Calcium binding1
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977090_710194.07389.0Calcium binding2
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947054_706594.05431.0Calcium binding1
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947090_710194.05431.0Calcium binding2
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641122_112705939.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641414_141705939.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641986_198905939.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164698_70305939.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647222_735105939.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931122_112794.05431.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931414_141794.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931986_198994.05431.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293698_70394.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937222_735194.05431.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971122_112794.07389.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971414_141794.07389.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971986_198994.07389.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297698_70394.07389.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977222_735194.07389.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941122_112794.05431.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941414_141794.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941986_198994.05431.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394698_70394.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947222_735194.05431.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164194_29805939.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647041_707605939.0DomainEF-hand 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647077_711205939.0DomainEF-hand 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647117_718905939.0DomainGAR
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-16478_18105939.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164868_92505939.0DomainSH3
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293194_29894.05431.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937041_707694.05431.0DomainEF-hand 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937077_711294.05431.0DomainEF-hand 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937117_718994.05431.0DomainGAR
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-29378_18194.05431.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293868_92594.05431.0DomainSH3
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297194_29894.07389.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977041_707694.07389.0DomainEF-hand 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977077_711294.07389.0DomainEF-hand 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977117_718994.07389.0DomainGAR
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-29778_18194.07389.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297868_92594.07389.0DomainSH3
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394194_29894.05431.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947041_707694.05431.0DomainEF-hand 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947077_711294.05431.0DomainEF-hand 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947117_718994.05431.0DomainGAR
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-39478_18194.05431.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394868_92594.05431.0DomainSH3
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641_29505939.0RegionNote=Actin-binding
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647117_738805939.0RegionC-terminal tail
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1647313_732805939.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931_29594.05431.0RegionNote=Actin-binding
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937117_738894.05431.0RegionC-terminal tail
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2937313_732894.05431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971_29594.07389.0RegionNote=Actin-binding
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977117_738894.07389.0RegionC-terminal tail
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2977313_732894.07389.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941_29594.05431.0RegionNote=Actin-binding
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947117_738894.05431.0RegionC-terminal tail
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3947313_732894.05431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641050_107305939.0RepeatNote=LRR 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641128_115405939.0RepeatNote=LRR 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641187_121005939.0RepeatNote=LRR 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641257_128205939.0RepeatNote=LRR 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164148_17105939.0RepeatNote=LRR 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641577_162105939.0RepeatNote=Plectin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641654_169605939.0RepeatNote=Plectin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641769_180905939.0RepeatNote=Plectin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641811_184805939.0RepeatNote=Plectin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1641855_188605939.0RepeatNote=Plectin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1642290_233205939.0RepeatNote=Plectin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1642367_241005939.0RepeatNote=Plectin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164240_26405939.0RepeatNote=LRR 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1642411_243705939.0RepeatNote=Plectin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1642501_254305939.0RepeatNote=Plectin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1642581_261205939.0RepeatNote=Plectin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1642686_273005939.0RepeatNote=Plectin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1643239_326205939.0RepeatNote=LRR 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1643264_328305939.0RepeatNote=LRR 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1643646_366905939.0RepeatNote=LRR 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1643696_372005939.0RepeatNote=LRR 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164377_39905939.0RepeatNote=LRR 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1643883_395705939.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1643936_395805939.0RepeatNote=LRR 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644000_410805939.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644125_415005939.0RepeatNote=LRR 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644261_428705939.0RepeatNote=LRR 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-164441_46405939.0RepeatNote=LRR 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644466_457405939.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644511_453405939.0RepeatNote=LRR 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644601_462405939.0RepeatNote=LRR 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644769_479205939.0RepeatNote=LRR 18
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644800_490405939.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1644909_501205939.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645051_507605939.0RepeatNote=LRR 19
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645172_519405939.0RepeatNote=LRR 20
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645236_534105939.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645281_530405939.0RepeatNote=LRR 21
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645348_545005939.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645455_555705939.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645695_571905939.0RepeatNote=LRR 22
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645783_588505939.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1645804_582805939.0RepeatNote=LRR 23
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646005_611005939.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646115_621905939.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646225_632805939.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646333_643905939.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646443_654705939.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646496_651905939.0RepeatNote=LRR 24
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646552_665805939.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646665_676605939.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000289893-1646771_687405939.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931050_107394.05431.0RepeatNote=LRR 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931128_115494.05431.0RepeatNote=LRR 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931187_121094.05431.0RepeatNote=LRR 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931257_128294.05431.0RepeatNote=LRR 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293148_17194.05431.0RepeatNote=LRR 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931577_162194.05431.0RepeatNote=Plectin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931654_169694.05431.0RepeatNote=Plectin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931769_180994.05431.0RepeatNote=Plectin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931811_184894.05431.0RepeatNote=Plectin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2931855_188694.05431.0RepeatNote=Plectin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2932290_233294.05431.0RepeatNote=Plectin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2932367_241094.05431.0RepeatNote=Plectin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293240_26494.05431.0RepeatNote=LRR 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2932411_243794.05431.0RepeatNote=Plectin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2932501_254394.05431.0RepeatNote=Plectin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2932581_261294.05431.0RepeatNote=Plectin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2932686_273094.05431.0RepeatNote=Plectin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2933239_326294.05431.0RepeatNote=LRR 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2933264_328394.05431.0RepeatNote=LRR 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2933646_366994.05431.0RepeatNote=LRR 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2933696_372094.05431.0RepeatNote=LRR 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293377_39994.05431.0RepeatNote=LRR 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2933883_395794.05431.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2933936_395894.05431.0RepeatNote=LRR 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934000_410894.05431.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934125_415094.05431.0RepeatNote=LRR 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934261_428794.05431.0RepeatNote=LRR 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-293441_46494.05431.0RepeatNote=LRR 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934466_457494.05431.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934511_453494.05431.0RepeatNote=LRR 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934601_462494.05431.0RepeatNote=LRR 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934769_479294.05431.0RepeatNote=LRR 18
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934800_490494.05431.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2934909_501294.05431.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935051_507694.05431.0RepeatNote=LRR 19
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935172_519494.05431.0RepeatNote=LRR 20
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935236_534194.05431.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935281_530494.05431.0RepeatNote=LRR 21
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935348_545094.05431.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935455_555794.05431.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935695_571994.05431.0RepeatNote=LRR 22
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935783_588594.05431.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2935804_582894.05431.0RepeatNote=LRR 23
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936005_611094.05431.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936115_621994.05431.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936225_632894.05431.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936333_643994.05431.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936443_654794.05431.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936496_651994.05431.0RepeatNote=LRR 24
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936552_665894.05431.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936665_676694.05431.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000361689-2936771_687494.05431.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971050_107394.07389.0RepeatNote=LRR 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971128_115494.07389.0RepeatNote=LRR 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971187_121094.07389.0RepeatNote=LRR 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971257_128294.07389.0RepeatNote=LRR 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297148_17194.07389.0RepeatNote=LRR 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971577_162194.07389.0RepeatNote=Plectin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971654_169694.07389.0RepeatNote=Plectin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971769_180994.07389.0RepeatNote=Plectin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971811_184894.07389.0RepeatNote=Plectin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2971855_188694.07389.0RepeatNote=Plectin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2972290_233294.07389.0RepeatNote=Plectin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2972367_241094.07389.0RepeatNote=Plectin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297240_26494.07389.0RepeatNote=LRR 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2972411_243794.07389.0RepeatNote=Plectin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2972501_254394.07389.0RepeatNote=Plectin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2972581_261294.07389.0RepeatNote=Plectin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2972686_273094.07389.0RepeatNote=Plectin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2973239_326294.07389.0RepeatNote=LRR 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2973264_328394.07389.0RepeatNote=LRR 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2973646_366994.07389.0RepeatNote=LRR 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2973696_372094.07389.0RepeatNote=LRR 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297377_39994.07389.0RepeatNote=LRR 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2973883_395794.07389.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2973936_395894.07389.0RepeatNote=LRR 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974000_410894.07389.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974125_415094.07389.0RepeatNote=LRR 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974261_428794.07389.0RepeatNote=LRR 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-297441_46494.07389.0RepeatNote=LRR 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974466_457494.07389.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974511_453494.07389.0RepeatNote=LRR 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974601_462494.07389.0RepeatNote=LRR 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974769_479294.07389.0RepeatNote=LRR 18
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974800_490494.07389.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2974909_501294.07389.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975051_507694.07389.0RepeatNote=LRR 19
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975172_519494.07389.0RepeatNote=LRR 20
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975236_534194.07389.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975281_530494.07389.0RepeatNote=LRR 21
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975348_545094.07389.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975455_555794.07389.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975695_571994.07389.0RepeatNote=LRR 22
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975783_588594.07389.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2975804_582894.07389.0RepeatNote=LRR 23
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976005_611094.07389.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976115_621994.07389.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976225_632894.07389.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976333_643994.07389.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976443_654794.07389.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976496_651994.07389.0RepeatNote=LRR 24
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976552_665894.07389.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976665_676694.07389.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000372915-2976771_687494.07389.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941050_107394.05431.0RepeatNote=LRR 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941128_115494.05431.0RepeatNote=LRR 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941187_121094.05431.0RepeatNote=LRR 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941257_128294.05431.0RepeatNote=LRR 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394148_17194.05431.0RepeatNote=LRR 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941577_162194.05431.0RepeatNote=Plectin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941654_169694.05431.0RepeatNote=Plectin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941769_180994.05431.0RepeatNote=Plectin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941811_184894.05431.0RepeatNote=Plectin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3941855_188694.05431.0RepeatNote=Plectin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3942290_233294.05431.0RepeatNote=Plectin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3942367_241094.05431.0RepeatNote=Plectin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394240_26494.05431.0RepeatNote=LRR 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3942411_243794.05431.0RepeatNote=Plectin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3942501_254394.05431.0RepeatNote=Plectin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3942581_261294.05431.0RepeatNote=Plectin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3942686_273094.05431.0RepeatNote=Plectin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3943239_326294.05431.0RepeatNote=LRR 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3943264_328394.05431.0RepeatNote=LRR 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3943646_366994.05431.0RepeatNote=LRR 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3943696_372094.05431.0RepeatNote=LRR 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394377_39994.05431.0RepeatNote=LRR 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3943883_395794.05431.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3943936_395894.05431.0RepeatNote=LRR 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944000_410894.05431.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944125_415094.05431.0RepeatNote=LRR 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944261_428794.05431.0RepeatNote=LRR 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-394441_46494.05431.0RepeatNote=LRR 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944466_457494.05431.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944511_453494.05431.0RepeatNote=LRR 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944601_462494.05431.0RepeatNote=LRR 17
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944769_479294.05431.0RepeatNote=LRR 18
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944800_490494.05431.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3944909_501294.05431.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945051_507694.05431.0RepeatNote=LRR 19
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945172_519494.05431.0RepeatNote=LRR 20
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945236_534194.05431.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945281_530494.05431.0RepeatNote=LRR 21
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945348_545094.05431.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945455_555794.05431.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945695_571994.05431.0RepeatNote=LRR 22
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945783_588594.05431.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3945804_582894.05431.0RepeatNote=LRR 23
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946005_611094.05431.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946115_621994.05431.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946225_632894.05431.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946333_643994.05431.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946443_654794.05431.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946496_651994.05431.0RepeatNote=LRR 24
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946552_665894.05431.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946665_676694.05431.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39696915chr1:37307540ENST00000545844-3946771_687494.05431.0RepeatNote=Spectrin 17
TgeneGRIK3chr1:39696915chr1:37307540ENST0000037309181632_563442.0920.0Topological domainExtracellular


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MACF1
GRIK3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to MACF1-GRIK3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to MACF1-GRIK3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource