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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MACF1-LSAMP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MACF1-LSAMP
FusionPDB ID: 50610
FusionGDB2.0 ID: 50610
HgeneTgene
Gene symbol

MACF1

LSAMP

Gene ID

23499

4045

Gene namemicrotubule actin crosslinking factor 1limbic system associated membrane protein
SynonymsABP620|ACF7|LIS9|MACF|OFC4IGLON3|LAMP
Cytomap

1p34.3

3q13.31

Type of geneprotein-codingprotein-coding
Descriptionmicrotubule-actin cross-linking factor 1620 kDa actin binding proteinactin cross-linking family protein 7macrophin 1 isoformtrabeculin-alphalimbic system-associated membrane proteinIgLON family member 3
Modification date2020031320200313
UniProtAcc

Q9UPN3

Q13449

Ensembl transtripts involved in fusion geneENST idsENST00000289893, ENST00000317713, 
ENST00000361689, ENST00000372915, 
ENST00000539005, ENST00000545844, 
ENST00000564288, ENST00000567887, 
ENST00000476350, ENST00000484793, 
ENST00000536367, ENST00000602421, 
ENST00000498645, ENST00000539563, 
ENST00000490035, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score46 X 37 X 13=2212620 X 18 X 11=3960
# samples 4434
** MAII scorelog2(44/22126*10)=-5.65209532630239
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(34/3960*10)=-3.54189377882927
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MACF1 [Title/Abstract] AND LSAMP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MACF1(39847824)-LSAMP(116163802), # samples:2
Anticipated loss of major functional domain due to fusion event.MACF1-LSAMP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-LSAMP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-LSAMP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-LSAMP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MACF1-LSAMP seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MACF1-LSAMP seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMACF1

GO:0030334

regulation of cell migration

27693509

HgeneMACF1

GO:0043001

Golgi to plasma membrane protein transport

15265687

HgeneMACF1

GO:0045773

positive regulation of axon extension

22705394

HgeneMACF1

GO:0051893

regulation of focal adhesion assembly

27693509


check buttonFusion gene breakpoints across MACF1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across LSAMP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-29-1778-01AMACF1chr1

39847824

+LSAMPchr3

116163802

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000545844MACF1chr139847824+ENST00000490035LSAMPchr3116163802-16640777010877842558
ENST00000567887MACF1chr139847824+ENST00000490035LSAMPchr3116163802-229861411634141304698
ENST00000372915MACF1chr139847824+ENST00000490035LSAMPchr3116163802-22820139506139644652
ENST00000361689MACF1chr139847824+ENST00000490035LSAMPchr3116163802-1658477145277282558
ENST00000539005MACF1chr139847824+ENST00000490035LSAMPchr3116163802-1652176515276652537
ENST00000317713MACF1chr139847824+ENST00000490035LSAMPchr3116163802-1658477145277282558
ENST00000564288MACF1chr139847824+ENST00000490035LSAMPchr3116163802-2349514625771146394622
ENST00000289893MACF1chr139847824+ENST00000490035LSAMPchr3116163802-18169929913193133060

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000545844ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0007611450.99923885
ENST00000567887ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0010181460.9989818
ENST00000372915ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0009252110.9990748
ENST00000361689ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0007089440.99929106
ENST00000539005ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0004438530.9995561
ENST00000317713ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0007089440.99929106
ENST00000564288ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0020347650.9979652
ENST00000289893ENST00000490035MACF1chr139847824+LSAMPchr3116163802-0.0006671380.99933285

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50610_50610_1_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000289893_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=3060AA_BP=
MQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPLSVVEAIEKRIISETVGLK
ILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSL
KSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSN
DLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSI
CIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGH
QRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINK
VKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGS
HIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELL
EEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAI
SGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLI
SLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPE
TKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDI
ESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGG
IVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQ
SAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQ
EKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLY
QETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLS
REIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDP
ARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSF
LPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTR
QLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKN
LQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQL
DALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAER
ALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELE
EAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKAR
HQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKEL
ENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLN
MLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQET
TDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREM
VTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELN
LEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTET
SMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLK
YEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLL
VTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSIDPNMLNAQKQQVQDLGR

--------------------------------------------------------------

>50610_50610_2_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000317713_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=2558AA_BP=
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES

--------------------------------------------------------------

>50610_50610_3_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000361689_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=2558AA_BP=
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES

--------------------------------------------------------------

>50610_50610_4_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000372915_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=4652AA_BP=
MLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLD
PAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKL
VNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDM
ERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQH
TILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAV
ERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQ
DELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKL
ERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAEL
IWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVK
ENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISV
KAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYL
RKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISEL
KNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMD
HVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSR
LTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALF
AEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRL
EEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKE
KKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPE
TGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQ
GLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEA
QLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGE
ILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPC
SKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVR
LPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASR
GHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETD
GNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLL
NEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETA
TRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGL
LEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQ
AFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQ
AIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANM
IQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFG
CKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIREN
QGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKE
ADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESD
GKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRK
DLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLE
TSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQ
PLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKT
KVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLR
LLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQ
DDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKID
ALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHN
LTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVI
SHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVE
KLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQ
SQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFE
QLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALD
LCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLV
EEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKE
ANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATE

--------------------------------------------------------------

>50610_50610_5_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000539005_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=2537AA_BP=
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAELE
QNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLSI

--------------------------------------------------------------

>50610_50610_6_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000545844_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=2558AA_BP=
MSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPLHEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNK
HLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHF
QISDIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRL
LDAEDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFK
ETEILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLA
KNTLQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPP
STLTTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVE
ELGSSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRN
YFSELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIK
RKYSCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQR
TKWKVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIM
KNLQAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTD
RDAWQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAE
LLVKGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVI
AQLEIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDY
ELQLMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVST
LARNTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQ
QLQSQLAHQTEQKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEEN
QTKLSPRELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGME
QLSGASLEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSL
AQSEAELKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFK
EGKEPSEIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQL
QEELAEHQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEG
KQVSSLSSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFE
HLSGKLQQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKE
REKDASSCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQG
KTGSILPSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSP
TKTETVKAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAES

--------------------------------------------------------------

>50610_50610_7_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000564288_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=4622AA_BP=
MEMPLLDSSYLPPTIFILTHVLGVAGVLYWKRHARGRADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLE
PAGLKTLRLVSMPSWCHTNNEEQAEEDDDDVPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQIS
DIYISGESGDMSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDA
EDVDVPSPDEKSVITYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETE
ILAKEREKGRIEELYKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNT
LQADAAHLESGQPVQCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTL
TTTHLKAEPLTKATHSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELG
SSVKEARLYEGKMSQNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFS
ELTMELEEKQDVFRSLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKY
SCDHNTSLSRLEDLLQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKW
KVISPTGNEAMVPSVCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNL
QAHYEDFLQDSRDSVLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDA
WQDNALRIAEQEHTQEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLV
KGYEIKLSQEEVVLADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQL
EIRQSELESIQEVLGDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQ
LMTYKAFVESQQKSPGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLAR
NTQGKATSSETKESTDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQ
SQLAHQTEQKECRAVAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDA
LALISRLTESRGPLSVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKI
GLLDLMQRCIVHQESGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQD
MACAILIRQLQTGGIIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKA
LFLPATTEILSWKKAIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNG
QRLLLLDKELMETLTSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVE
TEDSSVENPEQDLFVEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKK
EHQPLRNTSFTCQNEQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQN
IAGGSMMMSEKTDEEDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDS
QTCESLTTEEVINEGLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTL
GLVDVADQPELINLEKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSV
DNAFRHGLIGEDLAEKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEA
VLSPGMMHGIVDPENCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTAT
GKRLTLASALEEKLVDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEF
LGKDMLIACNQTAEMSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSL
GQVSLTHPYSECDFKLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMN
ARVKSKREKREVIVEESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHL
DALTLFSSKQANEGKVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQD
SWVTSKTKETKHQISSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEK
FLEMANPNVAGLEAGSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPG
SEQTPFMTAPEGKGNGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLV
SQELECVNQIIISQPQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSK
GSNSEIDVDSLNLCLQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQM
EQEALVKTLQKQQNTCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSP
RELTALREKLHQAKEQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGAS
LEKGALDTTDGYMGVNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAE
LKQVQTLQDELQKFLQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPS
EIGNLVKDKLKDATERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAE
HQVPVEKLQKVARDIMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSL
SSGVIQEALATNMKLKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKL
QQFMENKSRMLASGNQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDAS
SCQEQLDEFRKLVRTFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSIL
PSVGSSVGSVNGYHTCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETV
KAQAESNKAFLAELEQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWL

--------------------------------------------------------------

>50610_50610_8_MACF1-LSAMP_MACF1_chr1_39847824_ENST00000567887_LSAMP_chr3_116163802_ENST00000490035_length(amino acids)=4698AA_BP=
MLPKSQCSLWDPFCLLTFTPFSFRSLLPGLPGPPAAAPAWAMSSSDEETLSERSCRSERSCRSERSYRSERSGSLSPCPPGDTLPWNLPL
HEQKKRKSQDSVLDPAERAVVRVADERDRVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLEPAGLKTLRLVSMPS
WCHTNNEEQAEEDDDDVPREKGRMRFHRLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGDMSAK
EKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLVDMERVQIQSNRENLEQAFEVAERLGVTRLLDAEDVDVPSPDEKSVI
TYVSSIYDAFPKVPEGGEGISATEVDSRWQEYQSRVDSLIPWIKQHTILMSDKTFPQNPVELKALYNQYIHFKETEILAKEREKGRIEEL
YKLLEVWIEFGRIKLPQGYHPNDVEEEWGKLIIEMLEREKSLRPAVERLELLLQIANKIQNGALNCEEKLTLAKNTLQADAAHLESGQPV
QCESDVIMYIQECEGLIRQLQVDLQILRDENYYQLEELAFRVMRLQDELVTLRLECTNLYRKGHFTSLELVPPSTLTTTHLKAEPLTKAT
HSSSTSWFRKPMTRAELVAISSSEDEGNLRFVYELLSWVEEMQMKLERAEWGNDLPSVELQLETQQHIHTSVEELGSSVKEARLYEGKMS
QNFHTSYAETLGKLETQYCKLKETSSFRMRHLQSLHKFVSRATAELIWLNEKEEEELAYDWSDNNSNISAKRNYFSELTMELEEKQDVFR
SLQDTAELLSLENHPAKQTVEAYSAAVQSQLQWMKQLCLCVEQHVKENTAYFQFFSDARELESFLRNLQDSIKRKYSCDHNTSLSRLEDL
LQDSMDEKEQLIQSKSSVASLVGRSKTIVQLKPRSPDHVLKNTISVKAVCDYRQIEITICKNDECVLEDNSQRTKWKVISPTGNEAMVPS
VCFLIPPPNKDAIEMASRVEQSYQKVMALWHQLHVNTKSLISWNYLRKDLDLVQTWNLEKLRSSAPGECHQIMKNLQAHYEDFLQDSRDS
VLFSVADRLRLEEEVEACKARFQHLMKSMENEDKEETVAKMYISELKNIRLRLEEYEQRVVKRIQSLASSRTDRDAWQDNALRIAEQEHT
QEDLQQLRSDLDAVSMKCDSFLHQSPSSSSVPTLRSELNLLVEKMDHVYGLSTVYLNKLKTVDVIVRSIQDAELLVKGYEIKLSQEEVVL
ADLSALEAHWSTLRHWLSDVKDKNSVFSVLDEEIAKAKVVAEQMSRLTPERNLDLERYQEKGSQLQERWHRVIAQLEIRQSELESIQEVL
GDYRACHGTLIKWIEETTAQQEMMKPGQAEDSRVLSEQLSQQTALFAEIERNQTKLDQCQKFSQQYSTIVKDYELQLMTYKAFVESQQKS
PGKRRRMLSSSDAITQEFMDLRTRYTALVTLTTQHVKYISDALRRLEEEEKVVEEEKQEHVEKVKELLGWVSTLARNTQGKATSSETKES
TDIEKAILEQQVLSEELTTKKEQVSEAIKTSQIFLAKHGHKLSEKEKKQISEQLNALNKAYHDLCDGSANQLQQLQSQLAHQTEQKECRA
VAGVIDLGTVEIFPIFKAMQKGLLDQDTGLVLLESQVIMSGLIAPETGENLSLEEGIARNLINPQMYQQLRELQDALALISRLTESRGPL
SVVEAIEKRIISETVGLKILEAHLATGGFSLSPSENCINLEEAFHQGLISAWLHSVLESYLRTSKNLIDPNTAEKIGLLDLMQRCIVHQE
SGFKLLPVKQLAGGMVSLKSGRKVSIFRAVQEGLIDRQVTVRLLEAQLFAGGIVDPRTGHRLTVEEAVRHNLIDQDMACAILIRQLQTGG
IIDTVTGQRLTIDEAVSNDLVAAKIALVILESLWSFMGLLWPESGEILPITDALEQGIVSTELAHKILSNRQHIKALFLPATTEILSWKK
AIESGILDRDLANNLKSICIPDVMPHMQLADSAEQNINPGAAVLPCSKSHPKATASQSENLLFQLMTHSYINVQNGQRLLLLDKELMETL
TSRDEYQTSPPKVVEIGHQRQKTPEGLQESANVKISGTFSSGWTVRLPEFQFSSQNKEYPDREDCTTEKGKKTTVETEDSSVENPEQDLF
VEQKERNPNIDALKVINKVKLEVQRQLIGTQREDQTAVSVRENASRGHLLTIPPAEAEGVPLVVDKDVFSVETPKKEHQPLRNTSFTCQN
EQAHTLETEYIHDETGGSHIKPQSKKLQVQVKKTLGIKLELKSETDGNVHPLDKKEMLKKTFLAKDDHKESQEAQNIAGGSMMMSEKTDE
EDSGREIFLSCSHPLELLEEATLNVLSAQLLDGGIFHEQTGQKLLLNEAISRGIVPSHTAVKLMEKLNMFQGFFDSQTCESLTTEEVINE
GLMDEKLLHNVLMADKAISGVLDPRTQTLCSVKDAVTVGLLDKETATRILERQVVTGGIIDLKRGKKVSVTLASTLGLVDVADQPELINL
EKASKGRDAEKTVRERLISLQMETTGLIDPDSKAPLTVVQSIDRGLLEREEAVRLLTKQVVDGGIIHHISGMRLSVDNAFRHGLIGEDLA
EKLKRVENLNIHQIFNPETKENISLPKAIKLDLITSDLKREIQEVQAFTGNFVDLISGQRLTLAEAKKEGLLTNEAVLSPGMMHGIVDPE
NCRIVPYSELVKKCKIDIESGQRYLEVIPFSDIKDGVSDKVLTLSQAIQLGKVDFASTLKVLEAQANTGGIIDTATGKRLTLASALEEKL
VDENMVRIIASHQVLNGGIVDIFSDQRVTLVEAIEKRLISPELANMIQIDSSEFSDHRAQIEKQEGIEVCALQNEFLGKDMLIACNQTAE
MSCNKVEESERLFQVENQSAQEKVKVRVSDGEQAKKSREISLKEFGCKDQRKPRMSSDAKEFISIINPHNLKGKSLGQVSLTHPYSECDF
KLKEVARNNMGNDTNEEQEKAVTKIEIISHMKQSTSCLDSEEIRENQGEVILEVQETYCETSGKLPSEQVLQQPMNARVKSKREKREVIV
EESIRTCKPAFLSEEKLYQETAIRDEHDSHIKSQPREMTSSEKGKEADTEMGFSITFKIEESSSQVVPQGISVKHLDALTLFSSKQANEG
KVNNLSLCLTLKPEENLSREIACGAQSEPFPCMTPRPEGLHYQESDGKAQVTGPSQISKTDKSFQGTTRQETNYQDSWVTSKTKETKHQI
SSSNECKEKSYQEVSFDPARGLKLEEITVSRPDSKEVRYLEFSDRKDLHHQGSKSDDKLCGTLKSEIATQELTGEKFLEMANPNVAGLEA
GSIEDIVTQRGSRVLGSFLPEKLFKGVSQKENTGQQNAIISPTVLETSEEKTVSLTVCSAVKTEKTPQEKLRESPGSEQTPFMTAPEGKG
NGGVNPEPFRATQNVFTRQLCLEHDEKLVSYLSLLRNIEMRTKQIQPLELNLAELQDLLCQAKVLERELKDLTTLVSQELECVNQIIISQ
PQEVPAQLLKALEKDAKNLQKSLSSVSDTWNSRLLHFQNAVEIEKTKVLNQHTQLEGRLQDLRAWVGNKNLILNSKGSNSEIDVDSLNLC
LQQYEDLKQPMAERKAQLDALAFDIQFFISEHAQDLSPQQNRQMLRLLNELQRSFQDILEQTAAQVDALQGHLQQMEQEALVKTLQKQQN
TCHQQLEDLCSWVGQAERALAGHQGRTTQQDLSALQKNQSDLKDLQDDIQNRATSFATVVKDIEGFMEENQTKLSPRELTALREKLHQAK
EQYEALQEETRVAQKELEEAVTSALQQETEKSKAAKELAENKKKIDALLDWVTSVGSSGGQLLTNLPGMEQLSGASLEKGALDTTDGYMG
VNQAPEKLDKQCEMMKARHQELLSQQQNFILATQSAQAFLDQHGHNLTPEEQQMLQQKLGELKEQYSTSLAQSEAELKQVQTLQDELQKF
LQDHKEFESWLERSEKELENMHKGGSSPETLPSLLKRQGSFSEDVISHKGDLRFVTISGQKVLDMENSFKEGKEPSEIGNLVKDKLKDAT
ERYTALHSKCTRLGSHLNMLLGQYHQFQNSADSLQAWMQACEANVEKLLSDTVASDPGVLQEQLATTKQLQEELAEHQVPVEKLQKVARD
IMEIEGEPAPDHRHVQETTDSILSHFQSLSYSLAERSSLLQKAIAQSQSVQESLESLLQSIGEVEQNLEGKQVSSLSSGVIQEALATNMK
LKQDIARQKSSLEATREMVTRFMETADSTTAAVLQGKLAEVSQRFEQLCLQQQEKESSLKKLLPQAEMFEHLSGKLQQFMENKSRMLASG
NQPDQDITHFFQQIQELNLEMEDQQENLDTLEHLVTELSSCGFALDLCQHQDRVQNLRKDFTELQKTVKEREKDASSCQEQLDEFRKLVR
TFQKWLKETEGSIPPTETSMSAKELEKQIEHLKSLLDDWASKGTLVEEINCKGTSLENLIMEITAPDSQGKTGSILPSVGSSVGSVNGYH
TCKDLTEIQCDMSDVNLKYEKLGGVLHERQESLQAILNRMEEVHKEANSVLQWLESKEEVLKSMDAMSSPTKTETVKAQAESNKAFLAEL
EQNSPKIQKVKEALAGLLVTYPNSQEAENWKKIQEELNSRWERATEVTVARQRQLEESASHLACFQAAESQLRPWLMEKELMMGVLGPLS

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:39847824/chr3:116163802)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MACF1

Q9UPN3

LSAMP

Q13449

FUNCTION: [Isoform 2]: F-actin-binding protein which plays a role in cross-linking actin to other cytoskeletal proteins and also binds to microtubules (PubMed:15265687, PubMed:20937854). Plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex (PubMed:20937854). Acts as a positive regulator of Wnt receptor signaling pathway and is involved in the translocation of AXIN1 and its associated complex (composed of APC, CTNNB1 and GSK3B) from the cytoplasm to the cell membrane (By similarity). Has actin-regulated ATPase activity and is essential for controlling focal adhesions (FAs) assembly and dynamics (By similarity). Interaction with CAMSAP3 at the minus ends of non-centrosomal microtubules tethers microtubules minus-ends to actin filaments, regulating focal adhesion size and cell migration (PubMed:27693509). May play role in delivery of transport vesicles containing GPI-linked proteins from the trans-Golgi network through its interaction with GOLGA4 (PubMed:15265687). Plays a key role in wound healing and epidermal cell migration (By similarity). Required for efficient upward migration of bulge cells in response to wounding and this function is primarily rooted in its ability to coordinate microtubule dynamics and polarize hair follicle stem cells (By similarity). As a regulator of actin and microtubule arrangement and stabilization, it plays an essential role in neurite outgrowth, branching and spine formation during brain development (By similarity). {ECO:0000250|UniProtKB:Q9QXZ0, ECO:0000269|PubMed:15265687, ECO:0000269|PubMed:20937854, ECO:0000269|PubMed:27693509}.FUNCTION: Mediates selective neuronal growth and axon targeting. Contributes to the guidance of developing axons and remodeling of mature circuits in the limbic system. Essential for normal growth of the hyppocampal mossy fiber projection (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641122_11273056.05939.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641414_14173056.05939.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641986_19893056.05939.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064698_7033056.05939.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931122_11272554.05431.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931414_14172554.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931986_19892554.05431.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093698_7032554.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971122_11274621.07389.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971414_14174621.07389.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971986_19894621.07389.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597698_7034621.07389.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941122_11272554.05431.0Compositional biasNote=Poly-Ser
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941414_14172554.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941986_19892554.05431.0Compositional biasNote=Poly-Leu
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194698_7032554.05431.0Compositional biasNote=Poly-Glu
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064194_2983056.05939.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+206478_1813056.05939.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064868_9253056.05939.0DomainSH3
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093194_2982554.05431.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+509378_1812554.05431.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093868_9252554.05431.0DomainSH3
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597194_2984621.07389.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+559778_1814621.07389.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597868_9254621.07389.0DomainSH3
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194194_2982554.05431.0DomainCalponin-homology (CH) 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+519478_1812554.05431.0DomainCalponin-homology (CH) 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194868_9252554.05431.0DomainSH3
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641_2953056.05939.0RegionNote=Actin-binding
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931_2952554.05431.0RegionNote=Actin-binding
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971_2954621.07389.0RegionNote=Actin-binding
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941_2952554.05431.0RegionNote=Actin-binding
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641050_10733056.05939.0RepeatNote=LRR 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641128_11543056.05939.0RepeatNote=LRR 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641187_12103056.05939.0RepeatNote=LRR 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641257_12823056.05939.0RepeatNote=LRR 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064148_1713056.05939.0RepeatNote=LRR 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641577_16213056.05939.0RepeatNote=Plectin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641654_16963056.05939.0RepeatNote=Plectin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641769_18093056.05939.0RepeatNote=Plectin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641811_18483056.05939.0RepeatNote=Plectin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20641855_18863056.05939.0RepeatNote=Plectin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20642290_23323056.05939.0RepeatNote=Plectin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20642367_24103056.05939.0RepeatNote=Plectin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064240_2643056.05939.0RepeatNote=LRR 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20642411_24373056.05939.0RepeatNote=Plectin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20642501_25433056.05939.0RepeatNote=Plectin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20642581_26123056.05939.0RepeatNote=Plectin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20642686_27303056.05939.0RepeatNote=Plectin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064377_3993056.05939.0RepeatNote=LRR 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+2064441_4643056.05939.0RepeatNote=LRR 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931050_10732554.05431.0RepeatNote=LRR 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931128_11542554.05431.0RepeatNote=LRR 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931187_12102554.05431.0RepeatNote=LRR 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931257_12822554.05431.0RepeatNote=LRR 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093148_1712554.05431.0RepeatNote=LRR 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931577_16212554.05431.0RepeatNote=Plectin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931654_16962554.05431.0RepeatNote=Plectin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931769_18092554.05431.0RepeatNote=Plectin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931811_18482554.05431.0RepeatNote=Plectin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50931855_18862554.05431.0RepeatNote=Plectin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50932290_23322554.05431.0RepeatNote=Plectin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50932367_24102554.05431.0RepeatNote=Plectin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093240_2642554.05431.0RepeatNote=LRR 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50932411_24372554.05431.0RepeatNote=Plectin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50932501_25432554.05431.0RepeatNote=Plectin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093377_3992554.05431.0RepeatNote=LRR 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+5093441_4642554.05431.0RepeatNote=LRR 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971050_10734621.07389.0RepeatNote=LRR 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971128_11544621.07389.0RepeatNote=LRR 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971187_12104621.07389.0RepeatNote=LRR 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971257_12824621.07389.0RepeatNote=LRR 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597148_1714621.07389.0RepeatNote=LRR 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971577_16214621.07389.0RepeatNote=Plectin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971654_16964621.07389.0RepeatNote=Plectin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971769_18094621.07389.0RepeatNote=Plectin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971811_18484621.07389.0RepeatNote=Plectin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55971855_18864621.07389.0RepeatNote=Plectin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55972290_23324621.07389.0RepeatNote=Plectin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55972367_24104621.07389.0RepeatNote=Plectin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597240_2644621.07389.0RepeatNote=LRR 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55972411_24374621.07389.0RepeatNote=Plectin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55972501_25434621.07389.0RepeatNote=Plectin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55972581_26124621.07389.0RepeatNote=Plectin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55972686_27304621.07389.0RepeatNote=Plectin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55973239_32624621.07389.0RepeatNote=LRR 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55973264_32834621.07389.0RepeatNote=LRR 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55973646_36694621.07389.0RepeatNote=LRR 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55973696_37204621.07389.0RepeatNote=LRR 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597377_3994621.07389.0RepeatNote=LRR 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55973883_39574621.07389.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55973936_39584621.07389.0RepeatNote=LRR 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974000_41084621.07389.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974125_41504621.07389.0RepeatNote=LRR 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974261_42874621.07389.0RepeatNote=LRR 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+5597441_4644621.07389.0RepeatNote=LRR 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974466_45744621.07389.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974511_45344621.07389.0RepeatNote=LRR 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974601_46244621.07389.0RepeatNote=LRR 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941050_10732554.05431.0RepeatNote=LRR 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941128_11542554.05431.0RepeatNote=LRR 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941187_12102554.05431.0RepeatNote=LRR 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941257_12822554.05431.0RepeatNote=LRR 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194148_1712554.05431.0RepeatNote=LRR 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941577_16212554.05431.0RepeatNote=Plectin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941654_16962554.05431.0RepeatNote=Plectin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941769_18092554.05431.0RepeatNote=Plectin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941811_18482554.05431.0RepeatNote=Plectin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51941855_18862554.05431.0RepeatNote=Plectin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51942290_23322554.05431.0RepeatNote=Plectin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51942367_24102554.05431.0RepeatNote=Plectin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194240_2642554.05431.0RepeatNote=LRR 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51942411_24372554.05431.0RepeatNote=Plectin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51942501_25432554.05431.0RepeatNote=Plectin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194377_3992554.05431.0RepeatNote=LRR 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+5194441_4642554.05431.0RepeatNote=LRR 4
TgeneLSAMPchr1:39847824chr3:116163802ENST0000049003507132_2140339.0DomainNote=Ig-like C2-type 2
TgeneLSAMPchr1:39847824chr3:116163802ENST0000049003507219_3040339.0DomainNote=Ig-like C2-type 3
TgeneLSAMPchr1:39847824chr3:116163802ENST000004900350729_1220339.0DomainNote=Ig-like C2-type 1

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647054_70653056.05939.0Calcium binding1
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647090_71013056.05939.0Calcium binding2
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937054_70652554.05431.0Calcium binding1
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937090_71012554.05431.0Calcium binding2
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977054_70654621.07389.0Calcium binding1
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977090_71014621.07389.0Calcium binding2
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947054_70652554.05431.0Calcium binding1
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947090_71012554.05431.0Calcium binding2
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647222_73513056.05939.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937222_73512554.05431.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977222_73514621.07389.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947222_73512554.05431.0Compositional biasNote=Ser-rich
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647041_70763056.05939.0DomainEF-hand 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647077_71123056.05939.0DomainEF-hand 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647117_71893056.05939.0DomainGAR
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937041_70762554.05431.0DomainEF-hand 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937077_71122554.05431.0DomainEF-hand 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937117_71892554.05431.0DomainGAR
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977041_70764621.07389.0DomainEF-hand 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977077_71124621.07389.0DomainEF-hand 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977117_71894621.07389.0DomainGAR
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947041_70762554.05431.0DomainEF-hand 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947077_71122554.05431.0DomainEF-hand 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947117_71892554.05431.0DomainGAR
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647117_73883056.05939.0RegionC-terminal tail
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20647313_73283056.05939.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937117_73882554.05431.0RegionC-terminal tail
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50937313_73282554.05431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977117_73884621.07389.0RegionC-terminal tail
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55977313_73284621.07389.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947117_73882554.05431.0RegionC-terminal tail
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51947313_73282554.05431.0RegionNote=4 X 4 AA tandem repeats of [GS]-S-R-[AR]
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20643239_32623056.05939.0RepeatNote=LRR 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20643264_32833056.05939.0RepeatNote=LRR 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20643646_36693056.05939.0RepeatNote=LRR 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20643696_37203056.05939.0RepeatNote=LRR 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20643883_39573056.05939.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20643936_39583056.05939.0RepeatNote=LRR 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644000_41083056.05939.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644125_41503056.05939.0RepeatNote=LRR 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644261_42873056.05939.0RepeatNote=LRR 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644466_45743056.05939.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644511_45343056.05939.0RepeatNote=LRR 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644601_46243056.05939.0RepeatNote=LRR 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644769_47923056.05939.0RepeatNote=LRR 18
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644800_49043056.05939.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20644909_50123056.05939.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645051_50763056.05939.0RepeatNote=LRR 19
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645172_51943056.05939.0RepeatNote=LRR 20
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645236_53413056.05939.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645281_53043056.05939.0RepeatNote=LRR 21
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645348_54503056.05939.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645455_55573056.05939.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645695_57193056.05939.0RepeatNote=LRR 22
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645783_58853056.05939.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20645804_58283056.05939.0RepeatNote=LRR 23
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646005_61103056.05939.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646115_62193056.05939.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646225_63283056.05939.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646333_64393056.05939.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646443_65473056.05939.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646496_65193056.05939.0RepeatNote=LRR 24
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646552_66583056.05939.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646665_67663056.05939.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000289893+20646771_68743056.05939.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50932581_26122554.05431.0RepeatNote=Plectin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50932686_27302554.05431.0RepeatNote=Plectin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50933239_32622554.05431.0RepeatNote=LRR 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50933264_32832554.05431.0RepeatNote=LRR 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50933646_36692554.05431.0RepeatNote=LRR 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50933696_37202554.05431.0RepeatNote=LRR 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50933883_39572554.05431.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50933936_39582554.05431.0RepeatNote=LRR 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934000_41082554.05431.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934125_41502554.05431.0RepeatNote=LRR 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934261_42872554.05431.0RepeatNote=LRR 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934466_45742554.05431.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934511_45342554.05431.0RepeatNote=LRR 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934601_46242554.05431.0RepeatNote=LRR 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934769_47922554.05431.0RepeatNote=LRR 18
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934800_49042554.05431.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50934909_50122554.05431.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935051_50762554.05431.0RepeatNote=LRR 19
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935172_51942554.05431.0RepeatNote=LRR 20
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935236_53412554.05431.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935281_53042554.05431.0RepeatNote=LRR 21
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935348_54502554.05431.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935455_55572554.05431.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935695_57192554.05431.0RepeatNote=LRR 22
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935783_58852554.05431.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50935804_58282554.05431.0RepeatNote=LRR 23
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936005_61102554.05431.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936115_62192554.05431.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936225_63282554.05431.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936333_64392554.05431.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936443_65472554.05431.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936496_65192554.05431.0RepeatNote=LRR 24
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936552_66582554.05431.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936665_67662554.05431.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000361689+50936771_68742554.05431.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974769_47924621.07389.0RepeatNote=LRR 18
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974800_49044621.07389.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55974909_50124621.07389.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975051_50764621.07389.0RepeatNote=LRR 19
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975172_51944621.07389.0RepeatNote=LRR 20
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975236_53414621.07389.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975281_53044621.07389.0RepeatNote=LRR 21
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975348_54504621.07389.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975455_55574621.07389.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975695_57194621.07389.0RepeatNote=LRR 22
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975783_58854621.07389.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55975804_58284621.07389.0RepeatNote=LRR 23
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976005_61104621.07389.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976115_62194621.07389.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976225_63284621.07389.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976333_64394621.07389.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976443_65474621.07389.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976496_65194621.07389.0RepeatNote=LRR 24
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976552_66584621.07389.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976665_67664621.07389.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000372915+55976771_68744621.07389.0RepeatNote=Spectrin 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51942581_26122554.05431.0RepeatNote=Plectin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51942686_27302554.05431.0RepeatNote=Plectin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51943239_32622554.05431.0RepeatNote=LRR 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51943264_32832554.05431.0RepeatNote=LRR 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51943646_36692554.05431.0RepeatNote=LRR 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51943696_37202554.05431.0RepeatNote=LRR 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51943883_39572554.05431.0RepeatNote=Spectrin 1
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51943936_39582554.05431.0RepeatNote=LRR 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944000_41082554.05431.0RepeatNote=Spectrin 2
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944125_41502554.05431.0RepeatNote=LRR 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944261_42872554.05431.0RepeatNote=LRR 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944466_45742554.05431.0RepeatNote=Spectrin 3
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944511_45342554.05431.0RepeatNote=LRR 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944601_46242554.05431.0RepeatNote=LRR 17
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944769_47922554.05431.0RepeatNote=LRR 18
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944800_49042554.05431.0RepeatNote=Spectrin 4
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51944909_50122554.05431.0RepeatNote=Spectrin 5
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945051_50762554.05431.0RepeatNote=LRR 19
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945172_51942554.05431.0RepeatNote=LRR 20
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945236_53412554.05431.0RepeatNote=Spectrin 6
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945281_53042554.05431.0RepeatNote=LRR 21
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945348_54502554.05431.0RepeatNote=Spectrin 7
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945455_55572554.05431.0RepeatNote=Spectrin 8
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945695_57192554.05431.0RepeatNote=LRR 22
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945783_58852554.05431.0RepeatNote=Spectrin 9
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51945804_58282554.05431.0RepeatNote=LRR 23
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946005_61102554.05431.0RepeatNote=Spectrin 10
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946115_62192554.05431.0RepeatNote=Spectrin 11
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946225_63282554.05431.0RepeatNote=Spectrin 12
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946333_64392554.05431.0RepeatNote=Spectrin 13
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946443_65472554.05431.0RepeatNote=Spectrin 14
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946496_65192554.05431.0RepeatNote=LRR 24
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946552_66582554.05431.0RepeatNote=Spectrin 15
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946665_67662554.05431.0RepeatNote=Spectrin 16
HgeneMACF1chr1:39847824chr3:116163802ENST00000545844+51946771_68742554.05431.0RepeatNote=Spectrin 17


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MACF1
LSAMP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MACF1-LSAMP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MACF1-LSAMP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource