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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAGI1-LPP

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAGI1-LPP
	FusionPDB ID: 50784
	FusionGDB2.0 ID: 50784
		Hgene	Tgene
	Gene symbol	MAGI1	LPP
	Gene ID	154043	4026
	Gene name	CNKSR family member 3	LIM domain containing preferred translocation partner in lipoma
	Synonyms	CNK3\|CNK3/IPCEF1\|MAGI1	-
	Cytomap	6q25.2	3q27.3-q28
	Type of gene	protein-coding	protein-coding
	Description	connector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1	lipoma-preferred partnerLIM proteinlipoma preferred partner
	Modification date	20200320	20200313
	UniProtAcc	Q96QZ7	Q93052
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000330909, ENST00000402939, ENST00000483466, ENST00000497477, ENST00000470990,	ENST00000471917, ENST00000312675, ENST00000448637, ENST00000543006,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	19 X 13 X 10=2470	25 X 27 X 9=6075
	# samples	23	34
	** MAII score	log2(23/2470*10)=-3.42480527552766 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(34/6075*10)=-4.1592777572428 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAGI1 [Title/Abstract] AND LPP [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAGI1(66023670)-LPP(188326948), # samples:1 MAGI1(66023671)-LPP(188326949), # samples:1
Anticipated loss of major functional domain due to fusion event.	MAGI1-LPP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAGI1-LPP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAGI1-LPP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAGI1-LPP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAGI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across LPP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	TCGA-CG-5730-11A	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+
ChimerDB4	Non-Cancer	TCGA-CG-5730-11A	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000330909	MAGI1	chr3	66023670	-	ENST00000448637	LPP	chr3	188326948	+	5573	313	250	1170	306
ENST00000330909	MAGI1	chr3	66023670	-	ENST00000312675	LPP	chr3	188326948	+	17916	313	250	1722	490
ENST00000330909	MAGI1	chr3	66023670	-	ENST00000543006	LPP	chr3	188326948	+	17916	313	250	1722	490
ENST00000402939	MAGI1	chr3	66023670	-	ENST00000448637	LPP	chr3	188326948	+	5573	313	250	1170	306
ENST00000402939	MAGI1	chr3	66023670	-	ENST00000312675	LPP	chr3	188326948	+	17916	313	250	1722	490
ENST00000402939	MAGI1	chr3	66023670	-	ENST00000543006	LPP	chr3	188326948	+	17916	313	250	1722	490
ENST00000483466	MAGI1	chr3	66023670	-	ENST00000448637	LPP	chr3	188326948	+	5815	555	492	1412	306
ENST00000483466	MAGI1	chr3	66023670	-	ENST00000312675	LPP	chr3	188326948	+	18158	555	492	1964	490
ENST00000483466	MAGI1	chr3	66023670	-	ENST00000543006	LPP	chr3	188326948	+	18158	555	492	1964	490
ENST00000497477	MAGI1	chr3	66023670	-	ENST00000448637	LPP	chr3	188326948	+	5573	313	250	1170	306
ENST00000497477	MAGI1	chr3	66023670	-	ENST00000312675	LPP	chr3	188326948	+	17916	313	250	1722	490
ENST00000497477	MAGI1	chr3	66023670	-	ENST00000543006	LPP	chr3	188326948	+	17916	313	250	1722	490
ENST00000330909	MAGI1	chr3	66023671	-	ENST00000448637	LPP	chr3	188326949	+	5573	313	250	1170	306
ENST00000330909	MAGI1	chr3	66023671	-	ENST00000312675	LPP	chr3	188326949	+	17916	313	250	1722	490
ENST00000330909	MAGI1	chr3	66023671	-	ENST00000543006	LPP	chr3	188326949	+	17916	313	250	1722	490
ENST00000402939	MAGI1	chr3	66023671	-	ENST00000448637	LPP	chr3	188326949	+	5573	313	250	1170	306
ENST00000402939	MAGI1	chr3	66023671	-	ENST00000312675	LPP	chr3	188326949	+	17916	313	250	1722	490
ENST00000402939	MAGI1	chr3	66023671	-	ENST00000543006	LPP	chr3	188326949	+	17916	313	250	1722	490
ENST00000483466	MAGI1	chr3	66023671	-	ENST00000448637	LPP	chr3	188326949	+	5815	555	492	1412	306
ENST00000483466	MAGI1	chr3	66023671	-	ENST00000312675	LPP	chr3	188326949	+	18158	555	492	1964	490
ENST00000483466	MAGI1	chr3	66023671	-	ENST00000543006	LPP	chr3	188326949	+	18158	555	492	1964	490
ENST00000497477	MAGI1	chr3	66023671	-	ENST00000448637	LPP	chr3	188326949	+	5573	313	250	1170	306
ENST00000497477	MAGI1	chr3	66023671	-	ENST00000312675	LPP	chr3	188326949	+	17916	313	250	1722	490
ENST00000497477	MAGI1	chr3	66023671	-	ENST00000543006	LPP	chr3	188326949	+	17916	313	250	1722	490

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000330909	ENST00000448637	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.001117985	0.998882
ENST00000330909	ENST00000312675	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000336953	0.999663
ENST00000330909	ENST00000543006	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000336953	0.999663
ENST00000402939	ENST00000448637	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.001117985	0.998882
ENST00000402939	ENST00000312675	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000336953	0.999663
ENST00000402939	ENST00000543006	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000336953	0.999663
ENST00000483466	ENST00000448637	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.001190143	0.9988098
ENST00000483466	ENST00000312675	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000330217	0.9996698
ENST00000483466	ENST00000543006	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000330217	0.9996698
ENST00000497477	ENST00000448637	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.001117985	0.998882
ENST00000497477	ENST00000312675	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000336953	0.999663
ENST00000497477	ENST00000543006	MAGI1	chr3	66023670	-	LPP	chr3	188326948	+	0.000336953	0.999663
ENST00000330909	ENST00000448637	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.001117985	0.998882
ENST00000330909	ENST00000312675	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000336953	0.999663
ENST00000330909	ENST00000543006	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000336953	0.999663
ENST00000402939	ENST00000448637	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.001117985	0.998882
ENST00000402939	ENST00000312675	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000336953	0.999663
ENST00000402939	ENST00000543006	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000336953	0.999663
ENST00000483466	ENST00000448637	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.001190143	0.9988098
ENST00000483466	ENST00000312675	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000330217	0.9996698
ENST00000483466	ENST00000543006	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000330217	0.9996698
ENST00000497477	ENST00000448637	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.001117985	0.998882
ENST00000497477	ENST00000312675	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000336953	0.999663
ENST00000497477	ENST00000543006	MAGI1	chr3	66023671	-	LPP	chr3	188326949	+	0.000336953	0.999663

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50784_50784_1_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000330909_LPP_chr3_188326948_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_2_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000330909_LPP_chr3_188326948_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_3_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000330909_LPP_chr3_188326948_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_4_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000402939_LPP_chr3_188326948_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_5_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000402939_LPP_chr3_188326948_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_6_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000402939_LPP_chr3_188326948_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_7_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000483466_LPP_chr3_188326948_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_8_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000483466_LPP_chr3_188326948_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_9_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000483466_LPP_chr3_188326948_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_10_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000497477_LPP_chr3_188326948_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_11_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000497477_LPP_chr3_188326948_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_12_MAGI1-LPP_MAGI1_chr3_66023670_ENST00000497477_LPP_chr3_188326948_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_13_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000330909_LPP_chr3_188326949_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_14_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000330909_LPP_chr3_188326949_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_15_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000330909_LPP_chr3_188326949_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_16_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000402939_LPP_chr3_188326949_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_17_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000402939_LPP_chr3_188326949_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_18_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000402939_LPP_chr3_188326949_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_19_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000483466_LPP_chr3_188326949_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_20_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000483466_LPP_chr3_188326949_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_21_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000483466_LPP_chr3_188326949_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_22_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000497477_LPP_chr3_188326949_ENST00000312675_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

>50784_50784_23_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000497477_LPP_chr3_188326949_ENST00000448637_length(amino acids)=306AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE

--------------------------------------------------------------

>50784_50784_24_MAGI1-LPP_MAGI1_chr3_66023671_ENST00000497477_LPP_chr3_188326949_ENST00000543006_length(amino acids)=490AA_BP=21
MTCWGSSTAARRPSPSRPSDKSSTGSTASPPVSTPVTGHKRMVIPNQPPLTATKKSTLKPQPAPQAGPIPVAPIGTLKPQPQPVPASYTT
ASTSSRPTFNVQVKSAQPSPHYMAAPSSGQIYGSGPQGYNTQPVPVSGQCPPPSTRGGMDYAYIPPPGLQPEPGYGYAPNQGRYYEGYYA
AGPGYGGRNDSDPTYGQQGHPNTWKREPGYTPPGAGNQNPPGMYPVTGPKKTYITDPVSAPCAPPLQPKGGHSGQLGPSSVAPSFRPEDE
LEHLTKKMLYDMENPPADEYFGRCARCGENVVGEGTGCTAMDQVFHVDCFTCIICNNKLRGQPFYAVEKKAYCEPCYINTLEQCNVCSKP
IMERILRATGKAYHPHCFTCVMCHRSLDGIPFTVDAGGLIHCIEDFHKKFAPRCSVCKEPIMPAPGQEETVRIVALDRDFHVHCYRCEDC

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:66023670/chr3:188326948)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAGI1 Q96QZ7	LPP Q93052
FUNCTION: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250}.	FUNCTION: May play a structural role at sites of cell adhesion in maintaining cell shape and motility. In addition to these structural functions, it may also be implicated in signaling events and activation of gene transcription. May be involved in signal transduction from cell adhesion sites to the nucleus allowing successful integration of signals arising from soluble factors and cell-cell adhesion sites. Also suggested to serve as a scaffold protein upon which distinct protein complexes are assembled in the cytoplasm and in the nucleus. {ECO:0000269\|PubMed:10637295}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

17_105

104.33333333333333

1288.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

17_105

104.33333333333333

1463.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

17_105

104.33333333333333

1257.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

17_105

104.33333333333333

1161.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

17_105

104.33333333333333

1288.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

17_105

104.33333333333333

1463.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

17_105

104.33333333333333

1257.0

Domain

PDZ 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

17_105

104.33333333333333

1161.0

Domain

PDZ 1

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000312675

414_473

143.0

613.0

Domain

LIM zinc-binding 1

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000312675

474_534

143.0

613.0

Domain

LIM zinc-binding 2

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000312675

535_603

143.0

613.0

Domain

LIM zinc-binding 3

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000543006

414_473

143.0

613.0

Domain

LIM zinc-binding 1

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000543006

474_534

143.0

613.0

Domain

LIM zinc-binding 2

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000543006

535_603

143.0

613.0

Domain

LIM zinc-binding 3

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000312675

414_473

143.0

613.0

Domain

LIM zinc-binding 1

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000312675

474_534

143.0

613.0

Domain

LIM zinc-binding 2

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000312675

535_603

143.0

613.0

Domain

LIM zinc-binding 3

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000543006

414_473

143.0

613.0

Domain

LIM zinc-binding 1

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000543006

474_534

143.0

613.0

Domain

LIM zinc-binding 2

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000543006

535_603

143.0

613.0

Domain

LIM zinc-binding 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

1341_1344

104.33333333333333

1288.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

1398_1401

104.33333333333333

1288.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

402_421

104.33333333333333

1288.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

662_665

104.33333333333333

1288.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

978_988

104.33333333333333

1288.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

1341_1344

104.33333333333333

1463.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

1398_1401

104.33333333333333

1463.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

402_421

104.33333333333333

1463.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

662_665

104.33333333333333

1463.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

978_988

104.33333333333333

1463.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

1341_1344

104.33333333333333

1257.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

1398_1401

104.33333333333333

1257.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

402_421

104.33333333333333

1257.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

662_665

104.33333333333333

1257.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

978_988

104.33333333333333

1257.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

1341_1344

104.33333333333333

1161.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

1398_1401

104.33333333333333

1161.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

402_421

104.33333333333333

1161.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

662_665

104.33333333333333

1161.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

978_988

104.33333333333333

1161.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

1341_1344

104.33333333333333

1288.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

1398_1401

104.33333333333333

1288.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

402_421

104.33333333333333

1288.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

662_665

104.33333333333333

1288.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

978_988

104.33333333333333

1288.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

1341_1344

104.33333333333333

1463.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

1398_1401

104.33333333333333

1463.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

402_421

104.33333333333333

1463.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

662_665

104.33333333333333

1463.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

978_988

104.33333333333333

1463.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

1341_1344

104.33333333333333

1257.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

1398_1401

104.33333333333333

1257.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

402_421

104.33333333333333

1257.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

662_665

104.33333333333333

1257.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

978_988

104.33333333333333

1257.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

1341_1344

104.33333333333333

1161.0

Compositional bias

Note=Poly-Ala

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

1398_1401

104.33333333333333

1161.0

Compositional bias

Note=Poly-Arg

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

402_421

104.33333333333333

1161.0

Compositional bias

Note=Poly-Gln

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

662_665

104.33333333333333

1161.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

978_988

104.33333333333333

1161.0

Compositional bias

Note=Poly-Gly

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

1124_1206

104.33333333333333

1288.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

300_333

104.33333333333333

1288.0

Domain

WW 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

359_392

104.33333333333333

1288.0

Domain

WW 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

472_554

104.33333333333333

1288.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

643_721

104.33333333333333

1288.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

813_895

104.33333333333333

1288.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

96_287

104.33333333333333

1288.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

1124_1206

104.33333333333333

1463.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

300_333

104.33333333333333

1463.0

Domain

WW 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

359_392

104.33333333333333

1463.0

Domain

WW 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

472_554

104.33333333333333

1463.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

643_721

104.33333333333333

1463.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

813_895

104.33333333333333

1463.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

96_287

104.33333333333333

1463.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

1124_1206

104.33333333333333

1257.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

300_333

104.33333333333333

1257.0

Domain

WW 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

359_392

104.33333333333333

1257.0

Domain

WW 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

472_554

104.33333333333333

1257.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

643_721

104.33333333333333

1257.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

813_895

104.33333333333333

1257.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

96_287

104.33333333333333

1257.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

1124_1206

104.33333333333333

1161.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

300_333

104.33333333333333

1161.0

Domain

WW 1

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

359_392

104.33333333333333

1161.0

Domain

WW 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

472_554

104.33333333333333

1161.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

643_721

104.33333333333333

1161.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

813_895

104.33333333333333

1161.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

96_287

104.33333333333333

1161.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

1124_1206

104.33333333333333

1288.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

300_333

104.33333333333333

1288.0

Domain

WW 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

359_392

104.33333333333333

1288.0

Domain

WW 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

472_554

104.33333333333333

1288.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

643_721

104.33333333333333

1288.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

813_895

104.33333333333333

1288.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

96_287

104.33333333333333

1288.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

1124_1206

104.33333333333333

1463.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

300_333

104.33333333333333

1463.0

Domain

WW 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

359_392

104.33333333333333

1463.0

Domain

WW 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

472_554

104.33333333333333

1463.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

643_721

104.33333333333333

1463.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

813_895

104.33333333333333

1463.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

96_287

104.33333333333333

1463.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

1124_1206

104.33333333333333

1257.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

300_333

104.33333333333333

1257.0

Domain

WW 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

359_392

104.33333333333333

1257.0

Domain

WW 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

472_554

104.33333333333333

1257.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

643_721

104.33333333333333

1257.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

813_895

104.33333333333333

1257.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

96_287

104.33333333333333

1257.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

1124_1206

104.33333333333333

1161.0

Domain

PDZ 6

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

300_333

104.33333333333333

1161.0

Domain

WW 1

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

359_392

104.33333333333333

1161.0

Domain

WW 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

472_554

104.33333333333333

1161.0

Domain

PDZ 2

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

643_721

104.33333333333333

1161.0

Domain

PDZ 3

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

813_895

104.33333333333333

1161.0

Domain

PDZ 4

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

96_287

104.33333333333333

1161.0

Domain

Guanylate kinase-like

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000330909

103_110

104.33333333333333

1288.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000402939

103_110

104.33333333333333

1463.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000483466

103_110

104.33333333333333

1257.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023670

chr3:188326948

ENST00000497477

103_110

104.33333333333333

1161.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000330909

103_110

104.33333333333333

1288.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000402939

103_110

104.33333333333333

1463.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000483466

103_110

104.33333333333333

1257.0

Nucleotide binding

ATP

Hgene

MAGI1

chr3:66023671

chr3:188326949

ENST00000497477

103_110

104.33333333333333

1161.0

Nucleotide binding

ATP

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000312675

41_370

143.0

613.0

Compositional bias

Note=Pro-rich

Tgene

LPP

chr3:66023670

chr3:188326948

ENST00000543006

41_370

143.0

613.0

Compositional bias

Note=Pro-rich

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000312675

41_370

143.0

613.0

Compositional bias

Note=Pro-rich

Tgene

LPP

chr3:66023671

chr3:188326949

ENST00000543006

41_370

143.0

613.0

Compositional bias

Note=Pro-rich

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

LPP

ATP5J2, PPP2R1A, ELAVL1, EGLN2, VHL, CLNS1A, PNPO, HNRNPL, CPT1A, HSPA5, AGFG1, ALAD, ARPC3, ARPC4, CALR, DBNL, HSPBP1, IPO11, P3H1, DPP9, EFTUD1, FEN1, FKBP10, RPRD1B, SAE1, SURF2, UFM1, NIF3L1, NPLOC4, OGT, PPME1, PPP2R5D, RANGAP1, RDX, SH3GLB1, TPRKB, UBE3A, ZPR1, SUZ12, RNF2, COPS5, GMPPA, PICALM, NINL, XPO1, Sestd1, Ppp2r3a, CDH1, PTPN21, PPP2R3A, WDYHV1, SERPINB2, PDLIM7, LPXN, CBLC, MRPL38, WASF3, MTNR1A, G3BP1, TES, EFTUD2, ESR2, KIAA1429, HDAC2, DYRK1A, SH2D3C, DCP1A, RIN3, ACTB, EZR, GFAP, IMPDH2, KRT19, MAPRE1, PEX14, PFN1, PRPH, SQSTM1, SYNE3, TJP2, VASP, VCL, VIM, ZYX, NAA40, KIAA0408, SLC9A3R2, AJUBA, PLEKHG2, COQ3, SLU7, FHL2, FBXW7, nsp14,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAGI1
LPP

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MAGI1	chr3:66023670	chr3:188326948	ENST00000330909	-	1	25	970_1066	104.33333333333333	1288.0	FCHSD2
Hgene	MAGI1	chr3:66023670	chr3:188326948	ENST00000402939	-	1	23	970_1066	104.33333333333333	1463.0	FCHSD2
Hgene	MAGI1	chr3:66023670	chr3:188326948	ENST00000483466	-	1	23	970_1066	104.33333333333333	1257.0	FCHSD2
Hgene	MAGI1	chr3:66023670	chr3:188326948	ENST00000497477	-	1	21	970_1066	104.33333333333333	1161.0	FCHSD2
Hgene	MAGI1	chr3:66023671	chr3:188326949	ENST00000330909	-	1	25	970_1066	104.33333333333333	1288.0	FCHSD2
Hgene	MAGI1	chr3:66023671	chr3:188326949	ENST00000402939	-	1	23	970_1066	104.33333333333333	1463.0	FCHSD2
Hgene	MAGI1	chr3:66023671	chr3:188326949	ENST00000483466	-	1	23	970_1066	104.33333333333333	1257.0	FCHSD2
Hgene	MAGI1	chr3:66023671	chr3:188326949	ENST00000497477	-	1	21	970_1066	104.33333333333333	1161.0	FCHSD2

Top

Related Drugs to MAGI1-LPP

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MAGI1-LPP

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	LPP	C0087031	Juvenile-Onset Still Disease	1	CTD_human
Tgene	LPP	C3495559	Juvenile arthritis	1	CTD_human
Tgene	LPP	C3714758	Juvenile psoriatic arthritis	1	CTD_human
Tgene	LPP	C4552091	Polyarthritis, Juvenile, Rheumatoid Factor Negative	1	CTD_human
Tgene	LPP	C4704862	Polyarthritis, Juvenile, Rheumatoid Factor Positive	1	CTD_human