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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAGI1-SUCLG2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAGI1-SUCLG2
FusionPDB ID: 50792
FusionGDB2.0 ID: 50792
HgeneTgene
Gene symbol

MAGI1

SUCLG2

Gene ID

154043

8801

Gene nameCNKSR family member 3succinate-CoA ligase GDP-forming subunit beta
SynonymsCNK3|CNK3/IPCEF1|MAGI1G-SCS|GBETA|GTPSCS
Cytomap

6q25.2

3p14.1

Type of geneprotein-codingprotein-coding
Descriptionconnector enhancer of kinase suppressor of ras 3CNK homolog protein 3connector enhancer of KSR 3maguin-like proteinmembrane associated guanylate kinase, WW and PDZ domain containing 1membrane-associated guanylate kinase-interacting protein-like 1succinate--CoA ligase [GDP-forming] subunit beta, mitochondrialGTP-specific succinyl-CoA synthetase beta subunitGTP-specific succinyl-CoA synthetase subunit betaSCS-betaGsuccinate-CoA ligase GDP-forming beta subunitsuccinyl-CoA ligase [GDP-forming] s
Modification date2020032020200313
UniProtAcc

Q96QZ7

.
Ensembl transtripts involved in fusion geneENST idsENST00000330909, ENST00000402939, 
ENST00000483466, ENST00000497477, 
ENST00000470990, 		ENST00000492795, 
ENST00000307227, ENST00000493112, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score19 X 13 X 10=24706 X 5 X 4=120
# samples 238
** MAII scorelog2(23/2470*10)=-3.42480527552766
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAGI1 [Title/Abstract] AND SUCLG2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAGI1(66023671)-SUCLG2(67451275), # samples:2
SUCLG2(67546222)-MAGI1(65607763), # samples:1
Anticipated loss of major functional domain due to fusion event.MAGI1-SUCLG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAGI1-SUCLG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAGI1-SUCLG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAGI1-SUCLG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
SUCLG2-MAGI1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
SUCLG2-MAGI1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
MAGI1-SUCLG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MAGI1-SUCLG2 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAGI1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across SUCLG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-61-1918-01AMAGI1chr3

66023671

-SUCLG2chr3

67579610

-
ChimerDB4PRADTCGA-KK-A5A1MAGI1chr3

65607647

-SUCLG2chr3

67579610

-
ChimerDB4PRADTCGA-ZG-A9KY-01AMAGI1chr3

66023671

-SUCLG2chr3

67451275

-
ChimerDB4PRADTCGA-ZG-A9KYMAGI1chr3

66023670

-SUCLG2chr3

67451275

-
ChimerDB4PRADTCGA-ZG-A9KYMAGI1chr3

66023671

-SUCLG2chr3

67451275

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000330909MAGI1chr366023670-ENST00000493112SUCLG2chr367451275-743313250573107
ENST00000330909MAGI1chr366023670-ENST00000307227SUCLG2chr367451275-15753135420181
ENST00000402939MAGI1chr366023670-ENST00000493112SUCLG2chr367451275-743313250573107
ENST00000402939MAGI1chr366023670-ENST00000307227SUCLG2chr367451275-15753135420181
ENST00000483466MAGI1chr366023670-ENST00000493112SUCLG2chr367451275-985555492815107
ENST00000483466MAGI1chr366023670-ENST00000307227SUCLG2chr367451275-18175557842261
ENST00000497477MAGI1chr366023670-ENST00000493112SUCLG2chr367451275-743313250573107
ENST00000497477MAGI1chr366023670-ENST00000307227SUCLG2chr367451275-15753135420181
ENST00000330909MAGI1chr366023671-ENST00000493112SUCLG2chr367451275-743313250573107
ENST00000330909MAGI1chr366023671-ENST00000307227SUCLG2chr367451275-15753135420181
ENST00000402939MAGI1chr366023671-ENST00000493112SUCLG2chr367451275-743313250573107
ENST00000402939MAGI1chr366023671-ENST00000307227SUCLG2chr367451275-15753135420181
ENST00000483466MAGI1chr366023671-ENST00000493112SUCLG2chr367451275-985555492815107
ENST00000483466MAGI1chr366023671-ENST00000307227SUCLG2chr367451275-18175557842261
ENST00000497477MAGI1chr366023671-ENST00000493112SUCLG2chr367451275-743313250573107
ENST00000497477MAGI1chr366023671-ENST00000307227SUCLG2chr367451275-15753135420181
ENST00000330909MAGI1chr365607647-ENST00000493112SUCLG2chr367579610-169643001526508
ENST00000330909MAGI1chr365607647-ENST00000307227SUCLG2chr367579610-252843001502500
ENST00000330909MAGI1chr365607647-ENST00000492795SUCLG2chr367579610-169543001343447
ENST00000402939MAGI1chr365607647-ENST00000493112SUCLG2chr367579610-169643001526508
ENST00000402939MAGI1chr365607647-ENST00000307227SUCLG2chr367579610-252843001502500
ENST00000402939MAGI1chr365607647-ENST00000492795SUCLG2chr367579610-169543001343447
ENST00000483466MAGI1chr365607647-ENST00000493112SUCLG2chr367579610-19386722421768508
ENST00000483466MAGI1chr365607647-ENST00000307227SUCLG2chr367579610-27706722421744500
ENST00000483466MAGI1chr365607647-ENST00000492795SUCLG2chr367579610-19376722421585447
ENST00000497477MAGI1chr365607647-ENST00000493112SUCLG2chr367579610-169643001526508
ENST00000497477MAGI1chr365607647-ENST00000307227SUCLG2chr367579610-252843001502500
ENST00000497477MAGI1chr365607647-ENST00000492795SUCLG2chr367579610-169543001343447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000330909ENST00000493112MAGI1chr366023670-SUCLG2chr367451275-0.054709810.94529015
ENST00000330909ENST00000307227MAGI1chr366023670-SUCLG2chr367451275-0.1078048940.89219517
ENST00000402939ENST00000493112MAGI1chr366023670-SUCLG2chr367451275-0.054709810.94529015
ENST00000402939ENST00000307227MAGI1chr366023670-SUCLG2chr367451275-0.1078048940.89219517
ENST00000483466ENST00000493112MAGI1chr366023670-SUCLG2chr367451275-0.08536070.9146393
ENST00000483466ENST00000307227MAGI1chr366023670-SUCLG2chr367451275-0.140880550.8591194
ENST00000497477ENST00000493112MAGI1chr366023670-SUCLG2chr367451275-0.054709810.94529015
ENST00000497477ENST00000307227MAGI1chr366023670-SUCLG2chr367451275-0.1078048940.89219517
ENST00000330909ENST00000493112MAGI1chr366023671-SUCLG2chr367451275-0.054709810.94529015
ENST00000330909ENST00000307227MAGI1chr366023671-SUCLG2chr367451275-0.1078048940.89219517
ENST00000402939ENST00000493112MAGI1chr366023671-SUCLG2chr367451275-0.054709810.94529015
ENST00000402939ENST00000307227MAGI1chr366023671-SUCLG2chr367451275-0.1078048940.89219517
ENST00000483466ENST00000493112MAGI1chr366023671-SUCLG2chr367451275-0.08536070.9146393
ENST00000483466ENST00000307227MAGI1chr366023671-SUCLG2chr367451275-0.140880550.8591194
ENST00000497477ENST00000493112MAGI1chr366023671-SUCLG2chr367451275-0.054709810.94529015
ENST00000497477ENST00000307227MAGI1chr366023671-SUCLG2chr367451275-0.1078048940.89219517
ENST00000330909ENST00000493112MAGI1chr365607647-SUCLG2chr367579610-0.0005423470.99945766
ENST00000330909ENST00000307227MAGI1chr365607647-SUCLG2chr367579610-0.0001612420.9998387
ENST00000330909ENST00000492795MAGI1chr365607647-SUCLG2chr367579610-0.0004563040.9995436
ENST00000402939ENST00000493112MAGI1chr365607647-SUCLG2chr367579610-0.0005423470.99945766
ENST00000402939ENST00000307227MAGI1chr365607647-SUCLG2chr367579610-0.0001612420.9998387
ENST00000402939ENST00000492795MAGI1chr365607647-SUCLG2chr367579610-0.0004563040.9995436
ENST00000483466ENST00000493112MAGI1chr365607647-SUCLG2chr367579610-0.0005543210.9994456
ENST00000483466ENST00000307227MAGI1chr365607647-SUCLG2chr367579610-0.0001606920.9998393
ENST00000483466ENST00000492795MAGI1chr365607647-SUCLG2chr367579610-0.0004469450.999553
ENST00000497477ENST00000493112MAGI1chr365607647-SUCLG2chr367579610-0.0005423470.99945766
ENST00000497477ENST00000307227MAGI1chr365607647-SUCLG2chr367579610-0.0001612420.9998387
ENST00000497477ENST00000492795MAGI1chr365607647-SUCLG2chr367579610-0.0004563040.9995436

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>50792_50792_1_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000330909_SUCLG2_chr3_67579610_ENST00000307227_length(amino acids)=500AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_2_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000330909_SUCLG2_chr3_67579610_ENST00000492795_length(amino acids)=447AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY

--------------------------------------------------------------

>50792_50792_3_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000330909_SUCLG2_chr3_67579610_ENST00000493112_length(amino acids)=508AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_4_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000402939_SUCLG2_chr3_67579610_ENST00000307227_length(amino acids)=500AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_5_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000402939_SUCLG2_chr3_67579610_ENST00000492795_length(amino acids)=447AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY

--------------------------------------------------------------

>50792_50792_6_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000402939_SUCLG2_chr3_67579610_ENST00000493112_length(amino acids)=508AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_7_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000483466_SUCLG2_chr3_67579610_ENST00000307227_length(amino acids)=500AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_8_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000483466_SUCLG2_chr3_67579610_ENST00000492795_length(amino acids)=447AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY

--------------------------------------------------------------

>50792_50792_9_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000483466_SUCLG2_chr3_67579610_ENST00000493112_length(amino acids)=508AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_10_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000497477_SUCLG2_chr3_67579610_ENST00000307227_length(amino acids)=500AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_11_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000497477_SUCLG2_chr3_67579610_ENST00000492795_length(amino acids)=447AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY

--------------------------------------------------------------

>50792_50792_12_MAGI1-SUCLG2_MAGI1_chr3_65607647_ENST00000497477_SUCLG2_chr3_67579610_ENST00000493112_length(amino acids)=508AA_BP=144
MSKVIQKKNHWTSRVHECTVKRGPQGELGVTVLGGAEHGEFPYVGAVAAVEAAGLPGGGEGPRLGEGELLLEVQGVRVSGLPRYDVLGVI
DSCKEAVTFKAVRQGGRLNKDLRHFLNQRFQKGSPDHELQQTIRDNLYRHAVPYAKEIVLKAQILAGGRGKGVFNSGLKGGVHLTKDPNV
VGQLAKQMIGYNLATKQTPKEGVKVNKVMVAEALDISRETYLAILMDRSCNGPVLVGSPQGGVDIEEVAASNPELIFKEQIDIFEGIKDS
QAQRMAENLGFVGPLKSQAADQITKLYNLFLKIDATQVEVNPFGETPEGQVVCFDAKINFDDNAEFRQKDIFAMDDKSENEPIENEAAKY
DLKYIGLDGNIACFVNGAGLAMATCDIIFLNGGKPANFLDLGGGVKEAQVYQAFKLLTADPKVEAILVNIFGGIVNCAIIANGITKACRE

--------------------------------------------------------------

>50792_50792_13_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000330909_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=181AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_14_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000330909_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_15_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000402939_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=181AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_16_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000402939_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_17_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000483466_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=261AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_18_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000483466_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_19_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000497477_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=181AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_20_MAGI1-SUCLG2_MAGI1_chr3_66023670_ENST00000497477_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_21_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000330909_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=181AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_22_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000330909_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_23_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000402939_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=181AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_24_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000402939_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_25_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000483466_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=261AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_26_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000483466_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

>50792_50792_27_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000497477_SUCLG2_chr3_67451275_ENST00000307227_length(amino acids)=181AA_BP=1
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG

--------------------------------------------------------------

>50792_50792_28_MAGI1-SUCLG2_MAGI1_chr3_66023671_ENST00000497477_SUCLG2_chr3_67451275_ENST00000493112_length(amino acids)=107AA_BP=21
MTCWGSSTAARRPSPSRPSDKVEAILVNIFGGIVNCAIIANGITKACRELELKVPLVVRLEGTFMEKKGSYMHIKQETGNSNENITGIQE

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:66023671/chr3:67451275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAGI1

Q96QZ7

.
FUNCTION: May play a role as scaffolding protein at cell-cell junctions. May regulate acid-induced ASIC3 currents by modulating its expression at the cell surface (By similarity). {ECO:0000250}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-22517_105143.333333333333341288.0DomainPDZ 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-22317_105143.333333333333341463.0DomainPDZ 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-22317_105143.333333333333341257.0DomainPDZ 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-22117_105143.333333333333341161.0DomainPDZ 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-12517_105104.333333333333331288.0DomainPDZ 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-12317_105104.333333333333331463.0DomainPDZ 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-12317_105104.333333333333331257.0DomainPDZ 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-12117_105104.333333333333331161.0DomainPDZ 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-12517_105104.333333333333331288.0DomainPDZ 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-12317_105104.333333333333331463.0DomainPDZ 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-12317_105104.333333333333331257.0DomainPDZ 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-12117_105104.333333333333331161.0DomainPDZ 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225103_110143.333333333333341288.0Nucleotide bindingATP
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223103_110143.333333333333341463.0Nucleotide bindingATP
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223103_110143.333333333333341257.0Nucleotide bindingATP
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221103_110143.333333333333341161.0Nucleotide bindingATP
TgeneSUCLG2chr3:65607647chr3:67579610ENST0000030722711190_9275.33333333333333433.0Nucleotide bindingGTP
TgeneSUCLG2chr3:65607647chr3:67579610ENST0000049311211190_9275.33333333333333441.0Nucleotide bindingGTP
TgeneSUCLG2chr3:65607647chr3:67579610ENST00000307227111365_36775.33333333333333433.0RegionSubstrate binding%3B shared with subunit alpha
TgeneSUCLG2chr3:65607647chr3:67579610ENST00000493112111365_36775.33333333333333441.0RegionSubstrate binding%3B shared with subunit alpha
TgeneSUCLG2chr3:66023670chr3:67451275ENST00000307227811365_367354.0433.0RegionSubstrate binding%3B shared with subunit alpha
TgeneSUCLG2chr3:66023670chr3:67451275ENST00000493112811365_367354.0441.0RegionSubstrate binding%3B shared with subunit alpha
TgeneSUCLG2chr3:66023671chr3:67451275ENST00000307227811365_367354.0433.0RegionSubstrate binding%3B shared with subunit alpha
TgeneSUCLG2chr3:66023671chr3:67451275ENST00000493112811365_367354.0441.0RegionSubstrate binding%3B shared with subunit alpha

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-2251341_1344143.333333333333341288.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-2251398_1401143.333333333333341288.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225402_421143.333333333333341288.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225662_665143.333333333333341288.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225978_988143.333333333333341288.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-2231341_1344143.333333333333341463.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-2231398_1401143.333333333333341463.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223402_421143.333333333333341463.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223662_665143.333333333333341463.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223978_988143.333333333333341463.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-2231341_1344143.333333333333341257.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-2231398_1401143.333333333333341257.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223402_421143.333333333333341257.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223662_665143.333333333333341257.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223978_988143.333333333333341257.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-2211341_1344143.333333333333341161.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-2211398_1401143.333333333333341161.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221402_421143.333333333333341161.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221662_665143.333333333333341161.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221978_988143.333333333333341161.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-1251341_1344104.333333333333331288.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-1251398_1401104.333333333333331288.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125402_421104.333333333333331288.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125662_665104.333333333333331288.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125978_988104.333333333333331288.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-1231341_1344104.333333333333331463.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-1231398_1401104.333333333333331463.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123402_421104.333333333333331463.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123662_665104.333333333333331463.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123978_988104.333333333333331463.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-1231341_1344104.333333333333331257.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-1231398_1401104.333333333333331257.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123402_421104.333333333333331257.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123662_665104.333333333333331257.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123978_988104.333333333333331257.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-1211341_1344104.333333333333331161.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-1211398_1401104.333333333333331161.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121402_421104.333333333333331161.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121662_665104.333333333333331161.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121978_988104.333333333333331161.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-1251341_1344104.333333333333331288.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-1251398_1401104.333333333333331288.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125402_421104.333333333333331288.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125662_665104.333333333333331288.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125978_988104.333333333333331288.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-1231341_1344104.333333333333331463.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-1231398_1401104.333333333333331463.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123402_421104.333333333333331463.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123662_665104.333333333333331463.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123978_988104.333333333333331463.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-1231341_1344104.333333333333331257.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-1231398_1401104.333333333333331257.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123402_421104.333333333333331257.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123662_665104.333333333333331257.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123978_988104.333333333333331257.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-1211341_1344104.333333333333331161.0Compositional biasNote=Poly-Ala
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-1211398_1401104.333333333333331161.0Compositional biasNote=Poly-Arg
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121402_421104.333333333333331161.0Compositional biasNote=Poly-Gln
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121662_665104.333333333333331161.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121978_988104.333333333333331161.0Compositional biasNote=Poly-Gly
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-2251124_1206143.333333333333341288.0DomainPDZ 6
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225300_333143.333333333333341288.0DomainWW 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225359_392143.333333333333341288.0DomainWW 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225472_554143.333333333333341288.0DomainPDZ 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225643_721143.333333333333341288.0DomainPDZ 3
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225813_895143.333333333333341288.0DomainPDZ 4
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-22596_287143.333333333333341288.0DomainGuanylate kinase-like
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-2231124_1206143.333333333333341463.0DomainPDZ 6
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223300_333143.333333333333341463.0DomainWW 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223359_392143.333333333333341463.0DomainWW 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223472_554143.333333333333341463.0DomainPDZ 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223643_721143.333333333333341463.0DomainPDZ 3
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223813_895143.333333333333341463.0DomainPDZ 4
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-22396_287143.333333333333341463.0DomainGuanylate kinase-like
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-2231124_1206143.333333333333341257.0DomainPDZ 6
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223300_333143.333333333333341257.0DomainWW 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223359_392143.333333333333341257.0DomainWW 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223472_554143.333333333333341257.0DomainPDZ 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223643_721143.333333333333341257.0DomainPDZ 3
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223813_895143.333333333333341257.0DomainPDZ 4
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-22396_287143.333333333333341257.0DomainGuanylate kinase-like
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-2211124_1206143.333333333333341161.0DomainPDZ 6
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221300_333143.333333333333341161.0DomainWW 1
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221359_392143.333333333333341161.0DomainWW 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221472_554143.333333333333341161.0DomainPDZ 2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221643_721143.333333333333341161.0DomainPDZ 3
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221813_895143.333333333333341161.0DomainPDZ 4
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-22196_287143.333333333333341161.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-1251124_1206104.333333333333331288.0DomainPDZ 6
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125300_333104.333333333333331288.0DomainWW 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125359_392104.333333333333331288.0DomainWW 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125472_554104.333333333333331288.0DomainPDZ 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125643_721104.333333333333331288.0DomainPDZ 3
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125813_895104.333333333333331288.0DomainPDZ 4
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-12596_287104.333333333333331288.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-1231124_1206104.333333333333331463.0DomainPDZ 6
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123300_333104.333333333333331463.0DomainWW 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123359_392104.333333333333331463.0DomainWW 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123472_554104.333333333333331463.0DomainPDZ 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123643_721104.333333333333331463.0DomainPDZ 3
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123813_895104.333333333333331463.0DomainPDZ 4
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-12396_287104.333333333333331463.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-1231124_1206104.333333333333331257.0DomainPDZ 6
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123300_333104.333333333333331257.0DomainWW 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123359_392104.333333333333331257.0DomainWW 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123472_554104.333333333333331257.0DomainPDZ 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123643_721104.333333333333331257.0DomainPDZ 3
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123813_895104.333333333333331257.0DomainPDZ 4
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-12396_287104.333333333333331257.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-1211124_1206104.333333333333331161.0DomainPDZ 6
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121300_333104.333333333333331161.0DomainWW 1
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121359_392104.333333333333331161.0DomainWW 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121472_554104.333333333333331161.0DomainPDZ 2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121643_721104.333333333333331161.0DomainPDZ 3
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121813_895104.333333333333331161.0DomainPDZ 4
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-12196_287104.333333333333331161.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-1251124_1206104.333333333333331288.0DomainPDZ 6
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125300_333104.333333333333331288.0DomainWW 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125359_392104.333333333333331288.0DomainWW 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125472_554104.333333333333331288.0DomainPDZ 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125643_721104.333333333333331288.0DomainPDZ 3
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125813_895104.333333333333331288.0DomainPDZ 4
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-12596_287104.333333333333331288.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-1231124_1206104.333333333333331463.0DomainPDZ 6
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123300_333104.333333333333331463.0DomainWW 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123359_392104.333333333333331463.0DomainWW 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123472_554104.333333333333331463.0DomainPDZ 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123643_721104.333333333333331463.0DomainPDZ 3
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123813_895104.333333333333331463.0DomainPDZ 4
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-12396_287104.333333333333331463.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-1231124_1206104.333333333333331257.0DomainPDZ 6
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123300_333104.333333333333331257.0DomainWW 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123359_392104.333333333333331257.0DomainWW 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123472_554104.333333333333331257.0DomainPDZ 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123643_721104.333333333333331257.0DomainPDZ 3
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123813_895104.333333333333331257.0DomainPDZ 4
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-12396_287104.333333333333331257.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-1211124_1206104.333333333333331161.0DomainPDZ 6
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121300_333104.333333333333331161.0DomainWW 1
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121359_392104.333333333333331161.0DomainWW 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121472_554104.333333333333331161.0DomainPDZ 2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121643_721104.333333333333331161.0DomainPDZ 3
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121813_895104.333333333333331161.0DomainPDZ 4
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-12196_287104.333333333333331161.0DomainGuanylate kinase-like
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125103_110104.333333333333331288.0Nucleotide bindingATP
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123103_110104.333333333333331463.0Nucleotide bindingATP
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123103_110104.333333333333331257.0Nucleotide bindingATP
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121103_110104.333333333333331161.0Nucleotide bindingATP
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125103_110104.333333333333331288.0Nucleotide bindingATP
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123103_110104.333333333333331463.0Nucleotide bindingATP
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123103_110104.333333333333331257.0Nucleotide bindingATP
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121103_110104.333333333333331161.0Nucleotide bindingATP
TgeneSUCLG2chr3:65607647chr3:67579610ENST0000030722711146_27475.33333333333333433.0DomainATP-grasp
TgeneSUCLG2chr3:65607647chr3:67579610ENST0000049311211146_27475.33333333333333441.0DomainATP-grasp
TgeneSUCLG2chr3:66023670chr3:67451275ENST0000030722781146_274354.0433.0DomainATP-grasp
TgeneSUCLG2chr3:66023670chr3:67451275ENST0000049311281146_274354.0441.0DomainATP-grasp
TgeneSUCLG2chr3:66023671chr3:67451275ENST0000030722781146_274354.0433.0DomainATP-grasp
TgeneSUCLG2chr3:66023671chr3:67451275ENST0000049311281146_274354.0441.0DomainATP-grasp
TgeneSUCLG2chr3:66023670chr3:67451275ENST0000030722781190_92354.0433.0Nucleotide bindingGTP
TgeneSUCLG2chr3:66023670chr3:67451275ENST0000049311281190_92354.0441.0Nucleotide bindingGTP
TgeneSUCLG2chr3:66023671chr3:67451275ENST0000030722781190_92354.0433.0Nucleotide bindingGTP
TgeneSUCLG2chr3:66023671chr3:67451275ENST0000049311281190_92354.0441.0Nucleotide bindingGTP


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>444_MAGI1_66023671_SUCLG2_67451275_ranked_0.pdbMAGI16560764766023671ENST00000492795SUCLG2chr367451275-
MATLATAFLAASSRSMAEVMGSPLLLSIFWASWTLVPSSRTTRGTLSSSSRQALVIPLAMMAQLTIPPNILTRMASTLSDGLEGDGLLAA
VDDPQHVIAGQAGHPDPLHLQKQLPFAQPRALAAAGKPRCLDRRHRSDVRKLPVLRASQHRHPQLALGSPLHGAFVNPASPVVLLLDHFG
261


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MAGI1_pLDDT.png
all structure
all structure
SUCLG2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAGI1
SUCLG2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAGI1chr3:65607647chr3:67579610ENST00000330909-225970_1066143.333333333333341288.0FCHSD2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000402939-223970_1066143.333333333333341463.0FCHSD2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000483466-223970_1066143.333333333333341257.0FCHSD2
HgeneMAGI1chr3:65607647chr3:67579610ENST00000497477-221970_1066143.333333333333341161.0FCHSD2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000330909-125970_1066104.333333333333331288.0FCHSD2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000402939-123970_1066104.333333333333331463.0FCHSD2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000483466-123970_1066104.333333333333331257.0FCHSD2
HgeneMAGI1chr3:66023670chr3:67451275ENST00000497477-121970_1066104.333333333333331161.0FCHSD2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000330909-125970_1066104.333333333333331288.0FCHSD2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000402939-123970_1066104.333333333333331463.0FCHSD2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000483466-123970_1066104.333333333333331257.0FCHSD2
HgeneMAGI1chr3:66023671chr3:67451275ENST00000497477-121970_1066104.333333333333331161.0FCHSD2


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Related Drugs to MAGI1-SUCLG2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAGI1-SUCLG2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource