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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAN2A1-HTR4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAN2A1-HTR4
FusionPDB ID: 51094
FusionGDB2.0 ID: 51094
HgeneTgene
Gene symbol

MAN2A1

HTR4

Gene ID

4124

3360

Gene namemannosidase alpha class 2A member 15-hydroxytryptamine receptor 4
SynonymsAMan II|GOLIM7|MANA2|MANII5-HT4|5-HT4R
Cytomap

5q21.3

5q32

Type of geneprotein-codingprotein-coding
Descriptionalpha-mannosidase 2Golgi alpha-mannosidase IIgolgi integral membrane protein 7mannosidase, alpha type IImannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase5-hydroxytryptamine receptor 45-hydroxytryptamine (serotonin) receptor 4, G protein-coupled5-hydroxytryptamine receptor 4 transcript variant b25-hydroxytryptamine receptor 4 transcript variant b3cardiac 5-HT4 receptor
Modification date2020031320200313
UniProtAcc

Q16706

.
Ensembl transtripts involved in fusion geneENST idsENST00000261483, ENST00000505313, 
ENST00000314512, ENST00000521735, 
ENST00000360693, ENST00000362016, 
ENST00000377888, ENST00000517929, 
ENST00000519495, ENST00000520086, 
ENST00000520514, ENST00000354217, 
ENST00000521530, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 8=13444 X 4 X 3=48
# samples 144
** MAII scorelog2(14/1344*10)=-3.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAN2A1 [Title/Abstract] AND HTR4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAN2A1(109125228)-HTR4(147830835), # samples:2
Anticipated loss of major functional domain due to fusion event.MAN2A1-HTR4 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MAN2A1-HTR4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across MAN2A1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HTR4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-DX-A6YU-01AMAN2A1chr5

109125228

-HTR4chr5

147830835

-
ChimerDB4SARCTCGA-DX-A6YU-01AMAN2A1chr5

109125228

+HTR4chr5

147830835

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261483MAN2A1chr5109125228+ENST00000521530HTR4chr5147830835-323629957313082783

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261483ENST00000521530MAN2A1chr5109125228+HTR4chr5147830835-0.0018834260.9981166

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51094_51094_1_MAN2A1-HTR4_MAN2A1_chr5_109125228_ENST00000261483_HTR4_chr5_147830835_ENST00000521530_length(amino acids)=783AA_BP=749
MPRAPCRRSALSLRSSLWGPPFPVAGESRLERGARPRGGRQARAKAKGVWWRRRLGAEQGGDSHPHPRARRSRSPGEGSLRRLLPRVHSA
LSPLAEESVLAPSLSRKMKLSRQFTVFGSAIFCVVIFSLYLMLDRGHLDYPRNPRREGSFPQGQLSMLQEKIDHLERLLAENNEIISNIR
DSVINLSESVEDGPKSSQSNFSQGAGSHLLPSQLSLSVDTADCLFASQSGSHNSDVQMLDVYSLISFDNPDGGVWKQGFDITYESNEWDT
EPLQVFVVPHSHNDPGWLKTFNDYFRDKTQYIFNNMVLKLKEDSRRKFIWSEISYLSKWWDIIDIQKKDAVKSLIENGQLEIVTGGWVMP
DEATPHYFALIDQLIEGHQWLENNIGVKPRSGWAIDPFGHSPTMAYLLNRAGLSHMLIQRVHYAVKKHFALHKTLEFFWRQNWDLGSVTD
ILCHMMPFYSYDIPHTCGPDPKICCQFDFKRLPGGRFGCPWGVPPETIHPGNVQSRARMLLDQYRKKSKLFRTKVLLAPLGDDFRYCEYT
EWDLQFKNYQQLFDYMNSQSKFKVKIQFGTLSDFFDALDKADETQRDKGQSMFPVLSGDFFTYADRDDHYWSGYFTSRPFYKRMDRIMES
HLRAAEILYYFALRQAHKYKINKFLSSSLYTALTEARRNLGLFQHHDAITGTAKDWVVVDYGTRLFHSLMVLEKIIGNSAFLLILKDKLT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:109125228/chr5:147830835)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAN2A1

Q16706

.
FUNCTION: Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway. {ECO:0000250|UniProtKB:P28494}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN2A1chr5:109125228chr5:147830835ENST00000261483+12221_5647.66666666666661145.0Topological domainCytoplasmic
HgeneMAN2A1chr5:109125228chr5:147830835ENST00000261483+12226_26647.66666666666661145.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308117_1370429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308159_1920429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000360693081_190429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308214_2600429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308282_2940429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308316_3880429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930841_580429.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930880_930429.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608117_1370403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608159_1920403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000362016081_190403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608214_2600403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608282_2940403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608316_3880403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160841_580403.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160880_930403.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807117_1370389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807159_1920389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000377888071_190389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807214_2600389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807282_2940389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807316_3880389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880741_580389.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880780_930389.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906117_1370361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906159_1920361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000517929061_190361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906214_2600361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906282_2940361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906316_3880361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290641_580361.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290680_930361.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406117_1370.0412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406159_1920.0412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000520514061_190.0412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406214_2600.0412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406282_2940.0412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406316_3880.0412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140641_580.0412.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140680_930.0412.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308138_1580429.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308193_2130429.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930820_400429.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308261_2810429.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000036069308295_3150429.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930859_790429.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003606930894_1160429.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608138_1580403.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608193_2130403.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160820_400403.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608261_2810403.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000036201608295_3150403.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160859_790403.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003620160894_1160403.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807138_1580389.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807193_2130389.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880720_400389.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807261_2810389.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000037788807295_3150389.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880759_790389.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003778880794_1160389.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906138_1580361.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906193_2130361.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290620_400361.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906261_2810361.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000051792906295_3150361.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290659_790361.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005179290694_1160361.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406138_1580.0412.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406193_2130.0412.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140620_400.0412.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406261_2810.0412.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000052051406295_3150.0412.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140659_790.0412.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005205140694_1160.0412.0TransmembraneHelical%3B Name%3D3

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAN2A1chr5:109125228chr5:147830835ENST00000261483+122227_1144647.66666666666661145.0Topological domainLumenal
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268117_137384.0421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268159_192384.0421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000314512681_19384.0421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268214_260384.0421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268282_294384.0421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268316_388384.0421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126841_58384.0421.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126880_93384.0421.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757117_137358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757159_192358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000354217571_19358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757214_260358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757282_294358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757316_388358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175741_58358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175780_93358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046117_137358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046159_192358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000521530461_19358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046214_260358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046282_294358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046316_388358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304641_58358.6666666666667388.0Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304680_93358.6666666666667388.0Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557117_137384.0382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557159_192384.0382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST00000521735571_19384.0382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557214_260384.0382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557282_294384.0382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557316_388384.0382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355741_58384.0382.3333333333333Topological domainCytoplasmic
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355780_93384.0382.3333333333333Topological domainExtracellular
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268138_158384.0421.3333333333333TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268193_213384.0421.3333333333333TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126820_40384.0421.3333333333333TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268261_281384.0421.3333333333333TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000031451268295_315384.0421.3333333333333TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126859_79384.0421.3333333333333TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003145126894_116384.0421.3333333333333TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757138_158358.6666666666667388.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757193_213358.6666666666667388.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175720_40358.6666666666667388.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757261_281358.6666666666667388.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000035421757295_315358.6666666666667388.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175759_79358.6666666666667388.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000003542175794_116358.6666666666667388.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046138_158358.6666666666667388.0TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046193_213358.6666666666667388.0TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304620_40358.6666666666667388.0TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046261_281358.6666666666667388.0TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000052153046295_315358.6666666666667388.0TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304659_79358.6666666666667388.0TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005215304694_116358.6666666666667388.0TransmembraneHelical%3B Name%3D3
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557138_158384.0382.3333333333333TransmembraneHelical%3B Name%3D4
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557193_213384.0382.3333333333333TransmembraneHelical%3B Name%3D5
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355720_40384.0382.3333333333333TransmembraneHelical%3B Name%3D1
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557261_281384.0382.3333333333333TransmembraneHelical%3B Name%3D6
TgeneHTR4chr5:109125228chr5:147830835ENST0000052173557295_315384.0382.3333333333333TransmembraneHelical%3B Name%3D7
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355759_79384.0382.3333333333333TransmembraneHelical%3B Name%3D2
TgeneHTR4chr5:109125228chr5:147830835ENST000005217355794_116384.0382.3333333333333TransmembraneHelical%3B Name%3D3


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAN2A1
HTR4


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MAN2A1-HTR4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAN2A1-HTR4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource