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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAP2K4-MYH3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAP2K4-MYH3
	FusionPDB ID: 51209
	FusionGDB2.0 ID: 51209
		Hgene	Tgene
	Gene symbol	MAP2K4	MYH3
	Gene ID	6416	4621
	Gene name	mitogen-activated protein kinase kinase 4	myosin heavy chain 3
	Synonyms	JNKK\|JNKK1\|MAPKK4\|MEK4\|MKK4\|PRKMK4\|SAPKK-1\|SAPKK1\|SEK1\|SERK1\|SKK1	CPSFS1A\|CPSFS1B\|CPSKF1A\|CPSKF1B\|DA2A\|DA2B\|DA2B3\|DA8\|HEMHC\|MYHC-EMB\|MYHSE1\|SMHCE
	Cytomap	17p12	17p13.1
	Type of gene	protein-coding	protein-coding
	Description	dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1	myosin-3myosin heavy chain, fast skeletal muscle, embryonicmyosin, heavy chain 3, skeletal muscle, embryonicmyosin, heavy polypeptide 3, skeletal muscle, embryonicmyosin, skeletal, heavy chain, embryonic 1
	Modification date	20200329	20200314
	UniProtAcc	P45985	P11055
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000353533, ENST00000415385, ENST00000581941,	ENST00000226209, ENST00000583535,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 4 X 7=280	5 X 5 X 3=75
	# samples	13	5
	** MAII score	log2(13/280*10)=-1.10691520391651 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAP2K4 [Title/Abstract] AND MYH3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP2K4(11924318)-MYH3(10539170), # samples:3
Anticipated loss of major functional domain due to fusion event.	MAP2K4-MYH3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP2K4-MYH3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP2K4-MYH3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAP2K4-MYH3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAP2K4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MYH3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-61-1914-01A	MAP2K4	chr17	11924318	+	MYH3	chr17	10539170	-
ChimerDB4	OV	TCGA-61-1914	MAP2K4	chr17	11924318	+	MYH3	chr17	10539170	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000353533	MAP2K4	chr17	11924318	+	ENST00000226209	MYH3	chr17	10539170	-	2272	178	63	2144	693
ENST00000353533	MAP2K4	chr17	11924318	+	ENST00000583535	MYH3	chr17	10539170	-	2271	178	63	2144	693
ENST00000415385	MAP2K4	chr17	11924318	+	ENST00000226209	MYH3	chr17	10539170	-	2262	168	53	2134	693
ENST00000415385	MAP2K4	chr17	11924318	+	ENST00000583535	MYH3	chr17	10539170	-	2261	168	53	2134	693

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000353533	ENST00000226209	MAP2K4	chr17	11924318	+	MYH3	chr17	10539170	-	0.004278385	0.9957216
ENST00000353533	ENST00000583535	MAP2K4	chr17	11924318	+	MYH3	chr17	10539170	-	0.004241232	0.9957587
ENST00000415385	ENST00000226209	MAP2K4	chr17	11924318	+	MYH3	chr17	10539170	-	0.004244865	0.9957552
ENST00000415385	ENST00000583535	MAP2K4	chr17	11924318	+	MYH3	chr17	10539170	-	0.004210805	0.99578923

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51209_51209_1_MAP2K4-MYH3_MAP2K4_chr17_11924318_ENST00000353533_MYH3_chr17_10539170_ENST00000226209_length(amino acids)=693AA_BP=38
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

--------------------------------------------------------------

>51209_51209_2_MAP2K4-MYH3_MAP2K4_chr17_11924318_ENST00000353533_MYH3_chr17_10539170_ENST00000583535_length(amino acids)=693AA_BP=38
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

--------------------------------------------------------------

>51209_51209_3_MAP2K4-MYH3_MAP2K4_chr17_11924318_ENST00000415385_MYH3_chr17_10539170_ENST00000226209_length(amino acids)=693AA_BP=38
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

--------------------------------------------------------------

>51209_51209_4_MAP2K4-MYH3_MAP2K4_chr17_11924318_ENST00000415385_MYH3_chr17_10539170_ENST00000583535_length(amino acids)=693AA_BP=38
MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS
RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE
DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI
AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR
SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE
RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL
EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:11924318/chr17:10539170)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP2K4 P45985	MYH3 P11055
FUNCTION: Dual specificity protein kinase which acts as an essential component of the MAP kinase signal transduction pathway. Essential component of the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. With MAP2K7/MKK7, is the one of the only known kinase to directly activate the stress-activated protein kinase/c-Jun N-terminal kinases MAPK8/JNK1, MAPK9/JNK2 and MAPK10/JNK3. MAP2K4/MKK4 and MAP2K7/MKK7 both activate the JNKs by phosphorylation, but they differ in their preference for the phosphorylation site in the Thr-Pro-Tyr motif. MAP2K4 shows preference for phosphorylation of the Tyr residue and MAP2K7/MKK7 for the Thr residue. The phosphorylation of the Thr residue by MAP2K7/MKK7 seems to be the prerequisite for JNK activation at least in response to proinflammatory cytokines, while other stimuli activate both MAP2K4/MKK4 and MAP2K7/MKK7 which synergistically phosphorylate JNKs. MAP2K4 is required for maintaining peripheral lymphoid homeostasis. The MKK/JNK signaling pathway is also involved in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis. Whereas MAP2K7/MKK7 exclusively activates JNKs, MAP2K4/MKK4 additionally activates the p38 MAPKs MAPK11, MAPK12, MAPK13 and MAPK14. {ECO:0000269\|PubMed:7716521}.	FUNCTION: Muscle contraction.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000353533

5_19

38.333333333333336

400.0

Compositional bias

Note=Gly/Ser-rich

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000415385

5_19

38.333333333333336

411.0

Compositional bias

Note=Gly/Ser-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000353533

102_367

38.333333333333336

400.0

Domain

Protein kinase

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000415385

102_367

38.333333333333336

411.0

Domain

Protein kinase

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000353533

108_116

38.333333333333336

400.0

Nucleotide binding

ATP

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000415385

108_116

38.333333333333336

411.0

Nucleotide binding

ATP

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000353533

364_387

38.333333333333336

400.0

Region

Note=DVD domain

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000353533

37_52

38.333333333333336

400.0

Region

Note=D domain

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000415385

364_387

38.333333333333336

411.0

Region

Note=DVD domain

Hgene

MAP2K4

chr17:11924318

chr17:10539170

ENST00000415385

37_52

38.333333333333336

411.0

Region

Note=D domain

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

840_1933

1285.3333333333333

1941.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

840_1933

1285.3333333333333

1941.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

33_82

1285.3333333333333

1941.0

Domain

Myosin N-terminal SH3-like

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

782_811

1285.3333333333333

1941.0

Domain

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

86_779

1285.3333333333333

1941.0

Domain

Myosin motor

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

33_82

1285.3333333333333

1941.0

Domain

Myosin N-terminal SH3-like

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

782_811

1285.3333333333333

1941.0

Domain

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

86_779

1285.3333333333333

1941.0

Domain

Myosin motor

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

179_186

1285.3333333333333

1941.0

Nucleotide binding

ATP

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

179_186

1285.3333333333333

1941.0

Nucleotide binding

ATP

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

656_678

1285.3333333333333

1941.0

Region

Note=Actin-binding

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000226209

758_772

1285.3333333333333

1941.0

Region

Note=Actin-binding

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

656_678

1285.3333333333333

1941.0

Region

Note=Actin-binding

Tgene

MYH3

chr17:11924318

chr17:10539170

ENST00000583535

758_772

1285.3333333333333

1941.0

Region

Note=Actin-binding

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1421_MAP2K4_11924318_MYH3_10539170_ranked_0.pdb	MAP2K4	11924318	11924318	ENST00000583535	MYH3	chr17	10539170	-	MAAPSPSGGGGSGGGSGSGTPGPVGSPAPGHPAVSSMQGELSRQLEEKESIVSQLSRSKQAFTQQTEELKRQLEEENKAKNALAHALQSS RHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQDSEEQVEAVNAKCASLEKTKQRLQGEVE DLMVDVERANSLAAALDKKQRNFDKVLAEWKTKCEESQAELEASLKESRSLSTELFKLKNAYEEALDQLETVKRENKNLEQEIADLTEQI AENGKTIHELEKSRKQIELEKADIQLALEEAEAALEHEEAKILRIQLELTQVKSEIDRKIAEKDEEIEQLKRNYQRTVETMQSALDAEVR SRNEAIRLKKKMEGDLNEIEIQLSHANRQAAETLKHLRSVQGQLKDTQLHLDDALRGQEDLKEQLAIVERRANLLQAEVEELRATLEQTE RARKLAEQELLDSNERVQLLHTQNTSLIHTKKKLETDLMQLQSEVEDASRDARNAEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNL EQTVKDLQHRLDEAEQLALKGGKKQIQKLETRIRELEFELEGEQKKNTESVKGLRKYERRVKELTYQSEEDRKNVLRLQDLVDKLQVKVK	693

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MAP2K4_pLDDT.png

MYH3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAP2K4
MYH3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MAP2K4-MYH3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAP2K4-MYH3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source