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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAP3K3-BRIP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAP3K3-BRIP1
	FusionPDB ID: 51303
	FusionGDB2.0 ID: 51303
		Hgene	Tgene
	Gene symbol	MAP3K3	BRIP1
	Gene ID	4215	83990
	Gene name	mitogen-activated protein kinase kinase kinase 3	BRCA1 interacting protein C-terminal helicase 1
	Synonyms	MAPKKK3\|MEKK3	BACH1\|FANCJ\|OF
	Cytomap	17q23.3	17q23.2
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3	Fanconi anemia group J proteinATP-dependent RNA helicase BRIP1BRCA1-associated C-terminal helicase 1BRCA1-binding helicase-like protein BACH1BRCA1/BRCA2-associated helicase 1
	Modification date	20200313	20200315
	UniProtAcc	Q99759	Q9BX63
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000361357, ENST00000361733, ENST00000577395, ENST00000579585, ENST00000584573, ENST00000577784,	ENST00000583837, ENST00000259008, ENST00000577598,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 10 X 8=800	12 X 15 X 7=1260
	# samples	13	13
	** MAII score	log2(13/800*10)=-2.62148837674627 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1260*10)=-3.27684020535882 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAP3K3 [Title/Abstract] AND BRIP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP3K3(61744420)-BRIP1(59763526), # samples:4
Anticipated loss of major functional domain due to fusion event.	MAP3K3-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K3-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K3-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K3-BRIP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAP3K3	GO:0035556	intracellular signal transduction	15001576
Hgene	MAP3K3	GO:0046777	protein autophosphorylation	15001576
Tgene	BRIP1	GO:0006357	regulation of transcription by RNA polymerase II	14504288

Fusion gene breakpoints across MAP3K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across BRIP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-2Z-A9JI-01A	MAP3K3	chr17	61744420	-	BRIP1	chr17	59763526	-
ChimerDB4	KIRP	TCGA-2Z-A9JI-01A	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-
ChimerDB4	KIRP	TCGA-2Z-A9JI	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000579585	MAP3K3	chr17	61744420	+	ENST00000259008	BRIP1	chr17	59763526	-	3866	661	66	1835	589
ENST00000579585	MAP3K3	chr17	61744420	+	ENST00000577598	BRIP1	chr17	59763526	-	2055	661	66	1070	334
ENST00000584573	MAP3K3	chr17	61744420	+	ENST00000259008	BRIP1	chr17	59763526	-	4135	930	335	2104	589
ENST00000584573	MAP3K3	chr17	61744420	+	ENST00000577598	BRIP1	chr17	59763526	-	2324	930	335	1339	334
ENST00000361733	MAP3K3	chr17	61744420	+	ENST00000259008	BRIP1	chr17	59763526	-	4027	822	320	1996	558
ENST00000361733	MAP3K3	chr17	61744420	+	ENST00000577598	BRIP1	chr17	59763526	-	2216	822	320	1231	303
ENST00000361357	MAP3K3	chr17	61744420	+	ENST00000259008	BRIP1	chr17	59763526	-	4118	913	318	2087	589
ENST00000361357	MAP3K3	chr17	61744420	+	ENST00000577598	BRIP1	chr17	59763526	-	2307	913	318	1322	334
ENST00000577395	MAP3K3	chr17	61744420	+	ENST00000259008	BRIP1	chr17	59763526	-	3757	552	50	1726	558
ENST00000577395	MAP3K3	chr17	61744420	+	ENST00000577598	BRIP1	chr17	59763526	-	1946	552	50	961	303

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000579585	ENST00000259008	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000381239	0.99961877
ENST00000579585	ENST00000577598	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000766804	0.99923325
ENST00000584573	ENST00000259008	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000425137	0.99957484
ENST00000584573	ENST00000577598	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000977732	0.99902225
ENST00000361733	ENST00000259008	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000625735	0.99937433
ENST00000361733	ENST00000577598	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.002130045	0.99786997
ENST00000361357	ENST00000259008	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000426178	0.99957377
ENST00000361357	ENST00000577598	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000969789	0.99903023
ENST00000577395	ENST00000259008	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.000563335	0.9994367
ENST00000577395	ENST00000577598	MAP3K3	chr17	61744420	+	BRIP1	chr17	59763526	-	0.001688099	0.9983119

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51303_51303_1_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361357_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=589AA_BP=199
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS
PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT
PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE
EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH

--------------------------------------------------------------

>51303_51303_2_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361357_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=334AA_BP=199
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS

--------------------------------------------------------------

>51303_51303_3_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361733_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=558AA_BP=168
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH
STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS
IISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTD
KCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPED
TDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEI

--------------------------------------------------------------

>51303_51303_4_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000361733_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=303AA_BP=168
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH
STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS

--------------------------------------------------------------

>51303_51303_5_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000577395_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=558AA_BP=168
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH
STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS
IISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKATPELGSSENSASSPPRFKTEKMESKTVLPFTD
KCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSEEDKQSTSNRDFETEAEDESIYFTPELYDPED
TDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILHIEESKIDDIDGNVKTTWINELELGKTHEIEI

--------------------------------------------------------------

>51303_51303_6_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000577395_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=303AA_BP=168
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAGDINTIYQPPEPRSRHLSVRLSKWVRQQIQHH
STFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLSPENFVEDEAKICVQELQCPKIITKNSPLPSS

--------------------------------------------------------------

>51303_51303_7_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000579585_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=589AA_BP=199
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS
PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT
PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE
EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH

--------------------------------------------------------------

>51303_51303_8_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000579585_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=334AA_BP=199
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS

--------------------------------------------------------------

>51303_51303_9_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000584573_BRIP1_chr17_59763526_ENST00000259008_length(amino acids)=589AA_BP=199
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS
PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT
PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE
EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH

--------------------------------------------------------------

>51303_51303_10_MAP3K3-BRIP1_MAP3K3_chr17_61744420_ENST00000584573_BRIP1_chr17_59763526_ENST00000577598_length(amino acids)=334AA_BP=199
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG
DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:61744420/chr17:59763526)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP3K3 Q99759	BRIP1 Q9BX63
FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269\|PubMed:12912994, ECO:0000269\|PubMed:14661019, ECO:0000269\|PubMed:14743216, ECO:0000269\|PubMed:9006902}.	FUNCTION: DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1. {ECO:0000269\|PubMed:11301010, ECO:0000269\|PubMed:14983014, ECO:0000269\|PubMed:16116421, ECO:0000269\|PubMed:16153896}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000361357

44_123

198.33333333333334

658.0

Domain

PB1

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000361733

44_123

167.33333333333334

627.0

Domain

PB1

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000579585

44_123

198.33333333333334

658.0

Domain

PB1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000361357

362_622

198.33333333333334

658.0

Domain

Protein kinase

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000361733

362_622

167.33333333333334

627.0

Domain

Protein kinase

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000579585

362_622

198.33333333333334

658.0

Domain

Protein kinase

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000361357

368_376

198.33333333333334

658.0

Nucleotide binding

ATP

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000361733

368_376

167.33333333333334

627.0

Nucleotide binding

ATP

Hgene

MAP3K3

chr17:61744420

chr17:59763526

ENST00000579585

368_376

198.33333333333334

658.0

Nucleotide binding

ATP

Tgene

BRIP1

chr17:61744420

chr17:59763526

ENST00000259008

11_442

858.3333333333334

1250.0

Domain

Helicase ATP-binding

Tgene

BRIP1

chr17:61744420

chr17:59763526

ENST00000259008

158_175

858.3333333333334

1250.0

Motif

Nuclear localization signal

Tgene

BRIP1

chr17:61744420

chr17:59763526

ENST00000259008

393_396

858.3333333333334

1250.0

Motif

Note=DEAH box

Tgene

BRIP1

chr17:61744420

chr17:59763526

ENST00000259008

185_192

858.3333333333334

1250.0

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1252_MAP3K3_61744420_BRIP1_59763526_1252_MAP3K3_61744420_BRIP1_59763526_ranked_0.pdb	MAP3K3	61744420	61744420	ENST00000577598	BRIP1	chr17	59763526	-	MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHNSSSPHSGVSRQVRIKASQSAG DINTIYQPPEPRSRHLSVRLSKWVRQQIQHHSTFESALESLAEFSKKHQKVLNVSIKDRTNIQDNESTLEVTSLKYSTSPYLLEAASHLS PENFVEDEAKICVQELQCPKIITKNSPLPSSIISRKEKNDPVFLEEAGKAEKIVISRSTSPTFNKQTKRVSWSSFNSLGQYFTGKIPKAT PELGSSENSASSPPRFKTEKMESKTVLPFTDKCESSNLTVNTSFGSCPQSETIISSLKIDATLTRKNHSEHPLCSEEALDPDIELSLVSE EDKQSTSNRDFETEAEDESIYFTPELYDPEDTDEEKNDLAETDRGNRLANNSDCILAKDLFEIRTIKEVDSAREVKAEDCIDTKLNGILH	589

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MAP3K3_pLDDT.png

BRIP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAP3K3
BRIP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MAP3K3-BRIP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAP3K3-BRIP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source