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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAP3K3-DDX42

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAP3K3-DDX42
FusionPDB ID: 51305
FusionGDB2.0 ID: 51305
HgeneTgene
Gene symbol

MAP3K3

DDX42

Gene ID

4215

11325

Gene namemitogen-activated protein kinase kinase kinase 3DEAD-box helicase 42
SynonymsMAPKKK3|MEKK3DDX42P|RHELP|RNAHP|SF3B8|SF3b125
Cytomap

17q23.3

17q23.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 3MAP/ERK kinase kinase 3MAPK/ERK kinase kinase 3MEK kinase 3MEKK 3ATP-dependent RNA helicase DDX42DEAD (Asp-Glu-Ala-Asp) box helicase 42DEAD (Asp-Glu-Ala-Asp) box polypeptide 42SF3b DEAD box proteinsplicing factor 3B-associated 125 kDa proteinsplicing factor 3b, subunit 8
Modification date2020031320200313
UniProtAcc

Q99759

Q86XP3

Ensembl transtripts involved in fusion geneENST idsENST00000361357, ENST00000361733, 
ENST00000577395, ENST00000579585, 
ENST00000584573, ENST00000577784, 
ENST00000582985, ENST00000578681, 
ENST00000583590, ENST00000359353, 
ENST00000389924, ENST00000457800, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 10 X 8=80015 X 18 X 10=2700
# samples 1318
** MAII scorelog2(13/800*10)=-2.62148837674627
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(18/2700*10)=-3.90689059560852
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAP3K3 [Title/Abstract] AND DDX42 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAP3K3(61735267)-DDX42(61886920), # samples:1
MAP3K3(61729953)-DDX42(61895627), # samples:1
Anticipated loss of major functional domain due to fusion event.MAP3K3-DDX42 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K3-DDX42 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K3-DDX42 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K3-DDX42 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K3-DDX42 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
MAP3K3-DDX42 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
MAP3K3-DDX42 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K3

GO:0035556

intracellular signal transduction

15001576

HgeneMAP3K3

GO:0046777

protein autophosphorylation

15001576

TgeneDDX42

GO:0008104

protein localization

19377511


check buttonFusion gene breakpoints across MAP3K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DDX42 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerKB4..MAP3K3chr17

61729916

+DDX42chr17

61729916

+
ChiTaRS5.0N/AKF612910MAP3K3chr17

61735267

+DDX42chr17

61886920

+
ChiTaRS5.0N/AKF612911MAP3K3chr17

61729953

+DDX42chr17

61895627

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000579585MAP3K3chr1761735267+ENST00000578681DDX42chr1761886920+3124540662204712
ENST00000579585MAP3K3chr1761735267+ENST00000583590DDX42chr1761886920+3124540662204712
ENST00000579585MAP3K3chr1761735267+ENST00000359353DDX42chr1761886920+2205540662204712
ENST00000579585MAP3K3chr1761735267+ENST00000389924DDX42chr1761886920+3123540662204712
ENST00000579585MAP3K3chr1761735267+ENST00000457800DDX42chr1761886920+3123540662204712
ENST00000584573MAP3K3chr1761735267+ENST00000578681DDX42chr1761886920+33938093352473712
ENST00000584573MAP3K3chr1761735267+ENST00000583590DDX42chr1761886920+33938093352473712
ENST00000584573MAP3K3chr1761735267+ENST00000359353DDX42chr1761886920+24748093352473713
ENST00000584573MAP3K3chr1761735267+ENST00000389924DDX42chr1761886920+33928093352473712
ENST00000584573MAP3K3chr1761735267+ENST00000457800DDX42chr1761886920+33928093352473712
ENST00000361733MAP3K3chr1761735267+ENST00000578681DDX42chr1761886920+32857013202365681
ENST00000361733MAP3K3chr1761735267+ENST00000583590DDX42chr1761886920+32857013202365681
ENST00000361733MAP3K3chr1761735267+ENST00000359353DDX42chr1761886920+23667013202365682
ENST00000361733MAP3K3chr1761735267+ENST00000389924DDX42chr1761886920+32847013202365681
ENST00000361733MAP3K3chr1761735267+ENST00000457800DDX42chr1761886920+32847013202365681
ENST00000361357MAP3K3chr1761735267+ENST00000578681DDX42chr1761886920+33767923182456712
ENST00000361357MAP3K3chr1761735267+ENST00000583590DDX42chr1761886920+33767923182456712
ENST00000361357MAP3K3chr1761735267+ENST00000359353DDX42chr1761886920+24577923182456712
ENST00000361357MAP3K3chr1761735267+ENST00000389924DDX42chr1761886920+33757923182456712
ENST00000361357MAP3K3chr1761735267+ENST00000457800DDX42chr1761886920+33757923182456712
ENST00000577395MAP3K3chr1761735267+ENST00000578681DDX42chr1761886920+3015431502095681
ENST00000577395MAP3K3chr1761735267+ENST00000583590DDX42chr1761886920+3015431502095681
ENST00000577395MAP3K3chr1761735267+ENST00000359353DDX42chr1761886920+2096431502095682
ENST00000577395MAP3K3chr1761735267+ENST00000389924DDX42chr1761886920+3014431502095681
ENST00000577395MAP3K3chr1761735267+ENST00000457800DDX42chr1761886920+3014431502095681
ENST00000579585MAP3K3chr1761729953+ENST00000359353DDX42chr1761895627+5203896634191
ENST00000579585MAP3K3chr1761729953+ENST00000389924DDX42chr1761895627+14383896634191
ENST00000579585MAP3K3chr1761729953+ENST00000457800DDX42chr1761895627+14383896634191
ENST00000584573MAP3K3chr1761729953+ENST00000359353DDX42chr1761895627+7896583620121
ENST00000584573MAP3K3chr1761729953+ENST00000389924DDX42chr1761895627+17076583620121
ENST00000584573MAP3K3chr1761729953+ENST00000457800DDX42chr1761895627+17076583620121
ENST00000361733MAP3K3chr1761729953+ENST00000359353DDX42chr1761895627+6815503470116
ENST00000361733MAP3K3chr1761729953+ENST00000389924DDX42chr1761895627+15995503470116
ENST00000361733MAP3K3chr1761729953+ENST00000457800DDX42chr1761895627+15995503470116
ENST00000361357MAP3K3chr1761729953+ENST00000359353DDX42chr1761895627+7726413451115
ENST00000361357MAP3K3chr1761729953+ENST00000389924DDX42chr1761895627+16906413451115
ENST00000361357MAP3K3chr1761729953+ENST00000457800DDX42chr1761895627+16906413451115
ENST00000577395MAP3K3chr1761729953+ENST00000359353DDX42chr1761895627+41128040616480
ENST00000577395MAP3K3chr1761729953+ENST00000389924DDX42chr1761895627+1329280831108885
ENST00000577395MAP3K3chr1761729953+ENST00000457800DDX42chr1761895627+1329280831108885

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000579585ENST00000578681MAP3K3chr1761735267+DDX42chr1761886920+0.0011558390.99884415
ENST00000579585ENST00000583590MAP3K3chr1761735267+DDX42chr1761886920+0.0011558390.99884415
ENST00000579585ENST00000359353MAP3K3chr1761735267+DDX42chr1761886920+0.0033625530.99663746
ENST00000579585ENST00000389924MAP3K3chr1761735267+DDX42chr1761886920+0.0011494280.9988506
ENST00000579585ENST00000457800MAP3K3chr1761735267+DDX42chr1761886920+0.0011494280.9988506
ENST00000584573ENST00000578681MAP3K3chr1761735267+DDX42chr1761886920+0.0014167690.9985832
ENST00000584573ENST00000583590MAP3K3chr1761735267+DDX42chr1761886920+0.0014167690.9985832
ENST00000584573ENST00000359353MAP3K3chr1761735267+DDX42chr1761886920+0.0038100940.99618983
ENST00000584573ENST00000389924MAP3K3chr1761735267+DDX42chr1761886920+0.001408670.99859136
ENST00000584573ENST00000457800MAP3K3chr1761735267+DDX42chr1761886920+0.001408670.99859136
ENST00000361733ENST00000578681MAP3K3chr1761735267+DDX42chr1761886920+0.0012598770.99874014
ENST00000361733ENST00000583590MAP3K3chr1761735267+DDX42chr1761886920+0.0012598770.99874014
ENST00000361733ENST00000359353MAP3K3chr1761735267+DDX42chr1761886920+0.0034588740.9965411
ENST00000361733ENST00000389924MAP3K3chr1761735267+DDX42chr1761886920+0.0012525970.99874735
ENST00000361733ENST00000457800MAP3K3chr1761735267+DDX42chr1761886920+0.0012525970.99874735
ENST00000361357ENST00000578681MAP3K3chr1761735267+DDX42chr1761886920+0.0014778070.9985222
ENST00000361357ENST00000583590MAP3K3chr1761735267+DDX42chr1761886920+0.0014778070.9985222
ENST00000361357ENST00000359353MAP3K3chr1761735267+DDX42chr1761886920+0.0039044620.9960956
ENST00000361357ENST00000389924MAP3K3chr1761735267+DDX42chr1761886920+0.0014693720.9985306
ENST00000361357ENST00000457800MAP3K3chr1761735267+DDX42chr1761886920+0.0014693720.9985306
ENST00000577395ENST00000578681MAP3K3chr1761735267+DDX42chr1761886920+0.001009390.9989906
ENST00000577395ENST00000583590MAP3K3chr1761735267+DDX42chr1761886920+0.001009390.9989906
ENST00000577395ENST00000359353MAP3K3chr1761735267+DDX42chr1761886920+0.0028670210.997133
ENST00000577395ENST00000389924MAP3K3chr1761735267+DDX42chr1761886920+0.00100350.99899656
ENST00000577395ENST00000457800MAP3K3chr1761735267+DDX42chr1761886920+0.00100350.99899656
ENST00000579585ENST00000359353MAP3K3chr1761729953+DDX42chr1761895627+0.085748030.9142519
ENST00000579585ENST00000389924MAP3K3chr1761729953+DDX42chr1761895627+0.0852910650.9147089
ENST00000579585ENST00000457800MAP3K3chr1761729953+DDX42chr1761895627+0.0852910650.9147089
ENST00000584573ENST00000359353MAP3K3chr1761729953+DDX42chr1761895627+0.1100951950.88990486
ENST00000584573ENST00000389924MAP3K3chr1761729953+DDX42chr1761895627+0.08116120.9188388
ENST00000584573ENST00000457800MAP3K3chr1761729953+DDX42chr1761895627+0.08116120.9188388
ENST00000361733ENST00000359353MAP3K3chr1761729953+DDX42chr1761895627+0.143026580.85697347
ENST00000361733ENST00000389924MAP3K3chr1761729953+DDX42chr1761895627+0.600008960.39999107
ENST00000361733ENST00000457800MAP3K3chr1761729953+DDX42chr1761895627+0.600008960.39999107
ENST00000361357ENST00000359353MAP3K3chr1761729953+DDX42chr1761895627+0.1070929840.892907
ENST00000361357ENST00000389924MAP3K3chr1761729953+DDX42chr1761895627+0.122682660.8773173
ENST00000361357ENST00000457800MAP3K3chr1761729953+DDX42chr1761895627+0.122682660.8773173
ENST00000577395ENST00000359353MAP3K3chr1761729953+DDX42chr1761895627+0.096965530.9030345
ENST00000577395ENST00000389924MAP3K3chr1761729953+DDX42chr1761895627+0.649361850.3506382
ENST00000577395ENST00000457800MAP3K3chr1761729953+DDX42chr1761895627+0.649361850.3506382

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51305_51305_1_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000361357_DDX42_chr17_61895627_ENST00000359353_length(amino acids)=115AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_2_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000361357_DDX42_chr17_61895627_ENST00000389924_length(amino acids)=115AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_3_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000361357_DDX42_chr17_61895627_ENST00000457800_length(amino acids)=115AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_4_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000361733_DDX42_chr17_61895627_ENST00000359353_length(amino acids)=116AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_5_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000361733_DDX42_chr17_61895627_ENST00000389924_length(amino acids)=116AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_6_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000361733_DDX42_chr17_61895627_ENST00000457800_length(amino acids)=116AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_7_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000577395_DDX42_chr17_61895627_ENST00000359353_length(amino acids)=80AA_BP=1

--------------------------------------------------------------

>51305_51305_8_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000577395_DDX42_chr17_61895627_ENST00000389924_length(amino acids)=85AA_BP=

--------------------------------------------------------------

>51305_51305_9_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000577395_DDX42_chr17_61895627_ENST00000457800_length(amino acids)=85AA_BP=

--------------------------------------------------------------

>51305_51305_10_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000579585_DDX42_chr17_61895627_ENST00000359353_length(amino acids)=91AA_BP=
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRWST

--------------------------------------------------------------

>51305_51305_11_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000579585_DDX42_chr17_61895627_ENST00000389924_length(amino acids)=91AA_BP=
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRWST

--------------------------------------------------------------

>51305_51305_12_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000579585_DDX42_chr17_61895627_ENST00000457800_length(amino acids)=91AA_BP=
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRWST

--------------------------------------------------------------

>51305_51305_13_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000584573_DDX42_chr17_61895627_ENST00000359353_length(amino acids)=121AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_14_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000584573_DDX42_chr17_61895627_ENST00000389924_length(amino acids)=121AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_15_MAP3K3-DDX42_MAP3K3_chr17_61729953_ENST00000584573_DDX42_chr17_61895627_ENST00000457800_length(amino acids)=121AA_BP=
MSSMPPVRPWWRWRRRWLRSVSVTSAAGAACRGPGRRGRQRAWLRAGGAGCALGPRRLPRLRLRLRPRPGAVASAGWPATSRALLGSAQP

--------------------------------------------------------------

>51305_51305_16_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361357_DDX42_chr17_61886920_ENST00000359353_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_17_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361357_DDX42_chr17_61886920_ENST00000389924_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_18_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361357_DDX42_chr17_61886920_ENST00000457800_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_19_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361357_DDX42_chr17_61886920_ENST00000578681_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_20_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361357_DDX42_chr17_61886920_ENST00000583590_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_21_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361733_DDX42_chr17_61886920_ENST00000359353_length(amino acids)=682AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_22_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361733_DDX42_chr17_61886920_ENST00000389924_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_23_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361733_DDX42_chr17_61886920_ENST00000457800_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_24_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361733_DDX42_chr17_61886920_ENST00000578681_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_25_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000361733_DDX42_chr17_61886920_ENST00000583590_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_26_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000577395_DDX42_chr17_61886920_ENST00000359353_length(amino acids)=682AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_27_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000577395_DDX42_chr17_61886920_ENST00000389924_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_28_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000577395_DDX42_chr17_61886920_ENST00000457800_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_29_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000577395_DDX42_chr17_61886920_ENST00000578681_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_30_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000577395_DDX42_chr17_61886920_ENST00000583590_length(amino acids)=681AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQSDVRIKFEHNGERRIIAFSRPVKYEDVEHKVTTVFGQPLDLHYMNNEL
SILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLF
SATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVTKKANAEELANNLKQEGHNLGL
LHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLTPKDSNFAGDLVRNL
EGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNNNVMSNYEAYKPSTGAMGDRLTAMKAAFQSQY
KSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGFGNTGNISGAPVTYPSAGAQGVNNTASGNNSR
EGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDGHRHGENRHGGSAGRHGENRGANDGRNGESRK

--------------------------------------------------------------

>51305_51305_31_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000579585_DDX42_chr17_61886920_ENST00000359353_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_32_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000579585_DDX42_chr17_61886920_ENST00000389924_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_33_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000579585_DDX42_chr17_61886920_ENST00000457800_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_34_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000579585_DDX42_chr17_61886920_ENST00000578681_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_35_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000579585_DDX42_chr17_61886920_ENST00000583590_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_36_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000584573_DDX42_chr17_61886920_ENST00000359353_length(amino acids)=713AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_37_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000584573_DDX42_chr17_61886920_ENST00000389924_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_38_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000584573_DDX42_chr17_61886920_ENST00000457800_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_39_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000584573_DDX42_chr17_61886920_ENST00000578681_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

>51305_51305_40_MAP3K3-DDX42_MAP3K3_chr17_61735267_ENST00000584573_DDX42_chr17_61886920_ENST00000583590_length(amino acids)=712AA_BP=1
MDEQEALNSIMNDLVALQMNRRHRMPGYETMKNKDTGHSNRQKKHNSSSSALLNSPTVTTSSCAGASEKKKFLSDVRIKFEHNGERRIIA
FSRPVKYEDVEHKVTTVFGQPLDLHYMNNELSILLKNQDDLDKAIDILDRSSSMKSLRILLLSQDRNHGRLIDHVKKKATNLQRVSYLVF
DEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATFRKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFT
SSGSVLLFVTKKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFKKKDIPVLVATDVAARGLDIPSIKTVINYDVARDIDTHTHRI
GRTGRAGEKGVAYTLLTPKDSNFAGDLVRNLEGANQHVSKELLDLAMQNAWFRKSRFKGGKGKKLNIGGGGLGYRERPGLGSENMDRGNN
NVMSNYEAYKPSTGAMGDRLTAMKAAFQSQYKSHFVAASLSNQKAGSSAAGASGWTSAGSLNSVPTNSAQQGHNSPDSPVTSAAKGIPGF
GNTGNISGAPVTYPSAGAQGVNNTASGNNSREGTGGSNGKRERYTENRGSSRHSHGETGNRHSDSPRHGDGGRHGDGYRHPESSSRHTDG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:61735267/chr17:61886920)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K3

Q99759

DDX42

Q86XP3

FUNCTION: Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators. {ECO:0000269|PubMed:12912994, ECO:0000269|PubMed:14661019, ECO:0000269|PubMed:14743216, ECO:0000269|PubMed:9006902}.FUNCTION: ATP-dependent RNA helicase. Binds to partially double-stranded RNAs (dsRNAs) in order to unwind RNA secondary structures. Unwinding is promoted in the presence of single-strand binding proteins. Mediates also RNA duplex formation thereby displacing the single-strand RNA binding protein. ATP and ADP modulate its activity: ATP binding and hydrolysis by DDX42 triggers RNA strand separation, whereas the ADP-bound form of the protein triggers annealing of complementary RNA strands. Involved in the survival of cells by interacting with TP53BP2 and thereby counteracting the apoptosis-stimulating activity of TP53BP2. Relocalizes TP53BP2 to the cytoplasm. {ECO:0000269|PubMed:16397294, ECO:0000269|PubMed:19377511}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000361357+61744_123158.0658.0DomainPB1
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000361733+51644_123127.0627.0DomainPB1
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000579585+71844_123158.0658.0DomainPB1
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017116_1570820.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018116_1570939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017116_1570.0939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019116_1570939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019116_1570939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017175_1780820.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61729953chr17:61895627ENST0000035935301743_460820.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017654_6590820.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017762_8830820.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017819_8710820.0Compositional biasNote=His-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018175_1780939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61729953chr17:61895627ENST0000038992401843_460939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018654_6590939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018762_8830939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018819_8710939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017175_1780.0939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61729953chr17:61895627ENST0000045780001743_460.0939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017654_6590.0939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017762_8830.0939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017819_8710.0939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019175_1780939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61729953chr17:61895627ENST0000057868101943_460939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019654_6590939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019762_8830939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019819_8710939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019175_1780939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61729953chr17:61895627ENST0000058359001943_460939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019654_6590939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019762_8830939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019819_8710939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817654_659265.0820.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817762_883265.0820.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817819_871265.0820.0Compositional biasNote=His-rich
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918654_659384.0939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918762_883384.0939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918819_871384.0939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817654_659384.0939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817762_883384.0939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817819_871384.0939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019654_659384.0939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019762_883384.0939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019819_871384.0939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019654_659384.0939.0Compositional biasNote=Poly-Gly
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019762_883384.0939.0Compositional biasNote=Gly-rich
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019819_871384.0939.0Compositional biasNote=His-rich
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017284_4590820.0DomainHelicase ATP-binding
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017487_6320820.0DomainHelicase C-terminal
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018284_4590939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018487_6320939.0DomainHelicase C-terminal
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017284_4590.0939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017487_6320.0939.0DomainHelicase C-terminal
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019284_4590939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019487_6320939.0DomainHelicase C-terminal
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019284_4590939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019487_6320939.0DomainHelicase C-terminal
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817284_459265.0820.0DomainHelicase ATP-binding
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817487_632265.0820.0DomainHelicase C-terminal
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918487_632384.0939.0DomainHelicase C-terminal
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817487_632384.0939.0DomainHelicase C-terminal
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019487_632384.0939.0DomainHelicase C-terminal
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019487_632384.0939.0DomainHelicase C-terminal
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017253_2810820.0MotifNote=Q motif
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017407_4100820.0MotifNote=DEAD box
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018253_2810939.0MotifNote=Q motif
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018407_4100939.0MotifNote=DEAD box
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017253_2810.0939.0MotifNote=Q motif
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017407_4100.0939.0MotifNote=DEAD box
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019253_2810939.0MotifNote=Q motif
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019407_4100939.0MotifNote=DEAD box
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019253_2810939.0MotifNote=Q motif
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019407_4100939.0MotifNote=DEAD box
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817407_410265.0820.0MotifNote=DEAD box
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918407_410384.0939.0MotifNote=DEAD box
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817407_410384.0939.0MotifNote=DEAD box
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019407_410384.0939.0MotifNote=DEAD box
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019407_410384.0939.0MotifNote=DEAD box
TgeneDDX42chr17:61729953chr17:61895627ENST00000359353017297_3040820.0Nucleotide bindingATP
TgeneDDX42chr17:61729953chr17:61895627ENST00000389924018297_3040939.0Nucleotide bindingATP
TgeneDDX42chr17:61729953chr17:61895627ENST00000457800017297_3040.0939.0Nucleotide bindingATP
TgeneDDX42chr17:61729953chr17:61895627ENST00000578681019297_3040939.0Nucleotide bindingATP
TgeneDDX42chr17:61729953chr17:61895627ENST00000583590019297_3040939.0Nucleotide bindingATP
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817297_304265.0820.0Nucleotide bindingATP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000361357+117362_6220658.0DomainProtein kinase
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000361357+11744_1230658.0DomainPB1
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000361733+116362_6220627.0DomainProtein kinase
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000361733+11644_1230627.0DomainPB1
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000579585+118362_6220658.0DomainProtein kinase
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000579585+11844_1230658.0DomainPB1
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000361357+617362_622158.0658.0DomainProtein kinase
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000361733+516362_622127.0627.0DomainProtein kinase
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000579585+718362_622158.0658.0DomainProtein kinase
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000361357+117368_3760658.0Nucleotide bindingATP
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000361733+116368_3760627.0Nucleotide bindingATP
HgeneMAP3K3chr17:61729953chr17:61895627ENST00000579585+118368_3760658.0Nucleotide bindingATP
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000361357+617368_376158.0658.0Nucleotide bindingATP
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000361733+516368_376127.0627.0Nucleotide bindingATP
HgeneMAP3K3chr17:61735267chr17:61886920ENST00000579585+718368_376158.0658.0Nucleotide bindingATP
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817116_157265.0820.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918116_157384.0939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817116_157384.0939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019116_157384.0939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019116_157384.0939.0Coiled coilOntology_term=ECO:0000255
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817175_178265.0820.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61735267chr17:61886920ENST0000035935381743_46265.0820.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918175_178384.0939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61735267chr17:61886920ENST0000038992491843_46384.0939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817175_178384.0939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61735267chr17:61886920ENST0000045780081743_46384.0939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019175_178384.0939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61735267chr17:61886920ENST00000578681101943_46384.0939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019175_178384.0939.0Compositional biasNote=Poly-Glu
TgeneDDX42chr17:61735267chr17:61886920ENST00000583590101943_46384.0939.0Compositional biasNote=Poly-Ser
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918284_459384.0939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817284_459384.0939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019284_459384.0939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019284_459384.0939.0DomainHelicase ATP-binding
TgeneDDX42chr17:61735267chr17:61886920ENST00000359353817253_281265.0820.0MotifNote=Q motif
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918253_281384.0939.0MotifNote=Q motif
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817253_281384.0939.0MotifNote=Q motif
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019253_281384.0939.0MotifNote=Q motif
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019253_281384.0939.0MotifNote=Q motif
TgeneDDX42chr17:61735267chr17:61886920ENST00000389924918297_304384.0939.0Nucleotide bindingATP
TgeneDDX42chr17:61735267chr17:61886920ENST00000457800817297_304384.0939.0Nucleotide bindingATP
TgeneDDX42chr17:61735267chr17:61886920ENST000005786811019297_304384.0939.0Nucleotide bindingATP
TgeneDDX42chr17:61735267chr17:61886920ENST000005835901019297_304384.0939.0Nucleotide bindingATP


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAP3K3
DDX42


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to MAP3K3-DDX42


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAP3K3-DDX42


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource