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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAP3K7-DCTN4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAP3K7-DCTN4
	FusionPDB ID: 51347
	FusionGDB2.0 ID: 51347
		Hgene	Tgene
	Gene symbol	MAP3K7	DCTN4
	Gene ID	6885	51164
	Gene name	mitogen-activated protein kinase kinase kinase 7	dynactin subunit 4
	Synonyms	CSCF\|FMD2\|MEKK7\|TAK1\|TGF1a	DYN4\|P62
	Cytomap	6q15	5q33.1
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1	dynactin subunit 4dynactin 4 (p62)dynactin p62 subunitdynactin subunit p62
	Modification date	20200313	20200313
	UniProtAcc	P57077	Q9UJW0
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000369320, ENST00000369325, ENST00000369327, ENST00000369329, ENST00000369332, ENST00000479630,	ENST00000521093, ENST00000424236, ENST00000446090, ENST00000447998,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 8 X 6=432	5 X 7 X 4=140
	# samples	10	7
	** MAII score	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAP3K7 [Title/Abstract] AND DCTN4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP3K7(91256976)-DCTN4(150110302), # samples:1
Anticipated loss of major functional domain due to fusion event.	MAP3K7-DCTN4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K7-DCTN4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K7-DCTN4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. MAP3K7-DCTN4 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. MAP3K7-DCTN4 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. MAP3K7-DCTN4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAP3K7	GO:0000186	activation of MAPKK activity	8663074\|9079627
Hgene	MAP3K7	GO:0000187	activation of MAPK activity	9079627
Hgene	MAP3K7	GO:0007252	I-kappaB phosphorylation	11460167
Hgene	MAP3K7	GO:0007254	JNK cascade	9079627
Hgene	MAP3K7	GO:0043507	positive regulation of JUN kinase activity	11460167
Hgene	MAP3K7	GO:0043966	histone H3 acetylation	18838386
Hgene	MAP3K7	GO:0051403	stress-activated MAPK cascade	9079627

Fusion gene breakpoints across MAP3K7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DCTN4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-B6-A401	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369325	MAP3K7	chr6	91256976	-	ENST00000447998	DCTN4	chr5	150110302	-	4578	1210	0	1868	622
ENST00000369325	MAP3K7	chr6	91256976	-	ENST00000424236	DCTN4	chr5	150110302	-	4270	1210	0	1868	622
ENST00000369325	MAP3K7	chr6	91256976	-	ENST00000446090	DCTN4	chr5	150110302	-	2160	1210	0	1868	622
ENST00000369327	MAP3K7	chr6	91256976	-	ENST00000447998	DCTN4	chr5	150110302	-	4584	1216	6	1874	622
ENST00000369327	MAP3K7	chr6	91256976	-	ENST00000424236	DCTN4	chr5	150110302	-	4276	1216	6	1874	622
ENST00000369327	MAP3K7	chr6	91256976	-	ENST00000446090	DCTN4	chr5	150110302	-	2166	1216	6	1874	622
ENST00000369332	MAP3K7	chr6	91256976	-	ENST00000447998	DCTN4	chr5	150110302	-	4740	1372	114	2030	638
ENST00000369332	MAP3K7	chr6	91256976	-	ENST00000424236	DCTN4	chr5	150110302	-	4432	1372	114	2030	638
ENST00000369332	MAP3K7	chr6	91256976	-	ENST00000446090	DCTN4	chr5	150110302	-	2322	1372	114	2030	638
ENST00000369329	MAP3K7	chr6	91256976	-	ENST00000447998	DCTN4	chr5	150110302	-	4740	1372	114	2030	638
ENST00000369329	MAP3K7	chr6	91256976	-	ENST00000424236	DCTN4	chr5	150110302	-	4432	1372	114	2030	638
ENST00000369329	MAP3K7	chr6	91256976	-	ENST00000446090	DCTN4	chr5	150110302	-	2322	1372	114	2030	638

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369325	ENST00000447998	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000197853	0.9998022
ENST00000369325	ENST00000424236	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000196079	0.99980396
ENST00000369325	ENST00000446090	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000710487	0.9992895
ENST00000369327	ENST00000447998	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000199569	0.9998005
ENST00000369327	ENST00000424236	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000197377	0.99980265
ENST00000369327	ENST00000446090	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.00071239	0.99928766
ENST00000369332	ENST00000447998	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000203163	0.9997968
ENST00000369332	ENST00000424236	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000204818	0.99979526
ENST00000369332	ENST00000446090	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000682414	0.99931765
ENST00000369329	ENST00000447998	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000203163	0.9997968
ENST00000369329	ENST00000424236	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000204818	0.99979526
ENST00000369329	ENST00000446090	MAP3K7	chr6	91256976	-	DCTN4	chr5	150110302	-	0.000682414	0.99931765

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51347_51347_1_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369325_DCTN4_chr5_150110302_ENST00000424236_length(amino acids)=622AA_BP=403
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV
KLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKD
PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPE
FNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDE

--------------------------------------------------------------

>51347_51347_2_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369325_DCTN4_chr5_150110302_ENST00000446090_length(amino acids)=622AA_BP=403
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV
KLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKD
PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPE
FNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDE

--------------------------------------------------------------

>51347_51347_3_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369325_DCTN4_chr5_150110302_ENST00000447998_length(amino acids)=622AA_BP=403
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV
KLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKD
PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPE
FNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDE

--------------------------------------------------------------

>51347_51347_4_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369327_DCTN4_chr5_150110302_ENST00000424236_length(amino acids)=622AA_BP=403
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV
KLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKD
PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPE
FNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDE

--------------------------------------------------------------

>51347_51347_5_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369327_DCTN4_chr5_150110302_ENST00000446090_length(amino acids)=622AA_BP=403
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV
KLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKD
PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPE
FNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDE

--------------------------------------------------------------

>51347_51347_6_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369327_DCTN4_chr5_150110302_ENST00000447998_length(amino acids)=622AA_BP=403
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAFIVELRQLSRVNHPNIV
KLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLLVAGGTVLKICDFGTAC
DIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKNLPKPIESLMTRCWSKD
PSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDTIKRLESKLLKNQAKQQ
SESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIKRSLRCRKCEHNLSKPE
FNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPPKELVLAGKDAAAEYDE

--------------------------------------------------------------

>51347_51347_7_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369329_DCTN4_chr5_150110302_ENST00000424236_length(amino acids)=638AA_BP=419
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF
IVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
VAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN
LPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDT
IKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIK
RSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPP
KELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVE

--------------------------------------------------------------

>51347_51347_8_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369329_DCTN4_chr5_150110302_ENST00000446090_length(amino acids)=638AA_BP=419
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF
IVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
VAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN
LPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDT
IKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIK
RSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPP
KELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVE

--------------------------------------------------------------

>51347_51347_9_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369329_DCTN4_chr5_150110302_ENST00000447998_length(amino acids)=638AA_BP=419
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF
IVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
VAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN
LPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDT
IKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIK
RSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPP
KELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVE

--------------------------------------------------------------

>51347_51347_10_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369332_DCTN4_chr5_150110302_ENST00000424236_length(amino acids)=638AA_BP=419
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF
IVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
VAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN
LPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDT
IKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIK
RSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPP
KELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVE

--------------------------------------------------------------

>51347_51347_11_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369332_DCTN4_chr5_150110302_ENST00000446090_length(amino acids)=638AA_BP=419
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF
IVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
VAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN
LPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDT
IKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIK
RSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPP
KELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVE

--------------------------------------------------------------

>51347_51347_12_MAP3K7-DCTN4_MAP3K7_chr6_91256976_ENST00000369332_DCTN4_chr5_150110302_ENST00000447998_length(amino acids)=638AA_BP=419
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEVVGRGAFGVVCKAKWRAKDVAIKQIESESERKAF
IVELRQLSRVNHPNIVKLYGACLNPVCLVMEYAEGGSLYNVLHGAEPLPYYTAAHAMSWCLQCSQGVAYLHSMQPKALIHRDLKPPNLLL
VAGGTVLKICDFGTACDIQTHMTNNKGSAAWMAPEVFEGSNYSEKCDVFSWGIILWEVITRRKPFDEIGGPAFRIMWAVHNGTRPPLIKN
LPKPIESLMTRCWSKDPSQRPSMEEIVKIMTHLMRYFPGADEPLQYPCQYSDEGQSNSATSTGSFMDIASTNTSNKSDTNMEQVPATNDT
IKRLESKLLKNQAKQQSESGRLSLGASRGSSVESLPPTSEGKRMSADMSEIEARIAATTVTTLQQRLLQPDFQPVCASQLYPRHKHLLIK
RSLRCRKCEHNLSKPEFNPTSIKFKIQLVAVNYIPEVRIMSIPNLRYMKESQVLLTLTNPVENLTHVTLFECEEGDPDDINSTAKVVVPP
KELVLAGKDAAAEYDELAEPQDFQDDPDIIAFRKANKVGIFIKVTPQREEGEVTVCFKMKHDFKNLAAPIRPIEESDQGTEVIWLTQHVE

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:91256976/chr5:150110302)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP3K7 P57077	DCTN4 Q9UJW0
	FUNCTION: Could have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Could be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369325

8_14

403.3333333333333

519.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369327

8_14

403.3333333333333

492.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369329

8_14

403.3333333333333

607.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369332

8_14

403.3333333333333

580.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369325

36_291

403.3333333333333

519.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369327

36_291

403.3333333333333

492.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369329

36_291

403.3333333333333

607.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369332

36_291

403.3333333333333

580.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369325

42_50

403.3333333333333

519.0

Nucleotide binding

ATP

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369327

42_50

403.3333333333333

492.0

Nucleotide binding

ATP

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369329

42_50

403.3333333333333

607.0

Nucleotide binding

ATP

Hgene

MAP3K7

chr6:91256976

chr5:150110302

ENST00000369332

42_50

403.3333333333333

580.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DCTN4

chr6:91256976

chr5:150110302

ENST00000424236

152_172

184.33333333333334

404.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DCTN4

chr6:91256976

chr5:150110302

ENST00000446090

152_172

248.33333333333334

468.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

DCTN4

chr6:91256976

chr5:150110302

ENST00000447998

152_172

241.33333333333334

461.0

Coiled coil

Ontology_term=ECO:0000255

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAP3K7
DCTN4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MAP3K7-DCTN4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAP3K7-DCTN4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source