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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MAP3K7-KIAA1009

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MAP3K7-KIAA1009
FusionPDB ID: 51349
FusionGDB2.0 ID: 51349
HgeneTgene
Gene symbol

MAP3K7

KIAA1009

Gene ID

6885

22832

Gene namemitogen-activated protein kinase kinase kinase 7centrosomal protein 162
SynonymsCSCF|FMD2|MEKK7|TAK1|TGF1aC6orf84|KIAA1009|QN1
Cytomap

6q15

6q14.2-q14.3

Type of geneprotein-codingprotein-coding
Descriptionmitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1centrosomal protein of 162 kDacentrosomal protein 162kDaprotein QN1 homolog
Modification date2020031320200320
UniProtAcc

P57077

.
Ensembl transtripts involved in fusion geneENST idsENST00000369325, ENST00000369327, 
ENST00000369329, ENST00000369332, 
ENST00000369320, ENST00000479630, 
ENST00000461137, ENST00000257766, 
ENST00000403245, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 8 X 6=4323 X 3 X 2=18
# samples 103
** MAII scorelog2(10/432*10)=-2.11103131238874
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MAP3K7 [Title/Abstract] AND KIAA1009 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MAP3K7(91296482)-KIAA1009(84872989), # samples:2
Anticipated loss of major functional domain due to fusion event.MAP3K7-KIAA1009 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K7-KIAA1009 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K7-KIAA1009 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MAP3K7-KIAA1009 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMAP3K7

GO:0000186

activation of MAPKK activity

8663074|9079627

HgeneMAP3K7

GO:0000187

activation of MAPK activity

9079627

HgeneMAP3K7

GO:0007252

I-kappaB phosphorylation

11460167

HgeneMAP3K7

GO:0007254

JNK cascade

9079627

HgeneMAP3K7

GO:0043507

positive regulation of JUN kinase activity

11460167

HgeneMAP3K7

GO:0043966

histone H3 acetylation

18838386

HgeneMAP3K7

GO:0051403

stress-activated MAPK cascade

9079627


check buttonFusion gene breakpoints across MAP3K7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIAA1009 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-VR-A8EXMAP3K7chr6

91296482

-KIAA1009chr6

84872989

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369325MAP3K7chr691296482-ENST00000257766KIAA1009chr684872989-277612001946648
ENST00000369325MAP3K7chr691296482-ENST00000403245KIAA1009chr684872989-277612001946648
ENST00000369327MAP3K7chr691296482-ENST00000257766KIAA1009chr684872989-278212661952648
ENST00000369327MAP3K7chr691296482-ENST00000403245KIAA1009chr684872989-278212661952648
ENST00000369332MAP3K7chr691296482-ENST00000257766KIAA1009chr684872989-29382821142108664
ENST00000369332MAP3K7chr691296482-ENST00000403245KIAA1009chr684872989-29382821142108664
ENST00000369329MAP3K7chr691296482-ENST00000257766KIAA1009chr684872989-29382821142108664
ENST00000369329MAP3K7chr691296482-ENST00000403245KIAA1009chr684872989-29382821142108664

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369325ENST00000257766MAP3K7chr691296482-KIAA1009chr684872989-0.0007736220.99922633
ENST00000369325ENST00000403245MAP3K7chr691296482-KIAA1009chr684872989-0.0007736220.99922633
ENST00000369327ENST00000257766MAP3K7chr691296482-KIAA1009chr684872989-0.0007772980.99922264
ENST00000369327ENST00000403245MAP3K7chr691296482-KIAA1009chr684872989-0.0007772980.99922264
ENST00000369332ENST00000257766MAP3K7chr691296482-KIAA1009chr684872989-0.0006554210.9993445
ENST00000369332ENST00000403245MAP3K7chr691296482-KIAA1009chr684872989-0.0006554210.9993445
ENST00000369329ENST00000257766MAP3K7chr691296482-KIAA1009chr684872989-0.0006554210.9993445
ENST00000369329ENST00000403245MAP3K7chr691296482-KIAA1009chr684872989-0.0006554210.9993445

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51349_51349_1_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369325_KIAA1009_chr6_84872989_ENST00000257766_length(amino acids)=648AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK
ILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGIL
KRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIK
ALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDR
RMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE
NSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLL
EELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHR

--------------------------------------------------------------

>51349_51349_2_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369325_KIAA1009_chr6_84872989_ENST00000403245_length(amino acids)=648AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK
ILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGIL
KRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIK
ALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDR
RMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE
NSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLL
EELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHR

--------------------------------------------------------------

>51349_51349_3_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369327_KIAA1009_chr6_84872989_ENST00000257766_length(amino acids)=648AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK
ILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGIL
KRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIK
ALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDR
RMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE
NSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLL
EELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHR

--------------------------------------------------------------

>51349_51349_4_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369327_KIAA1009_chr6_84872989_ENST00000403245_length(amino acids)=648AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQAKDQIAYVTGEKLYEIK
ILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAKKIQDLERQVKEMEGIL
KRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQEQLLACKLNQHDSPRIK
ALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKREIQDLSKTVERLQKDR
RMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISEKNELKMKSEAVMNQFE
NSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVVSEVREEILQKEITKLL
EELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKFRTELDSILDVLRELHR

--------------------------------------------------------------

>51349_51349_5_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369329_KIAA1009_chr6_84872989_ENST00000257766_length(amino acids)=664AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQA
KDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAK
KIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQE
QLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKR
EIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE
KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVV
SEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF

--------------------------------------------------------------

>51349_51349_6_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369329_KIAA1009_chr6_84872989_ENST00000403245_length(amino acids)=664AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQA
KDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAK
KIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQE
QLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKR
EIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE
KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVV
SEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF

--------------------------------------------------------------

>51349_51349_7_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369332_KIAA1009_chr6_84872989_ENST00000257766_length(amino acids)=664AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQA
KDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAK
KIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQE
QLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKR
EIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE
KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVV
SEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF

--------------------------------------------------------------

>51349_51349_8_MAP3K7-KIAA1009_MAP3K7_chr6_91296482_ENST00000369332_KIAA1009_chr6_84872989_ENST00000403245_length(amino acids)=664AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEEKEKDSLLEDIKRLKQDKQALEVDFEKMKKERDQA
KDQIAYVTGEKLYEIKILEETHKQEISRLQKRLQWYAENQELLDKDALRLREANEEIEKLKLEIEKLKAESGNPSIRQKIRLKDKAADAK
KIQDLERQVKEMEGILKRRYPNSLPALILAASAAGDTVDKNTVEFMEKRIKKLEADLEGKDEDAKKSLRTMEQQFQKMKIQYEQRLEQQE
QLLACKLNQHDSPRIKALEKELDDIKEAHQITVRNLEAEIDVLKHQNAELDVKKNDKDDEDFQSIEFQVEQAHAKAKLVRLNEELAAKKR
EIQDLSKTVERLQKDRRMMLSNQNSKGREEMSAKRAKKDVLHSSKGNANSFPGTLDSKLYQPHTFTDSHVSEVLQENYRLKNELEGLISE
KNELKMKSEAVMNQFENSMRRVKEDTAAHIASLKASHQREIEKLLCQNAVENSSSKVAELNRKIATQEVLIRHFQSQVNELQSKQESLVV
SEVREEILQKEITKLLEELREAKENHTPEMKHFVGLEKKIKQMEMRHAQREQELQQIIQQTHQVVETEQNKEVEKWKRLAQLKNRELEKF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:91296482/chr6:84872989)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MAP3K7

P57077

.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369325-1168_1440.0519.0Compositional biasNote=Poly-Ser
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369327-1158_1440.0492.0Compositional biasNote=Poly-Ser
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369329-1178_1440.0607.0Compositional biasNote=Poly-Ser
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369332-1168_1440.0580.0Compositional biasNote=Poly-Ser
TgeneKIAA1009chr6:91296482chr6:84872989ENST0000025776617271171_1206719.01328.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1009chr6:91296482chr6:84872989ENST0000025776617271235_1386719.01328.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1009chr6:91296482chr6:84872989ENST0000040324517271171_1206795.01404.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1009chr6:91296482chr6:84872989ENST0000040324517271235_1386795.01404.0Coiled coilOntology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369325-11636_29140.0519.0DomainProtein kinase
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369327-11536_29140.0492.0DomainProtein kinase
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369329-11736_29140.0607.0DomainProtein kinase
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369332-11636_29140.0580.0DomainProtein kinase
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369325-11642_5040.0519.0Nucleotide bindingATP
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369327-11542_5040.0492.0Nucleotide bindingATP
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369329-11742_5040.0607.0Nucleotide bindingATP
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369332-11642_5040.0580.0Nucleotide bindingATP
TgeneKIAA1009chr6:91296482chr6:84872989ENST000002577661727617_670719.01328.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1009chr6:91296482chr6:84872989ENST000002577661727698_1121719.01328.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1009chr6:91296482chr6:84872989ENST000004032451727617_670795.01404.0Coiled coilOntology_term=ECO:0000255
TgeneKIAA1009chr6:91296482chr6:84872989ENST000004032451727698_1121795.01404.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MAP3K7
KIAA1009


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369325-1161_30040.0519.0MAPK8IP1
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369327-1151_30040.0492.0MAPK8IP1
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369329-1171_30040.0607.0MAPK8IP1
HgeneMAP3K7chr6:91296482chr6:84872989ENST00000369332-1161_30040.0580.0MAPK8IP1


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Related Drugs to MAP3K7-KIAA1009


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MAP3K7-KIAA1009


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource