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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAP3K7-SMAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAP3K7-SMAP1
	FusionPDB ID: 51353
	FusionGDB2.0 ID: 51353
		Hgene	Tgene
	Gene symbol	MAP3K7	SMAP1
	Gene ID	6885	60682
	Gene name	mitogen-activated protein kinase kinase kinase 7	small ArfGAP 1
	Synonyms	CSCF\|FMD2\|MEKK7\|TAK1\|TGF1a	SMAP-1
	Cytomap	6q15	6q13
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase kinase kinase 7TGF-beta activated kinase 1transforming growth factor-beta-activated kinase 1	stromal membrane-associated protein 1stromal membrane-associated GTPase-activating protein 1
	Modification date	20200313	20200313
	UniProtAcc	P57077	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000369325, ENST00000369327, ENST00000369329, ENST00000369332, ENST00000369320, ENST00000479630,	ENST00000422334, ENST00000316999, ENST00000370452, ENST00000370455,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 8 X 6=432	9 X 7 X 6=378
	# samples	10	9
	** MAII score	log2(10/432*10)=-2.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/378*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAP3K7 [Title/Abstract] AND SMAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP3K7(91296483)-SMAP1(71546644), # samples:1
Anticipated loss of major functional domain due to fusion event.	MAP3K7-SMAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K7-SMAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K7-SMAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAP3K7-SMAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAP3K7	GO:0000186	activation of MAPKK activity	8663074\|9079627
Hgene	MAP3K7	GO:0000187	activation of MAPK activity	9079627
Hgene	MAP3K7	GO:0007252	I-kappaB phosphorylation	11460167
Hgene	MAP3K7	GO:0007254	JNK cascade	9079627
Hgene	MAP3K7	GO:0043507	positive regulation of JUN kinase activity	11460167
Hgene	MAP3K7	GO:0043966	histone H3 acetylation	18838386
Hgene	MAP3K7	GO:0051403	stress-activated MAPK cascade	9079627

Fusion gene breakpoints across MAP3K7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SMAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8080-01A	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000369325	MAP3K7	chr6	91296483	-	ENST00000316999	SMAP1	chr6	71546644	+	1780	120	0	947	315
ENST00000369325	MAP3K7	chr6	91296483	-	ENST00000370452	SMAP1	chr6	71546644	+	1868	120	0	935	311
ENST00000369325	MAP3K7	chr6	91296483	-	ENST00000370455	SMAP1	chr6	71546644	+	2629	120	0	947	315
ENST00000369327	MAP3K7	chr6	91296483	-	ENST00000316999	SMAP1	chr6	71546644	+	1786	126	6	953	315
ENST00000369327	MAP3K7	chr6	91296483	-	ENST00000370452	SMAP1	chr6	71546644	+	1874	126	6	941	311
ENST00000369327	MAP3K7	chr6	91296483	-	ENST00000370455	SMAP1	chr6	71546644	+	2635	126	6	953	315
ENST00000369332	MAP3K7	chr6	91296483	-	ENST00000316999	SMAP1	chr6	71546644	+	1942	282	114	1109	331
ENST00000369332	MAP3K7	chr6	91296483	-	ENST00000370452	SMAP1	chr6	71546644	+	2030	282	114	1097	327
ENST00000369332	MAP3K7	chr6	91296483	-	ENST00000370455	SMAP1	chr6	71546644	+	2791	282	114	1109	331
ENST00000369329	MAP3K7	chr6	91296483	-	ENST00000316999	SMAP1	chr6	71546644	+	1942	282	114	1109	331
ENST00000369329	MAP3K7	chr6	91296483	-	ENST00000370452	SMAP1	chr6	71546644	+	2030	282	114	1097	327
ENST00000369329	MAP3K7	chr6	91296483	-	ENST00000370455	SMAP1	chr6	71546644	+	2791	282	114	1109	331

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000369325	ENST00000316999	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000616711	0.9993832
ENST00000369325	ENST00000370452	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.00044301	0.99955696
ENST00000369325	ENST00000370455	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000321487	0.9996785
ENST00000369327	ENST00000316999	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.00061264	0.9993874
ENST00000369327	ENST00000370452	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000455297	0.9995447
ENST00000369327	ENST00000370455	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000337805	0.99966216
ENST00000369332	ENST00000316999	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000668202	0.9993318
ENST00000369332	ENST00000370452	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000491859	0.99950814
ENST00000369332	ENST00000370455	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000367172	0.99963284
ENST00000369329	ENST00000316999	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000668202	0.9993318
ENST00000369329	ENST00000370452	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000491859	0.99950814
ENST00000369329	ENST00000370455	MAP3K7	chr6	91296483	-	SMAP1	chr6	71546644	+	0.000367172	0.99963284

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51353_51353_1_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369325_SMAP1_chr6_71546644_ENST00000316999_length(amino acids)=315AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDD
LDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFT
SQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLS

--------------------------------------------------------------

>51353_51353_2_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369325_SMAP1_chr6_71546644_ENST00000370452_length(amino acids)=311AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDD
LDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFT
SQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLS

--------------------------------------------------------------

>51353_51353_3_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369325_SMAP1_chr6_71546644_ENST00000370455_length(amino acids)=315AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDD
LDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFT
SQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLS

--------------------------------------------------------------

>51353_51353_4_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369327_SMAP1_chr6_71546644_ENST00000316999_length(amino acids)=315AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDD
LDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFT
SQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLS

--------------------------------------------------------------

>51353_51353_5_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369327_SMAP1_chr6_71546644_ENST00000370452_length(amino acids)=311AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDD
LDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFT
SQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLS

--------------------------------------------------------------

>51353_51353_6_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369327_SMAP1_chr6_71546644_ENST00000370455_length(amino acids)=315AA_BP=40
MSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAVAPVTNGNTTVPPLNDD
LDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQQSTPGVFMGPTNIPFT
SQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQSKFGLPQAQQPQWSLS

--------------------------------------------------------------

>51353_51353_7_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369329_SMAP1_chr6_71546644_ENST00000316999_length(amino acids)=331AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAV
APVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQ
QSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQ

--------------------------------------------------------------

>51353_51353_8_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369329_SMAP1_chr6_71546644_ENST00000370452_length(amino acids)=327AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAV
APVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQ
QSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQ

--------------------------------------------------------------

>51353_51353_9_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369329_SMAP1_chr6_71546644_ENST00000370455_length(amino acids)=331AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAV
APVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQ
QSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQ

--------------------------------------------------------------

>51353_51353_10_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369332_SMAP1_chr6_71546644_ENST00000316999_length(amino acids)=331AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAV
APVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQ
QSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQ

--------------------------------------------------------------

>51353_51353_11_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369332_SMAP1_chr6_71546644_ENST00000370452_length(amino acids)=327AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAV
APVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQ
QSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQ

--------------------------------------------------------------

>51353_51353_12_MAP3K7-SMAP1_MAP3K7_chr6_91296483_ENST00000369332_SMAP1_chr6_71546644_ENST00000370455_length(amino acids)=331AA_BP=56
MSGWHRSRPHRAPRGIMSTASAASSSSSSSAGEMIEAPSQVLNFEEIDYKEIEVEELQKKDQQLEPKKSTSPKKAAEPTVDLLGLDGPAV
APVTNGNTTVPPLNDDLDIFGPMISNPLPATVMPPAQGTPSAPAAATLSTVTSGDLDLFTEQTTKSEEVAKKQLSKDSILSLYGTGTIQQ
QSTPGVFMGPTNIPFTSQAPAAFQGFPSMGVPVPAAPGLIGNVMGQSPSMMVGMPMPNGFMGNAQTGVMPLPQNVVGPQGGMVGQMGAPQ

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:91296483/chr6:71546644)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP3K7 P57077	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369325

8_14

40.0

519.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369327

8_14

40.0

492.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369329

8_14

40.0

607.0

Compositional bias

Note=Poly-Ser

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369332

8_14

40.0

580.0

Compositional bias

Note=Poly-Ser

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369325

36_291

40.0

519.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369327

36_291

40.0

492.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369329

36_291

40.0

607.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369332

36_291

40.0

580.0

Domain

Protein kinase

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369325

42_50

40.0

519.0

Nucleotide binding

ATP

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369327

42_50

40.0

492.0

Nucleotide binding

ATP

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369329

42_50

40.0

607.0

Nucleotide binding

ATP

Hgene

MAP3K7

chr6:91296483

chr6:71546644

ENST00000369332

42_50

40.0

580.0

Nucleotide binding

ATP

Tgene

SMAP1

chr6:91296483

chr6:71546644

ENST00000316999

18_136

165.0

441.0

Domain

Arf-GAP

Tgene

SMAP1

chr6:91296483

chr6:71546644

ENST00000370452

18_136

165.0

437.0

Domain

Arf-GAP

Tgene

SMAP1

chr6:91296483

chr6:71546644

ENST00000370455

18_136

192.0

468.0

Domain

Arf-GAP

Tgene

SMAP1

chr6:91296483

chr6:71546644

ENST00000316999

33_56

165.0

441.0

Zinc finger

C4-type

Tgene

SMAP1

chr6:91296483

chr6:71546644

ENST00000370452

33_56

165.0

437.0

Zinc finger

C4-type

Tgene

SMAP1

chr6:91296483

chr6:71546644

ENST00000370455

33_56

192.0

468.0

Zinc finger

C4-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAP3K7
SMAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MAP3K7	chr6:91296483	chr6:71546644	ENST00000369325	-	1	16	1_300	40.0	519.0	MAPK8IP1
Hgene	MAP3K7	chr6:91296483	chr6:71546644	ENST00000369327	-	1	15	1_300	40.0	492.0	MAPK8IP1
Hgene	MAP3K7	chr6:91296483	chr6:71546644	ENST00000369329	-	1	17	1_300	40.0	607.0	MAPK8IP1
Hgene	MAP3K7	chr6:91296483	chr6:71546644	ENST00000369332	-	1	16	1_300	40.0	580.0	MAPK8IP1

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Related Drugs to MAP3K7-SMAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAP3K7-SMAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source