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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAP4-CCDC12

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAP4-CCDC12
	FusionPDB ID: 51366
	FusionGDB2.0 ID: 51366
		Hgene	Tgene
	Gene symbol	MAP4	CCDC12
	Gene ID	4134	151903
	Gene name	microtubule associated protein 4	coiled-coil domain containing 12
	Synonyms	-	-
	Cytomap	3p21.31	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	microtubule-associated protein 4MAP-4	coiled-coil domain-containing protein 12
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4K4	Q96BQ5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000264724, ENST00000360240, ENST00000383737, ENST00000395734, ENST00000420772, ENST00000426837, ENST00000441748, ENST00000434267, ENST00000439356, ENST00000462206,	ENST00000605358, ENST00000292314, ENST00000425441, ENST00000546280,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 31 X 16=21328	5 X 9 X 9=405
	# samples	61	13
	** MAII score	log2(61/21328*10)=-5.12779563263872 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/405*10)=-1.63941028474353 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAP4 [Title/Abstract] AND CCDC12 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP4(47912303)-CCDC12(46982555), # samples:2
Anticipated loss of major functional domain due to fusion event.	MAP4-CCDC12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP4-CCDC12 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP4-CCDC12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAP4-CCDC12 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAP4-CCDC12 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MAP4-CCDC12 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across MAP4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CCDC12 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-G9-6339-01A	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-
ChimerDB4	PRAD	TCGA-G9-6339	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-
ChimerDB4	PRAD	TCGA-G9-6339	MAP4	chr3	47912348	-	CCDC12	chr3	46982555	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000264724	MAP4	chr3	47912303	-	ENST00000425441	CCDC12	chr3	46982555	-	2800	2064	0	2468	822
ENST00000264724	MAP4	chr3	47912303	-	ENST00000292314	CCDC12	chr3	46982555	-	2795	2064	0	2468	822
ENST00000264724	MAP4	chr3	47912303	-	ENST00000546280	CCDC12	chr3	46982555	-	2795	2064	0	2468	822
ENST00000420772	MAP4	chr3	47912303	-	ENST00000425441	CCDC12	chr3	46982555	-	3132	2396	344	2800	818
ENST00000420772	MAP4	chr3	47912303	-	ENST00000292314	CCDC12	chr3	46982555	-	3127	2396	344	2800	818
ENST00000420772	MAP4	chr3	47912303	-	ENST00000546280	CCDC12	chr3	46982555	-	3127	2396	344	2800	818
ENST00000441748	MAP4	chr3	47912303	-	ENST00000425441	CCDC12	chr3	46982555	-	1662	926	5	1330	441
ENST00000441748	MAP4	chr3	47912303	-	ENST00000292314	CCDC12	chr3	46982555	-	1657	926	5	1330	441
ENST00000441748	MAP4	chr3	47912303	-	ENST00000546280	CCDC12	chr3	46982555	-	1657	926	5	1330	441

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000264724	ENST00000425441	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.003845555	0.9961545
ENST00000264724	ENST00000292314	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.003779921	0.99622005
ENST00000264724	ENST00000546280	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.003779921	0.99622005
ENST00000420772	ENST00000425441	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.01643344	0.9835666
ENST00000420772	ENST00000292314	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.016298158	0.9837018
ENST00000420772	ENST00000546280	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.016298158	0.9837018
ENST00000441748	ENST00000425441	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.001394586	0.99860543
ENST00000441748	ENST00000292314	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.001374424	0.99862564
ENST00000441748	ENST00000546280	MAP4	chr3	47912303	-	CCDC12	chr3	46982555	-	0.001374424	0.99862564

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51366_51366_1_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000264724_CCDC12_chr3_46982555_ENST00000292314_length(amino acids)=822AA_BP=0
METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLESAACEKLPTPTPQVVKEGDSFPDTLAKNGQEIAPAQISKSLMVDNYT
KDGVPGQERPKGPSAVVPSTSTGGVALPITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKG
HLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSP
KSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKED
KSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTS
KAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQ
TVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP
SRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVP
EDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAV

--------------------------------------------------------------

>51366_51366_2_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000264724_CCDC12_chr3_46982555_ENST00000425441_length(amino acids)=822AA_BP=0
METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLESAACEKLPTPTPQVVKEGDSFPDTLAKNGQEIAPAQISKSLMVDNYT
KDGVPGQERPKGPSAVVPSTSTGGVALPITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKG
HLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSP
KSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKED
KSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTS
KAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQ
TVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP
SRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVP
EDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAV

--------------------------------------------------------------

>51366_51366_3_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000264724_CCDC12_chr3_46982555_ENST00000546280_length(amino acids)=822AA_BP=0
METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLESAACEKLPTPTPQVVKEGDSFPDTLAKNGQEIAPAQISKSLMVDNYT
KDGVPGQERPKGPSAVVPSTSTGGVALPITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKG
HLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSP
KSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKED
KSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTS
KAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQ
TVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP
SRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVP
EDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAV

--------------------------------------------------------------

>51366_51366_4_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000420772_CCDC12_chr3_46982555_ENST00000292314_length(amino acids)=818AA_BP=0
MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSI
EMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQE
TSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIR
DHDKELEKLSSTEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVG
EEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQ
VCQRGEKQPGQTALAGKKEIEVTATQSTPSFLFEKPPRDGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPS
KPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPS
TTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDED
LKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAAT

--------------------------------------------------------------

>51366_51366_5_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000420772_CCDC12_chr3_46982555_ENST00000425441_length(amino acids)=818AA_BP=0
MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSI
EMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQE
TSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIR
DHDKELEKLSSTEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVG
EEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQ
VCQRGEKQPGQTALAGKKEIEVTATQSTPSFLFEKPPRDGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPS
KPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPS
TTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDED
LKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAAT

--------------------------------------------------------------

>51366_51366_6_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000420772_CCDC12_chr3_46982555_ENST00000546280_length(amino acids)=818AA_BP=0
MSLSDKQTASLTAAYGQLSKGKPAECRMDSPKEISQAGFEWQRTEGKLNEIGLNVSMDGQPKDGLVKNASFLEQNKLCFFEGKLDKELSI
EMQDKDCQEASGHLESRYVISETCHPLEGNSVHQKTSEFHLGLIEGPDKNKTIPVQGKVAGKNGLETKSQSDLDFPGAADIPTRYVKEQE
TSVWNPSFHPVAQGSLGSREATPGEMENSITPGCPVIGVVNDNSEQLKCESPLLVSLAHPAPIIEHSPTTIPPITMVFTQEHLNASCHIR
DHDKELEKLSSTEEAVLNQAPQQKKAVRRALSECSHLSVPPAVNLADKYPELPAREEPSSGLLPPPSSPMPSPTPGKLGAPAMKRSMTVG
EEQTASYKLSPGKLPILSTKEIPPFICEEPVAKKREELAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQ
VCQRGEKQPGQTALAGKKEIEVTATQSTPSFLFEKPPRDGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPS
KPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSPSTLLPKKPTADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPS
TTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDED
LKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAVDAAT

--------------------------------------------------------------

>51366_51366_7_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000441748_CCDC12_chr3_46982555_ENST00000292314_length(amino acids)=441AA_BP=1
MAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALAGKKEIEVTATQSTPSFLFEKPP
RDGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP
STLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSST
TPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEK

--------------------------------------------------------------

>51366_51366_8_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000441748_CCDC12_chr3_46982555_ENST00000425441_length(amino acids)=441AA_BP=1
MAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALAGKKEIEVTATQSTPSFLFEKPP
RDGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP
STLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSST
TPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEK

--------------------------------------------------------------

>51366_51366_9_MAP4-CCDC12_MAP4_chr3_47912303_ENST00000441748_CCDC12_chr3_46982555_ENST00000546280_length(amino acids)=441AA_BP=1
MAHFSNSSSNSGKKELGTAGLYLHSKLEQIPEGSSKEKGQEDFSETRIDSCSQVCQRGEKQPGQTALAGKKEIEVTATQSTPSFLFEKPP
RDGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPIADAKAPEKRASPSKPASAPASRSGSKSTQTVAKTTTAAAVASTGPSSRSP
STLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMPSRPSTTPFIDKKPTSAKPSST
TPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVPEDEDLKKRRVPQAKPVAVEEK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:47912303/chr3:46982555)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP4 Q9Y4K4	CCDC12 Q96BQ5
FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269\|PubMed:9038372}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

248_545

953.0

1153.0

Region

Note=17 X 14 AA tandem repeats

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

248_545

953.0

1136.0

Region

Note=17 X 14 AA tandem repeats

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

248_261

953.0

1153.0

Repeat

Note=1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

262_275

953.0

1153.0

Repeat

Note=2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

276_289

953.0

1153.0

Repeat

Note=3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

290_303

953.0

1153.0

Repeat

Note=4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

304_317

953.0

1153.0

Repeat

Note=5

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

318_331

953.0

1153.0

Repeat

Note=6

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

332_345

953.0

1153.0

Repeat

Note=7

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

346_351

953.0

1153.0

Repeat

Note=8%3B truncated

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

352_377

953.0

1153.0

Repeat

Note=26 residues 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

378_403

953.0

1153.0

Repeat

Note=26 residues 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

408_421

953.0

1153.0

Repeat

Note=9

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

422_433

953.0

1153.0

Repeat

Note=10

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

434_447

953.0

1153.0

Repeat

Note=11

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

448_461

953.0

1153.0

Repeat

Note=12

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

462_475

953.0

1153.0

Repeat

Note=13

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

476_489

953.0

1153.0

Repeat

Note=14

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

490_503

953.0

1153.0

Repeat

Note=15

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

504_517

953.0

1153.0

Repeat

Note=16

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

532_545

953.0

1153.0

Repeat

Note=17

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

923_953

953.0

1153.0

Repeat

Note=Tau/MAP 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

248_261

953.0

1136.0

Repeat

Note=1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

262_275

953.0

1136.0

Repeat

Note=2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

276_289

953.0

1136.0

Repeat

Note=3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

290_303

953.0

1136.0

Repeat

Note=4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

304_317

953.0

1136.0

Repeat

Note=5

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

318_331

953.0

1136.0

Repeat

Note=6

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

332_345

953.0

1136.0

Repeat

Note=7

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

346_351

953.0

1136.0

Repeat

Note=8%3B truncated

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

352_377

953.0

1136.0

Repeat

Note=26 residues 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

378_403

953.0

1136.0

Repeat

Note=26 residues 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

408_421

953.0

1136.0

Repeat

Note=9

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

422_433

953.0

1136.0

Repeat

Note=10

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

434_447

953.0

1136.0

Repeat

Note=11

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

448_461

953.0

1136.0

Repeat

Note=12

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

462_475

953.0

1136.0

Repeat

Note=13

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

476_489

953.0

1136.0

Repeat

Note=14

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

490_503

953.0

1136.0

Repeat

Note=15

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

504_517

953.0

1136.0

Repeat

Note=16

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

532_545

953.0

1136.0

Repeat

Note=17

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

923_953

953.0

1136.0

Repeat

Note=Tau/MAP 1

Tgene

CCDC12

chr3:47912303

chr3:46982555

ENST00000546280

117_144

32.0

167.0

Coiled coil

Ontology_term=ECO:0000255

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

248_545

100.0

Region

Note=17 X 14 AA tandem repeats

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

248_545

100.0

Region

Note=17 X 14 AA tandem repeats

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

1023_1053

953.0

1153.0

Repeat

Note=Tau/MAP 3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

1054_1085

953.0

1153.0

Repeat

Note=Tau/MAP 4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000360240

992_1022

953.0

1153.0

Repeat

Note=Tau/MAP 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

1023_1053

953.0

1136.0

Repeat

Note=Tau/MAP 3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

1054_1085

953.0

1136.0

Repeat

Note=Tau/MAP 4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000395734

992_1022

953.0

1136.0

Repeat

Note=Tau/MAP 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

1023_1053

100.0

Repeat

Note=Tau/MAP 3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

1054_1085

100.0

Repeat

Note=Tau/MAP 4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

248_261

100.0

Repeat

Note=1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

262_275

100.0

Repeat

Note=2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

276_289

100.0

Repeat

Note=3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

290_303

100.0

Repeat

Note=4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

304_317

100.0

Repeat

Note=5

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

318_331

100.0

Repeat

Note=6

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

332_345

100.0

Repeat

Note=7

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

346_351

100.0

Repeat

Note=8%3B truncated

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

352_377

100.0

Repeat

Note=26 residues 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

378_403

100.0

Repeat

Note=26 residues 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

408_421

100.0

Repeat

Note=9

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

422_433

100.0

Repeat

Note=10

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

434_447

100.0

Repeat

Note=11

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

448_461

100.0

Repeat

Note=12

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

462_475

100.0

Repeat

Note=13

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

476_489

100.0

Repeat

Note=14

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

490_503

100.0

Repeat

Note=15

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

504_517

100.0

Repeat

Note=16

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

532_545

100.0

Repeat

Note=17

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

923_953

100.0

Repeat

Note=Tau/MAP 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000434267

992_1022

100.0

Repeat

Note=Tau/MAP 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

1023_1053

100.0

Repeat

Note=Tau/MAP 3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

1054_1085

100.0

Repeat

Note=Tau/MAP 4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

248_261

100.0

Repeat

Note=1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

262_275

100.0

Repeat

Note=2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

276_289

100.0

Repeat

Note=3

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

290_303

100.0

Repeat

Note=4

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

304_317

100.0

Repeat

Note=5

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

318_331

100.0

Repeat

Note=6

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

332_345

100.0

Repeat

Note=7

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

346_351

100.0

Repeat

Note=8%3B truncated

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

352_377

100.0

Repeat

Note=26 residues 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

378_403

100.0

Repeat

Note=26 residues 2

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

408_421

100.0

Repeat

Note=9

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

422_433

100.0

Repeat

Note=10

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

434_447

100.0

Repeat

Note=11

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

448_461

100.0

Repeat

Note=12

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

462_475

100.0

Repeat

Note=13

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

476_489

100.0

Repeat

Note=14

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

490_503

100.0

Repeat

Note=15

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

504_517

100.0

Repeat

Note=16

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

532_545

100.0

Repeat

Note=17

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

923_953

100.0

Repeat

Note=Tau/MAP 1

Hgene

MAP4

chr3:47912303

chr3:46982555

ENST00000439356

992_1022

100.0

Repeat

Note=Tau/MAP 2

Tgene

CCDC12

chr3:47912303

chr3:46982555

ENST00000546280

8_28

32.0

167.0

Coiled coil

Ontology_term=ECO:0000255

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1603_MAP4_47912303_CCDC12_46982555_ranked_0.pdb	MAP4	47912303	47912303	ENST00000546280	CCDC12	chr3	46982555	-	METTGDQGIEGMAYMDENRNITFTCPRTPSELINKSSPLEVLESAACEKLPTPTPQVVKEGDSFPDTLAKNGQEIAPAQISKSLMVDNYT KDGVPGQERPKGPSAVVPSTSTGGVALPITTAIETVNIHGDHSLKNKAELADSMKNEAGIDEGHVIGESESVHSGASKHSVEKVTELAKG HLLPGVPVEDQSLPGEARALEGYADRGNFPAHPVNEEKETKEGSVAVQIPDLLEDKAQKLSFCEDQNAQDRNSKGSDSLNKKVDLTLLSP KSENDKLKEISLACKITELESVSLPTPEIQSDFLHSKVEAPPSEVADTLVIMTASKGVRLPEPKDKILETPQKMTEKSESKTPGEGKKED KSRMAEPMKGYMRPTKSRGLTPLLPKSTIQEQERHKQLKSAGIARPEEGRPVVSGTGNDITTPPNKELPPSPEKKTKPLATTQPAKTSTS KAKTQPTSLPKQPAPTTIGGLNKKPMSLASGLVPAAPPKRPAVASARPSILPSKDVKPKPIADAKAPEKRASPSKPASAPASRSGSKSTQ TVAKTTTAAAVASTGPSSRSPSTLLPKKPTAIKTEGKPAEVKKMTAKSVPADLSRPKSTSTSSMKKTTTLSGTAPAAGVVPSRVKATPMP SRPSTTPFIDKKPTSAKPSSTTPRLSRLATNTSAPDLKNVRSKVGSTENIKHQPGGGRDKEDGEPKTKHLREEEEEGEKHRELRLRNYVP EDEDLKKRRVPQAKPVAVEEKVKEQLEAAKPEPVIEEVDLANLAPRKPDWDLKRDVAKKLEKLKKRTQRAIAELIRERLKGQEDSLASAV	822

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MAP4_pLDDT.png

CCDC12_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAP4
CCDC12

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to MAP4-CCDC12

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to MAP4-CCDC12

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source