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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAP4K3-EML4

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAP4K3-EML4
	FusionPDB ID: 51390
	FusionGDB2.0 ID: 51390
		Hgene	Tgene
	Gene symbol	MAP4K3	EML4
	Gene ID	8491	27436
	Gene name	mitogen-activated protein kinase kinase kinase kinase 3	EMAP like 4
	Synonyms	GLK\|MAPKKKK3\|MEKKK 3\|MEKKK3\|RAB8IPL1	C2orf2\|ELP120\|EMAP-4\|EMAPL4\|ROPP120
	Cytomap	2p22.1	2p21
	Type of gene	protein-coding	protein-coding
	Description	mitogen-activated protein kinase kinase kinase kinase 3MAPK/ERK kinase kinase kinase 3MEK kinase kinase 3germinal center kinase-like kinasegerminal center kinase-related protein kinase	echinoderm microtubule-associated protein-like 4echinoderm microtubule associated protein like 4restrictedly overexpressed proliferation-associated proteinropp 120
	Modification date	20200313	20200313
	UniProtAcc	Q8IVH8	Q9HC35
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263881, ENST00000341681, ENST00000484274, ENST00000437545, ENST00000474502, ENST00000536018,	ENST00000401738, ENST00000453191, ENST00000482660, ENST00000318522, ENST00000402711,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 6 X 7=378	9 X 10 X 6=540
	# samples	10	10
	** MAII score	log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/540*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAP4K3 [Title/Abstract] AND EML4 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	MAP4K3(39605207)-EML4(42507990), # samples:2
Anticipated loss of major functional domain due to fusion event.	MAP4K3-EML4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAP4K3-EML4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAP4K3	GO:0006468	protein phosphorylation	9275185
Hgene	MAP4K3	GO:0009411	response to UV	9275185
Hgene	MAP4K3	GO:0034612	response to tumor necrosis factor	9275185
Hgene	MAP4K3	GO:0035556	intracellular signal transduction	9275185

Fusion gene breakpoints across MAP4K3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EML4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-QK-A8ZB-01A	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000263881	MAP4K3	chr2	39605207	-	ENST00000318522	EML4	chr2	42507990	+	5099	479	313	2757	814
ENST00000263881	MAP4K3	chr2	39605207	-	ENST00000402711	EML4	chr2	42507990	+	3295	479	313	2757	814
ENST00000341681	MAP4K3	chr2	39605207	-	ENST00000318522	EML4	chr2	42507990	+	5088	468	302	2746	814
ENST00000341681	MAP4K3	chr2	39605207	-	ENST00000402711	EML4	chr2	42507990	+	3284	468	302	2746	814
ENST00000484274	MAP4K3	chr2	39605207	-	ENST00000318522	EML4	chr2	42507990	+	4852	232	66	2510	814
ENST00000484274	MAP4K3	chr2	39605207	-	ENST00000402711	EML4	chr2	42507990	+	3048	232	66	2510	814

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000263881	ENST00000318522	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+	0.000246482	0.99975353
ENST00000263881	ENST00000402711	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+	0.000580406	0.99941957
ENST00000341681	ENST00000318522	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+	0.00025024	0.9997497
ENST00000341681	ENST00000402711	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+	0.000584649	0.9994154
ENST00000484274	ENST00000318522	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+	0.000234749	0.9997652
ENST00000484274	ENST00000402711	MAP4K3	chr2	39605207	-	EML4	chr2	42507990	+	0.000594176	0.99940586

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51390_51390_1_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000263881_EML4_chr2_42507990_ENST00000318522_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

>51390_51390_2_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000263881_EML4_chr2_42507990_ENST00000402711_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

>51390_51390_3_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000341681_EML4_chr2_42507990_ENST00000318522_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

>51390_51390_4_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000341681_EML4_chr2_42507990_ENST00000402711_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

>51390_51390_5_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000484274_EML4_chr2_42507990_ENST00000318522_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

>51390_51390_6_MAP4K3-EML4_MAP4K3_chr2_39605207_ENST00000484274_EML4_chr2_42507990_ENST00000402711_length(amino acids)=814AA_BP=55
MGPAMNPGFDLSRRNPQEDFELIQRIGSGTYGDVYKARNVNTGELAAIKVIKLEPEGEYIKMFMRGRPITMFIPSDVDNYDDIRTELPPE
KLKLEWAYGYRGKDCRANVYLLPTGKIVYFIASVVVLFNYEERTQRHYLGHTDCVKCLAIHPDKIRIATGQIAGVDKDGRPLQPHVRVWD
SVTLSTLQIIGLGTFERGVGCLDFSKADSGVHLCIIDDSNEHMLTVWDWQKKAKGAEIKTTNEVVLAVEFHPTDANTIITCGKSHIFFWT
WSGNSLTRKQGIFGKYEKPKFVQCLAFLGNGDVLTGDSGGVMLIWSKTTVEPTPGKGPKGVYQISKQIKAHDGSVFTLCQMRNGMLLTGG
GKDRKIILWDHDLNPEREIEVPDQYGTIRAVAEGKADQFLVGTSRNFILRGTFNDGFQIEVQGHTDELWGLATHPFKDLLLTCAQDRQVC
LWNSMEHRLEWTRLVDEPGHCADFHPSGTVVAIGTHSGRWFVLDAETRDLVSIHTDGNEQLSVMRYSIDGTFLAVGSHDNFIYLYVVSEN
GRKYSRYGRCTGHSSYITHLDWSPDNKYIMSNSGDYEILYWDIPNGCKLIRNRSDCKDIDWTTYTCVLGFQVFGVWPEGSDGTDINALVR
SHNRKVIAVADDFCKVHLFQYPCSKAKAPSHKYSAHSSHVTNVSFTHNDSHLISTGGKDMSIIQWKLVEKLSLPQNETVADTTLTKAPVS
STESVIQSNTPTPPPSQPLNETAEEESRISSSPTLLENSLEQTVEPSEDHSEEESEEGSGDLGEPLYEEPCNEISKEQAKATLLEDQQDP

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:39605207/chr2:42507990)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAP4K3 Q8IVH8	EML4 Q9HC35
FUNCTION: May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. {ECO:0000269\|PubMed:9275185}.	FUNCTION: Essential for the formation and stability of microtubules (MTs) (PubMed:16890222, PubMed:31409757). Required for the organization of the mitotic spindle and for the proper attachment of kinetochores to MTs (PubMed:25789526). Promotes the recruitment of NUDC to the mitotic spindle for mitotic progression (PubMed:25789526). {ECO:0000269\|PubMed:16890222, ECO:0000269\|PubMed:25789526, ECO:0000269\|PubMed:31409757}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP4K3

chr2:39605207

chr2:42507990

ENST00000263881

22_30

51.333333333333336

895.0

Nucleotide binding

ATP

Hgene

MAP4K3

chr2:39605207

chr2:42507990

ENST00000341681

22_30

51.333333333333336

874.0

Nucleotide binding

ATP

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

259_297

222.33333333333334

982.0

Repeat

Note=WD 1

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

301_348

222.33333333333334

982.0

Repeat

Note=WD 2

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

356_396

222.33333333333334

982.0

Repeat

Note=WD 3

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

403_438

222.33333333333334

982.0

Repeat

Note=WD 4

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

445_484

222.33333333333334

982.0

Repeat

Note=WD 5

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

500_538

222.33333333333334

982.0

Repeat

Note=WD 6

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

543_579

222.33333333333334

982.0

Repeat

Note=WD 7

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

582_621

222.33333333333334

982.0

Repeat

Note=WD 8

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

625_662

222.33333333333334

982.0

Repeat

Note=WD 9

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

668_704

222.33333333333334

982.0

Repeat

Note=WD 10

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

711_750

222.33333333333334

982.0

Repeat

Note=WD 11

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

760_818

222.33333333333334

982.0

Repeat

Note=WD 12

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

825_864

222.33333333333334

982.0

Repeat

Note=WD 13

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

259_297

164.33333333333334

924.0

Repeat

Note=WD 1

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

301_348

164.33333333333334

924.0

Repeat

Note=WD 2

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

356_396

164.33333333333334

924.0

Repeat

Note=WD 3

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

403_438

164.33333333333334

924.0

Repeat

Note=WD 4

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

445_484

164.33333333333334

924.0

Repeat

Note=WD 5

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

500_538

164.33333333333334

924.0

Repeat

Note=WD 6

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

543_579

164.33333333333334

924.0

Repeat

Note=WD 7

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

582_621

164.33333333333334

924.0

Repeat

Note=WD 8

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

625_662

164.33333333333334

924.0

Repeat

Note=WD 9

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

668_704

164.33333333333334

924.0

Repeat

Note=WD 10

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

711_750

164.33333333333334

924.0

Repeat

Note=WD 11

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

760_818

164.33333333333334

924.0

Repeat

Note=WD 12

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

825_864

164.33333333333334

924.0

Repeat

Note=WD 13

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAP4K3

chr2:39605207

chr2:42507990

ENST00000263881

16_273

51.333333333333336

895.0

Domain

Protein kinase

Hgene

MAP4K3

chr2:39605207

chr2:42507990

ENST00000263881

556_867

51.333333333333336

895.0

Domain

CNH

Hgene

MAP4K3

chr2:39605207

chr2:42507990

ENST00000341681

16_273

51.333333333333336

874.0

Domain

Protein kinase

Hgene

MAP4K3

chr2:39605207

chr2:42507990

ENST00000341681

556_867

51.333333333333336

874.0

Domain

CNH

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000318522

1_249

222.33333333333334

982.0

Region

Microtubule-binding

Tgene

EML4

chr2:39605207

chr2:42507990

ENST00000402711

1_249

164.33333333333334

924.0

Region

Microtubule-binding

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
EML4	NEK6, ARL4D, ARIH2, ELAVL1, EML4, ILK, PRPS1, TUBB2A, TUBB2B, FBXW11, NTRK1, SPICE1, DCTN1, TFEB, Nek9, NUDC, EML1, FBXO28, TUBB3, CTAGE5, TUBB, TKT, PHKG2, NEK7, SKP1, EFTUD2, FGF11, MYC, CDK9, KIAA1429, ATG16L1, Bach1, N, HCVgp1, TUBA1B, DDRGK1, TP53, KIF2A, MAPRE1, MAPRE3, TRIM36, TUBA4A, WDR5, C15orf59, C1QTNF1, PABPN1L, BAG2, CAPSL, PRPS2, HSPA8, TUBB6, KXD1, ZNF174, GPS2, NEK9,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAP4K3
EML4

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to MAP4K3-EML4

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAP4K3-EML4

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	EML4	C0007131	Non-Small Cell Lung Carcinoma	6	CTD_human
Tgene	EML4	C0027627	Neoplasm Metastasis	2	CTD_human
Tgene	EML4	C0152013	Adenocarcinoma of lung (disorder)	2	CTD_human
Tgene	EML4	C0006118	Brain Neoplasms	1	CTD_human
Tgene	EML4	C0153633	Malignant neoplasm of brain	1	CTD_human
Tgene	EML4	C0496899	Benign neoplasm of brain, unspecified	1	CTD_human
Tgene	EML4	C0750974	Brain Tumor, Primary	1	CTD_human
Tgene	EML4	C0750977	Recurrent Brain Neoplasm	1	CTD_human
Tgene	EML4	C0750979	Primary malignant neoplasm of brain	1	CTD_human
Tgene	EML4	C1527390	Neoplasms, Intracranial	1	CTD_human