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level3

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:MAPRE1-KMT2A

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: MAPRE1-KMT2A
	FusionPDB ID: 51644
	FusionGDB2.0 ID: 51646
		Hgene	Tgene
	Gene symbol	MAPRE1	KMT2A
	Gene ID	22919	4297
	Gene name	microtubule associated protein RP/EB family member 1	lysine methyltransferase 2A
	Synonyms	EB1	ALL-1\|CXXC7\|HRX\|HTRX1\|MLL\|MLL1\|MLL1A\|TRX1\|WDSTS
	Cytomap	20q11.21	11q23.3
	Type of gene	protein-coding	protein-coding
	Description	microtubule-associated protein RP/EB family member 1APC-binding protein EB1adenomatous polyposis coli-binding protein EB1end-binding protein 1	histone-lysine N-methyltransferase 2ACXXC-type zinc finger protein 7lysine (K)-specific methyltransferase 2Alysine N-methyltransferase 2Amixed lineage leukemia 1myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila)trithorax-like
	Modification date	20200313	20200319
	UniProtAcc	Q15691	Q03164
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000375571,	ENST00000420751, ENST00000354520, ENST00000389506, ENST00000534358,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	10 X 7 X 7=490	31 X 72 X 3=6696
	# samples	12	79
	** MAII score	log2(12/490*10)=-2.02974734339405 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(79/6696*10)=-3.08337496948588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: MAPRE1 [Title/Abstract] AND KMT2A [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KMT2A(118353212)-MAPRE1(31434422), # samples:1 MAPRE1(31427663)-KMT2A(118354896), # samples:1
Anticipated loss of major functional domain due to fusion event.	KMT2A-MAPRE1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KMT2A-MAPRE1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MAPRE1-KMT2A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	MAPRE1	GO:0031115	negative regulation of microtubule polymerization	11943150
Hgene	MAPRE1	GO:0035372	protein localization to microtubule	19632184\|21820309
Tgene	KMT2A	GO:0044648	histone H3-K4 dimethylation	25561738
Tgene	KMT2A	GO:0045944	positive regulation of transcription by RNA polymerase II	20861184
Tgene	KMT2A	GO:0051568	histone H3-K4 methylation	19556245
Tgene	KMT2A	GO:0065003	protein-containing complex assembly	15199122
Tgene	KMT2A	GO:0080182	histone H3-K4 trimethylation	20861184
Tgene	KMT2A	GO:0097692	histone H3-K4 monomethylation	25561738\|26324722

Fusion gene breakpoints across MAPRE1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across KMT2A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	MAPRE1	chr20	31427662	+	KMT2A	chr11	118354897
ChimerKB3	.	.	MAPRE1	chr20	31427662	+	KMT2A	chr11	118354897	+
ChiTaRS5.0	N/A	AY752859	MAPRE1	chr20	31427663	+	KMT2A	chr11	118354896	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000375571	MAPRE1	chr20	31427662	+	ENST00000534358	KMT2A	chr11	118354897	+	13221	736	139	8568	2809
ENST00000375571	MAPRE1	chr20	31427662	+	ENST00000389506	KMT2A	chr11	118354897	+	10305	736	139	8559	2806
ENST00000375571	MAPRE1	chr20	31427662	+	ENST00000354520	KMT2A	chr11	118354897	+	10970	736	139	8445	2768
ENST00000375571	MAPRE1	chr20	31427663	+	ENST00000534358	KMT2A	chr11	118354896	+	13221	736	139	8568	2809
ENST00000375571	MAPRE1	chr20	31427663	+	ENST00000389506	KMT2A	chr11	118354896	+	10305	736	139	8559	2806
ENST00000375571	MAPRE1	chr20	31427663	+	ENST00000354520	KMT2A	chr11	118354896	+	10970	736	139	8445	2768

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000375571	ENST00000534358	MAPRE1	chr20	31427663	+	KMT2A	chr11	118354896	+	0.000289677	0.99971026
ENST00000375571	ENST00000389506	MAPRE1	chr20	31427663	+	KMT2A	chr11	118354896	+	0.000512864	0.99948716
ENST00000375571	ENST00000354520	MAPRE1	chr20	31427663	+	KMT2A	chr11	118354896	+	0.000589817	0.99941015

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>51644_51644_1_MAPRE1-KMT2A_MAPRE1_chr20_31427662_ENST00000375571_KMT2A_chr11_118354897_ENST00000354520_length(amino acids)=2768AA_BP=199
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQL
ENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAK
LFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTAL
LNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSD
GGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKG
PGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNV
HMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFL
NGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTS
FTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIG
SRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLD
GSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLH
LRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLK
PEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIE
STSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYG
EEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVT
ATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLL
DTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSV
SSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDA
DHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVL
QTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPP
SGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDL
GSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGH
VTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQ
LQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTK
RFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAE
PKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLG
ILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATS
MDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNA

--------------------------------------------------------------

>51644_51644_2_MAPRE1-KMT2A_MAPRE1_chr20_31427662_ENST00000375571_KMT2A_chr11_118354897_ENST00000389506_length(amino acids)=2806AA_BP=199
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVV
CFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKK
VWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNL
PESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQ
QPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAV
LPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDS
ANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVY
CQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARK
RCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPT
QRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVV
DHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAP
QVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSR
DRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQ
APRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDG
PKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGG
EERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNC
HSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSE
LLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTIT
EKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDS
PGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQ
SLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKK
LAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDT
SHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQ
TPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSS
AVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDT
ASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICA
ESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKS
AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVI
RSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASN

--------------------------------------------------------------

>51644_51644_3_MAPRE1-KMT2A_MAPRE1_chr20_31427662_ENST00000375571_KMT2A_chr11_118354897_ENST00000534358_length(amino acids)=2809AA_BP=199
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVV
CFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKK
VWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEIL
SNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQ
DDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLP
NAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYG
DDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDK
KVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTD
ARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSY
SPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSA
KVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPK
LAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGS
SSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAK
ELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLML
PDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVIS
SGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKM
DNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESS
SSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRV
TITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNS
TDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLP
TSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRK
NKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTIS
QDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLG
TSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKA
LSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQ
QDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQ
ICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHL
RKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAG
NVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIED

--------------------------------------------------------------

>51644_51644_4_MAPRE1-KMT2A_MAPRE1_chr20_31427663_ENST00000375571_KMT2A_chr11_118354896_ENST00000354520_length(amino acids)=2768AA_BP=199
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVCCEPFHKFCLEENERPLEDQL
ENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAK
LFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTAL
LNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSD
GGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKG
PGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNV
HMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFL
NGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTS
FTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIG
SRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLD
GSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLH
LRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLK
PEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIE
STSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYG
EEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVT
ATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLL
DTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSV
SSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDA
DHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVL
QTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPP
SGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDL
GSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGH
VTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQ
LQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTK
RFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAE
PKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLG
ILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATS
MDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNA

--------------------------------------------------------------

>51644_51644_5_MAPRE1-KMT2A_MAPRE1_chr20_31427663_ENST00000375571_KMT2A_chr11_118354896_ENST00000389506_length(amino acids)=2806AA_BP=199
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVV
CFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKK
VWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNL
PESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQ
QPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAV
LPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYGDDS
ANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDKKVY
CQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARK
RCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPT
QRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVV
DHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAP
QVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGSSSR
DRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQ
APRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDG
PKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGG
EERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNC
HSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESSSSE
LLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTIT
EKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDS
PGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQ
SLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRKNKK
LAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTISQDT
SHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQ
TPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSS
AVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDT
ASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQICA
ESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHLRKS
AFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVI
RSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASN

--------------------------------------------------------------

>51644_51644_6_MAPRE1-KMT2A_MAPRE1_chr20_31427663_ENST00000375571_KMT2A_chr11_118354896_ENST00000534358_length(amino acids)=2809AA_BP=199
MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDMLFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKI
IPVDKLVKGKFQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPKKPLTSSSAAPQRPISTQRTAAAPKAGPGVV
RKNPGVGNGDDEAAELMQQEKPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAENVWEMGGLGILTSVPITPRVV
CFLCASSGHVEFVYCQVCCEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPNYPTKPTKKKK
VWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEIL
SNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQ
DDQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLP
NAVLPPSLDHNYAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNPPPGIEDNRQCALCLTYG
DDSANDAGRLLYIGQNEWTHVNCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKNCVFLDDK
KVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTD
ARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSY
SPTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSA
KVVDHVLGPLNSSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSSKSSEGSAHNVAYPGIPK
LAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSIINEHMGS
SSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAK
ELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLML
PDGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVIS
SGGEERLASHNLFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGEKEHVTKSSVGHKNEPKM
DNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQALGESPESS
SSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRV
TITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNS
TDSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLP
TSQSLFPSASKGLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVATPSSGLKKRPISRLQTRK
NKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATAAGTSTIS
QDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLG
TSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKA
LSSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQ
QDTASVEQSSQKECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEKKPKKGLVFEISSDDGFQ
ICAESIEDAWKSLTDKVQEARSNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGSARAEVHL
RKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAG
NVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIED

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:118353212/chr11:31434422)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
MAPRE1 Q15691	KMT2A Q03164
FUNCTION: Plus-end tracking protein (+TIP) that binds to the plus-end of microtubules and regulates the dynamics of the microtubule cytoskeleton (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:23001180, PubMed:28726242, PubMed:28814570, PubMed:34608293). Promotes cytoplasmic microtubule nucleation and elongation (PubMed:12388762, PubMed:16109370, PubMed:19632184, PubMed:21646404, PubMed:28726242, PubMed:28814570). Involved in mitotic spindle positioning by stabilizing microtubules and promoting dynamic connection between astral microtubules and the cortex during mitotic chromosome segregation (PubMed:12388762, PubMed:34608293). Also acts as a regulator of minus-end microtubule organization: interacts with the complex formed by AKAP9 and PDE4DIP, leading to recruit CAMSAP2 to the Golgi apparatus, thereby tethering non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:28814570). Promotes elongation of CAMSAP2-decorated microtubule stretches on the minus-end of microtubules (PubMed:28814570). Acts as a regulator of autophagosome transport via interaction with CAMSAP2 (PubMed:28726242). May play a role in cell migration (By similarity). {ECO:0000250\|UniProtKB:Q61166, ECO:0000269\|PubMed:12388762, ECO:0000269\|PubMed:16109370, ECO:0000269\|PubMed:19632184, ECO:0000269\|PubMed:21646404, ECO:0000269\|PubMed:23001180, ECO:0000269\|PubMed:28726242, ECO:0000269\|PubMed:28814570, ECO:0000269\|PubMed:34608293}.	FUNCTION: Histone methyltransferase that plays an essential role in early development and hematopoiesis (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalytic subunit of the MLL1/MLL complex, a multiprotein complex that mediates both methylation of 'Lys-4' of histone H3 (H3K4me) complex and acetylation of 'Lys-16' of histone H4 (H4K16ac) (PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:24235145, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of 'Lys-4' of histone H3 (H3K4) via a non-processive mechanism. Part of chromatin remodeling machinery predominantly forms H3K4me1 and H3K4me2 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:25561738, PubMed:15960975, PubMed:12453419, PubMed:15960975, PubMed:19556245, PubMed:19187761, PubMed:20677832, PubMed:21220120, PubMed:26886794). Has weak methyltransferase activity by itself, and requires other component of the MLL1/MLL complex to obtain full methyltransferase activity (PubMed:19187761, PubMed:26886794). Has no activity toward histone H3 phosphorylated on 'Thr-3', less activity toward H3 dimethylated on 'Arg-8' or 'Lys-9', while it has higher activity toward H3 acetylated on 'Lys-9' (PubMed:19187761). Binds to unmethylated CpG elements in the promoter of target genes and helps maintain them in the nonmethylated state (PubMed:20010842). Required for transcriptional activation of HOXA9 (PubMed:12453419, PubMed:20677832, PubMed:20010842). Promotes PPP1R15A-induced apoptosis (PubMed:10490642). Plays a critical role in the control of circadian gene expression and is essential for the transcriptional activation mediated by the CLOCK-ARNTL/BMAL1 heterodimer (By similarity). Establishes a permissive chromatin state for circadian transcription by mediating a rhythmic methylation of 'Lys-4' of histone H3 (H3K4me) and this histone modification directs the circadian acetylation at H3K9 and H3K14 allowing the recruitment of CLOCK-ARNTL/BMAL1 to chromatin (By similarity). Also has auto-methylation activity on Cys-3882 in absence of histone H3 substrate (PubMed:24235145). {ECO:0000250\|UniProtKB:P55200, ECO:0000269\|PubMed:10490642, ECO:0000269\|PubMed:12453419, ECO:0000269\|PubMed:15960975, ECO:0000269\|PubMed:19187761, ECO:0000269\|PubMed:19556245, ECO:0000269\|PubMed:20010842, ECO:0000269\|PubMed:21220120, ECO:0000269\|PubMed:24235145, ECO:0000269\|PubMed:26886794, ECO:0000305\|PubMed:20677832}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPRE1

chr20:31427663

chr11:118354896

ENST00000375571

14_116

199.0

269.0

Domain

Calponin-homology (CH)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1703_1748

1362.0

3932.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

2018_2074

1362.0

3932.0

Domain

FYR N-terminal

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

3666_3747

1362.0

3932.0

Domain

FYR C-terminal

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

3829_3945

1362.0

3932.0

Domain

SET

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

3953_3969

1362.0

3932.0

Domain

Post-SET

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1703_1748

1362.0

3970.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

2018_2074

1362.0

3970.0

Domain

FYR N-terminal

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

3666_3747

1362.0

3970.0

Domain

FYR C-terminal

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

3829_3945

1362.0

3970.0

Domain

SET

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

3953_3969

1362.0

3970.0

Domain

Post-SET

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1703_1748

1362.0

3973.0

Domain

Bromo%3B divergent

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

2018_2074

1362.0

3973.0

Domain

FYR N-terminal

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

3666_3747

1362.0

3973.0

Domain

FYR C-terminal

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

3829_3945

1362.0

3973.0

Domain

SET

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

3953_3969

1362.0

3973.0

Domain

Post-SET

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

3906_3907

1362.0

3932.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

3906_3907

1362.0

3970.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

3906_3907

1362.0

3973.0

Region

S-adenosyl-L-methionine binding

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1431_1482

1362.0

3932.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1479_1533

1362.0

3932.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1566_1627

1362.0

3932.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1870_1910

1362.0

3932.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1931_1978

1362.0

3932.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1431_1482

1362.0

3970.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1479_1533

1362.0

3970.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1566_1627

1362.0

3970.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1870_1910

1362.0

3970.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1931_1978

1362.0

3970.0

Zinc finger

PHD-type 4

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1431_1482

1362.0

3973.0

Zinc finger

PHD-type 1

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1479_1533

1362.0

3973.0

Zinc finger

PHD-type 2

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1566_1627

1362.0

3973.0

Zinc finger

PHD-type 3

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1870_1910

1362.0

3973.0

Zinc finger

C2HC pre-PHD-type

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1931_1978

1362.0

3973.0

Zinc finger

PHD-type 4

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

MAPRE1

chr20:31427663

chr11:118354896

ENST00000375571

185_255

199.0

269.0

Domain

EB1 C-terminal

Hgene

MAPRE1

chr20:31427663

chr11:118354896

ENST00000375571

208_268

199.0

269.0

Region

Note=DCTN1-binding

Hgene

MAPRE1

chr20:31427663

chr11:118354896

ENST00000375571

220_242

199.0

269.0

Region

Note=APC-binding

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

137_143

1362.0

3932.0

Compositional bias

Note=Poly-Gly

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

17_102

1362.0

3932.0

Compositional bias

Note=Ala/Gly/Ser-rich

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

561_564

1362.0

3932.0

Compositional bias

Note=Poly-Pro

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

568_571

1362.0

3932.0

Compositional bias

Note=Poly-Pro

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

137_143

1362.0

3970.0

Compositional bias

Note=Poly-Gly

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

17_102

1362.0

3970.0

Compositional bias

Note=Ala/Gly/Ser-rich

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

561_564

1362.0

3970.0

Compositional bias

Note=Poly-Pro

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

568_571

1362.0

3970.0

Compositional bias

Note=Poly-Pro

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

137_143

1362.0

3973.0

Compositional bias

Note=Poly-Gly

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

17_102

1362.0

3973.0

Compositional bias

Note=Ala/Gly/Ser-rich

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

561_564

1362.0

3973.0

Compositional bias

Note=Poly-Pro

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

568_571

1362.0

3973.0

Compositional bias

Note=Poly-Pro

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

169_180

1362.0

3932.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

217_227

1362.0

3932.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

301_309

1362.0

3932.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

169_180

1362.0

3970.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

217_227

1362.0

3970.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

301_309

1362.0

3970.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

169_180

1362.0

3973.0

DNA binding

Note=A.T hook 1

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

217_227

1362.0

3973.0

DNA binding

Note=A.T hook 2

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

301_309

1362.0

3973.0

DNA binding

Note=A.T hook 3

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

123_134

1362.0

3932.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

147_152

1362.0

3932.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

6_25

1362.0

3932.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

123_134

1362.0

3970.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

147_152

1362.0

3970.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

6_25

1362.0

3970.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

123_134

1362.0

3973.0

Motif

Integrase domain-binding motif 1 (IBM1)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

147_152

1362.0

3973.0

Motif

Integrase domain-binding motif 2 (IBM2)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

6_25

1362.0

3973.0

Motif

Menin-binding motif (MBM)

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000354520

1147_1195

1362.0

3932.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000389506

1147_1195

1362.0

3970.0

Zinc finger

CXXC-type

Tgene

KMT2A

chr20:31427663

chr11:118354896

ENST00000534358

1147_1195

1362.0

3973.0

Zinc finger

CXXC-type

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (1199)	MAPRE1	chr20	31427662	+	KMT2A	chr11	118354897	+	MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDM LFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGK FQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPK KPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQE KPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKFVYCQVC CEPFHKFCLEENERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKC RNSYHPECLGPNYPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSH DFSLCHDCAKLFAKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCEN LSDEMYEILSNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTAL LNSRTTSHLLRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQD DQQPLDLEGVKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKAN SMVKSFFIRQMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHN YAQWQEREENSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILST DRSREDSPELNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHV NCALWSAEVFEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCT SNYHFMCSRAKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDF EGISLRRKFLNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQC SRVYWSTTDARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTS FTESSSKESQNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYS PTQRSPGCRPLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLS PQRSKLRIMSPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLN SSTSLGQNTSTSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSS SLKGEKTKVLSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSF AEPSSVSFSSKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKT LKLSGMSNRSSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQ VTTGEEGNLKPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAP PMQVEGSAKELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIE STSPTEPISASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLP DGPKPQEDGSFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSS TGKKRGKRSAEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHN LFREEEQCDLPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTE NLKIDRPEDAGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQL SSLESSRRVHTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMD FVLKNTPSMQALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQL PTTEPVDSSVSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAV ISDSGEKRVTITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDA DHISSPPCGSVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNST DSPGPSQISNAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQK IQLTSSVSSTPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASK GLLPMSHHQHLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSES SQRTDLSTTVATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSN MTLINFTPSQLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPL LPQSVGGTAATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTT PTSSASVPGHVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPP SSGMFPQLGTSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQ LQHVNQLLASKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKAL SSAVQASPTSPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGN GKKHKVSHLRTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQ KECGQPAGQVAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQ QEQKRKESITEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEAR SNARLKQLSFAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPE EANEPPLNPHGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEV QLKSARRATSMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDA GEMVIEYAGNVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNA ARFINHSCEPNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDA	2768

PDB file (1204) >>>1204.pdbFusion protein BP residue: 199 CIF file (1204) >>>1204.cif	MAPRE1	chr20	31427662	+	KMT2A	chr11	118354897	+	MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDM LFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGK FQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPK KPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQE KPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAEN VWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEEN ERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN YPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLF AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSDEMYEILSNL PESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHLLRY RQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEGVKR KMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIRQME RVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREENSH TEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPELNP PPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEVFED DDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSRAKN CVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKFLNG LEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTDARK RCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKESQNT AEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCRPLP SAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIMSPM RTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNTSTS SNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKVLSS KSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFSSKE ALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNRSSI INEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNLKPE FMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAKELQ APRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPISASE NPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDGSFK RRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRSAEG QVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCDLPK ISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPEDAGE KEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRVHTS TPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSMQAL GESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSSVSS SISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRVTIT EKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCGSVE QGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQISNAA VQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSSTPS VMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQHLH SFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTTVAT PSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPSQLP NHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTAATA AGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPGHVT LTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLGTSQ TPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLASKT GIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPTSPG GSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHLRTS SSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQVAV LPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESITEK KPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLSFAG VNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNPHGS ARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRATSMD LPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAGNVI RSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCEPNC YSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCGAKK	2806
3D view using mol* of 1204 (AA BP:199)


PDB file (1205) >>>1205.pdbFusion protein BP residue: 199 CIF file (1205) >>>1205.cif	MAPRE1	chr20	31427662	+	KMT2A	chr11	118354897	+	MAVNVYSTSVTSDNLSRHDMLAWINESLQLNLTKIEQLCSGAAYCQFMDM LFPGSIALKKVKFQAKLEHEYIQNFKILQAGFKRMGVDKIIPVDKLVKGK FQDNFEFVQWFKKFFDANYDGKDYDPVAARQGQETAVAPSLVAPALNKPK KPLTSSSAAPQRPISTQRTAAAPKAGPGVVRKNPGVGNGDDEAAELMQQE KPPPVNKQENAGTLNILSTLSNGNSSKQKIPADGVHRIRVDFKEDCEAEN VWEMGGLGILTSVPITPRVVCFLCASSGHVEFVYCQVCCEPFHKFCLEEN ERPLEDQLENWCCRRCKFCHVCGRQHQATKQLLECNKCRNSYHPECLGPN YPTKPTKKKKVWICTKCVRCKSCGSTTPGKGWDAQWSHDFSLCHDCAKLF AKGNFCPLCDKCYDDDDYESKMMQCGKCDRWVHSKCENLSGTEDEMYEIL SNLPESVAYTCVNCTERHPAEWRLALEKELQISLKQVLTALLNSRTTSHL LRYRQAAKPPDLNPETEESIPSRSSPEGPDPPVLTEVSKQDDQQPLDLEG VKRKMDQGNYTSVLEFSDDIVKIIQAAINSDGGQPEIKKANSMVKSFFIR QMERVFPWFSVKKSRFWEPNKVSSNSGMLPNAVLPPSLDHNYAQWQEREE NSHTEQPPLMKKIIPAPKPKGPGEPDSPTPLHPPTPPILSTDRSREDSPE LNPPPGIEDNRQCALCLTYGDDSANDAGRLLYIGQNEWTHVNCALWSAEV FEDDDGSLKNVHMAVIRGKQLRCEFCQKPGATVGCCLTSCTSNYHFMCSR AKNCVFLDDKKVYCQRHRDLIKGEVVPENGFEVFRRVFVDFEGISLRRKF LNGLEPENIHMMIGSMTIDCLGILNDLSDCEDKLFPIGYQCSRVYWSTTD ARKRCVYTCKIVECRPPVVEPDINSTVEHDENRTIAHSPTSFTESSSKES QNTAEIISPPSPDRPPHSQTSGSCYYHVISKVPRIRTPSYSPTQRSPGCR PLPSAGSPTPTTHEIVTVGDPLLSSGLRSIGSRRHSTSSLSPQRSKLRIM SPMRTGNTYSRNNVSSVSTTGTATDLESSAKVVDHVLGPLNSSTSLGQNT STSSNLQRTVVTVGNKNSHLDGSSSSEMKQSSASDLVSKSSSLKGEKTKV LSSKSSEGSAHNVAYPGIPKLAPQVHNTTSRELNVSKIGSFAEPSSVSFS SKEALSFPHLHLRGQRNDRDQHTDSTQSANSSPDEDTEVKTLKLSGMSNR SSIINEHMGSSSRDRRQKGKKSCKETFKEKHSSKSFLEPGQVTTGEEGNL KPEFMDEVLTPEYMGQRPCNNVSSDKIGDKGLSMPGVPKAPPMQVEGSAK ELQAPRKRTVKVTLTPLKMENESQSKNALKESSPASPLQIESTSPTEPIS ASENPGDGPVAQPSPNNTSCQDSQSNNYQNLPVQDRNLMLPDGPKPQEDG SFKRRYPRRSARARSNMFFGLTPLYGVRSYGEEDIPFYSSSTGKKRGKRS AEGQVDGADDLSTSDEDDLYYYNFTRTVISSGGEERLASHNLFREEEQCD LPKISQLDGVDDGTESDTSVTATTRKSSQIPKRNGKENGTENLKIDRPED AGEKEHVTKSSVGHKNEPKMDNCHSVSRVKTQGQDSLEAQLSSLESSRRV HTSTPSDKNLLDTYNTELLKSDSDNNNSDDCGNILPSDIMDFVLKNTPSM QALGESPESSSSELLNLGEGLGLDSNREKDMGLFEVFSQQLPTTEPVDSS VSSSISAEEQFELPLELPSDLSVLTTRSPTVPSQNPSRLAVISDSGEKRV TITEKSVASSESDPALLSPGVDPTPEGHMTPDHFIQGHMDADHISSPPCG SVEQGHGNNQDLTRNSSTPGLQVPVSPTVPIQNQKYVPNSTDSPGPSQIS NAAVQTTPPHLKPATEKLIVVNQNMQPLYVLQTLPNGVTQKIQLTSSVSS TPSVMETNTSVLGPMGGGLTLTTGLNPSLPTSQSLFPSASKGLLPMSHHQ HLHSFPAATQSSFPPNISNPPSGLLIGVQPPPDPQLLVSESSQRTDLSTT VATPSSGLKKRPISRLQTRKNKKLAPSSTPSNIAPSDVVSNMTLINFTPS QLPNHPSLLDLGSLNTSSHRTVPNIIKRSKSSIMYFEPAPLLPQSVGGTA ATAAGTSTISQDTSHLTSGSVSGLASSSSVLNVVSMQTTTTPTSSASVPG HVTLTNPRLLGTPDIGSISNLLIKASQQSLGIQDQPVALPPSSGMFPQLG TSQTPSTAAITAASSICVLPSTQTTGITAASPSGEADEHYQLQHVNQLLA SKTGIHSSQRDLDSASGPQVSNFTQTVDAPNSMGLEQNKALSSAVQASPT SPGGSPSSPSSGQRSASPSVPGPTKPKPKTKRFQLPLDKGNGKKHKVSHL RTSSSEAHIPDQETTSLTSGTGTPGAEAEQQDTASVEQSSQKECGQPAGQ VAVLPEVQVTQNPANEQESAEPKTVEEEESNFSSPLMLWLQQEQKRKESI TEKKPKKGLVFEISSDDGFQICAESIEDAWKSLTDKVQEARSNARLKQLS FAGVNGLRMLGILHDAVVFLIEQLSGAKHCRNYKFRFHKPEEANEPPLNP HGSARAEVHLRKSAFDMFNFLASKHRQPPEYNPNDEEEEEVQLKSARRAT SMDLPMPMRFRHLKKTSKEAVGVYRSPIHGRGLFCKRNIDAGEMVIEYAG NVIRSIQTDKREKYYDSKGIGCYMFRIDDSEVVDATMHGNAARFINHSCE PNCYSRVINIDGQKHIVIFAMRKIYRGEELTYDYKFPIEDASNKLPCNCG	2809
3D view using mol* of 1205 (AA BP:199)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MAPRE1_pLDDT.png

KMT2A_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

MAPRE1_KMT2A_1204_pLDDT.png (AA BP:199)

MAPRE1_KMT2A_1204_pLDDT_and_active_sites.png (AA BP:199)

MAPRE1_KMT2A_1204_violinplot.png (AA BP:199)

MAPRE1_KMT2A_1205_pLDDT.png (AA BP:199)

MAPRE1_KMT2A_1205_pLDDT_and_active_sites.png (AA BP:199)

MAPRE1_KMT2A_1205_violinplot.png (AA BP:199)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

MAPRE1_KMT2A_1204.png

MAPRE1_KMT2A_1205.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
1204	1.034	466	1.066	2000.719	0.5608	0.7184	0.9398	0.837	0.9358	0.8944	0.8722	Chain A: 1472,1473,1474,1475,1476,1477,1478,1679,1 680,1681,1682,1683,1685,1686,1687,1690,1691,2603,2 604,2605,2606,2607,2609,2610,2612,2613,2614,2615,2 616,2617,2618,2619,2620,2621,2623,2660,2661,2664,2 665,2666,2668,2669,2670,2671,2672,2675,2676,2677,2 678,2683,2693,2694,2695,2696,2705,2706,2709,2713,2 716,2717,2718,2719,2720,2721,2722,2723,2729,2734,2 735,2736,2737,2738,2739,2740,2741,2742,2743,2744,2 765,2779,2780,2781,2782,2783,2784,2792,2793,2794,2 795,2805,2806
1205	1.0223	290	1.0436	614.313	0.5397	0.7231	0.9187	0.4559	1.0131	0.45	0.6901	Chain A: 266,267,268,269,277,278,279,280,281,282,2 84,700,701,702,703,704,705,706,707,708,709,711,716 ,717,718,719,720,721,722,727,740,775,778,795,797,7 98,801,894,904,1135,1136,1138,1139,1140,1141,1142, 1143

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
KMT2A	PPIE, PPP1R15A, KMT2A, ASH2L, HCFC1, HCFC2, MEN1, RBBP5, WDR5, AVP, INS, OXT, MAP3K5, HDAC1, CTBP1, CBX4, BMI1, CREBBP, SMARCB1, CXXC1, MYB, CTNNB1, SNW1, E2F2, E2F4, E2F6, PSIP1, MLLT4, POLR2A, KAT8, RNF2, TP53, tat, SBF1, MTM1, SET, HIST1H3A, HIST1H4A, KAT6A, ELL, AFF1, AFF4, CDK9, CCNT1, CTR9, LEO1, PAF1, CDC73, WDR61, MLLT3, DOT1L, SKP2, HIST3H3, SVIL, HIST2H3C, SIN3A, MLLT1, RUNX1, CBFB, H3F3A, SIRT7, ASB2, TCEB1, TCEB2, CBX8, TOP1, TAF6, NCL, HECW2, LGR4, CSNK2A2, SENP3, SYMPK, PKN1, PIH1D1, KRAS, TAF1, CHD3, SMARCA2, SMARCC2, SMARCC1, HDAC2, RBBP4, RBBP7, TBP, MBD3, SAP30, RAN, TAF9, TASP1, HIST1H2BG, EWSR1, DYNLT1, KIF11, ING4, Cbx1, Set, ZNF131, ASB7, AR, CSNK2A1, OGT, BRD4, KDM5B, KDM5D, KDM6B, CKS1B, CKS2, CHD4, ESR2, AGR2, EZH2, FBXW7, SOX2, MED17, WDR82, ACTR8, GEMIN5, RUVBL1, MCM2, RTF1, MED15, MED8, MRGBP, MED14, HIST1H2BB, HIST1H2AB, KIAA1429, SP1, MYC, NR2C2, IRF2, PLEKHA4, DPY30, PTEN, NPM1, RPL13, CCT6A, TMCO1, ITGB1, ESR1, MYCN, SUPT5H, CIT, Pik3r2, FASN, LDLR, CDC27, KMT2B, SETD1A, KDM6A, KANSL2, BUB3, SETD1B, KANSL1, RERE, MCRS1, KMT2C, ZZZ3, MBIP, YEATS2, PAXIP1, KANSL3, KMT2D, BOD1L1, CSRP2BP, ZNF608, ATN1, PHF20L1, PHF20, NCOA6, TADA3, APEX1, ASF1A, CBX3, CD3EAP, CENPA, NUP50, POLR1E, TERF2IP, ZNF330, NAA40, PRKRA, SRSF4, KRR1, RPL13A, ABT1, CSNK2B, OASL, SRSF5, SRSF6, RPS9, FGFBP1, RPLP0, RPL36, KAL1, RPL3, PML, ELF1, ELF2, FEV, NHLH1, EN1, KLF12, KLF3, NFIX, NFYC, YY1, BRD3,
MAPRE1	APC, TERF1, COPS5, COPS8, CSN3, COPS7A, HDAC6, LRP1, APP, CDK2, AURKA, AURKB, TUBB, SPTAN1, FN1, VCAM1, IQCB1, ITGA4, CLIP1, TUBA1A, BAG3, LOC100158003, TUBB2A, CDK5RAP2, OLA1, SNRPD2, SNRPE, SNRPF, TBCB, YWHAZ, PAFAH1B1, PRKACA, PRKACB, STIM1, NAV1, NAV2, NAV3, TRIO, LMO2, POLE2, PSMA1, PDE4DIP, TROAP, PQBP1, MAPRE2, MAPRE1, MAPRE3, SPDYE2, CYLD, IKBKG, HSPA1A, TRAF2, ABCB1, STK11, BCL3, KAT2B, KAT5, MTUS2, KIF2C, MACF1, CLASP1, CLASP2, NUPR1, ABCE1, GAS2L1, DST, PPP1R13L, AKAP9, KIF18B, UNK, IPL1, CKAP5, SUMO3, UCHL3, NTRK1, EWSR1, SRPK2, CEP135, CEP290, LCA5, OFD1, CEP170, CEP104, DCTN1, CEP19, ACTN4, ACTN1, ADD1, ADD3, BLMH, CALM1, CALML3, CAPZA1, CD59, CLTA, CLTB, CLTC, CPM, CTNNA1, CTNNB1, DAB2, DBN1, DYNC1H1, DYNC1I2, EPS15, FLNA, FYN, GNAI2, HSP90AB1, ABLIM1, MYO1E, PCM1, PCNT, PLEC, PRKAR2A, QARS, SPTBN1, SSFA2, SVIL, TMOD1, TPM4, CLIP2, YES1, LUZP1, AXIN1, SORBS2, TAOK2, CEP350, SEC16A, WDR1, ACTR1A, PIBF1, DCTN2, SPAG5, RAB35, FGFR1OP, SYNPO, CEP162, CEP131, ERC1, COBL, LIMA1, SYBU, CEP72, MIB1, AFAP1, HYI, DYNLRB1, CCDC77, KNSTRN, NEXN, SPECC1, TBC1D31, SSX2IP, MISP, CD109, WDR90, TPRN, Prkacb, Prkar2a, U2AF2, CDH1, KLHL21, PRKAR2B, HSPA5, PSMB1, TANC2, PPP1CA, IFT52, G3BP1, SLAIN1, GTSE1, PRPF3, CASK, UBE2M, MB21D1, GPC1, ARHGEF2, KIAA1217, CD2AP, FAM83H, NDE1, CAMK2G, PKP3, JUP, CTTN, SEPT9, SLAIN2, TPT1, MAPT, SRC, BICD2, BIRC3, EP300, LRRK2, PAX6, MEOX2, KLHL12, MARCH7, ZNF653, SPDYE2B, CCSER1, C20orf202, GAS2L2, PLEKHA4, N, ORF3a, ENG, SHOC2, CDC42, BRD4, Apc2, HSPA12B, DNAJB5, DNAJC2, DNAJC6, CAMSAP2, COX8A, GOLGA1, KRT8, ARHGAP21, ARHGEF16, CAMSAP1, CAMSAP3, CBL, CCSER2, CEP170B, CKAP2, CKAP2L, DIAPH3, DIP2B, DNMBP, EIF4G2, EIF4H, EML4, HMMR, KIAA1191, KIF14, KIF1B, KIF2A, MAP1S, MAP2, MAP7, MAP7D1, MAP7D2, MAP7D3, MAP9, MAST4, NCKAP5L, PATL1, PEBP1, PLEKHA5, PPP1R13B, PRRC2A, PRRC2B, PSRC1, SH3D19, SKA3, TACC1, TACC2, TDRD3, TMEM131, TRIM36, TTBK2, UFD1L, ZC2HC1A, ALMS1, ANKRD26, ARHGAP17, C1orf198, CDKAL1, DCTN4, DLG5, DLGAP5, KIF11, LMO7, LPP, LSM14A, MAVS, MTUS1, NEK4, PABPC1, PLK1, RAPH1, SMARCE1, SND1, SYNJ2, TACC3, TANC1, VASP, VIM, WDR5, TTBK1, FCHO1, NBR1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
MAPRE1
KMT2A

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	MAPRE1	chr20:31427663	chr11:118354896	ENST00000375571	+	5	7	185_268	199.0	269.0	CDK5RAP2
Hgene	MAPRE1	chr20:31427663	chr11:118354896	ENST00000375571	+	5	7	124_268	199.0	269.0	MTUS2/TIP150

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Related Drugs to MAPRE1-KMT2A

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to MAPRE1-KMT2A

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	MAPRE1	C0043094	Weight Gain	1	CTD_human
Hgene	MAPRE1	C0151744	Myocardial Ischemia	1	CTD_human
Tgene	KMT2A	C2826025	Mixed phenotype acute leukemia	3	ORPHANET
Tgene	KMT2A	C0023418	leukemia	2	CTD_human
Tgene	KMT2A	C0023452	Childhood Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023453	L2 Acute Lymphoblastic Leukemia	2	CTD_human
Tgene	KMT2A	C0023466	Leukemia, Monocytic, Chronic	2	CTD_human
Tgene	KMT2A	C0023467	Leukemia, Myelocytic, Acute	2	CTD_human
Tgene	KMT2A	C0023470	Myeloid Leukemia	2	CTD_human
Tgene	KMT2A	C0026998	Acute Myeloid Leukemia, M1	2	CTD_human
Tgene	KMT2A	C1854630	Growth Deficiency and Mental Retardation with Facial Dysmorphism	2	CTD_human;GENOMICS_ENGLAND;ORPHANET
Tgene	KMT2A	C1879321	Acute Myeloid Leukemia (AML-M2)	2	CTD_human
Tgene	KMT2A	C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	2	CTD_human
Tgene	KMT2A	C0001418	Adenocarcinoma	1	CTD_human
Tgene	KMT2A	C0004403	Autosome Abnormalities	1	CTD_human
Tgene	KMT2A	C0005684	Malignant neoplasm of urinary bladder	1	CTD_human
Tgene	KMT2A	C0005695	Bladder Neoplasm	1	CTD_human
Tgene	KMT2A	C0007138	Carcinoma, Transitional Cell	1	CTD_human
Tgene	KMT2A	C0008625	Chromosome Aberrations	1	CTD_human
Tgene	KMT2A	C0023448	Lymphoid leukemia	1	CTD_human
Tgene	KMT2A	C0023465	Acute monocytic leukemia	1	CTD_human
Tgene	KMT2A	C0023479	Acute myelomonocytic leukemia	1	CTD_human
Tgene	KMT2A	C0024623	Malignant neoplasm of stomach	1	CTD_human
Tgene	KMT2A	C0033578	Prostatic Neoplasms	1	CTD_human
Tgene	KMT2A	C0036341	Schizophrenia	1	PSYGENET
Tgene	KMT2A	C0038356	Stomach Neoplasms	1	CTD_human
Tgene	KMT2A	C0149925	Small cell carcinoma of lung	1	CTD_human
Tgene	KMT2A	C0205641	Adenocarcinoma, Basal Cell	1	CTD_human
Tgene	KMT2A	C0205642	Adenocarcinoma, Oxyphilic	1	CTD_human
Tgene	KMT2A	C0205643	Carcinoma, Cribriform	1	CTD_human
Tgene	KMT2A	C0205644	Carcinoma, Granular Cell	1	CTD_human
Tgene	KMT2A	C0205645	Adenocarcinoma, Tubular	1	CTD_human
Tgene	KMT2A	C0270972	Cornelia De Lange Syndrome	1	ORPHANET
Tgene	KMT2A	C0280141	Acute Undifferentiated Leukemia	1	ORPHANET
Tgene	KMT2A	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene	KMT2A	C0856823	Undifferentiated type acute leukemia	1	ORPHANET
Tgene	KMT2A	C1535926	Neurodevelopmental Disorders	1	CTD_human
Tgene	KMT2A	C1708349	Hereditary Diffuse Gastric Cancer	1	CTD_human
Tgene	KMT2A	C2239176	Liver carcinoma	1	CTD_human
Tgene	KMT2A	C2930974	Acute erythroleukemia	1	CTD_human
Tgene	KMT2A	C2930975	Acute erythroleukemia - M6a subtype	1	CTD_human
Tgene	KMT2A	C2930976	Acute myeloid leukemia FAB-M6	1	CTD_human
Tgene	KMT2A	C2930977	Acute erythroleukemia - M6b subtype	1	CTD_human